34	4126706	16689796	2007-08-25 13:34	Data demonstrate that MrpC binds to at least eight sites in the upstream region of its promoter, and suggest a mechanism by which MrpC and FruA are regulated during the M. xanthus life cycle [MrpC]
34	4126706	17573816	2007-10-27 11:27	FrzS contains a novel 'pseudo-receiver domain' whose function requires recognition of the RD output face but not Asp phosphorylation.
34	4126706	17581122	2007-10-20 10:20	These experiments showed that FrzZ plays a direct role as an output of the Frz chemosensory pathway and that both CheY domains of FrzZ are functional. [FrzZ]
34	4126706	17590236	2007-10-27 10:14	FrzS has distinct domains required for residence at the leading cell pole, pole-to-pole transport and lagging cell pole.
34	4126706	18310035	2008-05-03 10:57	These results, together with the finding that CarF is located at the membrane, support the hypothesis that CarF acts as an anti-antisigma factor.[CarF in strain DK1050]
34	4126706	18315685	2008-04-05 12:04	findings reveal that light-induced carotenogenesis in M. xanthus is regulated by at least two parallel pathways orchestrated by a pair of paralogous genes, CarA and CarH, of which one, but not the other, is dependent on vitamin B12 [CarA, CarH]
34	4126706	18390653	2008-09-06 10:05	Results show that EspA plays a key role in the timing of expression of genes necessary for progression of cells through the developmental program: [EspA]
56	5814795	18355448	2008-05-17 10:24	The results indicate that the rRNA methyltransferase (Kmr) in Sorangium strains is a new member of the rRNA methyltransferases family.(Kmr)
139	2827859	15501399	2007-08-25 11:21	T cell recognition of the OspA epitope is important in the induction of autoimmunity in treatment-resistant Lyme arthritis [outer-surface protein A : Ospa]
139	2827859	15501774	2007-08-25 21:06	RpoS appears to serve as a stress-responsive activator of a subset of virulence determinants that, together with the RpoS-independent, differentially expressed regulon, encompass its genetic programs required for mammalian host adaptation. [RpoS]
139	2827859	15585873	2007-08-25 21:19	Site-directed mutagenesis of three putative coiled coil motifs of OspE reveals that these higher order structures of OspE are required for human factor H binding but not for infection-induced antibody binding. (outer surface protein E; OspE)
139	2827859	15917226	2007-08-25 10:58	ResT requires interprotomer communication to activate reaction chemistry. Unlike the tyrosine recombinases, however, the cleavage and strand transfer reactions on the two sides of the replicated telomere occur nearly simultaneously(ResT)
139	2827859	16041012	2007-08-25 21:04	rel-dependent accumulation of (p)ppGpp may be important for in vivo survival (rel protein)
139	2827859	16267308	2007-08-25 12:35	RpoS is required for the in vivo-specific repression of at least two RpoD-dependent B. burgdorferi loci, ospA and lp6.6 [RpoS]
139	2827859	16299277	2007-08-25 12:35	Previously uncharacterized epitopes that define the type specificity of the OspC antibody response were identified.(OspC)
139	2827859	16530476	2007-08-25 15:04	analysis of BbCRASP-1 indicates that its protein topology apparently evolved to provide a high affinity interaction site for complement factor H /FHL-1 and leads to an atomic-level hypothesis for the functioning of BbCRASP-1 [BbCRASP-1]
139	2827859	16530477	2007-08-25 15:04	propose that the main function of B. burgdorferi LuxS is to synthesize 4,5-dihydroxy-2,3-pentanedione (DPD) and that the Lyme disease spirochete utilizes a form of DPD as a pheromone to control gene expression [LuxS]
139	2827859	16553889	2007-08-25 14:11	P(ospF)-10 region is both necessary and sufficient for RpoS-dependent recognition in B. burgdorferi. (RpoS) (ospF)
139	2827859	16823038	2007-08-25 21:17	crystallization of OspA using rational surface engineering, which resulted in a 1.15 A resolution crystal structure; high-resolution structure revealed several features [OspA]
139	2827859	16926410	2007-08-25 13:30	Spirochetes with constitutive ospC expression were unable to establish chronic infections in immunocompetent mice. (ospC) (Strain B31 5A13)
139	2827859	17158906	2007-08-25 14:02	Borrelia burgdorferi uses OspC to resist innate host defenses immediately after transmission. (OspC)
139	2827859	17244195	2007-10-27 10:35	study solves the crystal structure of an Hbb-DNA complex in which the DNA is bent by over 180 degrees [Hbb]
139	2827859	17294937	2008-08-30 10:14	a clonal population of spirochetes was followed through a tick transmission cycle and showed that unlike in vertebrates, the vlsE locus is stable in ticks
139	2827859	17590233	2007-10-27 10:14	A model for regulation of rpoS has been proposed which provides mechanisms for multiple signalling pathways to modulate the expression of the sigma(S) regulon in B. burgdorferi.(rpoS)
139	2827859	17645733	2008-05-24 10:27	Data suggest that RpoS acts as a gatekeeper for the reciprocal regulation of genes involved in the establishment of infection within the mammalian host and the maintenance of spirochetes within the arthropod vector.
139	2827859	17714442	2007-12-08 12:43	Data are also presented that cast doubt on an immune evasion mechanism whereby VlsE directly masks other surface antigens similar to what has been observed for several other pathogens that undergo recombinational antigenic variation.[VlsE]
139	2827859	17947711	2007-12-08 10:16	majority of patients with Lyme arthritis initially have increased frequencies of OspA(161-175)-specific T cells[ OspA]
139	2827859	18697933	2008-09-20 10:49	crowding-induced shape changes may be important for protein function and malfunction in vivo[VlsE protein]
158	2827861	15664975	2007-08-25 13:12	Strains with mutations in either the prcA-prtP or the msp region showed altered expression of the other locus.  (msp = major outer sheath protein)
158	2827861	17101650	2007-08-25 13:28	The gene encoding the Treponema denticola factor H-like protein 1 (FHL-1) binding protein, FhbB, was recovered and characterized [FhbB]
158	2827861	17868382	2008-03-10 13:40	Msp inhibits the polarized accumulation of activated Rac and PI3-kinase products upon exposure to formyl-methionyl-leucyl-phenylalanine (fMLP).  [major outer sheath protein (Msp)]
160	2827863	15328557	2007-08-25 15:08	results demonstrated the existence for a superoxide-mediated electron transfer between rubredoxin and neelaredoxin and confirmed the physiological character of this electron transfer reaction [rubredoxin & neelaredoxin]
160	2827863	15489229	2007-08-25 14:38	the 32-kilodalton lipoprotein (Tp32) of Treponema pallidum is an L-methionine-binding protein [Tp32]
160	2827863	16109950	2007-08-25 13:04	presence of G homopolymeric repeats of variable lengths upstream of the tprF, tprI, tprG, and tprJ transcriptional start sites (tprF)
160	2827863	16239550	2007-08-25 11:59	interaction of T. pallidum adhesin Tp0751 with laminin, an association that is proposed to facilitate bacterial traversal of basement membranes and subsequent entry into the circulation and tissue invasion [adhesin Tp0751]
160	2827863	16345079	2007-08-25 13:02	Determination of TpF1 crystal structure (TpF1 antigen)
160	2827863	16511209	2007-08-25 10:53	crystallization and structure determination of Superoxide reductase from the syphilis spirochete Treponema pallidum
160	2827863	16791639	2007-08-25 10:14	The crystal structure of Treponema pallidum (Tp)superoxide reductase (SOR) was determined using soft X-rays and synchrotron radiation.(SOR)
160	2827863	17581125	2007-10-20 10:20	Our findings indicate that T. pallidum procures transition metals via the concerted utilization of its general metal (Tro) and Zn(2+) (Znu) transporters. [TroA, ZnuA]
173	2827865	15994324	2007-08-25 21:22	lmtA is a Leptospira interrogans enzyme with similarity to yeast Ste14p that methylates the 1-phosphate group of lipid A [lmtA]
173	2827865	16239521	2007-08-25 10:21	isolation and characterization of the immunopathogenic proteins LruA and LruB in Leptospira interrogans strains are reported[LruA; LruB]
173	2827865	16427313	2007-08-25 13:37	The CbiC crystal structures have been solved in two crystal forms (P4(2)2(1)2 and P3(1)21) diffracting to 3.0 and 2.3A resolution, respectively (CbiC).
173	2827865	17142914	2007-08-25 10:45	crystal belonged to space group C2, with unit-cell parameters a=293.5, b=125.6, c=87.6 A, beta=100.9 degrees. V(M) is calculated to be 2.4 A3 Da(-1), assuming there to be 12 protein molecules in the asymmetric unit[2-dehydro-3-deoxygalactarate aldolase]
173	2827865	17561415	2007-12-22 12:02	The crystal structure of LiOMT in complex with S-adenosylhomocysteine reported here is the first bacterial protein structure in this family.(SAM-dependent O-methyltransferase )
173	2827865	17630832	2008-05-10 10:28	Loa22 was expressed during host infection and is necessary for virulence of L. interrogans in the animal model.
173	2827865	17927957	2007-12-08 12:50	structure fold belongs to alpha/beta hydrolase superfamily with the characteristic 'catalytic triad' residues in the active site[homoserine O-acetyltransferase]
173	2827865	17956423	2008-01-12 11:59	The LIC10365 activated endothelium in such a manner that E-selectin and intercellular adhesion molecule 1 (ICAM-1) became upregulated in a dose-dependent fashion.[LIC10365]
173	2827865	18285490	2008-05-10 10:13	These studies show that LipL32 and an orthologous protein in P. tunicata are immunologically cross-reactive and function as ECM-interacting proteins via a conserved C-terminal region.[LipL32 in Leptospira interrogans serovar Manilae]
195	3204980	17510271	2007-08-25 12:20	In C. jejuni, tet(O) was plasmid-encoded in 54 % of tetracycline-resistant isolates, whereas in C. coli, tet(O) appeared to be located on the chromosome.
195	3293152	17419285	2007-08-25 10:41	RT-PCR showed unequal amounts of mRNA, indicating differential post-transcriptional processing of cjaA and cjaB mRNA possibly related to the presence of inverted repeats in the intergenic region [cjaA and cjaB from C. coli]
197	3979052	16367742	2007-08-25 21:12	detailed comparison of the quinol:fumarate reductase enzymes from C. jejuni and H. pylori with that of W. succinogenes [QFR]
197	3979052	16618123	2007-08-25 11:55	in vitro characterization of PglC as a bacillosamine 1-phosphoryl transferase provides direct evidence for the early steps in the C. jejuni N-linked glycosylation pathway [PglC]
197	3979052	16728396	2007-08-25 12:30	analysis of PseG of pseudaminic acid biosynthesis [PseG]
197	3979052	17166222	2007-08-25 15:03	results showed that the point mutation was responsible, via a lack of binding of the CmeR repressor, for increased expression of the CmeABC efflux pump and consecutive multidrug resistance [CmeR]
197	3979052	17510271	2007-08-25 12:20	In C. jejuni, tet(O) was plasmid-encoded in 54 % of tetracycline-resistant isolates, whereas in C. coli, tet(O) appeared to be located on the chromosome.[tet(O)protein]
197	3979052	17631632	2007-10-20 11:55	Analyses of transformation frequencies and glycosylation statuses of N-glycosylated proteins indicated partial suppression of pglF by pseC.[ pglF, pseC]
197	3979052	17686491	2007-11-10 12:44	The crystal structure of CmeR to 2.2 A resolution, revealed a dimeric two-domain molecule with an entirely helical architecture similar to members of the TetR family of transcriptional regulators.[CmerR]
197	3979052	17766267	2008-02-23 12:43	beta 1,3-galactosyltransferase CgtB variants from the bacterium Campylobacter jejuni have distinct acceptor specificities [CgtB]
197	3979052	17827292	2008-01-19 12:04	The C. jejuni ppk1 mutant was also defective for the virulence-associated phenotype of intraepithelial cell survival in a tissue culture infection model and exhibited a striking, dose-dependent chick colonization defect [polyphosphate kinase 1]
197	3979052	18284594	2008-05-24 10:05	Strain 81-176 demonstrated GADH activity, converting d-gluconate to 2-keto-d-gluconate, that was higher at 42 degrees C than at 37 degrees C. In contrast, cj0414 and cj0415 mutants lacked GADH activity.[cj0414 and cj0415 in strain 81-176]
197	3979052	18287287	2008-04-05 10:18	The results demonstrate that cytolethal distendin toxin CDT(+) C. jejuni strains adhere to and invade epithelial cells more efficiently than CDT(-) strains. CDT is responsible for intestinal pathology and the colon is the major target. [DT]
197	3979052	18323612	2008-05-03 10:27	Diffraction data have been collected from these crystal forms to 2.5 and 2.95 A resolution, respectively[ stationary-phase survival E]
197	3979052	18540372	2008-08-02 10:35	C. jejuni strains carrying a sialyltransferase gene (cst-II), which is essential for the biosynthesis of ganglioside-like lipooligosaccharides, are associated with the development of Guillain-Barre syndrome
197	3979052	18631239	2008-09-27 10:43	CetA has two transmembrane helices in a helical hairpin while CetB is a peripheral membrane protein tightly associated with the membrane. [CetA, CetB]
210	2827869	15113832	2007-08-25 12:53	The three-dimensional structure of H. pylori ACP and its structural characteristics were clarified using NMR and CD spectroscopy [Acyl carrier protein]
210	2827869	15133867	2007-08-25 11:14	Data suggest that VacA is a crucial element for Helicobacter pylori to escape from host immune defense by means of differentially regulating the expression of some related genes [vacA strain 11638]
210	2827869	15255779	2007-08-25 21:25	HU from the human pathogen Helicobacter pylori, which has been implicated in the development of ulcers and gastric cancer, exhibits enhanced thermal stability and distinct DNA substrate specificity [HU]
210	2827869	15272173	2007-08-25 13:46	crystal structure of UDP-glucose pyrophosphorylase [GalU]
210	2827869	15502329	2007-08-25 14:50	crystal structure of Spermidine Synthase [Spermidine Synthase]
210	2827869	15516585	2007-08-25 11:33	identified HP1523 as a homolog of RecG that influences recombination frequencies and demonstrate its importance in maintaining genomic integrity by limiting recombination events but is not involved in DNA repair [HP1523 strain JP26]
210	2827869	15583145	2007-08-25 14:50	interaction of HSP60 with TLR (toll-like receptors)in gastric epithelial cells contributes to development of gastic inflammation of H. pylori infection. [HSP60]
210	2827869	15629722	2007-08-25 14:44	is not involved in mismatch repair but inhibits homologous and homeologous recombination (MutS2)
210	2827869	15629943	2007-08-25 13:10	results demonstrate that periplasmic carbonic anhydrase is essential for survival of H. pylori in an acid environment studied in vitro [alpha-CA strain ATCC43504]
210	2827869	15667999	2007-08-25 14:16	results are consistent with an essential role of polyphosphate kinase (PPK) during the initial steps of colonisation of the mouse gastric mucosa and confirm that PPK may act on the virulence of H. pylori partly through an energy dependent mechanism [PPK]
210	2827869	15689619	2007-08-25 12:06	the sialic acid-binding SabA adhesin is a prerequisite for the nonopsonic activation of human neutrophils [SabA]
210	2827869	15695680	2007-08-25 21:24	a more active East Asian form of CagA with three tyrosine phosphorylation sites may underlie the high rate of gastric cancer in China. [CagA]
210	2827869	15764702	2007-08-25 13:40	crystal structure (ComB10)
210	2827869	15795230	2007-08-25 11:31	results point to the identification of a third distinct isoform of Pantothenate kinase (PanK) that accounts for the only known activity of the enzyme in pathogens such as Helicobacter pylori [PnaK]
210	2827869	15866208	2007-08-25 15:01	interacts with fibronectin and alters HeLa cell adhesion and cytoskeletal organization in vitro [VacA]
210	2827869	15942008	2007-08-25 11:20	cloning, genetic analysis and biochemical characterization of a leucyl aminopeptidase [eucyl amimnopeptidase]
210	2827869	16000239	2007-08-25 11:26	HP-NAP contributes to the continuous recruitment of neutrophils to the gastric mucosa of H. pylori infected individuals [HP-NAP (Helicobacer pylori neutrophil activating protein)]
210	2827869	16096320	2007-08-25 10:56	The global distribution of TEM-1 and ROB-1 beta-lactamases in Haemophilus influenzae isolated from patients with community-acquired respiratory tract infection during the first 4 years of the PROTEKT study (1999-2003) is reported.[TEM-1; ROB-1]
210	2827869	16104949	2007-08-25 10:21	VacA is associated with increased thrombin generation in gastric mucosa of patietns with gastroduodenal disorders infected with H. pylori [VacA]
210	2827869	16177315	2007-08-25 21:14	There are binding sites for ArsR within ureI promoter.(ureI) There are binding sites for ArsR within ureA promoter.(ureA) ArsR binding site of the ureA promoter demonstrates its role in acid-dependent activation of the promoter.(ArsR)
210	2827869	16182250	2007-08-25 15:04	The vacuolating activity of VacA is due mainly to the free-soluble form rather than the outer membrane vesicle-associated form of VacA.
210	2827869	16237435	2007-08-25 11:25	studies indicate that the ClpX power stroke is generated by ATP hydrolysis in a single subunit, rule out concerted and strict sequential ATP hydrolysis models, and provide evidence for a probabilistic sequence of nucleotide hydrolysis [clpX]
210	2827869	16240218	2007-08-25 14:14	The distribution of H. pylori vacA and cagA genotypes and their association with clinical outcomes in Iran are reported.[vacA; cagA]
210	2827869	16267295	2007-08-25 21:03	identified operators for NikR to which it binds with different affinities in a metal-responsive way; established a direct role for NikR as a positive regulator of transcription [NikR]
210	2827869	16354697	2007-08-25 13:37	Inhibition of focal adhesion kinase by SHP-2 plays a crucial role in the morphogenetic activity of Helicobacter pylori CagA.
210	2827869	16413022	2007-08-25 11:19	Results describe the cloning, characterization and enzymatic inhibition of a new malonyl-CoA:acyl carrier protein transacylase (MCAT) from Helicobacter pylori [MCAT].
210	2827869	16419067	2007-08-25 12:58	Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori [Hp-QAPRTase]
210	2827869	16428735	2007-08-25 14:12	essential for the colonization of H. pylori in mice [HpaA]
210	2827869	16428763	2007-08-25 14:12	binds directly to CD74 expressed on gastric epithelial cells and induces NF-kappaB activation and interleukin-8 (IL-8) production, and may contribute to the proinflammatory immune response seen during infection.
210	2827869	16481626	2007-08-25 10:54	This study revealed that AhpC of H. pylori acts as a peroxide reductase in reducing organic hydroperoxides and as a molecular chaperone for prevention of protein misfolding under oxidative stress.(AhpC)
210	2827869	16543403	2007-08-25 14:10	a role for urease and urease-derived ammonia in megasome formation and Helicobacter pylori survival [Urease]
210	2827869	16545604	2007-08-25 12:32	role of DsbI protein in Helicobacter pylori pathogenesis; demonstrated that a dsbI mutant impaired in disulfide bond formation revealed a greatly reduced ability to colonize mice gastric mucosa [DsbI]
210	2827869	16622049	2007-08-25 14:10	Although less VacA was observed for the cysteine mutants, vacuolating activity was detected, showing that the cysteines were not required for VacA function. [VacA]
210	2827869	16872629	2007-08-25 12:28	Altogether, Ni-free and Ni-bound structures have allowed determination of the route for nickel within HpNikR and reveal the cooperativity between the tetramerization domain and the DNA-binding domain. [NikR protein]
210	2827869	16879644	2007-08-25 10:13	The results suggest that HP0170 is a remote homologue of E. coli CheZ, and that CheZ homologues are found in a broader range of bacteria than previously supposed.[HP0170]
210	2827869	16882332	2007-08-25 21:26	XGPRTase is structurally similar to other phosphoribosyltransferase enzymes, but there were significant differences between the hood domain of H. pylori XGPRTase and other purine salvage phosphoribosyltransferases[XGPRTase]
210	2827869	16885452	2007-08-25 13:31	The activity of methionine sulfoxide reductase (Msr) in the repair of methionine-rich proteins under oxidative stress conditions is reported.[Msr]
210	2827869	16936028	2007-08-25 12:28	Besides its capacity to complement E. coli mutY strains, HP0142 expression resulted in a strong adenine DNA glycosylase activity. Disruption of HP1526 confirmed that this gene is responsible for the AP endonuclease activity. [HP0142 and HP1526]
210	2827869	16951684	2007-08-25 12:28	We identify the gene hp0421 as encoding the enzyme cholesterol-alpha-glucosyltransferase responsible for cholesterol glucosylation [hp0421]
210	2827869	16953176	2007-08-25 10:12	Study found no relationships between iceA genotypes and functional dyspepsia or duodenal ulcer, nor between clarithromycin resistance and iceA genotypes [Icea]
210	2827869	16961808	2007-08-25 21:17	Translocated CagA undergoes tyrosine phosphorylation in gastric adenocarcinoma cell line cells, and CagA involves disruption of cellular apical-junction complex in Madin-Darby canine kidney cells (CagA)
210	2827869	16997572	2007-08-25 12:27	we analyzed the amino acid sequence of HrcA that predicted association of this protein to the inner membrane, which was experimentally verified. The functionality of the purified protein was then confirmed with an in vitro DNA-binding assay.[HrcA]
210	2827869	17000720	2007-08-25 10:12	Bacterium-containing vacuoles originate through the fusion of late endocytic organelles; this process is mediated by the VacA-dependent retention of the small GTPase Rab7.
210	2827869	17021670	2007-08-25 12:26	The prevalence of cytotoxin-associated gene A positivity was significantly higher in Behcet's disease compared to the controls [cagA]
210	2827869	17030583	2007-08-25 21:02	In AZ-521 cells, which mainly express RPTPbeta, VacA, after binding to RPTPbeta in non-lipid raft microdomains on the cell surface, is localized with RPTPbeta in lipid rafts in a temperature- and VacA concentration-dependent process. (VacA)
210	2827869	17045509	2007-08-25 12:26	hp0015 is associated with adhesion, and hp0015, hp0016, and hp0017 are associated with natural transformation. Hp0017 has been named as virB4/comB4. Therefore, hp0015 and hp0016 are named as comB2 and comB3, respectively.[virB4, comB2, comB3]
210	2827869	17054063	2007-08-25 21:17	An in-frame hopH gene may be linked to gastroduodenal diseases because of association with other virulence factors or increased bacterial adherence & colonization; linkage with cagA indicates HopH may contribute to fitness of cagA-positive strains [HopH]
210	2827869	17077963	2008-04-12 13:10	Results describe the purification of branched-chain amino acid aminotransferase (BCAT) from Helicobacter pylori NCTC 11637.  [BCAT]
210	2827869	17144677	2007-08-25 12:25	structure-function relationships of residues in the fifth transmembrane domain (TM5) of the Na+/H+ antiporter A (NhaA) from Helicobacter pylori [Na+/H+ antiporter]
210	2827869	17199266	2007-08-25 14:03	Zn site in HypA rearranges upon coordination of a second metal ion.
210	2827869	17237808	2007-08-25 13:26	These results indicate that perturbation of the E-cadherin/beta-catenin complex by H. pylori CagA plays an important role in the development of intestinal metaplasia.
210	2827869	17244794	2007-08-25 13:25	results suggest that ERK and p38 MAPK signalling linked to the TLR2 recognition receptor in human monocytes may be an important pathway in H. pylori-HSP60-induced IL-8 secretion [HSP-60]
210	2827869	17253977	2007-12-15 12:01	Study found that VacA enhances the v-ATPase proton pump activity and the acidification of isolated endosomes in a chloride- dependent manner.[VacA protein]
210	2827869	17307742	2007-08-25 13:25	Helicobacter pylori formamidase AmiF has a cysteine-glutamate-lysine catalytic triad, as shown by crystallographic analysis
210	2827869	17329242	2007-08-25 13:25	GatCAB is equally efficient in glutamine-dependent transamidation of Asp-tRNAAsn and Glu-tRNAGln [GatCAB]
210	2827869	17371778	2007-08-25 12:21	The H.pylori neutrophil-activating protein is able to bind and condense DNA by a mechanism different from that described for E.coli Dps (neutrophil-activating protein).
210	2827869	17373705	2007-08-25 14:00	determined the solution structure of HP0495 [HP0495 ]
210	2827869	17416665	2007-09-08 12:36	study demonstrated that FolP is also a dihydropteroate reductase that derives its reducing power from soluble flavins, reduced FMN and reduced flavin adenine dinucleotide [FolP]
210	2827869	17428306	2007-08-25 13:24	Study identified Crk adapter proteins, Rac1 and H-Ras, but not RhoA or Cdc42 as crucial components of the CagA-induced phenotype.
210	2827869	17438024	2007-08-25 13:23	High levels of diversity of activity of CagA H. pylori strains in gastric epithelial cells and its association with polymorphism in CagA gene. [CagA]
210	2827869	17452475	2007-08-25 10:42	These results suggest that NF-kappaB and IKK signals via Ca(2+) influx and mitochondrial ROI play a role in the up-regulation of chemokine expression in eosinophils stimulated with H. pylori VacA. [VacA
210	2827869	17464061	2007-12-01 10:13	These results suggest that interactions between the nickel-binding accessory proteins HypA and UreE are required to allow nickel transfer from HypA eventually to the apourease in H. pylori.[HypA, UreE]
210	2827869	17484877	2007-08-25 10:05	Gamma-glutamyl transpeptidase is a novel immunosuppressive factor of H pylori inhibiting T-cell proliferation by induction of a cell cycle arrest in the G(1) phase [gamma glytamyltranspeptidase]
210	2827869	17507984	2007-08-25 21:23	H. pylori CagA specifically interacts with PAR1/MARK kinase, which has an essential role in epithelial cell polarity [cagA]
210	2827869	17548220	2008-04-12 11:16	investigated the prevalence of the vacA, cagA, cagE, iceA, and babA2 genotypes in Helicobacter pylori strains isolated from Thai dyspeptic patients [vacA, cagA, cagE, iceA, babA2]
210	2827869	17589941	2007-08-25 15:01	provides further evidence for a causal role of CagA+ H pylori infection in the immunopathogenesis of gastric cancer [CagA]
210	2827869	17645450	2007-10-27 12:23	HobA, a novel protein essential for initiation of H. pylori chromosome replication, which is conserved among, and unique to, epsilon proteobacteria, is described.[HobA]
210	2827869	17667716	2007-10-20 11:07	the combination of bacterial iceA1 and TNF-alpha 238 G to A polymorphism may be a risk factor for peptic ulcer disease in children infected with Helicobacter pylori [iceA-1]
210	2827869	17683397	2007-10-27 11:26	The structural homology between DiaA and HobA strongly supports their involvement in the replication process and these proteins could define a new structural family of replication regulators in bacteria.[DnaA & HobA]
210	2827869	17693507	2007-12-01 11:31	Comparative transcriptome analysis of the wild-type strain showed 14 of the 29 genes which were found to be positively regulated by HspR or HrcA code for proteins involved in flagellar biosynthesis.[HspR, HrcA]
210	2827869	17760724	2007-11-10 11:55	Diverse CagA and vacA genes are correlated with atrophic gastritis and gastric cancer in Helicobacter infections in Costa Rica. [CagA, VacA]
210	2827869	17786942	2008-01-19 10:52	These results indicate that VacA alone was able to inhibit the G1 to S progression of the cell cycle.[VacA]
210	2827869	17854597	2007-10-27 10:38	the vacA i-region is an important determinant of H pylori toxicity and the best independent marker of VacA-associated pathogenicity {Vac A]
210	2827869	17929881	2007-12-29 10:18	trimeric GatCAB aminoacyl-tRNA amidotransferases catalyze amidation of Asp-tRNAAsn &/or Glu-tRNAGln to Asn-tRNAAsn &/or Gln-tRNAGln, respectively, in bacteria lacking asparaginyl-tRNA synthetase &/or glutaminyl-tRNA synthetase[GatCAB amidotransferase]
210	2827869	17943123	2007-12-01 11:51	CagL interaction with integrin alpha5beta1 triggers CagA delivery into target cells as well as activation of focal adhesion kinase and Src [CagA and CagL]
210	2827869	17951983	2008-01-12 11:10	These results suggest that multiple amino acid substitutions in the transpeptidase region of PBP1 are closely related to amoxicillin resistance in H. pylori. [PBP1]
210	2827869	17960917	2008-01-26 12:52	Structural analysis was combined with site-directed mutagenesis of residues involved in maintaining the conformation of a loop region that covers the gamma-glutamyl binding site of gamma-glutamyltranspeptidase (gamma-glutamyltranspeptidase).
210	2827869	17972918	2007-12-15 11:55	HP1451 acts as an inhibitory factor of HP0525 to regulate Cag-mediated secretion, a suggestion confirmed by results of in vitro ATPase assay and in vivo pull-down experiments [HP1451,HP0525]
210	2827869	17981822	2008-07-12 10:17	Cystathionine gamma-synthase was cloned, expressed and the enzymatic properties with the substrate O-succinyl-l-homoserine were characterized (cystathionine {gamma}-synthase).
210	2827869	17993522	2008-02-16 10:29	The induction of the proinflammatory cytokines by JHP940, therefore, points to its putative role in chronic gastric inflammation and, possibly, the various other outcomes of H. pylori infection, including gastric cancer. [jhp940]
210	2827869	18001398	2008-02-16 11:34	The dupA gene has been identified as a novel virulent marker associated with an increased risk for duodenal ulcer.
210	2827869	18005242	2008-03-22 11:10	We demonstrate that H. pylori causes the recruitment of MARK2 from the cytosol to the plasma membrane, where it colocalizes with the bacteria and interacts with CagA.[CagA in strain G27]
210	2827869	18024122	2008-03-10 16:16	From these studies, we confirmed the principal role of alpha(1,2)-fucosyltransferase (futC) slipped-strand mispairing in Le antigenic variation in vitro and in vivo. [futC]
210	2827869	18031386	2008-03-29 10:22	The results show a high prevalence of functional sabA in Japanese clinical isolates.[sabA]
210	2827869	18067607	2008-08-09 10:18	Infection with oipA mutants reduced phosphorylation of Y397, Y576, Y577, Y861 and Y925, inhibited stress fibre formation and altered cell morphology: [OipA]
210	2827869	18078442	2008-05-03 10:03	Study found that H. pylori possesses numerous Rho-dependent and intrinsic terminators including some found in intragenic regions.[Rho]
210	2827869	18095659	2008-03-10 13:38	A detailed experimental and computational analysis of the thermostability and cofactor binding energetics of H. pylori flavodoxin is performed.[flavodoxin]
210	2827869	18167027	2008-04-19 10:25	These results show that the urease gene region of coccoid H. pylori is highly protected under various mild environmental conditions.[ureA,ureB]
210	2827869	18172719	2008-04-05 13:00	Tip-alpha is rather loosely connected to the inner membrane and potentially released during infection.[tip-alpha protein(hp0596)]
210	2827869	18186650	2008-03-22 12:54	Comparison of substrate binding and catalytic sites of PanK-III with that of eukaryotic PanK-II revealed drastic differences in the binding modes for both ATP and pantothenate substrates[pantothenate kinase III]
210	2827869	18191791	2008-03-10 14:58	Thus, H. pylori co-opts CD18 as a VacA receptor on human T lymphocytes to subvert the host immune response. [VacA]
210	2827869	18192401	2008-02-16 11:35	indicate the importance of CagA tyrosine phosphorylation, which enables CagA to deregulate SHP-2, in the development of H. pylori-associated neoplasms[CagA]
210	2827869	18192681	2008-05-31 10:29	results indicated that pbp-1A point mutations are responsible for amoxicillin resistance [pbp-1A]
210	2827869	18199531	2008-02-16 11:35	loss of CagA prevents development of cancer in gastric carcinogenesis model; OipA expression was detected more frequently among strains isolated from human subjects with gastric cancer precursor lesions versus persons with gastritis alone [CagA, OipA]
210	2827869	18205181	2008-06-07 10:41	observations suggest a possible involvement of HspB in the pathogenesis of H. pylori-related pathologies such as gastritis, ulcer and gastric cance [HspB]
210	2827869	18295231	2008-05-31 10:05	We provide the first insight into the structural basis for CagY(rpt2) assembly that accommodates both the variable motif sequence composition and the extensive contraction/expansion of repeat modules within the CagY(rpt2) region.[CagV]
210	2827869	18362137	2008-07-12 10:06	The participation of vesicle-associated membrane protein 7 as a partner of syntaxin 7 in VacA-induced vacuole formation is reported.[VacA]
210	2827869	18430002	2008-08-02 10:05	Colonization studies with HP0159 mutants of two mouse-colonizing strains, SS1 and M6, confirmed their inability to successfully colonize the murine stomach.[HP0159 in strains SS1 and M6]
210	2827869	18436587	2008-07-12 10:42	The association of dupA with the clinical outcomes and histopathological changes following H. pylori infection was evaluated.[dupA]
210	2827869	18443094	2008-07-12 10:32	These data indicate that the assembly of functional oligomeric VacA complexes is dependent on specific sequences, including amino acids 346 and 347, within the p55 amino-terminal subdomain. [VacA]
210	2827869	18474244	2008-08-09 10:30	For cancer risk, among Western strains, the most important factor is the number of cagA EPIYA-C segment; for peptic ulcer risk, it is the intermediate region type of vacA [caga and vaca]
210	2827869	18475010	2008-07-12 10:32	Daya describe the crystallization and preliminary crystallographic analysis of decameric and monomeric forms of C49S mutant thioredoxin-dependent AhpC from Helicobacter pylori.(
228	3758875	17635108	2008-01-05 14:54	the long linker region of Cel5G favours the catalytic efficiency at low and moderate temperatures by rendering the structure not only less compact, but also less stable and plays a crucial role in the adaptation to cold of this cellulolytic enzyme [Cel5g]
228	3758875	18328273	2008-07-12 10:36	S-glutathionylation of PhSOD could represent a further cold-adaptation strategy to improve the antioxidant cellular defence mechanism.[SOD]
228	3758875	18473957	2008-08-16 10:37	crystallographic study of iron superoxide dismutase [SOD]
235	4238482	17053080	2007-08-25 21:26	B. abortus-prpA mutant had a reduced capacity to establish a chronic infection in mice[prpA]
235	4238482	17686554	2007-11-10 12:44	rSurA or rDnaK induce partial protection against B. abortus infection and could be useful candidates for the development of subunit vaccines against brucellosis[SurA ]
235	4238482	18156262	2008-05-17 10:07	Data show that AlcR homolog DhbR (2,3-dihydroxybenzoic acid [2,3-DHBA] biosynthesis regulator) modulates the expression of the genes involved in 2,3-DHBA production, employing 2,3-DHBA or brucebactin as a coinducer [DhbR]
263	2827871	16908853	2007-08-25 21:08	tolC is a critical virulence factor of F. tularensis [tolC]
263	2827871	16958857	2007-08-25 21:21	The identification of the F. tularensis surface protein FsaP is reported, which, when expressed in nonadherent Escherichia coli, confers recombinant bacteria with the ability to bind to A549 cells.
263	2827871	18304778	2008-07-19 10:11	The LpnA-deficient strain showed equivalent ability to promote secretion of chemokines by human monocyte-derived macrophages as its wild-type counterpart.[Tul4]
263	2827871	18426883	2008-07-12 10:23	role in host cell adhesion, virulence, and fiber assembly. [pilT, pilF]
263	2827871	18474647	2008-08-09 10:44	the IglC, IglD, and MglA proteins each directly or indirectly critically contribute to the virulence of F. tularensis LVS, including its intracellular replication, cytoplasmic escape, and inhibition of acidification of the phagosomes.[IglC, IglD, MglA]
263	2827871	18789156	2008-10-04 10:13	the interaction between surface nucleolin and its bacterial ligand EF-Tu plays an important role in Francisella tularensis adhesion and entry process and may therefore facilitate invasion of host tissues [bacterial elongation factor Tu]
264	2827873	15339914	2007-08-25 13:12	lipid A 1-dephosphorylation catalyzed by LpxE occurs on the periplasmic surface of the inner membrane [LpxE]
264	2827873	15953029	2007-08-25 10:21	data show that the pathogenicity island protein IglC and its regulator MglA are essential for modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm [IglC],[MglA]
264	2827873	16467300	2007-08-25 21:09	expression cloning of a distinct F. novicida lipid A 4'-phosphatase gene, LpxF; it encodes a protein of 222 amino acid residues with six predicted membrane-spanning segments; findings indicate that LpxF faces the outer surface of the inner membrane [LpxF]
264	2827873	17360489	2007-08-25 14:00	LpxF represents a kind of virulence factor that confers a distinct lipid A phenotype, preventing Francisella from activating the host innate immune response and preventing the bactericidal actions of cationic peptides [LpxF]
264	2827873	17644593	2007-10-20 12:41	Our results suggested that MglA coordinates the stress response of F. tularensis and is likely essential for bacterial survival in harsh environments. [MglA]
266	4594721	18241666	2008-05-10 10:22	Report electron transfer kinetics between cytochrome c1 and cytochromes c552/c550.
266	4594721	18535143	2008-06-28 10:22	This work provides an underlying link between the various cupredoxin copper sites and possible experimental evidence in vitro for the evolutionary relationship between the cupredoxin proteins.[Cupredoxin, nitrous oxide reductase]
274	2827875	15039578	2007-08-25 14:53	Two crystal forms of KDGK from Thermus thermophilus were obtained by vapour-diffusion and microbatch methods. [2-keto-3-deoxygluconate kinase]
274	2827875	15113836	2007-08-25 12:53	ttMutS2 demonstrated the ability to bind double-stranded (ds) DNA, but, unlike ttMutS, ttMutS2 showed no specificity for mismatched duplexes [mutS2]
274	2827875	15162485	2007-08-25 13:06	three-dimensional NMR solution structure of NusG from Thermus thermophilus, which shows 43% amino acid sequence similarity to the Escherichia coli NusG [NusG]
274	2827875	15272172	2007-08-25 13:46	crystal structure of carboxypeptidase 1 [carboxypeptidase 1]
274	2827875	15388932	2007-08-25 12:07	Thermus thermophilus putative periplasmic glutamate/glutamine-binding protein 1099 x-ray crystallographic structure [TT1099]
274	2827875	15455210	2007-08-25 11:00	biochemical properties of the trehalose-6-phosphate synthase (otsA) and trehalose-6-phosphate phosphatase (otsB) in Thermus thermophilus RQ-1 [otsA and otsB]
274	2827875	15459330	2007-08-25 13:13	structures revealed the elements that are responsible for the oligomerization modes. The distributions of the electrostatic potential on the solvent-accessible surfaces suggested putative active sites(Thermus thermophilus HB8, TT1887 and TT1465)
274	2827875	15496593	2007-08-25 15:05	TT1383 is a novel dNTP triphosphohydrolase stimulated by dATP and dTTP
274	2827875	15502308	2007-08-25 14:50	crystal structure of RraA[RraA]
274	2827875	15627386	2007-08-25 21:13	The N-terminal helix was concluded to play no significant role in the specific binding of the S15 protein to its target on 16S rRNA[ribosomal protein S15]
274	2827875	15786714	2007-08-25 11:16	A thermostable beta-ketothiolase from T. thermophilus was isolated and characterized.
274	2827875	15791207	2007-08-25 13:09	crystal structure of the P-protein of the glycine cleavage system from Thermus thermophilus HB8 has been determined; first reported crystal structure of a P-protein [P-protein]
274	2827875	15843024	2007-08-25 10:58	crystal structures of two mutants of Thermus thermophilus EF-G, G16V and T84A, which exhibit Fusidic acid hypersensitivity and resistance in vitro [EG-F]
274	2827875	15923259	2007-08-25 14:49	Heptameric (L12)6/L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes [ribosomal proteins L12 & L10]
274	2827875	15937161	2007-08-25 14:15	The role of the individual enzyme components on protein maturation and activation of nitrate reductase in T. thermophilus is reported. [nar]
274	2827875	16155583	2007-08-25 10:21	The post-transfer-editing and product complexes of Thermus thermophilus LeuRS (LeuRSTT) with tRNA(Leu) at 2.9- to 3.3-A resolution was described. (LeuRSTT),(tRNA-Leu).
274	2827875	16162497	2007-08-25 13:04	The activity of the separately expressed and purified nucleotide binding domains of ClpB from T. thermophilus is reported.[clpB]
274	2827875	16235205	2007-08-25 14:23	structure and function of the dimanganese catalase are discussed[dimanganese catalase ]
274	2827875	16281059	2007-08-25 21:09	crystal structure of subunit F of vacuole-type ATPase/synthase was determined to of 2.2 A resolution; the subunit F exhibits two conformations, a 'retracted' form in the absence and an 'extended' form in the presence of ATP [V-ATPASE subunit F]
274	2827875	16284619	2007-08-25 14:14	Transition from the GTP-bound to the GDP-bound state involves substantial conformational changes of IF2 and of the entire ribosome.
274	2827875	16306270	2007-08-25 10:55	Using neutron spin-echo spectroscopy (NSE), normal mode analysis, and a statistical-mechanical framework, we reveal overdamped, coupled domain motion within DNA polymerase I from Thermus aquaticus [Taq polymerase]
274	2827875	16309701	2007-08-25 21:05	six of the 12 ancestral mutants of 3-isopropylmalate dehydrogenase tested showed thermal stability higher than that of the original enzyme[3-isopropylmalate dehydrogenase]
274	2827875	16330048	2007-08-25 10:19	comparison of the protein-RNA interactions in the L1-mRNA and L1-rRNA complexes identified amino acid residues of L1 crucial for recognition of its specific targets on the both RNAs [ribosomal protein L1 ]
274	2827875	16344484	2007-08-25 13:02	A study of the Thermus thermophilus chorismate mutase is described by using quantum mechanics (self-consistent-charge density-functional tight binding)/molecular mechanics, umbrella sampling, and the weighted histogram analysis method [chorismate mutase]
274	2827875	16511238	2007-08-25 10:53	X-ray crystallographic study of the L-fuculose-1-phosphate aldolase (FucA) from Thermus thermophilus HB8 [FucA]
274	2827875	16628221	2007-08-25 14:09	Results describe the structure, function, possible mechanism of action and regulation of Gfh1.
274	2827875	16680676	2007-08-25 10:52	rhodanese homologue TTHA0 is crystallized and its molecular structure exmined. (rhodanese homologue TTHA0613
274	2827875	16734421	2007-08-25 10:51	The crystal structure of EF-Tu x pulvomycin in complex with the guanylyl imino diphosphate at 1.4 A resolution reveals an antibiotic binding site extending from the domain 1-3 interface to domain 2, overlapping the domain 1-2-3 junction.(EF-Tu)
274	2827875	16782061	2007-08-25 21:17	versatile enzyme activities of TthNfo play an important role in counteracting DNA base damage in vivo[endonuclease IV]
274	2827875	16797545	2007-08-25 21:08	Two mutants, containing multiple mutations, were constructed and show greater thermal stabilities than the wild-type and single-point mutant 3-isopropylmalate dehydrogenase (IPMDHs) do. [3-Isopropylmalate dehydrogenase]
274	2827875	16830073	2007-08-25 10:13	Purified/characterized sulfite oxidase from Thermus thermophilus.
274	2827875	16834330	2007-08-25 21:02	Temperature dependence of the structure of the substrate and active site of the chorismate mutase E x S complex was studied.
274	2827875	16890241	2007-08-25 14:07	Report presents the crystal structure of the N-terminal domain of the Thermus thermophilus RNA helicase Hera in complex with adenosine monophosphate (AMP). [RNA helicase Hera]
274	2827875	16904687	2007-08-25 10:49	Data describe the cloning, over-expression, characterization of cognate ligands, and determination of the X-ray crystal structure of a glucose binding protein from Thermus thermophilus [TtGBP].
274	2827875	16952948	2007-08-25 13:29	We report the presence of Mlc in a thermophilic bacterium; Mlc is the first gene within an operon encoding an ABC transporter for glucose and mannose, including a glucose/mannose-binding protein and two permeases [Mlc]
274	2827875	17150214	2007-08-25 10:09	protein S1 binds in the region of the neck of the 30S ribosomal subunit inducing a conformational change of its structure[Ribosomal protein S1]
274	2827875	17186523	2007-08-25 21:16	2.1 A X-ray structure of FtsY from T. aquaticus bound to GDP [FtsY]
274	2827875	17214985	2007-08-25 14:02	In purified GcpE enzyme, a new transient iron-sulfur-based signal is detected in electron paramagnetic resonance spectroscopy.
274	2827875	17244532	2007-08-25 15:03	the conserved helix 3 of the M domain is specifically required for the DnaK-dependent shuffling of aggregated proteins, but not of soluble denatured substrates, to the pore entrance of the ClpB translocation channel. (ClpB)
274	2827875	17244533	2007-08-25 15:03	ClpB captures substrates on the upper surface of the AAA-1 ring before threading them through the ClpB hexamer in an ATP hydrolysis-driven step. (ClpB)
274	2827875	17272297	2007-08-25 14:01	The crystal structure of T. thermophilus RF2 is similar to the compact structures of E. coli RF2 (RF2).
274	2827875	17349960	2007-08-25 14:00	A network of interaction with the ribosome establishes the active GTP conformation of EF-G and thus facilitates GTP hydrolysis and tRNA translocation.[EF-G]
274	2827875	17477047	2007-08-25 21:23	The structure of protein SI of Thermus thermophilus (M = 61 kDa) in solution at low and moderate ionic strengths (0 M and 100 mM NaCl, respectively) has been studied by small-angle X-ray and neutron scattering.
274	2827875	17497305	2008-07-19 10:34	Purification and biochemical characterization of a T. thermophilus DING protein was achieved[DING phosphatase ]
274	2827875	17660830	2007-10-06 11:10	description of the crystal structure of the Thermus thermophilus ribosome recycling factor (RRF) bound to a 70S ribosomal complex containing a stop codon in the A site, a transfer RNA anticodon stem-loop in the P site and tRNA(fMet) in the E site [RRF]
274	2827875	17700703	2007-09-29 12:22	the crystal structures of the full-length Thermus thermophilus MgtE at 3.5 A resolution, and of the cytosolic domain in the presence and absence of Mg2+ at 2.3 A and 3.9 A resolutions, respectively [MgtE]
274	2827875	17855371	2007-12-15 12:45	dodecins can act as bifunctional cofactor storage proteins that sequester catalytic cofactors in prokaryotes very efficiently in an aggregated and unreactive state[ dodecin ]
274	2827875	17964262	2008-01-12 11:59	Indicate formation of ribonucleoprotein complex composed of aspartyl-tRNA synthetase (DRS2)/tRNA-dependent amidotransferase (AdT)/aspartyl-tRNA involved in asparagine biosynthesis.
274	2827875	18084085	2008-02-02 10:18	is a successful application of this approach to the integral membrane protein Thermus thermophilus cytochrome ba(3) oxidase[cytochrome ba3]
274	2827875	18154307	2008-03-10 14:58	CutA1 proteins from Thermus thermophilus (TtCutA1) and Oryza sativa (OsCutA1) and Pyrococcus horikoshii (PhCutA1)were examined, in order to elucidate the stabilization mechanism of PhCutA1.[CutA1]
274	2827875	18262540	2008-03-29 13:04	confirmed the tetrameric oligomerization state of TrmI[TrmI]
274	2827875	18339331	2008-07-12 10:06	Enzyme activity, as well as substrate binding, can be regulated by the salt mediated perturbation of the balance between open and closed forms.[NADH oxidase]
274	2827875	18343405	2008-05-17 10:07	ClpB forms a very dynamic complex, reshuffling subunits on a timescale comparable to steady-state ATP hydrolysis.(ClpB)
274	2827875	18393450	2008-06-07 10:29	domain structure of IF-2 [IF-2]
274	2827875	18393533	2008-06-07 10:29	computer simulations of the peptidyl transfer reaction in the T. thermophilus ribosome to address the role of L27 [rpmA]
274	2827875	18426222	2008-05-31 10:17	1.9 A resolution structure of Thermus thermophilus proline dehydrogenase inactivated by the mechanism-based inhibitor N-propargylglycine [proline dehydrogenase ]
287	2827877	14628143	2007-08-25 11:36	results indicate that calcium and magnesium enhance the production of protease IV; calcium increases in the cornea following infection with P. aeruginosa could favor production of protease IV[Protease IV]
287	2827877	15272179	2007-08-25 13:46	crystal structure of FpvA [FpvA]
287	2827877	15383719	2007-08-25 13:11	cloning, sequencing and characterization of lip8; Lip8 was categorized as an esterase which has higher activities against fatty acid methyl esters with short-chain fatty acids [lip8 strain LST-03]
287	2827877	15469505	2007-08-25 15:08	Data describe PtrA, which interacts directly with the type III transcriptional activator ExsA and specifically suppresses the expression of type III secretion genes in P. aeruginosa [PtrA][exsA]
287	2827877	15489449	2007-08-25 13:06	part of a protein scaffold that surrounds and protects newly formed polymers from AlgL degradation as they are transported within the periplasm for further modification and eventual transport out of the cell. [strain FRD1 and FRD2, AlgX]
287	2827877	15502343	2007-08-25 14:50	crystal structure of PhzG[PhzG]
287	2827877	15516485	2007-08-25 13:11	demonstrated that protease IV degrades the surfactant proteins SP-A and SP-D, resulting in reduction in host defense functions of these SPs, which may contribute to colonization of the lung [protease IV strain PA103-29]
287	2827877	15516570	2007-08-25 11:33	MucA downregulates T3SS genes and upregulates genes involved in alginate biosynthesis [MucA strain PAK]
287	2827877	15522089	2007-08-25 10:27	Data suggest that RtsM is a sensor protein at the start of a signalling cascade that induces expression of the type III secretion system in response to environmental signals [RtsM].
287	2827877	15583150	2007-08-25 13:11	conserved residues within the elastase propeptide are essential for chaperone and secretion ativities [TNP(thermolysin like neutral zinc metalloprotease)]
287	2827877	15619427	2007-08-25 12:05	PcrG, PcrV, PopN involved in negative regulation of ExoS expression and secretion, and required to ensure polarised delivery of effectors into target cells [PcrG, PcrV, PopN]
287	2827877	15629932	2007-08-25 13:10	investigated role of each amino acid of the AIRNLIRE motif in PilT; propose that this motif forms an amphipathic alpha helix which transmits signals between a surface-exposed protein interaction site and the ATPase core of PilT [PilT strain PAK, PA103]
287	2827877	15644204	2007-08-25 10:23	potential evolutionary path between Zn(2+)-free and Zn(2+)-dependent PBGS enyzmes [PBGS]
287	2827877	15659157	2007-08-25 10:59	RocS1, RocR and RocA1, which represent a variant of a classical two-component signal transduction pathway regulate the expression of fimbrial cup genes [RocS1, RocR, RocA1]
287	2827877	15686832	2007-08-25 14:49	degraded apolipophorin III from the haemolymph of Galleria mellonella larvae. [protease IV]
287	2827877	15687188	2007-08-25 14:49	mutations in PA2491 have significance as determinants of MexEF-OprN-mediated multidrug resistance in vivo [PA2491]
287	2827877	15687209	2007-08-25 13:10	We propose that the sadARS three-component system is required for later events in biofilm formation on an abiotic surface. [sadA], [sadR], [sadS].
287	2827877	15709980	2007-08-25 21:09	new findings support the hypothesis that a large surface, rather than a single amino acid, constitutes the MutL surface for interaction with MutH, and that the N- and C-terminal regions of MutL are involved in such interactions [mutL]
287	2827877	15715716	2007-08-25 11:20	Results indicated that the prevalence of PER-1- and OXA-10-like beta-lactamases remains high among ceftazidime-resistant P. aeruginosa isolates in Turkey. [PER-1, OXA-10]
287	2827877	15722359	2007-08-25 12:38	the presence of both NrdJa and NrdJb subunits are absolutely essential for enzyme activity [nrdJa and nrdJb]
287	2827877	15733922	2007-08-25 15:05	Results describe the crystal structure of the pyoverdine outer membrane receptor FpvA loaded with iron-free pyoverdine at 3.6 angstroms resolution [fpvA strain PAO503]
287	2827877	15752069	2007-08-25 14:49	determinants of UDP-N-acetylglucosamine C4 epimerase WbpP substrate specificity are not confined to the substrate-binding pocket and that longer range interactions are essential in allowing proper positioning of various ligands in the binding pocket[wbpP]
287	2827877	15790071	2007-08-25 14:48	putative urate oxidase gene was identified, cloned, and expressed in Escherichia coli [urate oxidase, strain Ps-x]
287	2827877	15790314	2007-08-25 15:08	The specific blocking of PA-IIL, a fucose-binding lectin of the human pathogen P. aeruginosa, by milk oligosaccharides, is demonstrated.
287	2827877	15819886	2007-08-25 12:37	Biochemical and spectroscopic characterization of phytophrome BphP [BphP]
287	2827877	15840577	2007-08-25 14:49	ChrR is a soluble quinone reductase of Pseudomonas putida that defends against H2O2 [ChrR]
287	2827877	15897197	2007-08-25 13:08	Asp-50, Arg-52, and His-84 are essential for the 3'-ribonuclease and 3'-phosphatase reactions of PaeLigD, DNA ligase D [LigD]
287	2827877	16107839	2007-08-25 11:05	four structures of a catalytically active complex between a fragment of Pseudomonas aeruginosa exotoxin A (ETA) and its protein substrate, translation elongation factor 2 (eEF2)[exotoxin A]
287	2827877	16139844	2007-08-25 14:34	Results describe at 2.0 A resolution the crystal structure of the pyochelin outer membrane receptor FptA bound to the iron-pyochelin isolated from Pseudomonas aeruginosa [Fe(III)-pyochelin; FptA]
287	2827877	16177314	2007-08-25 21:14	AlgL is bifunctional with a structural role in the scaffold and a role in degrading free alginate polymers in the periplasm (AlgL).
287	2827877	16267280	2007-08-25 21:03	isolates of Pseudomonas aeruginosa from the lung of cystic fibrosis patients underwent an adaptive change that deregulated zwf expression [zwf, strain FRD1]
287	2827877	16267307	2007-08-25 12:35	McpS, showed polar localization; overexpression of McpS resulted in a dominant-negative effect on chemotaxis and caused a loss of polar clustering of the general MCP population [McpS]
287	2827877	16289027	2007-08-25 10:56	APS reductase from Pseudomonas aeruginosa has been shown to form a disulfide-linked adduct with mono-cysteine variants of Escherichia coli thioredoxin and Chlamydomonas reinhardtii thioredoxin h1.(APS reductase)
287	2827877	16299285	2007-08-25 12:35	This study identifies an amino acid motif that is responsible for the membrane binding properties of the ExoS membrane localization domain.
287	2827877	16299320	2007-08-25 14:14	Glycosylation sites in the N terminus of flagellin (fliC)required for interaction with TLR5 were found.(fliC)
287	2827877	16322580	2007-08-25 10:55	crystal structures of WrbA from Pseudomonas aeruginosa and the complex with flavin mononucleotide [WrbA]
287	2827877	16376476	2007-08-25 10:55	AlgX might exert its function via interaction with MucD. Immunoelectron microscopic localisation of AlgX-strep tag II suggested a localisation close to the cytoplasmic membrane (AlgY and MucD).
287	2827877	16391057	2007-08-25 14:41	role of Alg8 in alginate production [Alg8]
287	2827877	16428760	2007-08-25 14:12	a newly identified activator that is involved in the expression of the TTSS by enhancing the exsCEBA transcriptional level.[PsrA]
287	2827877	16430860	2007-08-25 14:13	intact disulphide bond formation system is required for KatC activity and thus explaining the loss of this catalase in the cyanide-insensitive terminal oxidase mutant and overexpressing strains [KatC]
287	2827877	16446439	2007-08-25 10:55	DNA ligase D polymerase is a direct catalyst of mutagenic nonhomologous end-joining in vivo [DNA ligase D]
287	2827877	16533806	2007-08-25 10:53	The first in-depth spectroscopic and functional characterization of a cytoplasmic heme-binding protein (PhuS) from P. aeruginosa.[PhuS]
287	2827877	16540477	2007-08-25 14:11	analysis of the 3'-phosphoesterase component of the bacterial NHEJ protein, DNA ligase D [LigD]
287	2827877	16542460	2007-08-25 11:56	Risk factors and treatment outcome of BSI episodes caused by PER-1-positive Pa (PER-1-Pa) strains were compared to those caused by ESBL-negative Pa isolates (ESBL-N-Pa).[Per-1]
287	2827877	16542874	2007-08-25 13:35	findings suggest that during cystic fibrosis, mutS mutator strains evolve more frequently by independent mutational events and subsequent selection of the mutator phenotype than by the transmission of preselected mutS strains [mutS]
287	2827877	16584193	2007-08-25 15:04	heme oxygenase was studied by multinuclear and multidimensional NMR spectroscopy in its paramagnetic cyanide-inhibited (pa-HO-CN) and azide-inhibited (pa-HO-N3) forms [heme oxygenase]
287	2827877	16584201	2007-08-25 15:04	results support that exoenzyme S ADP-ribosylates and affects the function of the cytosolic protein, cyclophilin A (CpA), with the predominant functional effect relating to interference of CpA-cellular protein interactions [exoenzyme S]
287	2827877	16585778	2007-08-25 21:08	Bioinformatic, genetic, and biochemical approaches indicate that the PvdYII enzyme catalyzes acetylation of hydroxyornithine. [PvdYII]
287	2827877	16611230	2007-08-25 14:10	Ras proteins are an important cellular target for the P. aeruginosa toxin ExoS, which induces cell death during pathogenesis as a means of defending the bacterium against eukaryotic phagocytosis.[exoS]
287	2827877	16624803	2007-08-25 11:56	RhlG is a NADPH-dependent beta-ketoacyl reductase of the SDR protein superfamily and the beta-ketoacyl-acyl carrier of fatty acid synthesis does not carry the substrates for RhlG[RHLG]
287	2827877	16632613	2007-08-25 13:33	crystal structure of PagL to 2.0 angstrom resolution [PagL]
287	2827877	16634643	2007-08-25 14:09	Inhibitory metal ions bind at active-site residues, Cys249 & His162, & stabilize anionic form of Cys249. Results support proposed substrate-assisted mechanism for DDAH in which ligand binding modulates reactivity of active-site Cys.[dimethylargininase]
287	2827877	16677312	2007-08-25 10:52	Although DeltafimX mutants show limited in vitro cytotoxicity, they are as virulent as the wild-type strain in a murine model of acute pneumonia. (FimX)
287	2827877	16684886	2007-08-25 12:30	Data suggest tha SdsA1 is a secreted SDS hydrolase that allows the bacterium to use primary sulfates such as SDS as a sole carbon or sulfur source.
287	2827877	16689730	2007-08-25 13:34	LecA contributes to P. aeruginosa biofilm architecture under different environmental conditions.
287	2827877	16735731	2007-08-25 13:33	MfvR regulates pqsABCDE transcription in a complex manner and MfvR pathway regulation is complex and las-codependent for both quorum-sensing regulation and Pseudomas pathogenesis. [MvfR]
287	2827877	16786268	2007-08-25 11:54	cloning, sequence analysis and expression of perhydrolase from Pseudomonas aeruginosa KCTC2695 [perhydrolase]
287	2827877	16816388	2007-08-25 14:08	DNA ligase D (LigD) participates in a mutagenic pathway of nonhomologous end joining [LigD]
287	2827877	16819823	2007-08-25 21:08	Newly synthesized analogues of a reaction intermediate of porphobilinogen synthase have been employed in studying the active site and the catalytic mechanism of this early enzyme of tetrapyrrole biosynthesis.
287	2827877	16846224	2007-08-25 21:02	The Phe114Pro mutation results in a 90 mV decrease in the reduction potential of azurin, and removal of the second hydrogen bond to the Cys ligand seems to be the major cause of this change [azurin]
287	2827877	16861632	2007-08-25 12:28	We identify distinct signaling roles for the tandem receiver domains of RetS and present evidence suggesting that RetS may serve as a substrate for another sensor kinase.
287	2827877	16885449	2007-08-25 13:31	The RecA protein of Pseudomonas aeruginosa (RecA(Pa)) exhibits a more robust recombinase activity than its E. coli counterpart (RecA(Ec)) [RecA]
287	2827877	16889625	2007-08-25 14:06	data explain how the expression of the ADP-ribosylation of ExoS modifies the actin cytoskeleton and indicate that ExoS possesses redundant enzymatic activities to depolymerize the actin cytoskeleton [ExoS]
287	2827877	16914555	2007-08-25 10:13	Determining the structure of PchB is part of a larger effort to elucidate protein structures involved in siderophore biosynthesis[PchB]
287	2827877	16952938	2007-08-25 13:29	data show that AlgT inhibits flagellum biosynthesis in mucoid, nonmotile P. aeruginosa cystic fibrosis isolates by promoting expression of AmrZ, which subsequently represses fleQ.[AlgT, AmrZ, fleQ]
287	2827877	16966406	2007-08-25 21:21	The expression of ExoS in HeLa cells by eukaryotic expression vector effectively caused apoptosis in an ADP-ribosylation (ADPRT) activity-dependent manner.
287	2827877	16980486	2007-08-25 12:26	This finding demonstrates that the binding of ExsC to ExsD is required for transcriptional induction of the T3SS under calcium-limiting growth conditions.[ExsC, ExsD]
287	2827877	16980502	2007-08-25 12:26	In this work, we demonstrate that the loss of FlhF results in defective swimming and swarming motility of Pseudomonas aeruginosa.[FlhF]
287	2827877	16981723	2007-08-25 14:05	This data suggests heme transfer from PhuS to pa-HO is mediated via a specific protein-protein interaction.[heme oxygenase; PhuS]
287	2827877	16982831	2007-08-25 12:27	Flagellin transcription is repressed by neutrophil elastase in mucus.
287	2827877	17015462	2007-08-25 10:48	LecB is involved in pilus biogenesis and proteolytic activity.( LecB)
287	2827877	17028277	2007-08-25 10:11	RhlR expression regulated by homoserine lactone and Pseudomonas quinolone signal (PQS)-mediated quorum-sensing systems as well as by iron and phosphate availability dependent on PhoB. [RhlR, PhoB]
287	2827877	17030800	2007-08-25 10:47	Results report that Pseudomonas aeruginosa inhibits mammalian cytokinesis in a type III secretion system and exotoxin T (ExoT)-dependent manner.
287	2827877	17050810	2007-08-25 11:50	results indicated that the exoU gene is the major contributor to cytotoxicity in Madin-Darby canine kidney cells but is not related to bacterial colonization in mice [exoU]
287	2827877	17059825	2007-08-25 13:28	NMR structure of the cytosolic N-terminal domain (NRho) of P. aeruginosa Rhomboid; we suggest that NRho plays a role in scissile peptide bond selectivity by optimally positioning the Rhomboid active site relative to the membrane plane [rhomboid]
287	2827877	17095508	2007-08-25 11:49	crystal structures of heme oxygenase, which suggests a structural basis for ligand discrimination [heme oxygenase]
287	2827877	17128965	2007-08-25 12:25	postulated role of the invariant Glu-235 is to ion pair with the positively charged formimino group of the substrate[N-formimino-L-glutamate iminohydrolase]
287	2827877	17187075	2007-08-25 21:16	crystallographic structure of trimeric OprP at 1.9-A resolution, revealing an unprecedented 9-residue arginine 'ladder' that spans from the extracellular surface down through a constriction zone where phosphate is coordinated [OprP]
287	2827877	17202150	2007-08-25 21:11	simultaneous production of hemolytic phospholipase (PlcH) and ceramidase was induced by several lipids and PlcH-induced hemolysis was significantly enhanced by the action of the ceramidase [neutral ceramidase, hemolytic phospholipase C]
287	2827877	17349657	2007-08-25 21:20	The crystal structure of the full-length FpvA bound to iron-pyoverdine at 2.7 A resolution, was resolved.[Fpva]
287	2827877	17350728	2007-09-08 10:19	qacEdelta1 gene was detected in 213 of 331 clinical isolates of P. aeruginosa from 10 hospitals in China [qacEdelta1]
287	2827877	17360677	2007-08-25 10:06	A polyphosphate kinase 1 (ppk1) mutant of Pseudomonas aeruginosa exhibits multiple ultrastructural and functional defects. [Ppk1]
287	2827877	17400735	2007-08-25 13:23	These findings suggest that the membrane-bound nitrate reductase is critical for P. aeruginosa anaerobic growth with nitrate in the CF lung.[narG protein]
287	2827877	17453960	2007-08-25 11:45	Production of elastase during P. aeruginosa keratitis enhances ocular pathology, whereas alkaline protease production contributes to limited corneal erosion. (Elastase B)
287	2827877	17493134	2007-08-25 21:00	These results demonstrate the implication of both MutS and Pol IV in determining mucA as the main target for conversion to mucoidy.[MutS, MucA, Dna Polymerase IV]
287	2827877	17510267	2007-08-25 12:20	For some clinical isolates, cephalosporin resistance was dependent upon the interplay of ampC and oprF expression.[AmpD, OprF proteins]
287	2827877	17513180	2007-08-25 11:44	is the first report of a eubacterial species with several glyoxalase (Glx) encoding genes, and also of an organism possessing GlxI enzymes from both metal activation classes[gloA1 and gloA2]
287	2827877	17524545	2007-12-08 12:52	Because the gene encoding the outer membrane lipoprotein PelC is part of a putative gene cluster involved in exopolysaccharide biogenesis, it is suggested that PelC is a new member of the outer membrane auxiliary family of lipoproteins (PelC).
287	2827877	17586641	2008-01-19 11:13	The identification and characterization of PA4367, a gene involved in regulating surface-associated behaviors in Pseudomonas aeruginos, are reported.[PA4367]
287	2827877	17631634	2008-01-19 10:25	Chemical composition analyses and mannose- or galactose-specific lectin staining, followed by confocal laser scanning microscopy and electron microscopy, showed that Psl is a galactose-rich and mannose-rich exopolysaccharide.
287	2827877	17636129	2007-09-15 11:55	Only a small number of direct interactions govern mutual recognition of rubredoxin reductase and rubredoxin, corroborating the transient nature of the complex[ rubredoxin reductase ]
287	2827877	17645452	2007-10-27 12:23	Alg44 appears to be an essential component of the alginate biosynthetic apparatus, where, following binding of c-di-GMP, it controls polymerization or transport of the polysaccharide.
287	2827877	17657406	2008-03-29 11:13	The gene of the P.aeruginosa LST-03 lipase (Lip9) was cloned and expressed in Escherichia coli.
287	2827877	17676788	2007-11-10 12:44	The ground state electronic structure of oxidized azurin and its optical response have been investigated by combining hybrid quantum mechanics/molecular mechanics simulations with time-dependent density functional theory.(azurin)
287	2827877	17824927	2007-12-08 11:40	The PelD protein of Pseudomonas aeruginosa is a novel c-di-GMP receptor that mediates c-di-GMP regulation of PEL polysaccharide biosynthesis.[PelD]
287	2827877	17905228	2008-03-29 12:13	the phospholipase activity of the P. aeruginosa cytotoxin, ExoU, plays a role in the pathogenesis of corneal infection (ExoU)
287	2827877	17910958	2008-01-05 16:05	Role of Ser216 in orienting the N-acetyl group on N-acetylmuramic acid at the -1 subsite of membrane-bound lytic transglycosylase B (MltB) for its participation in a substrate-assisted mechanism of action (MltB).
287	2827877	17952093	2008-03-10 14:59	Data report the crystal structure of OprD from Pseudomonas aeruginosa, and suggest that the structure represents the general architecture of OprD channels [OprD]
287	2827877	18005110	2008-06-14 10:14	In strain 1244, topology studies showed that the two PilO regions associated with enzyme activity were located in the periplas.[PilO]
287	2827877	18028450	2008-03-22 12:55	TrpD is important for the induction of the quorum-sensing circuit, while PchH and PchI are involved in the induction of the type III secretion system.[TrpD, PchH and PchI in strain 22D10]
287	2827877	18065759	2008-04-05 13:00	the O-antigen biosynthesis enzyme WbpO is essential for flagellin glycosylation [WbpO]
287	2827877	18165298	2008-05-03 12:16	These studies support the hypothesis that type III toxins ExoS, -T and -Y enhance P. aeruginosa's invasive capabilities by interacting with multiple eukaryotic cytoskeletal components.[ExoS, ExoT, ExoY in strain PAK]
287	2827877	18174131	2008-03-29 10:22	Mutation of conserved WA or WB residues in any of the three ATPases abrogated twitching motility. [PilB, PilT and PilU in strain PAK]
287	2827877	18190582	2008-06-21 10:15	A strong correlation between quorum-sensing activity and virulence factor production was revealed for elastase. [elastase]
287	2827877	18214968	2008-07-26 10:05	These observations rationalize the high binding affinity of PA-IIL towards fucose.[Lectin II]
287	2827877	18227268	2008-04-05 11:11	Surface plasmon resonance revealed that recombinant PA0122 binds with high affinity to oxidized low-density lipoprotein and to its major subcomponent, lysophosphatidylcholine, but not to non-oxidized LDL.[PA0122]
287	2827877	18298082	2008-05-24 10:05	Analysis of gallium(III)-bound PvdI in solution reveals a distinct change in peptide backbone conformation upon binding to its receptor FpvAI allowing translocation of PvDI into the periplasm. (pyoverdine PvdI)
287	2827877	18316718	2008-04-12 11:06	Electrochemistry measurements on DNA-modified electrodes are used to probe the effects of binding to DNA on the redox potential of SoxR, a transcription factor that contains a [2Fe-2S] cluster and is activated through oxidation.[SoxR]
287	2827877	18326581	2008-05-17 10:07	RhlA is necessary and sufficient to form the acyl moiety of rhamnolipid.
287	2827877	18355276	2008-06-28 10:22	D20 an T180 substitutions significantly impair lipase secretion.
287	2827877	18366187	2008-06-14 10:24	catalytic turnover commences from the active configuration of the arginine deiminase(L-arginine) complex which consists of the Cys thiolate (nucleophile) and His imidazolium ion (general acid)[arginine deiminase]
287	2827877	18390657	2008-07-12 10:05	The role of the outer membrane protein Opr86 in biofilm formation by several P. aeruginosa isolates is reported.[Opr86]
287	2827877	18416536	2008-06-14 10:24	PhzS may use a different mechanism than its structural relatives[ PhzS]
287	2827877	18458065	2008-07-12 10:32	Repressor CifR negatively regulates cif gene expression. And we demonstrate that P. aeruginosa strains isolated from cystic fibrosis patient sputum with increased cif gene expression are impaired for the expression of the cifR gene. [Cif, CifR]
287	2827877	18512057	2008-10-04 10:28	The purified lasB enzyme was highly stable in the presence of dimethyl sulfoxide and methanol after 60 days. [lasB]
287	2827877	18524915	2008-08-09 10:11	Alg44 may act as a co-polymerase in concert with Alg8, the major GT, and that both inner-membrane proteins are required in vivo for the polymerization reaction leading to alginate production [Alg8; Alg44]
287	2827877	18583608	2008-07-19 10:40	study reports transient optical and infrared spectroscopic experiments that quantify the extent to which an intervening tryptophan residue can facilitate electron transfer between distant metal redox centers in a mutant azurin [azurin]
287	2827877	18611376	2008-09-13 10:06	The OpdK pore is relatively wide for a substrate-specific channel, and it is lined by a patch of arginine residues on one side and an electronegative pocket on the opposite side-features likely to be important for substrate selection (OpdK).
287	2827877	18722176	2008-09-20 10:49	KOPS (short DNA sequences) act solely as a loading site for FtsK, resulting in a unidirectionally oriented hexameric motor upon DNA.[FtsK]
287	2827877	18757728	2008-10-04 10:13	MexR is a redox regulator that senses peroxide stress to mediate antibiotic resistance in P. aeruginosa[MexR]
287	3399411	16127047	2007-08-25 12:44	P. aeruginosa has developed multidrug resistance by acquiring resistance determinants, including a novel member of the aac(6')-I family
292	4357605	17681542	2007-11-10 11:07	Mutants of DntR in which residues lining the proposed inducer-binding cavity were modified were constructed in order to identify the structural elements involved in inducer binding and to investigate the mechanism of transcriptional regulation by DntR.
294	3758879	16622054	2007-08-25 14:10	paper reports that lapD, a gene located adjacent to the lapA gene, plays a role in biofilm formation; model is proposed wherein the role of LapD in biofilm formation is modulating the secretion of the LapA adhesin [LapD]
294	3758879	16777062	2007-08-25 10:14	OprE and OprQ porins from P. fluorescens strain MF0 were purified and identified by MALDI-TOF mass spectrometry and N-terminal and internal microsequencing [OprE and OprQ]
294	3758879	16844437	2007-08-25 10:14	first crystal structure determination of CumD in an active form, with the Ser103 residue, one of the catalytically essential "triad", being intact[CumD]
294	3758879	16907738	2007-08-25 21:17	initial characterization of bolA; data on cell morphology, biofilm formation and bolA expression show distinct differences between the role of BolA in P. fluorescens and E. coli [bolA]
294	3758879	16932888	2007-08-25 11:52	OprF is involved in the bacterial environmental temperature sensing by P. fluorescens.(OprF)
294	3758879	16936061	2007-08-25 15:04	role of ptsP, orfT, and sss recombinase genes in wheat rhizosphere colonization [PtsP, orfT, sss recombinase]
294	3758879	17064262	2007-08-25 13:28	findings show show that a putative methyltransferase/wapQ operon is located downstream of colR/colS and that this operon is regulated by ColR/ColS [ColR, ColS, wapQ]
294	3758879	17277060	2007-08-25 13:25	NbaY is the first chemoreceptor in nitroaromatic metabolism to be identified[NbaY]
294	3758879	17379708	2007-12-01 10:37	Study shows that WspR is a diguanylate cyclase (DGC), structure-function analysis of 120 wspR mutants showed that the RYGGEEF motif of WspR is functionally conserved, with almost every mutation abolishing function.[WspR protein]
294	3758879	17573472	2007-10-20 10:20	In this study we demonstrate a metabolic network promoting NADPH production and limiting NADH synthesis as a consequence of an oxidative insult. [NADPH, NADH]
294	3758879	17612529	2007-09-22 10:19	three-dimensional structure of the DING protein, confirming a close similarity to the "Venus flytrap" structure seen in other human and bacterial phosphate-binding proteins[DING]
294	3758879	17713071	2007-09-15 11:55	Mutation of the HMG-CoA synthase encoding mupH gene in Pseudomonas fluorescens gives rise to a new metabolite formed from a truncated polyketide intermediate[HMG-CoA synthase ]
294	3758879	17993540	2008-05-03 12:17	massetolide A biosynthesis in Pseudomonas fluorescens SS101 is governed by three large NRPS genes, designated massA, massB, and massC.[massA, massB and massC]
294	3758879	18202367	2008-03-29 12:11	These data show that CbrAB plays a role in regulation of both carbon and nitrogen catabolism and maintains activity of catabolic pathways under different carbon:nitrogen ratios.[CbrAB, NtrBC]
294	3758879	18312599	2008-06-07 10:06	enzyme can behave as an efficient catalyst at low temperatures[ beta-lactamase]
294	3758879	18314961	2008-05-31 10:05	all thiamin-related intermediates are in a chiral environment on benzaldehyde lyase as reflected by their circular dichroism signatures[benzaldehyde lyase]
294	3758879	18405392	2008-06-07 10:18	The intergenic region 1698 was found to specify a novel GacA-controlled sRNA termed RgsA [GacA; RgsA]
294	3758879	18469122	2008-08-02 10:40	Fumarase C (FUM C) and H2O-forming NADH oxidase (NOX) play a pivotal role in the adaptation of Pseudomonas fluorescens to the toxicity of Al and Ga. [FUM C, NOX]
294	3758879	18547423	2008-08-02 10:35	StyR and IHF protein levels did not change in catabolite repression, implying that PstyA repression is achieved through an increase in the StyR-P/StyR ratio. [StyR, IHF]
303	1218757	17645451	2007-10-27 12:23	A dedicated genetic system was developed for the soil bacterium Pseudomonas putida aimed at deciphering the steps involved in the gain of responsiveness of the toluene-activated prokaryotic regulator XylR to the xenobiotic chemical 2,4 dinitrotoluene.
303	2827879	15489433	2007-08-25 14:38	novel membrane-localized regulator that controls the timing of flagellar development and affects motility, chemotaxis, and biofilm formation [MorA]
303	2827879	15491368	2007-08-25 14:51	Data suggest that transposition can be controlled by environmental cues sensed by a two-component signal transduction system, such as ColR-ColS [colR, colS].
303	2827879	15528532	2007-08-25 15:02	findings suggest that OprF could adopt two alternative conformations in the outer membrane and that folding is thermoregulated[OprF]
303	2827879	15542595	2007-08-25 10:27	crystal structure of the alkylsulfatase AtsK in complexes with succinate and with Fe(II)/succinate [AtsK]
303	2827879	15561717	2007-08-25 21:05	dpkA shows not malate dehydrogenase nor lactate dehydrogenase activity but catalyzed NADPH-dependent reduction of cyclic imines as Delta(1)-piperideine-2-carboxylate & Delta(1)-pyrroline-2-carboxylate to form L-pipecolate and L-proline respectively [dpkA]
303	2827879	15661012	2007-08-25 12:56	demonstrated that the expression of sfnFG is directly regulated by SfnR [SfnR]
303	2827879	15716266	2007-08-25 14:44	Tyr(33), Arg(66), and Trp(106) prevent tight binding of oxidized Pdx and facilitate dissociation from putidaredoxin reductase (putidaredoxin)
303	2827879	15893671	2007-08-25 12:45	The crystall structure of 2-Oxoquinoline 8-monooxygenase in oxidized, reduced and substrate bound states was determined.
303	2827879	15966730	2007-08-25 10:22	redox-dependent structural differences in Pdx correlate to dynamic changes observed before and may be linked to differences in binding and electron transfer properties between oxidized and reduced Pdx[putidaredoxin]
303	2827879	16011758	2007-08-25 21:03	identified the nitroreductase-family enzymes PnrA and PnrB from the TNT-degrading strain [PnrA, PnrB]
303	2827879	16046469	2007-08-25 21:24	Nucleotide sequences in the quinolone resistance-determining regions suggested that amino acid mutations in gyrA, gyrB and ParC of affected the susceptibility of P. putida to fluoroquinolones.[gyrA; gyrB; parC]
303	2827879	16061256	2007-08-25 13:40	Results describe the molecular cloning of the gene, qgdA, and solution of the three-dimensional structure of the Pseudomonas putida HK5 quinohemoprotein alcohol dehydrogenase ADH-IIG [ADH-IIG].
303	2827879	16084834	2007-08-25 12:36	kinetic analysis of the compound I intermediate for an artificial electron-driven P450cam catalytic pathway in solution
303	2827879	16085854	2007-08-25 12:44	first identification of phenylserine aldolase from P. putida 24-1 and its enzymologic characteristics as well as cloning and overexpression of its gene in Escherichia coli [phenylserine aldolase]
303	2827879	16104018	2007-08-25 10:21	Molecular Model of CsrA(CsrA).
303	2827879	16171781	2007-08-25 13:03	Amino acid sequence, secondary, and tertiary structures of catechol dioxygenase beta beta isozyme have been determined by X-ray crystallography.  (Pseudomoas arvilla catechol dioxygenase)
303	2827879	16321951	2007-08-25 11:59	cloning and determination of crystal strucdture;examination of substrate specificity of EST toward other linear esters revealed that the enzyme showed specific activity toward methyl esters and that it recognized the configuration at C-2 [EST]
303	2827879	16511124	2007-08-25 21:18	X-ray diffraction studies of the three components of the toluene 2,3-dioxygenase enzyme system [ReductaseTOL, FerredoxinTOL, OxygenaseTOL]
303	2827879	16511161	2007-08-25 11:57	preliminary diffraction structure of the Pseudomonas putida cytochrome P450cam operon repressor CamR [CamR]
303	2827879	16702539	2007-08-25 13:33	TodS-TodT two-component regulatory system recognizes a wide range of effectors and works with DNA-bending proteins [TodS, TodT]
303	2827879	16816194	2007-08-25 21:26	insight into structural features required for terminal alkane hydroxylation by CYP153A6 (newentry)
303	2827879	16846243	2007-08-25 21:02	The ligands Mn(2+), meso-tartrate, oxalate, and reduced nicotinamide adenine dinucleotide (NADH) bound to all TDH complexes with a stoichiometry of 1 per enzyme dimer[tartrate dehydrogenase]
303	2827879	17005994	2007-08-25 10:48	The data demonstrate that PdtK and PdtE constitute a bipartite outer-membrane/inner-membrane transport system for iron acquisition from Fe(III):PDTC. [PdtK, PdtE]
303	2827879	17047872	2007-09-04 17:07	Modelling the hydroxylation of camphor by P450cam, using combined quantum mechanics/molecular mechanics (QM/MM) methods.
303	2827879	17107553	2007-08-25 21:17	OxyR controlled expression of all the principal peroxide-degrading enzymes in P. putida [OxyR]
303	2827879	17144679	2007-08-25 12:25	Properties of quinaldine 4-oxidase proteins with substitutions of C48 and C60 (Fe2 of FeSII), and of the C120 ligand at Fe2 of FeSI, retained considerable activity and showed less pronounced changes in their EPR parameters. [Quinaldine 4-oxidase]
303	2827879	17289792	2007-12-01 12:13	Detailed information of the overall structure of l-Methionine gamma-lyase supplies a clear picture of the substrate- and pyridoxal-5'-phosphate-binding pockets. [l-Methionine gamma-lyase]
303	2827879	17331811	2007-08-25 11:45	ImuB and DnaE2 have roles in stationary-phase mutagenesis in Pseudomonas putida [ImuB, DNAE2]
303	2827879	17367138	2007-08-25 21:23	benzoylphosphonate acts as a mechanism-based inhibitor of benzoylformate decarboxylase, with inactivation resulting from phosphorylation of Ser26[benzoylformate decarboxylase]
303	2827879	17516050	2007-10-13 12:20	isoeugenol monooxygenase was isolated and characterized; the gene was also isolated from from Pseudomonas putida IE27[isoeugenol monooxygenase]
303	2827879	17526843	2007-11-10 10:20	The intracellular amount of cis,cis-muconate (CCM) is negatively affected by the catabolite repression control protein via downregulating the pheBA-encoded catechol 1,2-dioxygenase and the phenol monooxygenase, needed for CCM production. [pheBA]
303	2827879	17534563	2007-10-13 12:37	Analysis of the nucleotide sequence revealed that an open reading frame of 879 bp encoded a protein of 293 amino acids with a calculated molecular weight of 33712.6 kDa.[imidase]
303	2827879	17711452	2007-12-29 11:09	this is the first report of a PTS protein that is involved in bacterial assimilation of organosulfur compounds.(ptsP)
303	2827879	17768252	2007-12-01 11:52	Transcription of SfnA, a sulfate starvation induced gene is regulated by SfnR, a sigma54 dependent transactivator. [SfnA, SfnR]
303	2827879	17958702	2008-01-19 10:02	X-ray structures of the D-3-hydroxybutyrate dehydrogenase from Pseudomonas putida.
303	2827879	17986203	2008-06-14 10:24	In vitro studies revealed that TtgV and TtgT bind the same operator sites in both the ttgDEF and the ttgGHI promoters:[TtgV] and [TtgT]
303	2827879	18059561	2008-03-10 13:38	the presence of ACC deaminase generally inhibited tumour development on both tomato and castor bean plants.[1-aminocyclopropane-1-carboxylate deaminase]
303	2827879	18092808	2008-03-10 13:38	These results suggest that hydrophobic residues that reside on a flexible flap and define the topology of an active site through their van der Waals contacts with the substrate are quite tolerant of a variety of steric substitutions.[mandelate racemase]
303	2827879	18203859	2008-04-05 10:18	A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase (HSP hydroxylase), involved in nicotine degradation by Pseudomonas putida strain S16.
303	2827879	18219523	2008-07-12 10:06	Rsigma factor rpoS is over expressed in Pseudomonas putida NBRI0987 when grown under high temperature stress (40C)[rpoS]
303	2827879	18337694	2008-05-17 10:07	The differing activity of constructed translational fusions strongly indicated that the 5' UTR is involved in the translational regulation of RpoS expression in the stationary phase. [rpoS]
303	2827879	18353360	2008-05-17 10:33	the crystal structure of the homodimer DehI from Pseudomonas putida strain PP3 was presented.
303	2827879	18388982	2008-05-24 10:05	The data are interpreted in terms of a model in which AcdR and AcdB co-regulate the expression of the acdS gene.[AcdR, AcdB and AcdS in strain UW4]
303	2827879	18398009	2008-06-14 10:24	call into question the assigned roles for Ser-26, His-70, and His-281 [benzoylformate decarboxylase]
303	2827879	18400004	2008-07-26 10:36	These results suggest a key role of AcdS in the establishment and development of Gigaspora rosea symbiosis on cucumber.
303	2827879	18456803	2008-09-06 10:24	Results indicate that SfnR plays a role independent of CysB in the sulfate starvation-induced expression of the sfn operons: [SfnR CysB]
303	2827879	18556813	2008-07-12 10:32	intact structure of the enzyme is essential, and the flexibility of the non-conservative region at the C terminus of the enzyme is quite limited [D-hydantoinase]
303	2827879	18599835	2008-09-20 10:42	Three genes, termed psoA, psoB and psoC, were identified and shown to be involved in putisolvin biosynthesis. [psoA, psoB and psoC]
305	2827881	15195951	2007-08-25 13:52	FlhDC regulates the swimming motility of Ralstonia solanacearum during plant pathogenesis (FlhDC).
305	2827881	15522073	2007-08-25 10:28	data describe screening of hrpB-regulated genes in order to isolate type III-related pathogenicity genes[hrpB]
305	2827881	15597743	2007-08-25 10:27	The incidence of bacterial wilt of tobacco in the southeastern United States is partially explained by which avrA allele dominates the local R. solanacearum population. [avrA]
305	2827881	15923179	2007-08-25 14:49	x-ray crystallographic structure of fucose-binding lectin [RSL, R. solanacearum lectin]
305	2827881	16903354	2007-08-25 21:17	LrpE is associated with negatively regulating the production of Hrp pili on the cell surface of R. solanacearum to disperse bacterial cells from aggregates. [lrpE]
317	2827883	15546361	2007-08-25 14:45	These results indicate that the virulence activity of AvrRpt2 in Arabidopsis thaliana is likely to rely on the modification of host susceptibility factors other than, or in addition to, RIN4.
317	2827883	15597738	2007-08-25 10:27	AvrPto, an effector known for its ability to interact with the resistance gene Pto and induce Pto-mediated disease resistance, inhibited the hypersensitive response (HR) induced by nonhost pathogen interactions.
317	2827883	15733862	2007-08-25 15:05	crystal structure of ice nucleation protein [ice nucleation protein ]
317	2827883	15746386	2007-08-25 11:06	AvrRpt2 identified as a putative cysteine protease that results in elimination of the Arabidopsis protein RIN4; RIN4 cleavage serves as a signal to activate RPS2-mediated resistance; AvrRpt2 is activated by cyclophilin [AvrRp2]
317	2827883	15937188	2007-08-25 14:15	The characterization of three homologous TTCs, ShcO1, ShcS1, and ShcS2. ShcO1, ShcS1, and ShcS2 facilitated the type III secretion and/or translocation of their cognate effectors HopO1-1, HopS1, and HopS2, respectively. [ShcO1; ShcS1; ShcS2]
317	2827883	16192274	2007-08-25 13:03	crytstal structures of 3 forms of Delta(1)-Piperideine-2-carboxylate/Delta(1)-pyrroline-2-carboxylate reductase (dpkA): unliganded form, complex with NADPH & complex with NADPH & pyrrole-2-carboxylate [dpkA]
317	2827883	16399801	2007-08-25 12:34	AvrPto has evolved to mimic a substrate of a highly conserved plant kinase to enhance its virulence activity [AvrPto]
317	2827883	16478045	2007-08-25 11:57	RIN4 was attached to the plasma membrane at its carboxyl terminus; RIN4 was cleaved by AvrRpt2 at two PxFGxW motifs.[AvrRpt2]
317	2827883	16677306	2007-08-25 10:52	Nine single-site avrB mutations that affected avirulence localized to a solvent-accessible pocket in the protein structure. (AvrA)
317	2827883	16681835	2007-08-25 21:03	temporal or spatial cooperation between Orf1 and Orf2 is essential for normal maturation of flagellin; results suggest that glycosylation of flagellin in P. syringae pv. tabaci 6605 is required for bacterial virulence [orf1, orf2, flagellin]
317	2827883	16792692	2007-08-25 10:14	AvrPtoB has virulence activity and a role in suppressing the basal defense of Arabidopsis.
317	2827883	17028280	2007-08-25 10:11	Orf3 shows significant homology to a 3-oxoacyl-(acyl carrier protein) synthase III involved in flagellin glycosylation. It regulates virulence factors via quorum sensing. [3-oxoacyl-ACP synthase III]
317	2827883	17148606	2007-08-25 12:24	RAR1 molecularly links pathogen-associated molecular pattern (PAMP)-triggered immunity, effector virulence, and effector-triggered immunity [AvrB]
317	2827883	17215893	2007-08-25 13:26	mutation in exbD disrupts tagetitoxin production without compromising iron metabolism [exbD from Pseudomonas syringae pv. tagetis]
317	2827883	17215896	2007-08-25 13:26	gene contains insertions, and a deletion, affecting the formation of a beta-helix structure important for the enzyme activity leading to synthesis of inactive pectate lyase protein [pectate lyase from P. syringae pv. glycinea]
317	2827883	17254950	2008-06-28 10:34	SyrC is now identified as a Thr/Cl-Thr aminoacyltransferase, shuttling the Thr/Cl-Thr moiety between the pantetheinyl arms of the thiolation domain of SyrB1 and the thiolation domain in module nine of SyrE (SyrC)
317	2827883	17427805	2007-12-01 13:01	The data suggest that specific interaction with and modification of a cytosolic host target drives HopX recognition in resistant hosts and may contribute to virulence in susceptible hosts. [HopX protein]
317	2827883	17477524	2007-10-13 11:52	Access to a bona fide wild-type PcoC protein allowed unequivocal observation of intermediates involved in intermolecular redox copper transfer reactions[CopC]
317	2827883	17694048	2007-11-10 11:55	results show that AvrPto derepresses host defences by interacting with the two defence-inhibition loops of tomato protein kinase Pto [AvrPto]
317	2827883	17764515	2008-03-10 14:17	Data show AvrPtoB(1-307) promotes ethylene-associated virulence by interaction not with Pto but with another unknown host protein.
317	2827883	17918621	2007-12-29 10:18	The AvrRpt2 effector triggers strong local and systemic defense (called systemic acquired resistance [SAR]) responses in Arabidopsis thaliana plants
317	2827883	18068424	2008-09-27 10:24	Trp83 was mutated to Leu to study the effect of this mutation on CopC by means of fluorescence spectra and ultraviolet spectra.[CopC]
317	2827883	18158241	2008-03-29 11:16	AvrPto promotes infection in susceptible plants but triggers resistance in plants carrying the protein kinase Pto and the associated resistance protein Prf.  [AvrPto]
317	2827883	18227245	2008-04-05 10:18	Alternative sigma factor (AlgT) may act as a global regulator for virulence and in planta fitness traits of P. syringae independent of its role in exopolysaccharide biosynthesis.[AlgT]
317	2827883	18257685	2008-07-26 10:26	Expression of HopAM1 makes transgenic Arabidopsis hypersensitive to abscisic acid for stomatal closure and germination arrest (HopAM1).
317	2827883	18424557	2008-05-24 10:05	These data provide evidence of genetically separable disease resistance responses to AvrB and AvrRpm1 in Arabidopsis.[AvrB]
321	2648439	15516596	2007-08-25 22:21	Ultraviolet rays exposure and MDR activity increased the occurrence of mutations in cells without a significant reduction in overall fitness.
321	2648440	15516596	2007-08-25 22:21	Ultraviolet rays exposure and MDR activity increased the occurrence of mutations in cells without a significant reduction in overall fitness.
321	2827885	16541079	2007-08-25 10:53	the crystal structure of SyrB2 with both a chloride ion and alphaKG coordinated to the iron ion at 1.6 A resolution [SyrB2]
321	2827885	18363647	2008-06-07 10:18	The results suggest that P. syringae has the potential to utilize phcA to acquire nutrients from fungi in nutrient-limited environments like the phyllosphere by the novel mechanism of heterokaryon incompatibility induction.[phcA]
329	5955548	18340545	2008-09-13 10:26	Poly(3-hydroxybutyrate) depolymerase was secreted by the Type II pathway. [DepO]
339	2827887	15195946	2007-08-25 13:52	AvrXv4 functions like a SUMO protease during Xanthomonas-plant interactions (AvrXv4).
339	2827887	15491365	2007-08-25 14:51	Data suggest that HpaB promotes the secretion of a large set of effector proteins and prevents the delivery of non-effectors into the plant cell [HpaB]
339	2827887	15699208	2007-08-25 13:11	plays an important role in, but is not solely responsible for, both the adaptive and menadione-induced cross-protective responses to H2O2 killing in X. campestris. [katA]
339	2827887	15731101	2007-08-25 13:10	Crystal structure of N-acetylornithine transcarbamylase
339	2827887	15955530	2007-08-25 21:09	Transcription initiation site for virulence factor engA was determined.
339	2827887	15993009	2007-08-25 12:36	expression of both katA(catalase) and ahpC (alkyl hydroperoxide reductase) is controlled by the global peroxide sensor and transcriptional activator, OxyR [KatA, AphC, OxyR]
339	2827887	16511131	2007-08-25 11:57	X-ray analysis of XC229, a conserved hypothetical protein from Xanthomonas campestris
339	2827887	16511132	2007-08-25 11:57	X-ray analysis of XC5357 from Xanthomonas campestris
339	2827887	16511134	2007-08-25 11:57	X-ray characterization of a conserved hypothetical protein XC6422 from Xanthomonas campestris
339	2827887	16511191	2007-08-25 13:58	X-ray crystallographic analysis of XC847, a 3'-5' oligoribonuclease from Xanthomonas campestris [XC847]
339	2827887	16750290	2007-08-25 11:54	The structure of a novel acetylcitrulline deacetylase from Xanthomonas campestris has been solved by multiple-wavelength anomalous dispersion (MAD) using crystals grown from selenomethionine-substituted protein and refined at 1.75 A resolution. (argE)
339	2827887	16754966	2007-08-25 21:08	the determined structure of XC6422 shows that it belongs to the superfamily of serine alpha/beta-hydrolases, with an active site that is fully accessible to solvent owing to the absence of a lid domain [XC6422]
339	2827887	16940295	2007-08-25 13:22	RpfC modulates two different functions (virulence factor synthesis and DSF synthesis) by utilization of a conserved phosphorelay system and a novel domain-specific protein-protein interaction mechanism, respectively[RpfC]
339	2827887	17029242	2007-08-25 21:17	XC5357 ia a putative tetracenomycin polyketide synthesis protein adopting a cupin subfamily structure (XC5357)
339	2827887	17029243	2007-08-25 21:17	The crystal structure of XC847 from Xanthomonas campestris
339	2827887	17142901	2007-08-25 10:45	A novel N-acetylglutamate synthase/kinase bifunctional enzyme of arginine biosynthesis that was homologous to vertebrate N-acetylglutamate synthases was identified in Xanthomonas campestris.[N-acetylglutamate synthase/kinase]
339	2827887	17144652	2007-08-25 12:25	The functional promiscuity discovered for fuconate dehydratase highlights possible structural mechanisms for evolution of function in the enolase superfamily. [fuconate dehydratase]
339	2827887	17425781	2007-08-25 13:23	enzyme from X. campestris could become a good model for mammalian N-acetylglutamate synthase-kinase in structural, biochemical and biophysical studies[N-acetylglutamate synthase-kinase ]
339	2827887	17521358	2007-09-08 10:48	In the present study, the presence of poly ADP-ribose polymerase (PARP)-like activity associated with caspase-3-like protein of Xanthomonas campestris pv. glycines is reported.[caspase-3-like protein]
339	2827887	17600144	2007-11-10 10:19	A single amino acid substitution is sufficient to swap the substrate specificities of N-acetyl-L-ornithine transcarbamylase (N-acetyl-L-ornithine transcarbamylase).
339	2827887	17630971	2007-10-27 12:13	R286A mutation caused XpsE lose the ability to associate with the cytoplasmic membrane via XpsL(N); as a consequence, ATP hydrolysis by XpsE was uncoupled from protein secretion. (XpsE)
339	2827887	17957353	2008-06-14 10:14	The susceptibility of the mutant to unrelated chemicals indicated a general role for OmlA in maintaining membrane integrity.[OmlA in Xanthomonas campestris pv. phaseoli]
339	2827887	18042459	2008-01-26 12:02	The structures of reduced and organic hydroperoxides-oxidized OhrR, visualizing the structural mechanism of OHP induction.
339	2827887	18310017	2008-05-03 10:02	Our findings extend previous work on Clp and RpfF regulation to show that they both influence the expression of pehA in Xcc.[PehA, Clp and RpfF in strain Xc17]
339	2827887	18536723	2008-08-09 10:11	The structure of an intact OGT homolog and kinetic analysis of human OGT variants reveal a contiguous superhelical groove that directs substrates to the active site.[OGT]
339	2827887	18586823	2008-08-16 10:44	In addition to acting as a repressor of putative Zn(2+)-uptake systems, the Zur of the bacterial phytopathogen Xanthomonas campestris acts as an activator of a Zn(2+) efflux pump (Zur).
339	2827887	18599076	2008-07-26 10:32	FlgD comprises two individual domains, a flexible N-terminal domain that cannot be detected in the current study and a stable C-terminal domain that forms a stable dimer[flagellar hook-capping protein ]
341	3293154	15743446	2007-08-25 10:23	The XopX bacterial effector protein targets basic innate immunity in plants, resulting in enhanced plant disease susceptibility.
341	3293154	15807781	2007-08-25 11:31	Our data are consistent with the idea that AvrBs3 manipulates expression of plant genes involved in the establishment of compatible and incompatible interactions. [AvrBs3]
341	3293154	16353556	2007-08-25 11:58	the characterization of the Bs4 promoter and its application for low-level expression of bacterial type III effector proteins in planta [Bs4]
347	3292996	15973413	2007-08-25 14:34	cloning of the R gene Xa27 from rice and the cognate avr gene avrXa27 from Xanthomonas oryzae pv. oryzae [avrXa27]
347	3292996	17326805	2007-08-25 12:22	EglXoB endoglucanase is required for pathogenesis of rice bacterial blight disease. [EglXoB]
347	3292996	18545972	2008-08-09 10:11	the pilQ gene of X. oryzae pv. oryzae plays a critical role in pathogenicity, twitching motility, and biofilm formation [pilQ; strain KACC10859]
358	1224219	15387823	2007-08-25 14:52	Results suggest that dimers of TraM can multimerize TraR.
358	1224220	15387823	2007-08-25 14:52	Results suggest that dimers of TraM can multimerize TraR.
358	1224220	18007518	2008-01-26 11:10	Crystal structure of the AHL receptor protein TraR and its AHL signal N-(3- oxooctanoyl)-homoserine lactone.
358	1224321	15668378	2007-08-25 21:22	VirB4 acts as a docking site at the entrance of the type IV secretion system and transport substratses or proteins.
358	1224322	18165307	2008-05-17 10:07	Data show that in the absence of VirB5, association Tzs cell membranes was strongly reduced and VirB5 was required for efficient translocation of Tzs to the surface.
358	1224324	17244707	2007-08-25 11:47	NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system
358	1224325	16481621	2007-08-25 10:54	The first structure of a core component from the archetypal Agrobacterium tumefaciens T4SS: the 2.2-A resolution crystal structure of the VirB8 periplasmic domain was discribed.
358	1224326	17244707	2007-08-25 11:47	NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system
358	1224329	16816192	2007-08-25 21:26	Mediates the expression of virulence genes in response to plant host signals.
358	1224335	16194240	2007-08-25 15:07	Data suggest that Agrobacterium tumefaciens oncogenic suppressors inhibit T-DNA and VirE2 protein substrate binding to the VirD4 coupling protein.
358	1224338	15489437	2007-08-25 13:05	Osa blocks stable transfer of RSF1010 to plant cells by inhibiting transfer of VirE2, which is essential for the transfer of RSF1010 into plant cells.
358	1224338	15824315	2007-08-25 12:55	Data indicate that the ability of VIP1 to interact with the VirE2 protein component of the T-complex and localize to the cell nucleus is sufficient for transient genetic transformation.
358	1224338	16010006	2007-08-25 15:05	Agrobacterium protein links with histoness in plant chromatin.
358	1224338	16194240	2007-08-25 15:07	Data suggest that Agrobacterium tumefaciens oncogenic suppressors inhibit T-DNA and VirE2 protein substrate binding to the VirD4 coupling protein.
358	1224338	17060320	2007-08-25 21:08	Cooperative binding of VirE2 to single-stranded DNA releases VirE1, resulting in a controlled formation mechanism for the helical complex that is further promoted by macromolecular crowding.
358	1224339	17130174	2007-08-25 10:08	VirE3 is transported into the nucleus and there it may interact with the transcription factor pBrp to induce the expression of genes needed for plant tumor development
358	2827891	15474471	2007-08-25 12:50	gamma-resorcylic acid decarboxylase is a novel enzyme catalyzing carboxylation of resorcinol, 1,3-dihydroxybenzene [gamma-resorcylic acid decarboxylase]
358	2827891	15489437	2007-08-25 13:06	Osa protein blocks stable transfer of RSF1010 to plant cells by inhibiting transfer of VirE2, which is essential for the transfer of RSF1010 into plant cells, and not by inhibiting the actual transfer of RSF1010 itself. [Osa protein]
358	2827891	15878872	2007-08-25 11:31	analysis of phytochrome Agp1 from Agrobacterium tumefaciens and its bilin derivatives [Agp1]
358	2827891	16142903	2007-08-25 10:20	structural study of prokaryotic tadA [tadA]
358	2827891	17121858	2007-08-25 14:03	Agp1 phytochrome residues Asp-197 and His-250 control the proton affinity of the chromophore and Pfr formation [Agp1]
358	2827891	17376086	2007-08-25 13:25	TraR makes extensive sequence-specific contacts with tra box DNA. [TraR]
358	2827891	17614346	2007-11-10 10:19	The photoinduced primary reaction of the biliverdin binding phytochrome Agp1 (Agp1-BV) from Agrobacterium tumefaciens was investigated by sub-picosecond time-resolved Vis pump-IR probe spectroscopy.
358	2827891	18357593	2008-07-12 10:06	halohydrin dehalogenase has the unique capacity to form carbon-halogen, carbon-oxygen, carbon-sulfur, and carbon-carbon bonds [HheC]
359	874691	17166613	2007-08-25 15:03	rolB-transformed vitis amurensis calli are capable of producing up to 3.15% dry wt. of resveratrol.
359	2827893	12839726	2007-08-25 13:50	transgenic effects on Betula pendula growth and wood anatomy and chemistry
375	2827895	15966737	2007-08-25 10:22	more negative E(m) value thermodynamically limits proline reduction of the FAD cofactor in Bradyrhizobium japonicum PutA [PutA]
375	2827895	16475796	2007-08-25 12:34	structural changes of the heme & its binding pocket in Fe(II)deoxy & Fe(III) met states of wild-type BjFixLH oxygen sensor domain & 4 mutants of the highly conserved residue arginine 220 [FixLH]
375	2827895	17144653	2007-08-25 12:25	D-tartrate dehydratase-catalyzed reaction is a "simple" extension of the two-step reaction catalyzed by mandelate racemase base-catalyzed proton abstraction to generate a Magnesium-stabilized enediolate intermediate. [D-tartrate dehydratase]
375	2827895	17446273	2007-08-25 13:59	no sizeable doming is observed in the oxycomplex of the Bradyrhizobium japonicum FixL sensor domain (FixLH)[ FixL ]
375	2827895	18486632	2008-08-30 10:16	A gene encoding an avidin-like protein named bradavidin II was discovered in the genome of B. japonicum and cloned.(bradavidin II)
375	2827895	18539736	2008-08-16 10:44	The findings demonstrate that Irr is a transcriptional repressor that binds DNA with high affinity.[Irr in strain LO]
381	2827897	15550244	2007-08-25 12:06	we describe the initial functional characterization of a cyclic nucleotide regulated ion channel, MlotiK1, from the Mesorhizobium loti and present two structures of its cyclic nucleotide binding domain, with and without cAMP [MlotiK1]
381	2827897	17076666	2007-08-25 21:07	Transfer of the symbiotic island to non-symbiotic mesorhizobia required intS, rlxS and rdfS [intS, rlxS, rdfS]
381	2827897	17658468	2007-09-29 12:22	Data suggests that in addition to its role in substrate binding and selectivity, the active-site P-loop could play a wider structural role in arylamine N-acetyltransferase 1 (arylamine N-acetyltransferase 1).
381	2827897	17827288	2008-01-19 12:04	The 5-aminoimidazole-4-carboxamide ribonucleotide biosynthesis catalyzed by PurB is required for the establishment of symbiosis.[PurB]
381	2827897	17935718	2007-12-22 11:09	Ion translocation by MlotiK1 was studied (MlotiK1).
381	2827897	18216238	2008-03-10 13:37	The structure of the transmembrane regions of the bacterial cyclic nucleotide-regulated channel MlotiK1, a non-voltage-gated 6 TM channel was determined. (MlotiK1)
382	2827899	15458403	2007-08-25 14:50	described mutant forms of DctD that activated transcription efficiently from a dctA'-'lacZ reporter gene that possessed the upstream activation sequences (UAS), but not from a reporter gene that lacked the UAS. [DctD]
382	2827899	15632443	2007-08-25 12:06	description of three distinct DNA sequence elements of the ExpG binding sites and their contribution to the specific binding process [ExpG strain2011]
382	2827899	15659691	2007-08-25 11:10	dctA deletion mutants that contain the mutant dctA alleles on a plasmid can proceed further in symbiotic development than null mutants of dctA. (dctA)
382	2827899	15899411	2007-08-25 22:21	findings supported the conclusion that RirA is the mediator of iron-responsive transcriptional repression of the two transcripts encoding the rhizobactin 1021 biosynthesis and transport genes [RirA]
382	2827899	16254442	2007-08-25 10:20	molecular cloning and biochemical characterization including substrate specificity, kinetcs and reaction conditions of L-N-carbamoylase [L-N-carbamoylase]
382	2827899	16274231	2007-08-25 13:39	Molecular model of the DNA-binding domain of FixJ that binds to the fixK promoter (fixj and fixk).
382	2827899	16285740	2007-08-25 10:56	oxygen dramatically inhibited the reaction of the RmFixL-RmFixJ complex with ATP but affected neither ATP binding nor RmFixL-RmFixJ complex formation [FixL, FixJ]
382	2827899	16406752	2007-08-25 10:19	The thermodynamic binding parameters of hydantoin racemase were studied (hydantoin racemase).
382	2827899	16478054	2007-08-25 11:57	The expression of the nolR gene in Sinorhizobium meliloti AK631 was investigated in relation to stage of growth, availability of nutrients, and different environmental stimuli using the nolR::lacZ fusion report system.
382	2827899	16513744	2007-08-25 13:35	bioinformatic, genetic, physiological, biochemical, and structural proof for reassignment of MotD, a protein previously thought to function as a cytoplasmic motility protein as a hook length regulator, FliK [MotD,FliK]
382	2827899	16672605	2007-08-25 10:15	GroEL/GroES production alone cannot explain the requirements for RpoH1 and RpoH2 in S. meliloti.
382	2827899	16903355	2007-08-25 21:17	The major role of BetS is as an emergency system involved in the rapid uptake of betaines in isolated and in planta osmotically stressed bacteroids of S. meliloti.
382	2827899	17015658	2007-08-25 10:10	An S. meliloti gene whose product is related to the human betaine-homocysteine methyl transferase enzyme has been identified and named bmt [bmt]
382	2827899	17377583	2007-08-25 12:21	BluB isolates and directs reduced flavin to activate molecular oxygen for its own cannibalization; role of BluB in the biosynthesis of the lower ligand of vitamin B(12), 5,6-dimethylbenzimidazole [BluB]
382	2827899	17486750	2007-08-25 10:05	The TolC protein of S. meliloti is assumed to be involved in the excretion of proteins ExsH and ExpE1.
382	2827899	17724847	2007-12-22 11:10	The importance of thioredoxin in melanin production in bacteria, through the regulation of laccase or tyrosinase activities, or both, by the redox state of structural or catalytic SH groups, is discussed. [trxL]
382	2827899	18630344	2008-08-16 10:12	signalling through the FeuP/FeuQ pathway is responsive to extracellular osmotic conditions, with low osmolarity stimulating ndvA expression.[FeuP, FeuQ in strain SU47]
384	4415076	17601173	2007-11-10 11:56	Multiple copies of rosR in R. leguminosarum bv. trifolii 24.2 increased exopolysaccharide production (RosR)
384	4415076	18156270	2008-05-03 13:10	RhaU of Rhizobium leguminosarum is a rhamnose mutarotase.[RhaU in strain Rlt100]
384	4415076	18310336	2008-05-17 10:24	A physical interaction between NifA and the hupSL promoter region was shown.(NifA) (hupS)(hupL)
384	4415076	18393991	2008-10-04 10:28	RapA1 protein functions are related to early legumes root adsorption and rhizosphere colonization. [RapA1]
384	4415076	18458328	2008-05-31 10:29	The purification, biochemical characterization, molecular genetic analysis, biological activity, and symbiotic function of a cell-bound bacterial cellulase (CelC2) enzyme from Rhizobium leguminosarum bv. trifolii.[CelC2]
394	962274	17921255	2007-12-15 10:18	The 3D structure of the TraR-TraM antiactivation complex was crystallographically determined.
394	962533	18487326	2008-08-09 10:30	This paper reports that the open reading frame y4zC of strain NGR234 encodes a novel rhizobial type 3 effector, termed NopT (for nodulation outer protein T).
394	962574	17921255	2007-12-15 10:18	The 3D structure of the TraR-TraM antiactivation complex was crystallographically determined.
394	2827901	15659692	2007-08-25 11:10	Rhizobium sp. strain NGR234 possesses a functional type three secretion system through which a number of proteins, called nodulation outer proteins (Nops), are delivered to the outside of the cell. (NopB)
394	2827901	16102002	2007-08-25 11:26	Mutation of nopP leads to a dramatic reduction in nodule numbers on F. congesta and T. vogelii.
394	2827901	17981961	2008-02-02 10:18	biochemical assays show here that NopA, NopB and NopX proteins interact directly with one another.[NopB & NopX]
394	2827901	18363648	2008-06-07 10:18	DNase I footprinting revealed that TtsI occupied not only the tts box consensus sequence, but also upstream and downstream regions in a concentration-dependent manner.[TtsI]
394	2886137	15915648	2005-05-31 17:23	NopA is associated with cell surface appendages produced by the type III secretion system
394	2886137	17981961	2008-02-02 10:18	biochemical assays show here that NopA, NopB and NopX proteins interact directly with one another.
435	2827903	15388921	2007-08-25 12:07	structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE) [purE]
435	2827903	16391084	2007-08-25 14:41	findings showed that AatA was a putative ABC transporter conferring acetic acid resistance on the host cell [AatA]
435	2827903	16819818	2007-08-25 21:17	PurE was examined focusing on its adaptation to acid pH and the roles of conserved residues His59 and His89.(PurE)
435	2827903	16843006	2007-08-25 10:13	partial purification of native alanine racemase & evidence that it is a rather stable enzyme. C-terminus has strong resemblance to the ssrA-encoded protein degradation signal [alanine racemase]
435	2827903	17087502	2007-08-25 21:07	The crystal structure of AaCS, complexed with oxaloacetate (OAA) and the inhibitor carboxymethyldethia-coenzyme A (CMX), was determined to 1.85 A resolution[citrate synthase, AarA gene product]
435	2827903	17655332	2007-10-13 12:36	The spectroscopic data are consistent with proton transfers involving His59 Ndelta that are invoked in the class I PurE mechanism.(PurE)
435	2827903	18502856	2008-08-09 10:12	AarC is succinyl-coenzyme A (CoA):acetate CoA-transferase, which replaces succinyl-CoA synthetase in a variant citric acid cycle.[AarC]
446	3293160	15773981	2007-08-25 14:48	SdeA is secreted into macrophages by L. pneumophila in an IcmS-dependent manner [SdeA, IcmS]
446	3293160	15845496	2007-08-25 21:13	PlaC is a major secreted lipolytic enzyme characterized as a protein with acyltransferase, phospholipase A, and lysophospholipase A activities. [PlaC]
446	3293160	16906144	2007-08-25 13:30	(DrrA)DrrA is a potent and highly specific Rab1 guanine nucleotide-exchange factor (GEF).
446	3293160	16926407	2007-08-25 13:30	Mip promotes the elaboration of a new type II exoprotein. (Mip)(Strain AA100)
446	3293160	17371403	2007-08-25 12:21	Host cells stimulate secretion and translocation of the LepA and LepB proteins by Icm/Dot TFSS. Translocation is inhibited by agents that depolymerize actin filaments and that secretion into the extracellular medium occurs upon cell contact. [LepA, LepB]
446	3293160	17947549	2007-12-01 11:51	findings show that SidM from Legionella pneumophila could act as both a GDP-GTP exchange factor and GDP-dissociation inhibitor-displacement factor (GDF) for Rab1 [SidM]
446	3293160	17952054	2007-12-15 11:07	L. pneumophila encodes proteins (DrrA and LepB) that regulate three distinct biochemical reactions critical for Rab GTPase membrane cycling to redirect Rab1 to the pathogen-occupied vacuole and to control Rab1 function [DrrA & LepB]
446	3293160	18083880	2008-03-10 15:45	ProA metalloprotease represents the first type II effector implicated in an intracellular infection event,in particular among protozoan hosts. [ProA]
446	3293160	18194518	2008-05-10 10:22	Virulence factor rtx in Legionella pneumophila, evidence suggesting it is a modular multifunctional protein
446	3293160	18279343	2008-06-14 10:14	Our data suggest a role for AnkH and AnkJ in modulation of phagosome biogenesis by L. pneumophila independent of evasion of lysosomal fusion and recruitment of the rough endoplasmic reticulum.[AnkH and AnkJ in strain AA100]
446	3293160	18337253	2008-06-21 10:05	demonstrated important differences to mammalian ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) and different sensitivities to NTPDase inhibitors that may reflect underlying structural variations[lpg1905]
446	3293160	18366641	2008-06-07 10:18	solution structure of free Mip77-213 and the Mip77-213-rapamycin complex by NMR spectroscopy
446	3293160	18403241	2008-07-19 10:11	mcoL gene encodes a multicopper oxidase, and is critical for growth under iron-limiting conditions or in the presence of ferrous iron. [mcoL]
446	3293160	18411263	2008-08-23 10:14	LqsA and CqsA belong to a family of pyridoxal 5'-phosphate-dependent autoinducer synthases, which produce the alpha-hydroxyketone signaling molecules LAI-1 and CAI-1
446	3293160	18426879	2008-07-12 10:23	We have established that LadC plays an important role in L. pneumophila infection.
470	3759986	17363424	2008-01-05 16:58	The results of this study suggest that decreased susceptibility to tigecycline in the A. calcoaceticus-A. baumannii complex is associated with the overexpression of the AdeABC multidrug efflux pump.[AdeA, AdeB, AdeC proteins]
470	3759986	17374723	2007-08-25 10:05	analysis of the crystal structure of the carbapenemase OXA-24 reveals insights into the mechanism of carbapenem hydrolysis [OXA-24]
470	3759986	17403709	2008-01-05 15:17	This study represents the first report of an AmpC beta-lactamase in A. baylyi, which was shown by biochemical and microbiological experiments to have a typical cephalosporinase profile. [AmpC beta lactamase]
470	3759986	17760880	2008-03-10 14:16	AbOmpA translocates to the nucleus by a novel monopartite nuclear localization signal (NLS).
470	3759986	17997983	2008-03-29 13:05	CarO participates in the selective uptake of L-ornithine, carbapenems, and other basic amino acids in A. baumannii (CarO).
470	3759986	18024522	2008-02-16 10:59	This is the first identification of a specific cell surface protein directly involved in biofilm formation by A. baumannii and suggests that Bap is involved in intercellular adhesion within the mature biofilm. [Bap]
470	3759986	18281398	2008-05-17 10:24	Autoinducer synthase AbaI from Acinetobacter baumannii strain M2 was cloned and characterized.(AbaI)
480	2827907	15501752	2007-08-25 21:06	essential for natural genetic transformation and is iron responsive and FUR regulated [PilA][pilQ][PilT]
480	2827907	15501773	2007-08-25 21:06	essential component of a hemin uptake and utilization system previously undescribed for M. catarrhalis, thus providing another mechanism of iron acquisition that may facilitate persistent colonization of the mucosal surface [HumA]
480	2827907	16107956	2007-08-25 21:05	observations show that both UspA1 and UspA2 are involved in adherence to epithelial cells via cell-associated fibronectin [UspA1, UspA2]
480	2827907	16148107	2007-08-25 15:07	UspA1/A2 exert their actions by absorbing and neutralizing C3 from serum and restrain complement activation(UspA1)(UspA2)
480	2827907	16177336	2007-08-25 21:14	outer membrane protein G1a is expressed during infection of the human respiratory tract and is a target of systemic and mucosal antibodies. (G1a)
480	2827907	16239560	2007-08-25 21:12	An lpxA gene encoding an acyltransferase responsible for the first step of lipid A biosynthesis was identified in the isogenic M. catarrhalis lpxA mutant in strain O35E; the potential use of the mutant as a vaccine strain is also reported.[lpxA]
480	2827907	16299321	2007-08-25 14:14	Cold shock at a physiologically relevant temperature of 26 degrees C induces the expression of at least one virulence factor (UspA1) in Moraxella catarrhalis. (UspA1)
480	2827907	16872370	2007-08-25 14:06	study shows that the region defined by monoclonal antibody 10F3 is a major surface epitope of CopB and that the sequence of this epitope is more variable than previously thought [CopB]
480	2827907	17073558	2007-08-25 13:29	MID is a T-cell-independent antigen.(MID)
480	2827907	17166229	2007-08-25 15:03	McmA is associated with adherence to human epithelial cells. [mcmA]
480	2827907	17391370	2007-08-25 13:59	Study reports that two distinct domains of the M. catarrhalis strain O35E OMPCD protein specify adherence. [outer membrane protein CD]
480	2827907	17471435	2007-08-25 12:20	In conclusion, M. catarrhalis induced apoptosis in pulmonary epithelial cells--a process that was triggered by interaction between CEACAM1 and UspA1. [UspA1]
480	2827907	17562762	2007-10-13 11:06	Introduction of the M. catarrhalis ETSU-9 uspA2H gene into Escherichia coli conferred biofilm formation ability on this recombinant strain. (uspA2, uspA2H)
480	2827907	17608944	2007-09-08 12:35	Hag is a major adherence factor for human cells derived from various anatomical sites relevant to pathogenesis by M. catarrhalis and its structure-function relationships differ from those of other, closely-related autotransporter proteins.[Hag]
480	2827907	18065547	2008-07-12 10:26	study describes the identification and characterization of a novel M. catarrhalis autotransporter (MapA) that exhibits acid phosphatase activity [MapA]
480	2827907	18069032	2008-04-19 11:50	An isogenic mutant of strain O35E, which lacked expression of the UspA1 adhesin, demonstrated not only severely impaired adherence (86%) to but also reduced invasion (77%) into Chang conjunctival cells in comparison with the wild-type strain.[UspA1]
480	2827907	18497748	2008-07-19 10:40	This explains how UspA1 can engage CEACAM1 at a site far distant from its head group, permitting closer proximity of the respective cell surfaces during infection.[UspA1]
485	3293162	16618494	2007-08-25 11:55	Results describe the crystal structures of MltA from Neisseria gonorrhoeae and Escherichia coli [MltA].
485	3293162	16796676	2007-08-25 11:53	farAB-encoded efflux pump in N. gonorrhoeae is modulated by the DNA binding activities of FarR and IHF.(FarR)(farA)(farB)
485	3293162	16954205	2007-08-25 13:30	genes involved in the truncated denitrification pathway of N. gonorrhoeae are key components of the small NarQP regulon, that NarP indirectly regulates P(norB) by stimulating NO production by AniA[NsrR, NarQ and NarP]
485	3293162	17015660	2007-08-25 10:10	Characterization of peptidoglycan fragments released during growth showed that an amiC mutant did not produce free disaccharide, consistent with a role for AmiC as an N-acetylmuramyl-l-alanine amidase [amiC]
485	3293162	17287984	2007-10-13 12:39	13 N-termminal residues of MinC determine interaction with FtsZ protein. [MinC, FtsZ]
485	3293162	17526702	2007-09-15 11:08	These data show that AtlA plays a role in type IV secretion of DNA that requires peptidoglycan breakdown without cell lysis.[AtlA]
485	3293162	17927698	2007-12-22 10:21	A novel relaxase homologue TraI is involved in DNA processing for Type IV secretion.  [TraI relaxase]
485	3293162	18174141	2008-03-29 10:22	Insertional inactivation of gonococcal nsrR, predicted to bind to this inverted repeat sequence, resulted in the loss of norB repression and eliminated NO induction capacity.[NsrR, norB in strain F62]
485	3293162	18310343	2008-05-17 10:24	Expression of the gonococcal fur gene in vitro and in human cervical epithelial cells was demonstrated.
485	3293162	18338854	2008-05-31 10:29	synergistic anion plays a structural and functional role in FbpA-mediated transport of iron across the periplasm and into the cytosol[FbpA]
485	3293162	18347046	2008-05-10 10:13	These data indicate that the conserved motif between residues 120 and 122 of the TbpA plug domain is critical for transferrin-iron utilization.[TbpA in strain FA19]
485	3293162	18390650	2008-07-12 10:05	The ampD mutant showed increased metabolism of exogenously added free disaccharide derived from peptidoglycan [ampD]
485	3293162	18426887	2008-08-09 10:30	These data suggest that the MntABC transporter is of importance for survival of Neisseria gonorrhoeae in the human host.[MntA, MntB, MntC]
485	3293162	18567658	2008-09-20 10:42	Data identified lytic transglycosylase D (LtgD) as responsible for release of peptidoglycan monomers from gonococci and suggested that these enzymes are involved in pathogenesis but not necessary for normal growth: [LtgD]
487	2827909	15014442	2007-08-25 13:20	crystal structure of the in vitro-folded translocator domain of the autotransporter NalP from Neisseria meningitidis [NalP]
487	2827909	15557807	2007-08-25 11:10	protein structure of methionine sulfoxide reductase B[methionine sulfoxide reductase B]
487	2827909	15660996	2007-08-25 12:49	findings show that NadA is a novel invasin which, when expressed on the surface of Escherichia coli, promotes adhesion to and invasion into Chang epithelial cells [NadA, strain 2996]
487	2827909	15661009	2007-08-25 12:46	identified inducible DNA repair system that might be used by the bacteria to adapt to its niches when it is colonizing a new host.[EXO VII]
487	2827909	15664958	2007-08-25 13:12	a novel surface-exposed lipoprotein which induces bactericidal antibodies against conformational epitopes in the BC domain (GNA 1870)
487	2827909	15731047	2007-08-25 14:49	required for proper capsule transport and surface expression of the liquidated polymer[LipA, LipB]
487	2827909	16123038	2007-08-25 11:30	MsbA does not have a critical role in phospholipid transport in Neisseria meningitidis [MsbA]
487	2827909	16177349	2007-08-25 21:14	De novo production of IgA1 protease was responsible for cleavage of PorA-bound IgA1 on encapsulated bacteria.(IgA1 protease)
487	2827909	16274664	2007-08-25 10:20	sialic acid synthases kinetics and preliminary mutagenesis experiments reveal the importance of C-terminal antifreeze protein domain [sialic acid synthase]
487	2827909	16299348	2007-08-25 14:14	laz mutant Neisseria meningitidis strains are hypersensitive to hydrogen peroxide and copper (laz).
487	2827909	16407174	2007-08-25 12:33	analysis of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis [GNA1870]
487	2827909	16455995	2007-08-25 13:58	Toll-Like Receptor 2 (TLR2) recognizes PorB through direct binding, and that PorB-induced cell activation is mediated by a TLR2/TLR1 complex [PorB]
487	2827909	16677307	2007-08-25 10:52	FNR positively controlled the transcription of nine transcriptional units, the most upregulated of which were the two operons NMB0388-galM and mapA-pgmbeta implicated in sugar metabolism and fermentation.
487	2827909	16785547	2007-08-25 21:17	GNA1870 is identified in the meningococcal outer membrane as a ligand of human complement regulatory protein factor H (fH); levels of GNA1870 expression correlate with fH binding.  [GNA1870]
487	2827909	16803596	2007-08-25 10:14	a putative role of NhhA in meningococcal pathogenesis and ascertain its structural and functional belonging to the emerging group of bacterial autotransporter adhesins with trimeric architecture.[NHHA]
487	2827909	17005811	2007-08-25 12:26	PenA gene sequence variation related to susceptibility to penicillins [penA]
487	2827909	17095508	2007-08-25 11:49	crystal structures of heme oxygenase, which suggests a structural basis for ligand discrimination [heme oxygenase]
487	2827909	17159226	2007-08-25 12:24	results yield novel information on the PilQ N-terminal location and function in the periplasm, and reveal a complex organization of the membrane-spanning secretin in vivo [PilQ]
487	2827909	17464074	2007-12-01 10:13	By assessing the DNA-binding activity of the native complex PilQ, as well as recombinant truncated PilQ monomers, it was shown that the N-terminal region of PilQ is involved in the interaction with DNA.[PilQ]
487	2827909	17526700	2007-09-15 11:08	These findings suggest a role for PilP in pilus biogenesis; PilP and PilQ interaction might have activity in pilus extrusion/retraction or related functions.[PilP, PilQ]
487	2827909	17620353	2007-10-13 11:06	Opa proteins within bacterial outer membrane vesicle preparations retain the capacity to bind human immunoreceptor tyrosine-based inhibitory motif-containing coinhibitory receptor CEACAM1 and inhibit T cell activation and proliferation.  (opa)
487	2827909	17766244	2007-12-15 12:45	In this study, the invariant amino acids of In this study, the invariant amino acids of N. meningitidis MsrB involved in the reductase step catalysis and in substrate binding have been characterized by the structure-function relationship approach. [pilb]
487	2827909	17893339	2007-12-01 10:15	results support a model in which surface-exposed motifs in PilX subunits stabilize bacterial aggregates against the disruptive force of pilus retraction and illustrate how a minor pilus component can enhance the functional properties of pili [PilX]
487	2827909	17897964	2007-12-29 12:47	The R.NmeDI enzyme recognizes a palindrome sequence and cleaves double-stranded DNA upstream and downstream of its recognition sequence (12/7) RCCGGY (7/12) (R = A/G, Y = C/T) cutting out a 25-bp fragment (R.NmeDI).
487	2827909	18000029	2008-04-05 11:12	Characterization of the alpha-2,8-polysialyltransferase from Neisseria meningitidis with synthetic acceptors, and the development of a self-priming polysialyltransferase fusion enzyme
487	2827909	18007659	2008-06-21 10:05	In strain HB-1, the functional core of Omp85 consists of its membrane domain and a single POTRA domain, that is, POTRA5[Omp85]
487	2827909	18255097	2008-03-29 12:11	Four structures of the MsrA domain of the PilB protein from Neisseria meningitidis, representative of four catalytic intermediates of the MsrA catalytic cycle, were determined by X-ray crystallography.[MsrA]
487	2827909	18433773	2008-06-14 10:23	Data report the high-resolution crystal structure of PilW, the partner lipoprotein of the type IV pilus secretin PilQ from Neisseria meningitidis, which defines a conserved class of Tfp biogenesis proteins in a wide variety of bacteria [PilW].
487	2827909	18664272	2008-09-13 10:45	PriA plays roles in preventing oxidative and nitrosative injury, and in intracellular meningococcal replication. [PriA]
518	2827913	15489442	2007-08-25 13:06	BfeR encodes an enterobactin-dependent positive regulator of bfeA transcription [BfeR]
518	2827913	16407269	2007-08-25 12:34	BopC is a type III secretion system protein crucial for inducing cytotoxicity and necrotic cell death during Bordetella infection of cultured mammalian cells [BopC]
518	2827913	18258259	2008-03-29 11:16	Arylmalonate decarboxylase has an aspartate transcarbamoylase fold consisting of two alpha/beta domains related by a pseudo dyad[arylmalonate decarboxylase ]
520	2827917	15341649	2007-08-25 11:35	data establish that delivery of AC toxin by intact B. pertussis is not dependent on the surface-associated AC toxin, but requires close association of live bacteria with target cells and the active secretion of AC toxin [AC toxin ]
520	2827917	15489442	2007-08-25 13:06	BfeR encodes an enterobactin-dependent positive regulator of bfeA transcription [BfeR]
520	2827917	15500977	2007-08-25 11:20	results indicate that other amino acid residues that are not present in the FHA(430-873) fragment may be necessary for heparin binding [FHA]
520	2827917	15687212	2007-08-25 13:10	Our data demonstrate that the BvgAS locus regulates biofilm development in Bordetella. [bvgA, bvgS strain BP536]
520	2827917	15716435	2007-08-25 13:10	We examined the roles of BvgR and RisA in the regulation of vrg6 in B. pertussis.[BvgR, RisA, vrg6]
520	2827917	15773988	2007-08-25 14:48	studies to determine precisely where BvgA-phosphate (BvgA approximately P) binds at the bipA promoter and how that binding contributes to the complex transcription pattern displayed by bipA [BvgA, BipA]
520	2827917	16138079	2007-08-25 12:36	crystal structures of the adenylyl cyclase domain (ACD) of CyaA with the C-terminal domain of calmodulin [cyaA]
520	2827917	16238621	2007-08-25 13:38	Data demonstrate the additive nature of BvgA binding site affinity and protein-protein interactions at different Bvg-regulated promoters [BvgA]
520	2827917	16284399	2007-08-25 15:04	The N-terminal 200 residues of FhaC constitute a functionally distinct domain that modulates the pore properties and may participate in FHA recognition. [FHAC]
520	2827917	16988232	2007-08-25 10:48	Expression of PagP and PagL in Bordetella pertussis leads to increased and decreased endotoxic activity of the LPS, respectively.(PagP) (PagL)
520	2827917	17339350	2007-08-25 10:43	These results indicate that tight association of PtlH with the membrane, likely through interactions with components of the transporter-PT complex, requires the toxin substrate, a specific subset of the Ptl proteins, and ATP. [PtlH]
520	2827917	17702945	2007-09-08 11:50	3.15 A crystal structure of FhaC was determined [FHaC]
520	2827917	17724074	2007-12-01 12:19	The attenuating effect of fauA inactivation suggests that ferric alcaligin transport of B. pertussis may be important for adaptation to iron-restricted host conditions that exist at the initial stages of infection.[FauA]
520	2827917	17976530	2008-03-22 10:19	Experiments with ACT mutants revealed, that the adenylate cyclase (AC) and repeat (RT) domains were not involved in voltage and pH sensing.[ACT]
520	2827917	18426886	2008-07-12 10:23	CyaA (adenylate cyclase toxin) impairs T-lymphocyte activation and chemotaxis inhibition of T-cell antigen receptor and chemokine receptor signaling via a cAMP/protein kinase A (PKA)-dependent pathway. [CyaA]
542	2827921	18310045	2008-05-03 10:57	the respiratory chain of Z. mobilis contains only one functional NAD(P)H dehydrogenase, product of the ndh gene.[ndh in strain ATCC29191]
546	2827923	16511092	2007-08-25 21:18	The crystal structure of MGL at 1.9 A resolution. The comparison of Pseudomonas putida and Trichomonas vaginalis structures revealed differences in PLP-binding residues and positioning of the surrounding flexible loops. (L-methionine gamma-lyase)
546	2827923	16615855	2007-08-25 13:34	Expression of the megL gene in the C. freundii genome occurs only upon induction by a significant amount of L-methionine.
546	2827923	16793353	2007-08-25 13:33	Replacement of Asp214 in tyrosine phenol-lyase (TPL) with Ala and Asn leads to alteration of active site conformations and to a decrease in the cofactor affinity of about four orders of magnitude. [TPL]
546	2827923	16878992	2007-08-25 21:03	These results are the first direct spectroscopic observation of alpha-aminoacrylate intermediates in the reactions of tyrosine phenol-lyase (TPL).
546	2827923	18287296	2008-04-05 10:18	It was concluded that production of KPC-2 combined with decreased expression of porins contributes to high-level resistance to carbapenems in C. freundii ZJ163. [KPC-2]
548	2827925	16820687	2007-08-25 14:07	Enzyme was cloned in E coli purified and examined crystallographically. (glycerophosphodiesterase) (newentry)
548	2827925	17306828	2007-08-25 10:07	Structure and function of a novel glycerophosphodiesterase from Enterobacter aerogenes.
548	2827925	17630782	2007-10-13 11:05	catalytic properties of glycerophosphodiesterase (GpdQ) and GpdQ hydrolyses a close analogue of EA 2192, the most toxic and persistent degradation product of the nerve agent VX: GpdQ
548	2827925	18160520	2008-09-06 10:05	E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149. [TME-149]
552	2827927	16404949	2007-08-25 11:58	We confirmed that DspA/E acts as a major cell-death inducer during disease and HR, because the dspA/E mutant is severely impaired in its ability to induce electrolyte leakage in apple and tobacco leaves [DspA/E]
552	2827927	16776298	2007-08-25 13:32	AvrRpt2EA acts as a virulence factor on immature pear fruits.
552	2827927	17211539	2007-08-25 11:47	A major Erwinia amylovora outer-membrane protein (Omp-EA) and the gene encoding for this protein (omp-EA) were isolated and characterized.  [Omp-EA]
552	2827927	17918630	2007-12-29 10:18	We sequenced the putative autoinducer-2 (AI-2) synthase gene luxS from E. amylovora
552	2827927	18616404	2008-09-06 10:41	Type three-secreted proteins DspA/E and HrpN induce cell death, activation of defense pathways, and ROS accumulation in Arabidopsis. [DspA/E and HrpN]
554	3292998	15995194	2007-08-25 11:06	The expR effect in E. carotovora subsp. carotovora is channeled via RsmA, a posttranscriptional regulator of E. carotovora subspecies. (rsmA)
554	3292998	16096274	2007-08-25 10:56	CarB is a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis [CarB]
562	1238603	17635860	2007-11-10 10:19	These results are consistent with the hypothesis that human immune responses against bundlin exert selective pressure on bfpA sequence divergence.
562	1238606	15866879	2007-08-25 12:37	BfpD ATPase activity is greatly enhanced by zinc and allosteric interactions with other Bfp proteins
562	1238622	15159578	2007-08-25 11:07	Crystallization of CcdB in complex with a GyrA fragment
562	1238683	17962420	2008-02-02 12:52	A critical regulatory protein, CI, is essential to the behavior of the phage lambda regulatory circuit. In the lysogenic state.
562	1238710	15257292	2007-08-25 12:08	Donor DNA binding by the TnsA/TnsC(495-555) complex is correlated with the activation of the TnsAB transposase
562	1238712	15257292	2007-08-25 12:08	Donor DNA binding by the TnsA/TnsC(495-555) complex is correlated with the activation of the TnsAB transposase
562	1238724	17259614	2007-08-25 14:02	It is proposed that TraJ is a functional part of the IncH-type coupling protein complex required for translocation of DNA through the cytoplasmic membrane.
562	1238761	17331537	2007-08-25 11:45	Conformational intermediate in E. coli topoisomerase III-DNA complexes.
562	1238761	18570879	2008-08-02 10:35	RecQ-like DNA helicases pair with cognate topoisomerase III enzymes to function in the maintenance of genomic integrity.
562	1238770	16672615	2007-08-25 10:15	The role of conserved amino acid residues in the polymerase domain of Escherichia coli primase has been studied by mutagenesis
562	1446498	16272376	2007-08-25 11:59	Fplasmid TraN appears to have two domains: the N-terminal region is involved in OmpA interaction with OmpA during MPS; and the C-terminal region, which is rich in conserved cysteine residues, is essential for conjugation.
562	1446514	16984922	2007-08-25 11:51	TraI is a highly processive monomeric helicase
562	1446514	17890221	2008-01-05 14:24	the metal-binding His cluster in TraI is a finely tuned structure that achieves a sufficient affinity for metal while avoiding the unfavorable electrostatics that would result from placing an acidic residue near the scissile phosphate of the bound ssDNA
562	1446522	16113321	2007-08-25 21:18	mutant of EPEC strain E2348/69 demonstrates close adherence to the epithelial cells of porcine ileal in vitro organ culture segments, with microvillous effacement but with no evidence of actin polymerization or pedestal formation
562	1446522	16436373	2007-08-25 12:34	the virulence mechanism of Tir is that Tir is released into the cytoplasm by the type III translocon and then independently inserts into the plasma membrane from a cytoplasmic location
562	1446526	16514151	2007-08-25 13:36	MBD (MerR metal-binding domain) expressed on the cell surface and in the cytosol afforded improved survival from Hg(II) exposure for E. coli
562	1446554	17955352	2008-04-19 11:11	review of ArsAB and ArsD function
562	1446589	16306264	2007-08-25 10:55	plasmid separation is driven by the polymerization of SopA
562	1446589	17166176	2007-08-25 15:03	results suggest that in vivo, SopB smothers DNA by spreading from sopC, allowing SopA-ATP polymerization which initiates plasmid displacement; we propose that SopB and nucleoid DNA regulate SopA polymerization and hence partition
562	1446590	17166176	2007-08-25 15:03	results suggest that in vivo, SopB smothers DNA by spreading from sopC, allowing SopA-ATP polymerization which initiates plasmid displacement; we propose that SopB and nucleoid DNA regulate SopA polymerization and hence partition
562	1446601	16677671	2007-08-25 12:31	Results provide evidence for a previously undetected intermediate along the pathway to forming the binding protein (SSB)-single-stranded DNA (65) complex.
562	2716475	16751571	2007-08-25 10:50	When tetracycline was present, tetA reduced acid tolerance and increased concentrations of total soluble proteins in stationary-phase Escherichia coli.
562	2716475	17517833	2007-10-20 11:08	interdomain loop mutation Asp190Cys of TetA(B) decreases affinity for tetracycline
562	2716476	16128817	2007-08-25 15:07	effect of mutations in the DNA reading head-core interface on the effector specific TetR(i2) variant
562	2716485	17295678	2007-08-25 10:07	emphasises of the epidemic potential of multiple-antibiotic-resistant CTX-M-15-producing E. coli in a country with low antibiotic usage and low prevalence of antimicrobial resistance.
562	2716485	18334490	2008-06-14 10:34	The characerization of an E. coli clone producing CTX-M-15 that is spreading through Europe and Africa is reported.
562	2716518	17483090	2007-09-15 12:40	SSB is a broadly conserved RecQ-binding protein
562	2716540	15213455	2007-08-25 11:21	NMR assignments for TEM-1
562	2716540	15326193	2007-08-25 21:14	Tyr-105 is important in substrate stabilization and discrimination in TEM-1 beta-lactamase.
562	2716540	15666541	2007-08-25 12:06	pH-dependent quenching of the fluorescence of tryptophan residues of TEM-1 beta-lactamase from E. coli.
562	2716549	18247525	2008-06-07 10:29	Data conclude that YciA is responsible for the efficient, "seemingly" indiscriminant, CoA-regulated hydrolysis of cellular acyl-CoA thioesters and hypothesize that this activity may support membrane biogenesis.
562	2827929	15014439	2007-08-25 13:20	2.0 A resolution crystal structure of the complex between the toxic domain of Colicin D and its immunity protein ImmD (Colicin D and ImmD)
562	2827929	15213443	2007-08-25 11:17	resonance assignment of a 'donor-strand complemented' AfaE from Escherichia coli [AfaE or Afa-3]
562	2827929	15213444	2007-08-25 14:37	resonance assignments of the 'donor-strand complemented' AfaD from E coli [AfaD]
562	2827929	15583337	2007-08-25 13:11	CNF1 is a candidate virulence factor in E coli infections in ferrets [CNF1]
562	2827929	15616284	2007-08-25 14:49	plasmid encoded quinolone resistance protein Qnr interacts with Escherichia coli DNA gyrase holoenzyme and its respective subunits GyrA and GyrB. [QNR]
562	2827929	15616333	2007-08-25 14:49	transposition mediated by ISEcp1B by recognizing a variety of DNA sequences as right inverted repeats.[bla(CTX-M-19]
562	2827929	15627395	2007-08-25 21:13	Analysis of the pH dependence of enzyme stability provides evidence that stable penicillin acylase conformation is maintained by salt bridges [penicillin acylase]
562	2827929	15690954	2007-08-25 12:06	The saa gene is commonly associated with bovine eae-negative verotoxin-producing Escherichia coli (VTEC) strains but not with ovine or caprine VTEC strains. [saa]
562	2827929	15789416	2007-08-25 14:48	Study of an Escherichia coli tRNA (m7G46) methyltransferase phylogeny, revealed the crucial residues for the formation of the substrate-binding site and the catalytic center, (tRNA (m7G46) methyltransferase)
562	2827929	15845460	2007-08-25 21:13	EspG modulates enteropathogen's host cytoskeleton function involving transient microtubule destruction and actin polymerization [EspG]
562	2827929	15853893	2007-08-25 21:19	Data show that expression of TetD activates transcription of a subset of the SoxS/MarA/Rob regulon genes and confers resistance to redox-cycling compounds and antibiotics [TetD].
562	2827929	15896790	2007-08-25 15:08	volume and enthalpy changes differ from the volume and enthalpy changes observed for CO dissociation from fully reduced cytochrome bo3 oxidase indicating that the heme o3/CuB active site dynamics are affected by the redox state of heme b [cytochrome bo3]
562	2827929	15946951	2007-08-25 11:05	An exxmination of crystal structure and substrate specificity of this enzyme (isoaspartyl aminoptidase0
562	2827929	15951570	2007-08-25 13:08	ParG protein is shown to be a transcriptional repressor of the parFG genes. (ParG protein)
562	2827929	15952768	2007-08-25 13:10	The structure of isoenzyme B (CysM) from Escherichia coli was established in a hexagonal crystal form at 2.7 A resolution. (CysM)
562	2827929	15979569	2007-08-25 13:40	Our results indicate that aprotinin molecules, reaching stable conformation before transport across the outer membrane, are degraded in the periplasm due to proteolysis. [aprotinin]
562	2827929	16040988	2007-08-25 21:04	locus for diffuse adherence, encodes a novel afimbrial adhesin (LdaH)
562	2827929	16114886	2007-08-25 14:14	Site directed mutagenesis of TolB binding region creates a binding site to colicin b9.  (colicin E9)
562	2827929	16166536	2007-08-25 21:18	the TolB box sequence in ColE9 is actually larger than the pentapeptide and extends from residues 34 to 46[COLE9]
562	2827929	16199570	2007-08-25 14:14	We have found a protein (named Cnu, for oriC-binding nucleoid-associated) that binds to a specific 26-base-pair sequence (named cnb) in the origin of replication of Escherichia coli, oriC [CNU]
562	2827929	16228285	2007-08-25 11:59	intrinsic differences between Tir from enterohemorrhagic and enteropathogenic strains of E coli were determined [Tir]
562	2827929	16239563	2007-08-25 21:12	The role of the afaE and afaD genes in the mortality of pregnant rats from intrauterine infection with E. coli is reported.[afaE; afaD]
562	2827929	16292342	2007-08-25 14:42	Methyltransferase core unit of EcoR124I loads the motor subunits onto adjacent DNA by allowing them to bind and initiate translocation (endodeoxyribonuclease EcoR124I)
562	2827929	16331988	2007-08-25 21:12	characterization of the substrate specificity and kinetic mechanism of the acetyl transfer reaction catalyzed by the aminoglycoside 3-N-acetyltransferase AAC(3)-IV [AAC(3)-IV].
562	2827929	16364916	2007-08-25 11:59	Results describe the crystal structure of the complex between E. coli RF1 and PrmC bound to the methyl donor product AdoHCy [RF1].
562	2827929	16476797	2007-08-25 13:36	Cell-bound haemolysin rather than cell-free HlyA was found responsible for the cell-detaching activity of E. coli strains tested. [Ehx or Hly-EHEC]
562	2827929	16582500	2007-08-25 13:34	OmpW from Escherichia coli was cloned and the protein was expressed in inclusion bodies a method method for refolding and purification was developed.
562	2827929	16624801	2007-08-25 11:56	biochemical analysis of binding of cytochrome bo3 from Escherichia coli
562	2827929	16688219	2007-08-25 13:34	Data show that the intrinsic hemolytic activity of ClyA is independent of its redox state, and that the assembly of both reduced and oxidized ClyA to the ring-shaped oligomer is triggered by contact with lipid or detergent.
562	2827929	16707668	2007-08-25 10:16	TolC and VceC are interchangeable for the functioning of the AcrAB and VceAB pumps. (VceC)
562	2827929	16707672	2007-08-25 10:16	Recomsbinant F1F0 ATP synthasewas blocked in ATP hydrolysis activity, and this activity was stimulated by the detergent lauryldimethylamine oxide. (F1F0-ATP synthase)
562	2827929	16781180	2007-08-25 13:32	This investigation has established a role for EspG2 in the disruption of the microtubule network and associated different espG and espG2 types with different groups of EPEC. [EspG2]
562	2827929	16801432	2007-08-25 11:53	it is concluded that expression of the Cfr rRNA methyltransferase confers a PhLOPSA resistance phenotype (resistance to five chemically distinct classes of antimicrobials: Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A [Cfr]
562	2827929	16842368	2007-08-25 11:53	Phosphorylation and dephosphorylation of poly(A) polymerase I (PAP I) effects the activity of the enzyme.
562	2827929	16848790	2007-08-25 11:52	Study reports that EPEC strain B171 produces a functional Cif and that delivery of purified Cif into HeLa cells induces cell cycle arrest and actin stress fibres, implying that Cif is necessary and sufficient for these effects. [Cif protein]
562	2827929	16861679	2007-08-25 13:31	Our results indicate that BarA-UvrY regulates virulence properties in Avian Pathogenic E. coli (APEC) [BARA, UvrY]
562	2827929	16885462	2007-08-25 13:31	fine-tuning of the CRP activity may be critical for bacterial viability and adaptability to changing osmotic conditions [crp]
562	2827929	16894158	2007-08-25 10:49	Results identify the 16-residue TolB binding epitope in the natively disordered T-domain of the nuclease colicin E9 (ColE9) and present the crystal structure of the complex [ColE9].
562	2827929	17015654	2007-08-25 10:10	The presence of the tetracycline resistance determinant tet(M) in human clinical isolates of Escherichia coli is described for the first time in this report [tet(M)]
562	2827929	17093030	2007-08-25 12:25	multiple genes associated with biofilm formation are regulated by aggR.[AggR]
562	2827929	17096428	2007-08-25 11:49	Homologous AroQ chorismate mutases from the thermophile Methanococcus jannaschii & the mesophile Escherichia coli were compared as to their capacity to accommodate extensive mutation. There were 10% less functional variants in the E coli AroQ.
562	2827929	17133368	2007-08-25 21:02	a high level of sodC expression occurred during the stationary phase and a high level of expression of the tpx gene was strongly induced only during the exponential growth of E coli O157-H7 [sodC, tpx]
562	2827929	17159217	2007-08-25 14:02	MarA, SoxS and Rob all contribute to virulence in vivo.[MarA, SoxS and Rob]
562	2827929	17241243	2007-08-25 21:02	Escherichia coli expressing the HEK protein can adhere to and invade epithelial cells. This is the first outer membrane protein in neonatal meningitiis E. coli to be directly implicated in epithelial cell invasion. [Hek protein]
562	2827929	17261809	2007-08-25 13:26	Stimulates ATP hydrolysis by ParF approximately 30-fold.  The mobile tails of ParG are crucial for this enhancement; arginine R19 within the tail is absolutely required.  (ParG)
562	2827929	17302825	2007-10-27 11:45	data suggest that Hbp can fold in the periplasm but must retain a certain degree of flexibility and/or modest width to allow translocation across the outer membrane [Hbp]
562	2827929	17314059	2007-08-25 10:43	The toxicity of EHEC-Hly to microvascular endothelial cells plausibly contributes to the virulence of the stx-negative E. coli O26 strains and to the pathogenesis of HUS. [Hly]
562	2827929	17351038	2007-08-25 10:06	The EAEC strain 60A imp operon differs structurally from previously described homologs [impB, strain 60A]
562	2827929	17382555	2007-08-25 12:21	we observed that MCP-1, and IL-8 to a lower extent, is produced in urine at higher concentrations in UTIs caused by UPECs carrying alpha-hly/cnf1 [cnf1]
562	2827929	17442572	2008-03-03 10:43	nleA is involved in the ability of bacteria to transmit between hosts.
562	2827929	17620350	2007-10-13 11:06	Rabbit-specific enteropathogenic Escherichia coli plasmid-encoded autotransporter adhesin.  (RpeA)
562	2827929	17683883	2008-03-10 14:17	Selection for F18(+)E. coli resistant pigs might be an attractive approach to prevent pigs from F18(+)E. coli infections, unlike to what has previously been postulated.
562	2827929	17729276	2008-04-19 12:46	computational analysis of the electrostatic properties of Lpp-56 (Braun's E. coli outer membrane lipoprotein (Lpp-56)) combining molecular dynamics simulations and continuum pK calculations
562	2827929	17873039	2008-01-19 12:54	All four components of the yej locus are required for microcin sensitivity in E. coli.[Yej]
562	2827929	17933489	2008-05-03 10:58	These results show that the DsbA is required for stable expression of outer membrane secretin EscC. [DsbA, EscC in strain 2348/69]
562	2827929	17933890	2008-01-12 11:10	the N-terminal third of mature AIDA-I is involved in binding of this protein to cultured epithelial cells.[Aida-I]
562	2827929	17936013	2008-05-10 10:05	A 3-dimensional map of melibiose permease was calculated from data obtained by electron crystallography. melB.
562	2827929	17984209	2008-01-26 10:18	Enteropathogenic Escherichia coli O125:H6 lacks the ability to utilize either Nck or TccP/TccP2 and hence triggers actin polymerization in vitro only inefficiently.[TccP; TccP2]
562	2827929	18005731	2007-12-15 11:56	Here we demonstrate that NleA compromises the Sec23/24 complex, a component of the mammalian COPII protein coat that shapes intracellular protein transport vesicles, by directly binding Sec24. [NleA]
562	2827929	18025097	2008-02-23 11:11	SitABCD, MntH, and FeoB could potentially promote bacterial survival during infection by facilitating the transport of these trace metals and by countering oxidative stress during infection of the host. [SitA, B, C & D, MntH, FeoB in strain 7122]
562	2827929	18029421	2008-02-16 12:56	mutagenesis study on intimin-binding domain of EPEC TIR & how mutations affect TIR-intimin association; a three-residue TIR hot spot is identified that mediates interaction; mutants altering beta-hairpin structure of TIR diminish binding affinity [TIR]
562	2827929	18039830	2008-02-23 11:31	the results suggest that PapB and FocB can form heterodimers and that these complexes can repress expression of the foc operon.[PapB and FocB in strain J96]
562	2827929	18086185	2008-03-22 12:54	Binding kinetics, mutational analysis and spectroscopic examination of CEA dimers suggest that Dr adhesins can dissociate CEA dimers prior to the binding of monomeric forms.[Dr adhesin]
562	2827929	18154319	2008-03-10 14:14	The superb activity of the 8-oxoguanine glycosylases Fpg, hOGG1, and Ntg1 toward removal of FapyG and FapyA in vitro suggests that these enzymes may act upon these oxidized lesions in vivo.(Fpg)
562	2827929	18160475	2008-03-22 11:09	Hek-mediated adherence is dependent on binding to glycosoaminoglycan. The ability to hemagglutinate, autoaggregate, adhere, and invade is contingent on a putative 25-amino-acid loop that is exposed to the outside of the bacterial cells.
562	2827929	18160483	2008-03-22 11:09	These results suggest that TolC promotes the aggregation and adhesion of EAEC 042 by secreting an assumed humoral factor.[TolC in strain EAEC 042]
562	2827929	18167139	2008-06-21 10:05	In the strain of Escherichia coli K1, data suggest the presence of two domains in the molecular structure of IbeA, with differential unfolding stabilities [IbeA]
562	2827929	18174135	2008-03-29 10:22	The paper demonstrates a direct link between FyuA and biofilm formation in iron-poor environments. [FyuA]
562	2827929	18206967	2008-03-22 12:54	Inserting a Phe near C46 in AhpC makes it inactive as a peroxidase. Some point mutants confer exhibit an enhanced reductase activity toward mixed disulfides between glutathione and glutaredoxin. [AhpC]
562	2827929	18271752	2008-07-12 10:16	Data demonstrate that the conserved 'amphiphilic' feature of HdeA is essential for exhibiting chaperone-like activity under extremely low pH conditions.
562	2827929	18310018	2008-05-03 10:57	the pattern of suppression suggests that two distinct sites on FliG interact with FliM, perhaps with two FliM molecules in a dimer per molecule of FliG.[FliM and FliG in strain HCB1]
562	2827929	18312396	2008-06-14 10:34	the rpoS tnaB double mutant exhibited decreased adherence.[rpoS and tnaB in strain AIEC O83:H1]
562	2827929	18327421	2008-08-23 10:38	GrlA upregulates the expression of LEE through binding of the LEE1 promoter, which in turn increases the level of LEE-encoded regulator allowing it to function as a downstream activator. [GrlA, Lee]
562	2827929	18366439	2008-05-24 10:05	Without l-rhamnose, RhaS does not effectively bind DNA while RhaR does not effectively contact RNAP. Upon l-rhamnose binding, both proteins undergo structural changes that enable transcription activation.[RhaS, RhaR in strain SME3000]
562	2827929	18408035	2008-08-02 10:05	findings demonstrate for that immunity release from enzymatic colicins occurs immediately after reduction of the disulfide bond of ColE9s-s leading to unfolding of the helical hairpin [ColE9]
562	2827929	18443089	2008-07-12 10:32	From these data, we speculate that Hly hemolysin (HlyA) and cytotoxic necrotizing factor type 1 (CNF1), may be largely responsible for the signs and symptoms of cystitis in humans infected with toxigenic UPEC. [HlyA, CNF1]
562	2827929	18452948	2008-06-28 10:22	Results describe mapping studies of the epitopes of three NhaA-specific conformational monoclonal antibodies, two of which drastically inhibit the antiporter.
562	2827929	18455185	2008-06-14 10:23	Results describe the crystal structure of QOR2, a new type of NADPH-dependent quinone oxidoreductase from Escherichia coli [QOR2].
562	2827929	18466920	2008-06-28 10:22	Results present a structural characterisation of a conformational state populated at low pH by the N-terminal domain of Escherichia coli HypF [HypN-F].
562	2827929	18524928	2008-08-09 10:11	[strain MC4100, genes IbpA and IbpB] IbpA/B protect Escherichia coli cells from oxidative damage caused by copper
562	2827929	18550551	2008-09-20 10:42	[strain YU423, glucose dehydrogenase]
562	2827929	18650806	2008-09-06 10:21	EspF(U) activates N-Wiskott-Aldrich syndrome protein by competitively disrupting the autoinhibited state [E.Coli O157:H7 strain not specified, EspF(U)]
562	2827929	18650809	2008-09-06 10:21	EspF(U) forms an amphipathic helix that binds the GTPase binding domain, mimicking interactions of the VCA domain in autoinhibited WASP.  [E.Coli O157:H7 strain not specified, EspF(U)]
562	2827929	18674541	2008-09-20 10:49	Results provide experimental evidence for the existence of a stable half-barrel subdomain in the (beta/alpha)8-barrel fold of TrpF [TrpF].
562	2827929	18704088	2008-09-06 10:21	the solution structure of the apo-thiolation-thioesterase (T-TE) di-domain fragment of the Escherichia coli enterobactin synthetase EntF NRPS subunit [no strain specified; EntF]
562	3244885	15740745	2007-08-25 11:31	Results describe the early folding events of Escherichia coli dihydrofolate reductase utilizing systematic sequence perturbation analysis.
562	3331902	18399998	2008-06-28 10:22	results show that temperature regulates cka expression at the level of transcription; it is proposed that the SOS response indirectly regulates thermoregulation of colicin K
562	3331909	17122402	2007-08-25 14:03	Sequencing of the colicin K-encoding pColK-K235 revealed a mosaic structure and the presence of the insertion sequence IS2.
562	3654480	16377616	2007-08-25 21:14	Results show that alpha-hemolysin insertion into membranes does not necessarily lead to membrane lysis.
562	3654480	17382555	2007-08-25 12:21	we observed that MCP-1, and IL-8 to a lower extent, is produced in urine at higher concentrations in UTIs caused by UPECs carrying alpha-hly/cnf1
562	3654538	16649659	2007-08-25 12:31	Effect of different mutations on ArdA activities was studied.
562	3654548	16455668	2007-08-25 10:55	both EspP and heterologous proteins containing EspPsp are targeted to the SecYEG complex post-translationally
562	3654563	17763334	2007-11-10 11:06	findings raise the possibility that SubAB (subtilase cytotoxin) directly contributes to pathology in humans infected with strains of STEC that produce both Shiga toxin and SubAB
562	3654564	17763334	2007-11-10 11:06	findings raise the possibility that SubAB (subtilase cytotoxin) directly contributes to pathology in humans infected with strains of STEC that produce both Shiga toxin and SubAB
562	3654610	16034673	2007-08-25 11:26	protein conformation and nickel binding site
562	3654610	18759453	2008-10-04 10:13	NikA can bind at least two different metal-chelator complexes.
562	3829242	16352839	2007-08-25 14:42	It appears that some, but not all, of the residues in both the N and C termini of CooA play a critical role in the intermolecular interactions of the major pilin with the other structural and assembly proteins.
562	3829281	18065540	2008-07-12 10:26	Data show that mutations in the pilS gene at Gly-56 or Tyr-57 produced type IV pili lacking PilV adhesin, which were inactive in liquid mating.
562	3829298	18042674	2008-03-10 15:45	Abrupt reversal of the unfolding pathway at low to moderate concentrations of the denaturant, but not at high concentration.
562	3829308	16359334	2007-08-25 12:58	results of the present study are consistent with the participation of ParA in an initial ParB-dependent plasmid pairing
562	3829309	16359334	2007-08-25 12:58	results of the present study are consistent with the participation of ParA in an initial ParB-dependent plasmid pairing
562	4397527	17326753	2007-09-15 10:21	Data indicate that a combination of ampC promoter mutations and other strain-specific factors combine to contribute to the magnitude of cefoxitin resistance in E. coli.
562	5951226	17457514	2008-07-12 10:33	Data show that the N-terminal region of MerA interacts with the cytoplasmic face of MerT, and that cysteine residues on the cytoplasmic face of MerT are required for maximal mercuric ion transport but not for the interaction with mercuric reductase.
562	5951229	17457514	2008-07-12 10:33	Data show that the N-terminal region of MerA interacts with the cytoplasmic face of MerT, and that cysteine residues on the cytoplasmic face of MerT are required for maximal mercuric ion transport but not for the interaction with mercuric reductase.
573	1238792	18303258	2008-05-17 10:24	Carbapenem resistance may spread among Enterobacteriaceae via the transferable enzyme bla (OXA-48).
573	2657583	16619144	2007-08-25 10:16	Correlation between the rmpA gene and virulence in terms of abscess formation for these hypermucoviscous K. pneumoniae strains
573	2657583	17599300	2007-08-25 21:11	Invasive liver abscess syndrome is associated with the hypermucoviscosity phenotype of K. pneumoniae strains and with the RmpA protein
573	2827931	15337448	2006-08-04 09:44	Study and synthesis of inhibitors of UDP-galacosyl mutase in this organism (UDP-galacosyl mutase)
573	2827931	15583388	2007-08-25 13:11	preliminary X-ray crystallographic studies of Klebsiella pneumoniae maltohexaose-producing alpha-amylase [alpha amylase]
573	2827931	15843027	2007-08-25 10:58	structures of Klebsiella pneumoniae UDP-galactopyranose mutase with FAD and with FADH- bound determined [UDP-galactopyranose mutase]
573	2827931	15917245	2007-08-25 14:16	microcin E492 assembles in vitro into amyloid-like fibrils having the same structural, morphological, tinctorial, and biochemical properties as the aggregates observed in the disease conditions (E492)
573	2827931	15937173	2007-08-25 14:15	Gla(KP) is a UDP-galacturonic acid C4-epimerase that provides UDP-galacturonic acid for core synthesis, and the enzyme was biochemically characterized because of its potentially important role in outer membrane stability.
573	2827931	16321933	2007-08-25 11:59	it is proposed that in order for nitrogen assimilation control protein (NAC) to exert strong repression of gdhA, it must form a tetramer that bridges the two sites at gdhA [NAC, gdhA]
573	2827931	16489427	2007-08-25 13:35	The isolation and distribution of the beta-lactamase CTX-M-3 (blaCTX-M-3) in K. pneumoniae isolates in Bulgaria is reported.[blaCTX-M-3]
573	2827931	16585742	2007-08-25 12:32	XerC(of Klebsiella pneumoniae) is an active recombinase whose action is impaired on the mwr recombination site of the multiresistance plasmid pJHCMW1 [XerC]
573	2827931	16619144	2007-08-25 10:16	Association of the magA gene with the hypermucoviscosity phenotype relevant to the pathogenesis of Klebsiella pneumoniae liver abscess in Taiwan. (magA gene)
573	2827931	16740122	2007-08-25 21:03	results establish that monomeric KpnI DNA methyltransferase is catalytically inactive & dimerisation is essential for M.KpnI to catalyse the methyl transfer reaction [KpnI DNA methyltransferase]
573	2827931	16785225	2007-08-25 12:30	characterization of a novel ceftazidime-hydrolysing CTX-M mutant, designated CTX-M-54, produced by Klebsiella pneumoniae clinical isolate BDK0419 and investigation of its genetic environment [CTX-M-54]
573	2827931	16803899	2007-08-25 12:29	These data define a role for Arg-244 in substrate and inhibitor binding in the SHV-1 beta-lactamase [SHV-1 beta-lactamase]
573	2827931	16809340	2007-08-25 14:07	Results describe the 1.6A resolution crystal structure of beta-lactamase SHV-1.Beta-lactamase inhibitor protein (BLIP).
573	2827931	16926155	2007-08-25 21:17	identify different functional states of the activator-sigma(54)-RNAP-promoter complex [sigma54]
573	2827931	17008388	2007-08-25 15:04	In Klebsiella pneumoniae CG43, deletion of the sensor gene kvgS reduced the kvgAS expression. This result shows an autoregulatory role of KvgS and a stress-responsive expression of the two-component system (2CS)[KvgAS]
573	2827931	17334724	2007-08-25 14:01	the putative promoter element of ISEcp1 is necessary for the high-level expression of blaCMY-4 to confer resistance to extended-spectrum cephalosporins [blaCMY-4]
573	2827931	17441734	2007-08-25 21:02	active site of KPC-2 has bicine buffer molecule which interacts via carboxyl group with conserved active site residues S130, K234, T235, & T237; they resemble interactions beta-lactam carboxyl moiety makes in Michaelis-Menten complex[KPC-2 beta lactamase]
573	2827931	17599300	2007-08-25 21:11	Invasive liver abscess syndrome is associated with the hypermucoviscosity phenotype of K. pneumoniae strains and with the magA [Maga A protein]
573	2827931	17944487	2007-12-29 11:08	VIM-12 was found to exhibit narrow substrate specificity limited mainly to penicillin & to a much lesser extent to imipenen. Meropenem was found to act as a noncompetitive inhibitor of the enzyme[VIM-12 beta-lactamase]
573	2827931	18258261	2008-03-29 11:16	report here the X-ray structures of the periplasmic sensor domain of CitA in the citrate-free and citrate-bound states[CitA]
573	2827931	18411285	2008-07-12 10:16	We have identified a novel regulatory gene in K. pneumoniae, fimK, capable of suppressing intracellular bacterial community (IBC) and biofilm formation and impeding UTI pathogenesis.  [FimK]
573	2827931	18424527	2008-08-02 10:39	Observations suggest that elevated intracellular levels of lysine reduce the affinity of ArgP for its binding site at the gdhA promoter, preventing ArgP from binding to and stimulating transcription from the promoter in vivo: [ArgP, gdhA]
573	2827931	18474655	2008-07-12 10:32	Infections in a murine model of UTI demonstrated that although the K. pneumoniae strain TOP52 required FimH(52) for invasion and IBC formation in the bladder, FimH(52) was not essential for early colonization. [FimH]
573	6384187	18498643	2008-08-09 10:40	19 ciprofloxacin-resistant clinical isolates of E. coli in pediatric patients in China were positive for the qnr gene
584	6187022	18192389	2008-07-12 10:36	Study discussed the possible role of the wosA gene product in signal transduction from solid surfaces to induce swarmer cell differentiation, possibly via alterations in the motor switch complex [wosA]
584	6187022	18405378	2008-05-31 10:16	Lrp negatively regulates its own gene in E. coli, and was shown to do so even more strongly in P. mirabilis, Lrp appears to activate its own gene in V. cholerae. [Lrp]
585	1238797	15629920	2007-08-25 13:10	results show that a portion of the pvuIIC gene between the C boxes and the initiation codon is responsible for C.PvuII-dependent expression of pvuIICR
585	2827933	15691229	2007-08-25 12:06	Chondroitinase ABC1 was subcloned & sequenced. His501, Tyr508, Glu653 & Arg560 are crucial for activity. The relative positions of these critical AAs within the active-site cleft of cABC I establishes this amino acid synergy as the enzyme active site.
585	2827933	16108757	2007-08-25 21:05	Site-directed mutagenesis of the recombinant chondroitinase ABC I with a structural model of the enzyme-substrate complex in order to investigate in detail the roles of active site amino acids in the catalytic action of the enzyme is reported.[cABC I]
585	2827933	16455316	2007-08-25 12:34	Replacement of Tyr72 by Phe leads to decrease in activity for L-tryptophan by 50,000-fold & to rearrangement of active site of Trpase. Alteration of catalytic properties in large degree originates from conformational change in active site[tryptophanase]
591	2827935	15823516	2007-08-25 12:45	both Cu,Zn superoxide dismutase genes are required to confer full virulence, sodC2 contributing slightly more than sodC1 to Salmonella pathogenesis[sodC1, sodC2]
592	2827937	16313619	2007-08-25 21:09	BapA contributes both to biofilm formation and invasion through the regular Salmonella infection route. [BapA]
592	2827937	16369016	2007-08-25 11:23	TlpA is a novel prokaryotic modulator of NF-kappa B activity and IL-1 beta secretion that contributes to serovar enteritidis virulence [TlpA; TIR-like protein A]
592	2827937	16622051	2007-08-25 14:10	functional characterization of FimH adhesins of Salmonella Enteritidis & Salmonella Typhimurium showed close similarities between these proteins; Salmonella Enteritidis FimH bound with highest K(d) to high-mannose type N-glycans carried by RNase B [FimH]
592	2827937	17379722	2007-12-01 10:38	Study indicates that AgfC and AgfE are important for AgfA extracellular assembly, facilitating the synthesis of Salmonella thin aggregative fimbriae. [AgfC, AgfE protein].
592	2827937	17626806	2007-09-15 10:22	The objectives of this study were to enumerate S. enteritidis colonization in fecal, cecal, and internal organs, and to compare the level of expression of hilA of experimentally challenged laying hens fed different diets.[hilA]
601	2827939	15292268	2007-08-25 14:52	Molecular structure of this enzyme (alpha-D-glucose-1-phosphate cytidylyltransferase) in this critter.
601	2827939	15634670	2007-08-25 10:27	kinetic and x-ray crystallographic analysis of alpha-D-Glucose-1-phosphate cytidylyltransferase [alpha-D-Glucose-1-phosphate cytidylyltransferase]
601	2827939	16177292	2007-08-25 11:25	Tsx porin plays critical roles in membrane assembly and integrity and thus in the virulence of serovar Typhi.(tsx)
601	2827939	16448800	2007-08-25 14:41	Salmonella RpoS, because it reacts to the presence of NO or its reactive derivatives, is thought to have a role in the pathogenicity of serovar Typhi [RpoS]
601	2827939	16489221	2007-08-25 13:35	these and other results suggest that the S. Typhi Tsx porin and ImpX inner membrane protein facilitate competing mechanisms of thymidine influx and efflux, respectively, to maintain the steady-state levels of internal nucleoside pools [tsx, impX]
601	2827939	16800641	2007-08-25 21:02	Future in vitro biosynthesis of Vi antigen may also be drug targets to inhibit Vi antigen production. (vi antigen) (newentry)
601	2827939	17555437	2007-08-25 13:58	We propose that IgeR may co-ordinate gene expression during Salmonella's transition from an extracellular to an intracellular environment. [IgeR]
601	2827939	17709421	2007-12-01 11:51	Study demonstrated that the stg fimbrial operon contributed to increased adherence to human epithelial cells. [stg protein]
601	2827939	17725620	2007-12-15 11:55	It is concluded that phoP genes appear to play a more important role than rpoS genes in both cellular invasion and virulence of S. typhi, but not in immunogenicity in mice.[phoP,rpoS]
601	2827939	18191792	2008-03-10 14:58	PltA and PltB associate with CdtB to form a multipartite toxin, and are required for the delivery of CdtB from an intracellular compartment to target cells via autocrine and paracrine pathways.[CdtB, PltA, PltB]
601	2827939	18434098	2008-09-20 10:43	HlyE hemolysin is a new virulence determinant.[HlyE]
602	2827941	15699204	2007-08-25 13:11	results suggest that SPI2 promotes intramacrophage survival by protecting Salmonella DNA from exposure to macrophage oxidants [Spi2]
602	2827941	15723538	2007-08-25 14:24	Structure-based sequence analysis and phylogenic tree construction reveal determinants of substrate specificity and divergence of families (2-isocitrate lyase)
602	2827941	15931226	2007-08-25 14:44	We propose that the PrgK protein family functions as an essential molecular platform for Type III secretion systems assembly [PrgK]
602	2827941	15980376	2007-08-25 10:57	FloR functions as transporter specific for structurally associated phenicol drugs which utilizes the proton motive force to energize an active efflux mechanism; identified two residues essential for efflux action [FloR]
602	2827941	16352830	2007-08-25 14:42	data support a model of regulation whereby, in response to unknown signals, the PreB sensor activates PreA, which in turn indirectly upregulates pmrCAB transcription [PreA, PreB]
602	2827941	16527815	2007-08-25 11:56	the surface of the signal-transducing protein EIIA(Glc) interacts with the MalK subunits of the maltose ATP-binding cassette transporter (MalFGK2) of Salmonella typhimurium [signal-transducing protein EIIA(Glc)]
602	2827941	16765505	2007-08-25 10:14	The immunodominant trimeric beta-barrel outer membrane protein OmpC from Salmonella typhi, the causative agent of typhoid, has been functionally characterized here
602	2827941	16949866	2007-08-25 10:12	we have determined that the sirA gene is activated by crp and cya.[sirA]
602	2827941	16980492	2007-08-25 12:26	In this work, we reveal the presence of a PhoP-activated operon within SPI-1. This operon is composed of the orgB and orgC genes, which encode a protein that interacts with the InvC ATPase and a putative effector protein of the TTSS. [PhoP, OrgB, OrgC]
602	2827941	17128975	2007-08-25 12:25	in diol dehydrase, binding of the coenzyme to the protein weakens the bond prior to binding of the substrate[diol dehydrase]
602	2827941	17145942	2007-08-25 21:16	SO13 and another Salmonella genomic island 1 gene(s) coordinately upregulate invasion in S. typhimurium DT104 exposed to rumen protozoa.[SO13]
602	2827941	17158898	2007-08-25 10:44	Here we report the identification of a Salmonella-specific translocated effector called SseL that is required for full virulence during murine typhoid-like disease.
602	2827941	17388786	2007-08-25 21:26	Our study describes the first T1SS-secreted protein that functions as a non-fimbrial adhesin in binding to eukaryotic cells. [SiiE]
602	2827941	17526833	2007-11-10 12:46	The results indicate the critical role of the NsrR-regulated Hmp in protection of Salmonella from nitrosative stress within and outside macrophages.[NsrR, Hmp]
602	2827941	17645553	2008-02-09 12:54	Study concludes that Salmonella pathogenicity island 2-dependent F-actin meshwork formation depends on the kinase activity of SteC, which resembles more closely eukaryotic than prokaryotic kinases.[SteC]
602	2827941	17696999	2008-02-16 10:03	findings demonstrate a role for SopD in manipulation of host-cell membrane during S. typhimurium invasion and reveal the nature of its cooperative action with SopB.[SopD and SopB]
602	2827941	17704217	2007-12-01 11:34	expression of Salmonella RstA was able to downregulate the expression of three RpoS-controlled genes (narZ, spvA, and bapA). This downregulation was achieved by a reduction in RpoS cellular levels.[RstA. RpoS]
602	2827941	17933888	2008-01-12 11:10	BaeSR system increases multidrug and metal resistance in Salmonella by inducing the AcrD and MdtABC drug efflux systems.[BaeS and BaeR]
602	2827941	17971080	2008-02-16 12:29	invR encodes a small non-coding RNA (sRNA) that represses the synthesis of the abundant OmpD porin. [invR in strain SL1344]
602	2827941	17993530	2008-02-02 10:18	Fur activates hilA transcription in a HilD-dependent manner.[Fur, HilA and HilD in strain ATCC 14028]
602	2827941	18024511	2008-02-02 11:09	We show that in Salmonella enterica serovar Typhimurium, deletion of the luxS gene polarizes flagellar phase variation toward the more immunogenic phase 1 flagellin. [LuxS in strain SL1344]
602	2827941	18086808	2008-03-22 12:02	In the present study, evidence is presented that a serovar Typhimurium SR-11 delta-frdABCD delta-sdhCDA double mutant is avirulent in BALB/c mice. [frdABCD and sdhCDA in strain SR-11]
602	2827941	18174139	2008-03-29 10:22	mutation studies revealed that the N-terminal 100-140 aa (especially amino acids 135-138) of SipB were required for its localization on the bacterial outer membrane.[SipB in strain SF530]
602	2827941	18176541	2008-06-21 10:24	Results show that the yliH in Salmonella more or less affects motility and adherence by enhancing these activities [yliH]
602	2827941	18200043	2008-03-10 14:58	Dwonregulates expression of MgtC virulence factor and assists in its degradation.  (MgtR)
602	2827941	18216858	2008-03-10 14:57	flagellar proteins of Salmonella enterica serovar Typhimurium are exported even in the absence of FliI
602	2827941	18227269	2008-04-05 11:11	These findings suggest that the putative transporter encoded by the yejABEF operon is involved in counteracting antimicrobial peptides, and that it contributes to the virulence of Salmonella.[yejA, yejB, yejE, yejF]
602	2827941	18310044	2008-05-03 10:57	The S. Typhimurium smpA mutant was attenuated in mice by both the oral and parenteral routes of infection, and SmpA appeared to be most important for the growth of S. Typhimurium at systemic sites.[SmpA in strain SL1344]
602	2827941	18358740	2008-06-07 10:18	The open reading frame of the dps gene, together with all the upstream regulatory elements, were cloned;this work shall aid further investigations into the mechanism of Dps glycosylation.(Dps)
602	2827941	18725540	2008-09-20 10:49	SopB mediates PI(3)P production on the SCV indirectly through recruitment of Rab5 and its effector Vps34.[SopB]
602	3259826	16176924	2007-08-25 22:21	efficient bacterial escape into the cytosol of epithelial cells requires HsRMA1-mediated SopA ubiquitination and contributes to Salmonella-induced enteropathogenicity
615	2653903	16187093	2007-08-25 14:43	results show that CopA has a role in copper homeostasis in Sma 274 and is clearly a factor impinging on regulation of the secondary metabolite, prodigiosin
615	2827943	15110941	2007-08-25 14:18	Omp1 shows a great sequence & structural homology to the family of outer membrane porins of enteric bacteria; Reconstitution of the purified protein into lipid bilayers demonstrated that it is a channel-forming component & slightly cation-selective[Omp1]
615	2827943	15496586	2007-08-25 15:05	ChiB hydrolyzes crystalline beta-chitin via a mechanism in which four exposed aromatic residues play important roles
615	2827943	15717865	2007-08-25 11:32	The digestion of the beta-chitin fibrils by ChiA occurred from the reducing end to the nonreducing end, whereas digestion by ChiB occurred from the non-reducing end to the reducing end [chiA & chiB]
615	2827943	15722393	2007-08-25 12:38	Amino acid substitution in the omega loop of chromosomal AmpC beta-lactamase in S. marcescens confers resistance to ceftazidime.
615	2827943	15840955	2007-08-25 12:02	swrW gene encoding putative serrawettin W1 synthetase was identified; putative SwrW was uni-modular nonribosomal peptide synthetase specifying only L-serine [swrW]
615	2827943	15929981	2007-08-25 21:22	chitin-binding protein CBP21 homologs occur in most chitin-degrading microorganisms,suggesting a general mechanism by which chitin-binding proteins enhance chitinolytic activity.
615	2827943	16113328	2007-08-25 21:18	involved in the regulation of swarming motility (NlpB); involved in the determination of cell-envelope-associated phenotypes (DapA)
615	2827943	16428843	2007-08-25 14:12	Greater retention of the glycosyl fragment at the active site of the -3 mutant of Serratia marcescens chitinase A might favor transglycosylation due to a stabilized conformation of its D313 [chitinase A]
615	2827943	16598824	2007-08-25 10:53	characterization of polyphosphate operon; it is composed of a polyphosphate promoter, polyphosphate kinase (ppk) and exopolyphosphatase (ppx) [ppk, ppx]
615	2827943	16774915	2007-08-25 10:51	heme transfer from the soluble HasA hemophore to its membrane-bound receptor HasR is driven by protein-protein interaction from a high to a lower affinity binding site [HasA, HasR]
615	2827943	16899219	2007-08-25 12:27	SpnT might be involved in regulation of DNA replication and swarming-related phenomenon independent of SpnIR. (SpnT)
615	2827943	16924143	2007-08-25 14:06	HexS was shown as a LysR type transcriptional regulator; it was a transcriptional negative regulator of the genes swrW encoding serrawettin W1 synthase and PigA for prodigiosin synthesis [hexS]
615	2827943	17113104	2007-08-25 21:26	while DHasA can bind two heme molecules, it is not able to deliver them to the receptor HasR [HasA, HasR]
615	2827943	17116887	2007-08-25 21:26	loss of processivity in the W97A mutant was accompanied by a 29-fold increase in the degradation rate for single-polymer chains as present in the soluble chitin-derivative chitosan[chitinase B]
615	2827943	17483227	2008-01-19 10:03	Mutations in three extracellular loops of HasR abolished hemophore HasA binding both in vivo and in vitro [HasR, HasA]
615	2827943	17675374	2007-12-01 13:07	Together, these data support a model in which OxyR contributes to early stages of S. marcescens biofilm formation by influencing fimbrial gene expression.[OxyR]
615	2827943	17951376	2008-01-19 12:04	HasB is specific to heme uptake in the natural host and in Escherichia coli expressing the S. marcescens receptor HasR.
615	2827943	18024518	2008-02-02 11:09	These results indicate that SmdAB is probably a heterodimeric multidrug efflux pump of the ABC family in S. marcescens.[SmdA & SmdB, in strain Db10]
615	2827943	18160520	2008-09-06 10:05	E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149. [TME-149]
615	2827943	18178744	2008-07-12 10:26	Data show that S. marcescens HemTUV permease and HemTUV orthologs present in many gram-negative pathogens form a class of heme-specific permeases different from the Dpp peptide/heme permease characterized in E. coli. Gene Name: HemTUV permease
615	2827943	18223092	2008-07-12 10:26	Results indicated that activated RssA-RssB signaling directly inhibits flhDC(Sm) promoter activity at 37 degrees C, and this inhibitory effect was comparatively alleviated at 30 degrees C [flhD, flhC, RssA and RssB]
615	2827943	18227249	2008-04-05 10:18	An increase in fluoroquinolone accumulation was observed for strains deficient in sdeB gene when compared to the parental strains.[SdeB]
615	2827943	18310921	2008-04-26 11:18	The gene responsible for multidrug resistance from chromosomal DNA of Serratia marcescens has been cloned.
615	2827943	18323665	2008-05-10 10:13	The high specificity of the interaction with the (non-chitinous) column material is mediated by aromatic residues that occur in the substrate-binding clefts and surfaces of the enzymes[chitinase C1]
615	2827943	18420186	2008-08-02 10:05	Three tryptic peptides of the chitosanase are identical to a chitin-binding protein Cbp21 from S. marcescens with 63% sequence coverage. (chitosanase)
615	2827943	18445479	2008-07-12 10:32	rssC is hierarchically classified as class II members in FlhDC(Sm) regulon, and reciprocally defect in rssC results in aberrant swarming and hypervirulence in S. marcescens.(rssC)
615	2827943	18449226	2008-07-26 10:16	SdeCDE knockout strains showed no change in antibiotic susceptibility in comparison with the parental strains for any of the substrates.[SdeC, SdeD, SdeE]
615	2827943	18451041	2008-07-12 10:32	in addition to uptake as N,N'-diacetylchitobiose, a proportion of the N,N'-diacetylchitobiose is converted to N-acetylglucosamine by chitobiase, mainly in the periplasm, and incorporated into the cytoplasm by NagE.[chitobiase in strain 2170]
622	3925313	17438026	2007-08-25 13:23	Regulation of virB by RyhB (iron responsive small RNA molecule) implicates iron as an environmental factor contributing to the complex regulation of Shigella virulence determinants. [RyhB, VirB]
622	3925313	18616281	2008-09-13 10:46	The heme ATP binding cassette (ABC) transporter, ShuUV, of Shigella dysenteriae has been incorporated into proteoliposomes and functionally characterized: [ShuUV]
623	876426	18304577	2008-04-26 11:17	The conservation of a negatively charged patch suggests it may have a role in binding other components of the type 3 secretion system.
623	876428	17626052	2007-09-15 11:55	tRNA-guanine transglycosylase may modulate the translation of VirF by base modification of the VirF encoding mRNA.
623	876431	15088068	2007-08-25 12:11	Data report the crystal structure of Spa15 and confirm that it belongs to a special subgroup of chaperones.
623	876431	15916611	2007-08-25 12:36	evidence presented that OspD1 associates with the chaperone Spa15 and MxiE and acts as an anti-activator until it is secreted
623	876433	18485071	2008-08-30 10:39	The crystal structure of the Spa40 reveals it is the surface features in this region, rather than the cleavage event itself, that are important for substrate binding.
623	876444	15731041	2007-08-25 14:49	data implicate IpaD as having an important role in targeting the Shigella effectors IpaB and IpaC to the plasma membrane of target cells for translocon formation
623	876444	16866368	2007-08-25 10:49	The unfolding of IpaD occurs as a two-step process, suggesting the presence of two structural domains which work in concert to control the productive release and presentation of IpaB and IpaC to the host-cell membrane.
623	876444	17077085	2007-08-25 13:28	The role of the N-terminal domain of IpaD, a type III secretion system needle tip protein, is to chaperone residues on the coiled-coil involved in interactions with the needle and/or itself.
623	876444	17827155	2007-12-15 12:45	Study identified key MxiH residues located in its PSNP loop and the contiguous surface that uniquely contribute to the formation of the IpaD-needle interface as determined by NMR chemical shift mapping.
623	876448	15731041	2007-08-25 14:49	requires IpaD for efficent insertion into cell membranes
623	876448	16401091	2007-08-25 21:23	Together with fluorescence quenching analyses, new functional and structural information is provided concerning IpaC and its insertion into phospholipid membranes.
623	876448	18188151	2008-04-12 10:21	Results indicate that cytoplasmic polar localization directs secretion of IpaC at the pole of Shigella, and may represent a mandatory step for type III secretion .
623	876451	15731041	2007-08-25 14:49	requires IpaD for efficent insertion into cell membranes
623	876451	17296762	2007-08-25 21:23	Deoxycholate promotes the stable recruitment of IpaB to the needle tip where it colocalizes with IpaD.
623	876451	17768231	2007-12-01 10:16	IpaB secretion promotes caspase-1 activation and macrophage apoptosis.
623	876451	18295791	2008-04-26 10:23	Analysis of the NE proteolytic products of the Shigella virulence factor IpaB shows that NE has specific cleavage sites.
623	876456	16246841	2007-08-25 21:01	Spa33 plays a central role as the C-ring component in recruiting/exporting type III secretion machinery-associated proteins
623	876514	15773990	2007-08-25 14:48	evidence that MxiE is produced by a frameshift between a 59-codon open reading frame (mxiEa) containing the translation start site & a 214-codon ORF (mxiEb) encoding the DNA binding domain; mxiEa encoded N-terminal part of MxiE required for MxiE function
623	876534	16501225	2007-08-25 21:21	Thermodynamic characterization of the structural stability of the MxiH protein.
623	876534	16511329	2007-08-25 12:33	A monodisperse truncation mutant of MxiH, the subunit of the needle from the Shigella flexneri type III secretion system (TTSS), has been overexpressed, purified and crystallographic analysis performed
623	876534	17617421	2007-10-20 11:07	analysis of electrostatic surfaces of the type III secretion needle proteins PrgI, BsaL, and MxiH
623	876534	17827155	2007-12-15 12:45	Study identified key MxiH residues located in its PSNP loop and the contiguous surface that uniquely contribute to the formation of the IpaD-needle interface as determined by NMR chemical shift mapping.
623	876595	17060328	2007-08-25 21:08	IpaA targets beta1 integrins and rho to promote actin cytoskeleton rearrangements necessary for Shigella entry
623	876595	17088427	2007-08-25 21:02	Invasin IpaA subverts vinculin's functions. Shigella flexneri utilizes a remarkable level of molecular mimicry of the talin-vinculin interaction to activate vinculin using invasin IpaA.
623	2827945	15766330	2007-08-25 21:19	the topology of GtrII has been determined [gtrII]
623	2827945	15916611	2007-08-25 12:36	identified ospD1 as a gene whose product negatively controls expression of genes regulated by secretion activity; evidence presented that OspD1 associates with the chaperone Spa15 and MxiE and acts as an anti-activator until it is secreted [OspD1]
623	2827945	16162672	2007-08-25 11:25	OspG negatively controls the host innate response induced by S. flexneri upon invasion of the epithelium.
623	2827945	16313621	2007-08-25 21:09	role of Fur and RyhB in the regulation of acid resistance [Fur, RyhB]
623	2827945	16498617	2007-08-25 10:17	YfiH protein could participate in the same pyrimidine salvage pathway as sfhB gene product[YfiH]
623	2827945	16861654	2007-08-25 13:31	Expression of both the sit and mntH promoters was repressed by either iron or manganese, partially dependent upon Fur and MntR, respectively. Only the mntH promoter exhibited OxyR-dependent induction in the presence of hydrogen peroxide. [SitA, MntH]
623	2827945	16927377	2007-08-25 10:12	report the crystal structure of YidB protein at 1.45 A resolution[YidB]
623	2827945	16988276	2007-08-25 12:27	OspF and OspC1 are essential for polymorphonuclear transepithelial migration. (OspF) (OspC1)
623	2827945	17095701	2007-08-25 21:17	results show Shigella movement in cytoplasm was hindered by microtubules; Shigella destroyed surrounding microtubules by secreting VirA; degradation of microtubules by VirA was dependent on its alpha-tubulin-specific cysteine protease-like activity [VirA]
623	2827945	17159983	2007-08-25 10:45	A Shigella flexneri protein effector OspF as a dually specific phosphatase that dephosphorylated mitogen-activated protein kinases in the nucleus, was identified.
623	2827945	17303758	2007-08-25 12:22	effects of OspF on the host immune signaling pathways, including those of nuclear factor kappaB(NFkappaB) and MAPKs [OspF]
623	2827945	18195027	2008-03-22 10:18	IscR was a positive regulator of suf expression in the presence of hydrogen peroxide and a negative regulator of isc expression in the absence of hydrogen peroxide.[IscR in strain SA100]
623	2827945	18375803	2008-06-07 10:18	We found that coiled-coil regions (CCRs) 2 and 3 are necessary for wild-type Oag chain length regulation by Wzz.[Wzz in strain RMA2162]
623	2827945	18378312	2008-08-02 10:39	These results suggest that induction of OspF is enhanced during Shigella invasion of dendritic cells and decreases the phosphorylation level of Erk1/2.[OspF]
623	2827945	18640128	2008-09-06 10:21	The crystal structure of a periplasmic l-aspartate/l-glutamate binding protein (DEBP) from Shigella flexneri complexed with an l-glutamate molecule has been determined and refined to an atomic resolution of 1.0 A.[DEBP]
624	2827947	16196210	2007-08-25 10:21	Data identify a 4.2 Md plasmid (pScol7) conferring colicin 7 (Scol7) production to transformants, and suggest that it could be imported to sensitive cells via the TonB transport system [Scol7].
630	1239113	17121817	2007-08-25 21:26	YopO kinase is activated by a novel G-actin binding process, and this appears to be crucial for its anti-host cell functions
630	1239118	16046625	2007-08-25 12:00	A structural model of the complex between YopT and SycT.
630	1239194	16239347	2007-08-25 15:01	LcrV O:8 contributes to virulence by TLR2-mediated IL-10 induction; testing seven LcrV groups in CD14/TLR2-transfected 293 cells showed that highest TLR2 activity was obtained with a peptide derived LcrV of Y. enterocolitica O:8 strains.
630	1239213	15629941	2007-08-25 13:10	the first seven codons of yopE, when fused to the reporter protein neomycin phosphotransferase (Npt), are sufficient for the secretion of YopE1-7-Npt when type III secretion is induced in vitro.
630	1239242	17624595	2008-03-29 10:56	Data show that YopP induces cleavage of RIP1 and caspase-8 at the level of the DISC independently of death receptors in dendritic cells.
630	1449458	15919371	2007-08-25 11:06	yersiniae exploit IL-10-involving Toll-like receptor tolerance mechanisms by the virulence factor LcrV
630	1449458	16254184	2007-08-25 11:25	LcrV forms a distinct structure at the tip of the needle, the tip complex
630	1449459	17015646	2007-08-25 10:10	We present evidence that clpXP expression increases after Dam overproduction and that the ClpP protease then degrades LcrG, thereby releasing a block in type III secretion.
630	1449467	16672607	2007-08-25 10:15	YscN and YscL of Yersinia enterocolitica, are characterized as the ATPase and ATPase regulator, respectively, of the type III secretion system of this organism.
630	1449467	17050689	2007-08-25 13:28	type III machines are programmed to secrete a sequence of proteins that can be disrupted when an impassable early substrate interacts with the YscN ATPase and blocks the transport of late substrates
630	1449469	18641141	2008-09-27 10:43	YscP-GST and YopR-GST blocked type III secretion.
630	1449474	18452514	2008-07-26 10:16	YscU auto-cleavage promotes interaction with YscL and recruitment of ATPase complexes that initiate type III secretion.
630	1449488	16672607	2007-08-25 10:15	YscN and YscL of Yersinia enterocolitica, are characterized as the ATPase and ATPase regulator, respectively, of the type III secretion system of this organism.
630	1449501	17921300	2008-01-12 11:10	the conserved glycine residue affects both the export and the stability of YadA and consequently some of its putative functions in pathogenesis.
630	1449501	18625735	2008-10-04 10:28	The authors conclude that Y. enterocolitica, via YadA and Ail, recruits functionally active FH to its surface. FH binding appears to be an important mechanism of the complement resistance of this pathogen.
630	2827949	15595388	2007-08-25 21:09	study demonstrates that the sodA mutation in Y. enterocolitica leads to loss of virulence and gain of immunogenicity in rabbits [sodA]
630	2827949	15773978	2007-08-25 14:48	new protein domain in YscP called T3S4 for Type III secretion substrate specificity switch was characterized [YscP]
630	2827949	16102009	2007-08-25 11:26	YscP needs to be secreted to exert its length control function but not its substrate-specificity switch function.
630	2827949	16299350	2007-08-25 14:14	The invasin-dependent route of systemic dissemination is clearly discernible in mice devoid of intestinal Peyer's patches and mesenteric lymph nodes. (invasin)
630	2827949	16359708	2007-08-25 14:41	the structure of the Yersinia enterocolitica RsmA homologue, which differs substantially from eukaryotic RNA-binding proteins and incorporates a novel class of RNA-binding site [RsmA].
630	2827949	16434053	2007-08-25 11:58	Results report the first crystal structure of Irp9 and also of its complex with the reaction products salicylate and pyruvate at 1.85 A and 2.1 A resolution, respectively [Irp9].
630	2827949	16468999	2007-08-25 21:27	PspB and PspC of Y. enterocolitica are dual function proteins, acting both as regulators and effectors of the phage-shock stress-response system.[PSPB, PSPC]
630	2827949	16511163	2007-08-25 11:57	preliminary X-ray diffraction structure of HemS [HemS]
630	2827949	16549664	2007-08-25 21:27	identification of RpoN-independent promoters both upstream and downstream of pspA; precise location of the PspF/RpoN-dependent promoter upstream of pspA was also determined [pspA]
630	2827949	16622050	2007-08-25 14:10	YopM specifically interacts with alpha1-antityrpsin (AAT); findings indicate that YopM does not interfere with the anti-protease inhibition activity of AAT; elastase efficiently degrades YopM [YopM]
630	2827949	16790812	2007-08-25 13:32	Systemic factor protein A (SfpA) is a novel virulence gene carried on the chromosome that is involved in colonization of the mouse mesenteric lymph nodes during acute Y. enterocolitica infection.
630	2827949	17015646	2007-08-25 10:10	This is the first example of posttranslational regulation of type III secretion by the Clp protease and adds a new flavor to the complex regulatory mechanisms underlying the controlled release of effector proteins from bacterial cells.[ClpP]
630	2827949	17397864	2007-08-25 10:42	Results describe the structure of an exopolygalacturonase from Yersinia enterocolitica, YeGH28 in a native form (solved to 2.19 A resolution) and a digalacturonic acid product complex (solved to 2.10 A resolution) [YeGH28].
630	2827949	17451747	2007-08-25 10:05	TogB is a 45.7 kDa periplasmic binding protein from Yersinia enterocolitica [TogB]
630	2827949	17567753	2008-01-19 12:03	structures of the JMJD2A catalytic core complexed with methylated H3K36 peptide substrates in the presence of Fe(II) and N-oxalylglycine (JMJD2A)
630	2827949	17571800	2007-08-25 21:16	YompC is involved in outer membrane permeability for beta-lactam antibiotics and tetracycline, and in resistance to these compounds, and may play a role in the adhesion properties [YompC]
630	2827949	17612396	2007-09-08 10:19	The picture of the Yersinia T3SS interactome is supplemented by identification of the SycO/YscM1 interaction.[SycO, YscM1]
630	2827949	17660406	2007-12-01 12:40	Data from invasin-lacZYA chromosomal gene fusion studies are presented indicating that OmpR acts to negatively regulate invasin expression at the transcriptional level.[invasin, OmpR]
630	2827949	17784909	2007-12-15 10:18	From these data, we hypothesize that RovA generally behaves as an anti-H-NS factor to alleviate transcriptional repression in Y. enterocolitica.[RovA]
630	2827949	18174138	2008-03-29 10:22	In a motility assay, a non-motile and a hyper-motile phenotype resulted from knockout mutations of the Flag-1 genes fliS1 and fliT, respectively.[fliS1 and fliT in strain W22703]
630	2827949	18201977	2008-04-05 10:18	These results suggest that in contrast to macrophages, in DC the YopP-dependent inhibition of NF-kappaB activation is not causative for the induction of cell death.[YopP]
630	2827949	18355278	2008-06-28 10:22	The Y. enterocolitica TolA supported the physiological function of the Tol system in E. coli, and conferred sensitivity to the TolA-dependent colicins. [TolA]
630	2827949	18451036	2008-07-12 10:32	Y. enterocolitica cells expressing H-NST(EPEC), a mutant H-NS, showed an altered growth rate and several differences in the protein expression pattern, including the ProV protein. [H-NS]
630	2827949	18487327	2008-08-09 10:30	These results demonstrate that the cognate C-terminal translocator domain of YadA is essential for bacterial survival in human serum and mouse virulence.[YadA in strain WA-314]
632	2827951	15502305	2007-08-25 14:50	partial crystal structure of YopN, SycN and YscB[YopN, SycN and YscB]
632	2827951	15701523	2007-08-25 21:09	crystal structure of YopN, SycN and YscB [ YopN, SycN, YscB]
632	2827951	15710615	2007-08-25 13:41	there are distinct binding sites for the PmrA and PhoP proteins in the promoters of the pbgP and ugd genes [ugd, pbgP]
632	2827951	16091038	2007-08-25 11:26	The YopN mutants that constitutively block Yop secretion require an intact TyeA-binding domain and TyeA to block secretion, but did not require an N-terminal secretion signal, an intact chaperone-binding domain or the SycN/YscB chaperone.
632	2827951	16120681	2007-08-25 11:26	at least one gene within this operon (ripA) is essential for Yersinia pestis to survive in activated macrophages [ripA]
632	2827951	16135236	2007-08-25 21:24	YscF needle is a multifunctional structure that participates in virulence protein secretion, in translocation of virulence proteins across eukaryotic membranes and in the cell contact- and calcium-dependent regulation of T3S.[YscF]
632	2827951	16511301	2007-08-25 12:33	Native construct (179 amino acids, MW = 20.5 kDa) was purified by standard chromatography & crystallized. These crystals have unit-cell parameters a=56.8, b=118.6, c=144.5 A, diffract to 3A & probably have two dimers per asymmetric unit[adenyl cyclase IV]
632	2827951	16768793	2007-08-25 21:26	gcvB gene encodes two small non-coding regulatory RNAs that repress dppA expression; a gcvB deletion is pleiotropic, suggesting that the sRNAs are likely involved in controlling genes in addition to dppA [GvcB]
632	2827951	16816182	2007-08-25 21:26	Invasin is positively regulated by RovA in both Y. enterocolitica and Yersinia pseudotuberculosis but negatively regulated by YmoA in Y. enterocolitica and H-NS in Y. pseudotuberculosis. (H-ns) (newentry)
632	2827951	16905149	2007-08-25 10:49	The crystal structure of the class IV adenylyl cyclase (AC) from Yersinia pestis (Yp) is reported at 1.9 A resolution [Adenylyl cyclase class IV].
632	2827951	16923070	2007-08-25 21:17	The results show that the Pla molecule has intrinsic adhesive properties and that purified transmembrane proteins coated onto FMPs can be used for functional assays. [Pla protein]
632	2827951	16926404	2007-08-25 13:30	YopJ is not essential for bubonic plague pathogenesis, instead, it appears to overlap and augment the immunomodulatory effects of other Y. pestis virulence factors.
632	2827951	16988239	2007-08-25 10:48	F1 and Psa inhibit the intracellular uptake of Y. pestis. (F1) (Psa)
632	2827951	17374882	2007-08-25 13:24	This article reports that there is little impact from lipid A modifications on the virulence of Y. pestis strains but there are potential improvements in the protective properties in attenuated vaccine strains.
632	2827951	17556003	2007-09-22 10:20	Weak interaction of LcrV and TLR2 does not contribute to the virulence of Yersinia pestis. [LcrV]
632	2827951	17644582	2007-10-20 12:41	These new results suggest that the intramolecular coiled coil in LcrV is required for LcrG interaction and activation of the T3SS. [LcrV]
632	2827951	17705129	2007-10-27 10:33	Yersinia may interfere with the adaptive responses necessary to clear the infection as well as establish a tolerant immune environment that leads to chronic infection/carrier state in the surviving host[ YopJ ]
632	2827951	18007034	2008-01-26 12:02	The first crystal structures of ABC system components from Y. pestis, OppA and PstS, are reported as complexes with their substrates [OppA and PstS]
632	2827951	18366809	2008-06-07 10:18	the PhoP-dependent mechanisms by which Y. pestis survives the antibacterial strategies employed by host macrophages
632	2827951	18566375	2008-08-02 10:35	LcrV Ag was also tested in mice and, as expected, age-associated loss of immunity was seen[LcrV]
632	3077338	16840777	2007-08-25 14:08	Data are consistent with progressive unfolding and cleavage of Caf1 from the amino terminus as it traverses the endosomal pathway, the availability of epitopes determining which pool of MHC class II is preferentially loaded.
632	3077338	18534189	2008-07-26 10:32	Molecular dynamics characterizations of Yersinia pestis Caf1 subunit in its monomeric-unbound and dimeric states was reported.
632	3077340	17376079	2007-08-25 13:25	These results suggest that the packing of the aggregation-prone subunit binding sequences into the hetero-domain is a novel molecular mechanism preventing unspecific aggregation of the free chaperone.
633	3293166	17223369	2007-08-25 13:26	findings suggest that any regulatory affect of LcrH on effector translocation would require exquisite control of YopB and YopD secretion [YopB, YopD, LcrH]
633	3293166	17438028	2007-08-25 13:23	The cytotoxic necrotizing factors CNF1 and CNF2 of Escherichia coli and CNF(Y) of Yersinia pseudotuberculosis bind to different cellular receptors but are released into the cytosol from acidified endosomes. [CNF(Y)]
633	3293166	17873031	2007-12-29 11:09	While only low levels of exported LcrV were required for in vitro effector translocation, fully functional export of LcrV was found to be a prerequisite for its role in virulence in the systemic murine infection model [LcrV]
633	3293166	18466299	2008-08-30 10:06	YpsI and YtbI quorum sensing systems modulate swimming motility by controlling gene expression of flhDC and fliA. [YpsI, YtbI flhDC, fliA]
644	4524511	17541836	2007-12-08 12:02	Open reading frame of A. hydrophila LamB channel protein consists of a signal peptide of 25 amino acids, two protein translation start sites ATG present at the 31st and 37th base pairs, a translation termination codon, TAA at 1333rd base pair.
645	2827953	15885977	2007-08-25 21:14	cloning and sequencing of the 40 kDa A. salmonicida porin; role in serum susceptibility and C1q binding [40 kDa C1q-binding outer membrane protein]
645	2827953	17237181	2007-08-25 10:08	We propose that the Aeromonas salmonicida AexT toxin is a novel member of the growing family of bacterial RhoGAPs. [ADP-ribosylating toxin AexT]
645	2827953	17981806	2008-02-16 12:47	Fusion of interleukin 2 (IL2) to the N terminus of R336A-aerolysin results in a hybrid that has little or no activity against cells that do not have an IL2 receptor.[Aerolysin]
648	3293168	16511010	2007-08-25 21:18	XynX is a xylanase from Aeromonas punctata which shows exo-like catalytic activities, was crystallized by the hanging-drop vapour-diffusion method. (XynX xylanase family 10)
648	3293168	18258115	2008-03-29 11:16	The quinolone resistance gene QnrS was identified from Aeromonas punctata subsp. punctata. The qnrS2 gene was located on IncU-type plasmids. [QnrS]
666	2827955	15375645	2007-08-25 10:28	single base substitution in the oriCIvc of the classical biotype has a significant effect on its replication initiation. [oriC]
666	2827955	15522078	2007-08-25 10:28	Results define the elements on the phage genome and bacterial chromosome required for CTXphi integration by XerC amd XerD [XerC, XerD]
666	2827955	15576780	2007-08-25 10:59	TcpH regulates virulence gene expression by controlling transcription activator TcpP proteolysis [TcpH,TcpP strain 0395]
666	2827955	15647287	2007-08-25 12:38	Data report the crystal structure of the transcriptional activator AphA to 2.2 angstrom resolution [AphA].
666	2827955	15684414	2007-08-25 12:59	crystal structure of the outer membrane protein VceC from Vibrio cholerae
666	2827955	15774863	2007-08-25 13:09	Identification of a complex of TcpC protein and TcpQ protein in the development of the V. cholerae pilus. [TcpC, TcpQ]
666	2827955	15838027	2007-08-25 13:09	results indicate that HapR autorepresses from a single binding site in the hapR promoter and suggest a model for the temporal regulation of its expression as its intracellular levels increase[HapR]
666	2827955	15838043	2007-08-25 13:09	results suggest that the differences in FlrC binding to various flagellar promoters results in the differences in transcription levels that mirror the relative requirement for the flagellar components within the flagellum [FlrC]
666	2827955	15843017	2007-08-25 10:58	The dimer of EpsL in this complex is very similar to the dimer seen in the crystal structure of the native cytoplasmic domain of EpsL [EpsL, EpsE]
666	2827955	15853890	2007-08-25 21:19	identification of the ToxT binding sites located between acfA and acfD required for transcriptional activation of both genes[ToxT, acfA, AcfD]
666	2827955	15883026	2007-08-25 11:07	clpB1 insertion mutant showed increased sensitivity towards high temperature, oxidative stress, and acid pH. ClpB1 also conferred thermotolerance to V. cholerae [ClpB1]
666	2827955	15978075	2007-08-25 13:08	results provide a model for how the genes in the acetoin biosynthetic operon are regulated in V. cholerae by AlsR and AphA in response to environmental signals [AlsR, AphA]
666	2827955	16099990	2007-08-25 14:43	Crystal structures of a cholera toxin A1 subunit (CTA1):ARF6-GTP (guanosine triphosphate) complex reveal that binding of the human activator elicits dramatic changes in CTA1 subunit loop regions that allow NAD+ to bind to the active site [CTA1]
666	2827955	16113288	2007-08-25 21:18	small regulatory RNA with diverse functions, ranging from iron homeostasis to the regulation of biofilm formation [RyhB]
666	2827955	16128567	2007-08-25 11:16	neruaminidase (VCNA)Asp-576 & Arg-577 were specifically labeled with fluorescent substrate suggesting that a flexible beta-turn structure containing this sequence may have a role in the dynamic nature of substrate recognition & catalytic action [VCNA]
666	2827955	16237027	2007-08-25 14:42	role of NspS in V. cholerae biofilm development; norspermidine activates biofilm formation in an MbaA- and NspS-dependent manner [NspS]
666	2827955	16262796	2007-08-25 11:25	results provide a model for a two-domain structure for ToxT, with an N-terminal dimerization and environmental sensing domain and a C-terminal DNA-binding domain. [ToxT]
666	2827955	16299312	2007-08-25 14:14	Fur has both positive and negative regulatory functions in virulence of Vibrio cholerae. (Fur)
666	2827955	16341015	2007-08-25 11:59	identification of GbpA protein required for efficient intestinal colonization that mediates attachment to both zooplankton and human epithelial cells by binding to a sugar present on both surfaces [GbpA]
666	2827955	16477602	2007-08-25 11:58	report X-ray crystal structures of T1485 and T1512 and compare them with other structures of similar fold and discuss the putative active site [T1485 and T1512]
666	2827955	16498616	2007-08-25 10:17	VC0702 may have a biochemical function that involves NTP binding and phosphatase activity of some kind, and is likely involved in regulation of the signaling pathway [VC0702]
666	2827955	16547031	2007-08-25 21:01	In V. cholerae, VqmA regulates hapR transcription directly by binding to its promoter region and expression of vqmA is cell density dependent and autoregulated. [VqmA; HapR]
666	2827955	16552056	2007-08-25 13:35	CTA1 utilizes the A1(3) subdomain for functional interaction with ADP-ribosylation factor (ARF) 6 and for efficient expression of in vivo enzyme activity
666	2827955	16553883	2007-08-25 14:11	ToxT binds independently as a monomer to each toxbox in the tcpA direct repeat. (ToxT) (tcpA)
666	2827955	16641988	2007-08-25 13:33	the crystal structure of an integron integrase (Vibrio cholerae IntIA) bound to an attC substrate [IntIA]
666	2827955	16754867	2007-08-25 13:32	Results demonstrate a key role for PrtV in Vibrio cholerae interaction with grazing predators [PrtV].
666	2827955	16952942	2007-08-25 13:29	iron transport systems, including a homologue of the ferrous transporter Feo and a periplasmic binding protein-dependent ATP binding cassette (ABC) transport system, termed Fbp, were identified in the V. cholerae genome sequence. [Feo, Fbp]
666	2827955	16978643	2007-08-25 10:12	Results describe the structure and function of both periplasmic domains of EpsC [EpsC].
666	2827955	16983078	2007-08-25 12:27	Repression of type IV mannose-sensitive hemagglutinin (MSHA) was mediated by the key virulence transcription factor ToxT, indicating that V. cholerae is able to coordinate both virulence gene activation and repression.[ToxT]
666	2827955	17116251	2007-08-25 12:24	HlyU exhibits structural features common to the SmtB/ArsR family of transcriptional repressors (HlyU).
666	2827955	17159897	2007-08-25 12:24	EpsE ATP hydrolysis is stimulated by EpsL and acidic phospholipids [EpsL, EpsE]
666	2827955	17181781	2007-08-25 10:46	Study identifies the nucleoid protein Fis as playing a major role in the V. cholerae quorum-sensing circuit.[Fis protein]
666	2827955	17233827	2007-08-25 14:01	The vpvC allele found in the rugose genetic background is more active at producing c-di-GMP while that in smooth genetic background is less active. [vpvC]
666	2827955	17277949	2007-10-13 12:22	We found that gene expression of this PTS system is influenced by catabolite regulation and also by an Mlc homologue (VC2007), which in E. coli is a global regulator of sugar metabolism. [Mlc]
666	2827955	17360576	2007-08-25 14:01	the essential function of CgtA is as a repressor of the stringent response that acts by regulating SpoT activity to maintain low ppGpp levels when bacteria are growing in a nutrient-rich environment [CgtA, SpoT]
666	2827955	17501920	2007-12-08 11:14	The results here provide a model for the dual activation of the aphA promoter by Lrp and VpsR as well as its dual repression by HapR and AphA.[HapR, AphA, Lrp, VspR]
666	2827955	17526705	2007-09-15 11:08	The crystal structure of HapR to 2.2-A resolution reveals a dimeric, two-domain molecule with an all-helical structure that is strongly conserved with members of the TetR family of transcriptional regulators.[HapR protein]
666	2827955	17585933	2007-09-29 10:24	These data provide compelling evidence of a role for dynamics in the catalytic cycle of DsbA.[DsbA]
666	2827955	17697110	2007-12-08 12:43	It was shown that under hydrodynamic conditions biofilms were formed independent of VspA and LuxO but were controlled by expression of RpoS a negative regulator of VpsA. [VpsA, LuxO, RpoS]
666	2827955	17698571	2007-11-10 11:06	The ability of V. cholerae to prevent clearance and establish this prolonged colonization was associated with the accessory toxins hemolysin, the multifunctional autoprocessing RTX toxin, and hemagglutinin/protease.[HlaA, RtxA, HapA]
666	2827955	17698573	2007-11-10 11:06	Hemolysin had the predominant role in lethality, with a secondary contribution by the multifunctional autoprocessing RTX (MARTX) toxin.[HlyA, RtxA]
666	2827955	17768239	2007-12-01 11:52	Our results indicate that cyclic AMP receptor protein (CRP) plays a crucial role in the V. cholerae life cycle by affecting quorum sensing and multiple genes required for survival of V. cholerae in the human host and the environment. [CRP]
666	2827955	17884842	2008-02-23 10:02	characterization of a unique chitin oligosaccharide deacetylase involved in chitin catabolic cascade in the marine bacterium Vibrio cholerae [chitin oligosaccharide deacetylase]
666	2827955	17905973	2007-12-29 10:19	results indicate that specific residues of OmpU play different roles in controlling the passage of various compounds [OmpU]
666	2827955	17919878	2008-05-03 10:28	these results support a main role of HlyA in the pathogenesis of the CT gene-negative V. cholerae non-O1, non-O139 strain and identify apoptosis as a previously unrecognized cell death pathway triggered by HlyA.[HlyA in strain VC175]
666	2827955	17921282	2008-02-16 10:29	results suggest a model for the regulatory input of cyclic AMP (cAMP) receptor protein (CRP) on exopolysaccharide biosynthesis [CRP]
666	2827955	17921296	2008-01-12 11:10	Analysis of the truncated EpsM mutants revealed that the region of EpsM from amino acids 100 to 135 is necessary for EpsM to form homo-oligomers, while residues 84 to 99 appear to be critical for a stable interaction with EpsL. [EpsM, EpsL]
666	2827955	18024585	2008-01-19 10:02	Comparison among 4 x-ray structures of MsbA, trapped in different conformations (2 nucleotide-bound structures & 2 without nucleotide) reveals a flexible hinge formed by extracellular loops 2 & 3, allowing large ranges of motion. MsbA.
666	2827955	18032386	2008-02-16 11:35	FabV defines a new class of enoyl-ACP reductase.[FabV]
666	2827955	18074211	2008-07-12 10:26	The 3D structure of hemagglutinin/protease [HA/P (vibriolysin)] was predicted based on its sequence homology with Pseudomonas aeruginosa elastase (HA/P).
666	2827955	18179420	2008-04-05 10:18	study found that the major MSHA pilin, MshA, was degraded in V. cholerae in a TcpJ-dependent fashion [MSHA, TcpJ]
666	2827955	18223081	2008-07-12 10:26	Data show that HapR, a major regulator of quorum sensing, binds to and directly represses the expression of the biofilm transcriptional activator, vpsT [vpsT]
666	2827955	18282004	2008-05-24 10:05	Results identify the key structural elements which complement the N-terminal part of FliMV and explain how the structure, shape, and surface properties of the FliM binding pocket of other CheYVs abrogate this function [FliM].
666	2827955	18405378	2008-05-31 10:16	Lrp negatively regulates its own gene in E. coli, and was shown to do so even more strongly in P. mirabilis, Lrp appears to activate its own gene in V. cholerae.[Lrp]
666	2827955	18411263	2008-08-23 10:14	LqsA and CqsA belong to a family of pyridoxal 5'-phosphate-dependent autoinducer synthases, which produce the alpha-hydroxyketone signaling molecules LAI-1 and CAI-1
666	2827955	18479458	2008-07-12 10:32	The extracellular matrix components fibronectin and fibrinogen were degraded by PrtV (PrtV).
666	2827955	18498110	2008-08-30 10:39	The X-ray crystal structure of lysostaphindetermined at 1.9-A resolution, is reported.[Lysostaphin]
666	2827955	18582406	2008-09-13 10:37	study found that the Vibrio cholerae hemolysin HlyA oligomer induced the expression of CXCR3 on B-1a cells [HlyA]
666	2827955	18586940	2008-09-20 10:42	The data indicate that VciB functions by promoting iron uptake via a ferrous, but not ferric, iron transport system: [VciB]
666	2827955	18606988	2008-09-06 10:41	hapR expression is also modulated by the regulatory network that governs flagellar assembly[hapR litR]
668	3293000	15660998	2005-12-19 16:22	Mutations that increase sensitivity to acyl-homoserine lactones occur mostly in the N-terminal domain
669	5563517	18298367	2008-07-12 10:16	Conserved cysteine residues in NqrD and NqrE subunits are necessary for the correct folding and/or the stability of the NADH:quinone oxidoreductase complex (NqrD and NqrH).
669	5563517	18692469	2008-09-06 10:21	Study used mutagenesis and suppressor analyses to identify the acyl-homoserine lactone(AHL)-binding domain of LuxN and discovered LuxN mutants that confer both decreased and increased AHL sensitivity.[LuxN]
670	2827957	15716457	2007-08-25 13:10	The regulation of thermostable direct hemolysin-related hemolysin (trh) transcription via its promoter region in V. parahaemolyticus. [trh]
670	2827957	16113292	2007-08-25 21:18	vpaH affects lateral flagellum biogenesis in trh-positive Vibrio parahaemolyticus strain TH3996 [vpaH]
670	2827957	16547050	2007-08-25 21:01	Three new regulators of swarming, swrZ, swrT, and opaR [swrZ, swrT, and opaR]
670	2827957	17116982	2007-08-25 21:26	These results indicate that the pvsC gene product functions as an inner membrane exporter of vibrioferrin. [PvsC]
670	2827957	17928925	2008-01-05 14:03	Two proteins, psuA and pvuA, are immunogenic and can produce synergistic effects during in vivo infection. (psuA and pvuA)
670	2827957	17942696	2007-12-01 11:51	Vibrio VopL is predicted to be a bacterial virulence factor that disrupts actin homeostasis during an enteric infection of the host.
670	2827957	17993539	2008-02-16 10:29	ScrC has intrinsic diguanylate cyclase and phosphodiesterase activities, that are controlled by ScrAB. Specifically, ScrC acts to form c-di-GMP and the phosphodiesterase activity plays a dominant role during surface translocation and in biofilms. [ScrC]
670	2827957	18026209	2008-01-05 16:55	The cytotoxicity against flounder gill cells and fish pathogenicity indicated a potential role for the zinc metalloprotease in pathogenesis. [Zinc metalloprotease]
670	2827957	18048926	2008-02-23 12:42	VmeA and VmeB genes encode an RND type of multidrug efflux transporter. [VmeA, VmeB]
670	2827957	18347050	2008-05-10 10:13	These phenotypes were abrogated in a mutant strain lacking the CI-T3S effector Vp1686, suggesting that the inhibiting actin polymerization may be a downstream effect of Vp1686-dependent GTPase inhibition.[Vp1686 in strain BCC23]
670	2827957	18599740	2008-08-23 10:10	study reports the crystal structure of a member of the solute sodium symporters, the Vibrio parahaemolyticus sodium/galactose symporter [SGLT]
672	2827959	15464986	2007-08-25 12:07	Results suggest that Vibrio vulnificus hemolyin/cytolysin VvhA is substantially produced in vivo and would contribute to the pathogenesis of V. vulnificus septicemia [VvhA strain MO6-24/O]
672	2827959	15686854	2007-08-25 14:49	adenylate cyclase of V. vulnificus appeared to play a global regulatory role in the expression of various virulence factors[cya, adenylate cyclase]
672	2827959	15731039	2007-08-25 14:49	cloning and characterization of PilA; role in bioilm formation, adherence to epithelial cells, and virulence. [PilA]
672	2827959	16267313	2007-08-25 12:35	cadBA genes were transcribed as a transcriptional operon by a single promoter, P(cadBA), which was activated by CadC in a pH-dependent manner [CadC]
672	2827959	16369026	2007-08-25 11:23	flagellin FlaB would serve as an efficacious mucosal adjuvant inducing protective immune responses through TLR5 activation. (FlaB)
672	2827959	16369029	2007-08-25 11:23	Essential in both the pathogenesis and the capsular polysaccharide biosynthesis of V. vulnificus.  (wbpP, UDP-N-acetyl-D-glucosamine C4 epimerase)
672	2827959	16513735	2007-08-25 13:35	findings demonstrate that PGI-LysAP has broad exopeptidase activity which may enhance V. vulnificus invasiveness by altering peptides involved in signal transduction pathways [PGI-LysAP]
672	2827959	16513751	2007-08-25 13:35	Cyclo(Phe-Pro)produced by Vibrio vulnificus upregulates the expression of ompU [ompU]
672	2827959	16573699	2007-08-25 21:09	PutR and CRP coactivate the expression of putAP operon promoter and exert their effect by cooperatively binding to the promoter. (PutR) (cAMP receptor protein)
672	2827959	16728960	2007-08-25 14:09	vvhA expression in swarming V. vulnificus is downregulated via the activity of the LuxS quorum-sensing system. (vvhA) (luxS)
672	2827959	16952939	2007-08-25 13:29	these results demonstrate that AphB and CadC function sequentially in a regulatory cascade to activate cadBA expression and that AphB activates the expression of cadC by directly binding to an upstream region of P(cadC).[AphB, CadC]
672	2827959	16988233	2007-08-25 10:48	This study indicates that OmpU is an important virulence factor involved in the adherence of V. vulnificus to the host cells.
672	2827959	17012399	2007-08-25 13:29	SoxR induces CadA (lysine decarboxylase)in response to superoxide stress [SoxR, CadA]
672	2827959	17241201	2007-08-25 21:02	study demonstrates novel findings that NtrC is involved in biofilm formation and that NtrC modulates LPS and EPS production via controlling expression of the gene encoding an ADP-glycero-manno-heptose-6-epimerase(gmhD) [ntrC, gmhD]
672	2827959	17263846	2007-08-25 13:26	VvpE has a role in the surface adherence and colonization of V. vulnificus by facilitating swarming, and in the mucosal invasion of V. vulnificus by destroying IgA and lactoferrin.
672	2827959	17285326	2007-10-13 11:53	These findings suggest that interaction with membrane cholesterol is required for activity of Vibrio vulnificus cytolysin. (VVC)
672	2827959	17557854	2007-10-13 12:37	Loss of PilD or PilA significantly reduces the ability of V. vulnificus to persist in Crassostrea virginica over a 66-h interval, strongly suggesting that pili expressed by this bacterium play a role in colonization or persistence in oysters. [PilD, PilA]
672	2827959	17640874	2007-10-27 12:59	IlpA of V. vulnificus functions as an immunostimulant to human cells via TLR2
672	2827959	17982702	2008-04-19 11:20	results indicate that phospholipase A (PLA)activity is important in V. vulnificus-induced cytotoxicity and lethality, suggesting a crucial role for PLA in the pathogenesis of V. vulnificus infection [PLA]
672	2827959	18227162	2008-04-19 12:13	gne, but not galE, is essential for LPS biosynthesis and virulence in the zoonotic serovar of V. vulnificus biotype 2 [gne]
672	2827959	18239413	2008-05-24 10:35	Nonribosomal peptide synthase genes (vvsA, vvsB) are responsible for the biosynthesis of siderophore in Vibrio vulnificus MO6-24/O are important for virulence of the pathogen in a mice model. [vvsA, vvsB]
672	2827959	18262748	2008-07-19 10:11	Metalloprotease (vvp) and the extracellular serine protease (vvhA) contribute to pathogenicity of V. vulnificus. [vvp, vvhA]
672	2827959	18604505	2008-09-13 10:06	The 34 kDa-VvpE is the major form secreted along with 45 kDa-VvpE from the early growth phase via the PilD-mediated type II general secretion system. [VvpE, pilD]
714	2827961	15598890	2007-08-25 21:03	structure of the Actinobacillus actinomycetemcomitans cytolethal distending toxin [Cdt]
714	2827961	15629928	2007-08-25 13:10	reported the presence of introns within the cdt gene of A. actinomycetemcomitans. [cdt]
714	2827961	15699156	2007-08-25 21:15	Although the CdtA and CdtC subunits of cytolethal distending toxin (Ctd) do not exhibit activity alone, each subunit is able to significantly enhance the ability of CdtB to induce G2 arrest in Jurkat cells. (cytolethal distending toxin CtdA, CtdB, CtdC)
714	2827961	15748814	2007-08-25 15:06	CagE-homologue may be critically involved in A. actinomycetemcomitans-induced tissue destruction, inflammation and subsequent adverse immunity in periodontal pathogenesis [CagE]
714	2827961	15870449	2007-08-25 14:24	cytolethal distending toxin C (CdtC) acts to bind cytolethal distending toxin B (CdtB) at the cell surface and transports it into the cell as a complex via an endosomal pathway blockable by monensin and brefeldin A [CdtC, CdtB]
714	2827961	16552030	2007-08-25 21:18	In contrast to the accepted view, Actinobacillus actinomycetemcomitans leukotoxin is able to lyse sheep and human erythrocytes in vitro.  (LtxA, leukotoxin)
714	2827961	16790775	2007-08-25 13:32	May play a role in the response of A. actinomycetemcomitans to autoinducer 2/N-octanoyl-L-homoserine lactone.  (ribose- binding protein; RbsB)
714	2827961	16926414	2007-08-25 13:30	The outer membrane protein 100 (Omp100; identified by molecular mass) is the component inducing the human beta-defensin 2 response.
714	2827961	16980493	2007-08-25 12:26	We demonstrate that the tadV gene encodes a prepilin peptidase that is both necessary and sufficient for proteolytic maturation of Flp1. TadV was also found to be required for maturation of the TadE and TadF pilin-like proteins [tadV]
714	2827961	16982823	2007-08-25 12:27	Single nucleotide polymorphism analysis of the cdt gene in clinical isolates identified a variation of a single amino acid at residue 281 of CdtB, which significantly affected CDT toxicity by modulating the chromatin-degrading activity of CdtB.
714	2827961	17041062	2007-08-25 10:10	Iron appears to play an important role in the regulation of leukotoxin (LtxA) secretion in A. actinomycetemcomitans in a manner independent of gene regulation.
714	2827961	17057091	2007-08-25 11:49	Required for the expression of novel appendages on the surface that mediate bacterial adhesion to collagen.  (EmaA=extracellular matrix protein adhesin A)
714	2827961	17526716	2007-09-15 11:08	These results suggest that A. actinomycetemcomitans possesses two proteins, LsrB and RbsB, that differentially interact with AI-2 and may function to inactivate or facilitate internalization of AI-2.[LsrB and RbsB]
714	2827961	17591788	2007-10-13 11:06	Biofilm growth of the luxS mutant exhibited lower total biomass and lower biofilm depth than those for the wild-type strain.  (LuxS)
714	2827961	17620359	2007-10-13 11:06	ApiA, a surface expressed A. actinomycetemcomitans adhesin also known as Omp100, modulates binding of A. actinomycetemcomitans to human buccal epithelial cells. (ApiA ; Omp100)
714	2827961	17635874	2007-10-13 10:19	A. actinomycetemcomitans Cu,Zn superoxide dismutase may protect both bacteria and leukotoxin from reactive species produced by host inflammatory cells during disease. (Cu,Zn superoxide dismutase)
714	2827961	17660409	2007-12-01 11:04	10 individual genotypes and 3 different forms of the protein were predicted; the prototypic, full-length EmaA (202 kDa) was only associated with serotypes b and c, which displayed antennae-like surface structures. [EmaA]
714	2827961	18310342	2008-05-17 10:24	The functional analysis of in-frame emaA deletion mutants has located the collagen binding activity to the amino terminus of the protein corresponding to amino acids 70 to 386.(EmaA)
714	2827961	18347033	2008-07-12 10:36	A. actinomycetemcomitans preferentially colonizes the ECM and with the evidence that EmaA interacts with the native collagen suggests that the adhesin is a virulence determinant of the bacterium in the initiation of infective endocarditis[EmaA]
714	2827961	18426882	2008-07-12 10:23	Taken together, these results, along with the lack of an aromatic amino acid-rich region in CdtC similar to that in CdtA, suggest that binding of the heterotoxin to its cell surface receptor is mediated predominantly by the CdtA subunit. [CdtA, CdtC]
714	2827961	18541661	2008-08-09 10:11	The ptsH mutant showed only partial hemolysis on blood agar and did not produce LtxA.[LtxA, PtsH]
714	2827961	18621903	2008-09-20 10:28	Findings suggest that MorC is critical for membrane morphology and leukotoxin secretion in A. actinomycetemcomitans: [MorC]
715	2827963	16699590	2007-08-25 10:52	data indicate that both FhuA and HgbA are conserved among all serotypes and biotypes of A. pleuropneumoniae and that HgbA, the receptor for porcine hemoglobin, may play a role in virulence [FhuA, HgbA]
715	2827963	17060463	2007-08-25 12:25	the identification of an A. pleuropneumoniae serotype 1 gene encoding a protein with similarity toother reported Leucine-responsive regulatory proteins
715	2827963	18378638	2008-07-12 10:06	The isogenic A. pleuropneumoniae fumarate reductase deletion mutant was shown to be significantly attenuated, thereby strongly supporting a crucial role for fumarate reductase in the pathogenesis of A. pleuropneumoniae infection.[frdABCD]
725	2827965	16085369	2007-08-25 12:36	Western and IgA cleavage assays together with clustering analysis showed that the F3031 IgA1 protease is most similar to the type 2 proteases produced by H. influenzae type c and e strains.[IgA1 protease ]
727	3974660	16262798	2007-08-25 11:25	role of siaP and siaQM in N-acetylneuraminic acid uptake [siaP, siaQM]
727	3974660	16267724	2007-08-25 12:35	An IS1016-bexA partial deletion in the capsule gene locus similar to that found in H. influenzae serotype b was identified in 2 isolates by means of PCR and sequencing of the IS1016-bexA junction.[bexA]
727	3974660	16421726	2007-08-25 21:09	on the basis of the data, Glutamate-134 is intrinsically involved in the hydrolysis reaction catalyzed by DapE and likely plays the role of a general acid and base [DapE]
727	3974660	16584170	2007-08-25 11:56	kinetic & structural analysis indicates that binding of bicarbonate in noncatalytic binding site of beta-carbonic anhydrase may modulate activity by influencing pH-dependent, cooperative transition between active & inactive forms [beta-carbonic anhydrase]
727	3974660	16584185	2007-08-25 15:04	sequence-activity relationships and key residues of porin P2 Loop 7 were identified; ability of mutant peptides to induce activation of signal transduction pathways and release of TNF-alpha and IL-6 has been determined [porin P2]
727	3974660	16648638	2007-08-25 14:09	all TpsB proteins have a modular structure, with a periplasmic domain that interacts with the cognate TpsA protein and with pore forming activity contained within the C terminus[HMW1B]
727	3974660	16682777	2007-08-25 11:55	crystallization of recombinant e (P4) and the acquisition of a 1.7 angstroms resolution native X-ray diffraction data set [e(P4)]
727	3974660	16688217	2007-08-25 13:34	Results present the crystal structure of the C-terminal end of Hia, corresponding to the entire Hia translocator domain and part of the passenger domain (residues 992-1098).
727	3974660	16702222	2007-08-25 13:33	The structure of SiaP in the presence of the sialic acid analogue 2,3-didehydro-2-deoxy-N-acetylneuraminic acid reveals the ligand bound in a deep cavity with its carboxylate group forming a salt bridge with a highly conserved Arg residue [SiaP]
727	3974660	16707679	2007-08-25 10:16	hcsA and hcsB gene products have complementary functions involved in the transport of polysaccharide across the outer membrane and are essential for virulence. (hcsA AND hcsB)
727	3974660	16723397	2007-08-25 11:54	crystal structures of diaminopimelate (DAP) epimerase from Haemophilus influenzae with two different isomers of the irreversible inhibitor and substrate mimic aziridino-DAP at 1.35- and 1.70-A resolution [DapF]
727	3974660	16735727	2007-08-25 13:33	isolated and characterized biophysical properties of HI1462 in relation to TolC in E coli. [HI1462]
727	3974660	16914439	2007-08-25 10:12	A hypervariable region in the central portion of the mod gene may encodes the target recognition domain of the Mod protein and that variability results in alterations to the recognition sequence of this type III restriction-modification system (mod).
727	3974660	16926409	2007-08-25 13:30	The P6 mutant cells demonstrated increased size, variability in size, vesicle formation, and fragility compared to the parent cells and showed hypersensitivity to selected antibiotics.
727	3974660	16988265	2007-08-25 12:27	These data support the hypothesis that the newly discovered igaB gene is a potential virulence factor in nontypeable H. influenzae. (igaB)
727	3974660	17147516	2007-08-25 13:27	results suggest that the transport of iron by FbpA is not dependent on binding of phosphate in the synergistic anion-binding site [FbpA]
727	3974660	17210913	2007-08-25 11:47	solved the structure of the rhomboid peptidase from Haemophilus influenzae (hiGlpG) to 2.2-A resolution [rhomboid peptidase]
727	3974660	17223537	2007-08-25 13:26	The significance of the dimeric structure of the alpha/beta-knot protein, YibK, from Haemophilus influenzae was investigated.
727	3974660	17317664	2007-08-25 11:47	properties of the degradation tag and the number of SspB.ClpX tethering interactions are the major factors that determine the extent to which the substrate and ClpX are engaged in ternary delivery complexes[ SspB ]
727	3974660	17496075	2008-01-19 12:47	study concludes that the NTHi vapBC-1 gene pair functions as a classical Toxin-antitoxin locus and that the induction of VapC-1 RNase activity leads to growth inhibition via the mechanism of mRNA cleavage[VapB-1 and VapC-1]
727	3974660	17496104	2008-01-19 12:03	Results demonstrate that mutation of the invariant glycine (G418A) within motif 2 led to attenuated transport activity, while mutation of the invariant glycine (G155A/V/E) within motif 1 had no discernible effect on activity [FbpA, FbpB, FbpC]
727	3974660	17675301	2007-10-06 10:52	The recognition site for the Mod methyltransferase in H. influenzae is 5'-CGAAT-3' (mod).
727	3974660	17693509	2007-12-01 11:31	In the current study, examination of purified HMW1B by size exclusion chromatography and negative staining electron microscopy revealed that the predominant species was a dimer.[HMW1B]
727	3974660	17880422	2007-12-15 11:07	In this study, we identified SiaR as a repressor of sialic acid transport and catabolism in nontypeable Haemophilus influenzae.[SiaR]
727	3974660	17981840	2008-02-16 12:47	An extensive secondary structure at the 5' end of sxy mRNA sequesters the ribosome-binding site and start codon in a stem-loop (sxy).
727	3974660	17984210	2008-02-23 10:23	In a collection of NTHI strains we found several strains in which there were two distinct but variant lic1D DNA sequences, genes predicted to encode the transferase responsible for directing the addition of PCho to LPS.[Lic1D]
727	3974660	18029420	2008-02-16 12:56	data strongly suggest that the mechanism of phosphotransfer in the uridyltransferase reaction in GlmU is primarily through an associative mechanism with a pentavalent phosphate intermediate and an inversion of stereochemistry [GlmU]
727	3974660	18069033	2008-04-19 11:50	In conclusion, we have discovered a novel non-typable Haemophilus influenzae outer membrane protein, protein E, with adhesive properties.[protein E in strain 772]
727	3974660	18212083	2008-04-19 11:19	results indicate that dsbA is required in vivo and that HbpA and additional DsbA-dependent factors are likely to participate in H. influenzae pathogenesis [dsbA]
727	3974660	18498176	2008-07-12 10:32	Aspartate 139 in the active site of serine acetyltransferase, in dyad linkage with histidine154, likely facilitates catalysis by increasing the basicity of His154; aspartate139 may also play a role during the catalytic reaction. (serine acetyltransferase)
728	2827969	17541831	2007-12-08 12:02	Complementation of a Saccharomyces cerevisiae gal10 deletion mutant with the galE gene confirmed that this gene encodes a UDP-galactose 4-epimerase (galE). (uridine diphosphate (UDP)-galactose 4-epimerase; galE)
738	3293172	15936788	2007-08-25 10:22	This is the first report describing the presence of aroA gene in H. parasuis; and the data presented here demonstrates a significant degree of aroA genetic diversity in H. parasuis [aroA]
738	3293172	16971306	2007-08-25 21:17	Unlike the H. influenzae P5 adhesin, the H. parasuis P5 protein does not bind carcinoembryonic antigen. (P5 adhesin)
738	3293172	17438055	2007-08-25 13:23	Pulsed-field gel electrophoresis was applied for the first time to H. parasuis and showed that beta-lactam resistance is due to clonal spread of a resistant strain, BB1018, bearing pB1000 expressing a functionally active ROB-1 beta-lactamase. [ROB-1]
747	2827973	15576804	2007-08-25 10:59	hssB, a functional heparosan synthase, is encoded outside of the capsule biosynthesis locus [hssB (heparosan synthase)]
747	2827973	15616323	2007-08-25 14:49	novel trimethoprim resistance gene was detected on the 11-kb plasmid pCCK154 from Pasteurella multocida. [dihydrofolate reductase (DfrA20)]
747	2827973	15814600	2007-08-25 14:24	results of this study showed that a plasmid-borne floR gene was responsible for chloramphenicol and florfenicol resistance in the bovine respiratory tract pathogen P. multocida [FloR}
747	2827973	15998577	2007-08-25 14:43	role for filamentous hemagglutinin in disease pathogenesis [FhaB2]
747	2827973	16475803	2007-08-25 12:34	Structures of truncated multifunctional P. multocida sialyltransferase have been determined by X-ray crystallography. Binding CMP to protein causes large closure of N-terminal Rossmann domain toward C-terminal nucleotide-binding domain[delta24PmST1]
747	2827973	16959770	2007-08-25 10:48	there is low amino acid similarity between the PmHAS and PmHS1 enzymes, and the relative placement of the GlcUA-transferase and GlcNAc-transferase domains within the two polypeptides is reversed[Heparosan synthase 1]
747	2827973	17156125	2007-08-25 14:03	We have identified a new phoX gene encoding the monomeric alkaline phosphatase from Pasteurella multocida X-73 [PhoX]
747	2827973	18160478	2008-03-22 11:09	These results support the hypothesis that the PM1665 protein is a member of a new family of fibronectin binding adhesins that are important in the adhesion of P. multocida to fibronectin.[PM1665 homolog in strain ATCC 43137]
747	2827973	18369188	2008-05-24 10:05	The last 180 amino acids, which encompass the C3 domain in the crystal structure of Pasteurella multocida toxin (PMT) , as the minimum domain sufficient to activate both NFAT and SRE signaling pathways.(PMT)
747	2827973	18521592	2008-10-04 10:28	The higher expression level and a broader substrate tolerance make PmNanA a better catalyst than EcNanA for synthesis of sialic acids and their derivatives. [NanA]
747	3283984	15980396	2007-08-25 10:57	identified as a spectinomycin/streptomycin resistance gene
770	3293002	16816958	2007-11-10 10:06	Subolesin is a candidate vaccine antigen that may contribute to control of multiple tick species and the reduction of tick-borne pathogens. [Subolesin]
777	2827975	15731054	2007-08-25 11:33	adaA, an immunodominant 28-kilodalton Coxiella burnetii outer membrane protein, specific to isolates associated with acute disease was identified and characterized [adaA]
777	2827975	17302824	2007-10-27 11:45	results establish the PmrA regulator as a fundamental regulator of the icm/dot type IV secretion system [PmrA]
781	2827977	16360032	2007-08-25 14:41	OmpB is a ligand for Ku70 [rOmpB]
782	2827979	15488766	2007-08-25 12:50	Results describe the sequence and posttranslational modifications of rickettsial ompB [ompB]
782	2827979	16574381	2007-08-25 11:56	RP828 identified as rickettsial adhesin by proteomic analysis [RP828]
813	2827981	15591067	2007-08-25 11:20	CTThyX is active as a tetramer with NADPH, methylenetetrahydrofolate, and dUMP required as substrates, serving as source of reducing equivalents, methyl donor, and methyl acceptor, respectively. dTMP and H(4)folate are products of the reaction [ThyX]
813	2827981	15629915	2007-08-25 13:10	resultant data show that C. trachomatis DcrA binds to native chlamydial genomic sequences and, overall, substantiate a functional relationship between chlamydial DcrA and the Fur family of regulators [DcrA strain E/UW-5CX]
813	2827981	15629922	2007-08-25 13:10	concluded that PrmC functions as an N5-glutamine AdoMet-dependent MTase, involved in methylation of release factors [PrmC strain L2/434/Bu]
813	2827981	15673471	2007-08-25 11:32	Functional surface expression, coupled with improved understanding of major outer membrane protein (MOMP) topology, could provide modified antigens for immunological studies and vaccination, including live subunit vaccines.[MOMP]
813	2827981	15948948	2007-08-25 11:06	characterization of the D-Ala-D-Ala ligase activity of chlamydial Ddl, a protein encoded as a fusion with MurC [Ddl]
813	2827981	16237037	2007-08-25 14:42	GroEL increased the ability of HrcA to bind to the CIRCE operator and to repress transcription [GroEL, HrcA]
813	2827981	16446444	2007-08-25 10:55	a vaccine protocol using recombinant PmpD to elicit neutralizing Ab in the absence of immunodominant type-specific antibody might be highly efficacious and surpass the level of protection achieved through natural immunity [polymorphic membrane protein D]
813	2827981	16527508	2007-08-25 11:56	The association between clinical symptoms and ompA genotype or serotype in patients with C. trachomatis infections is presented.[ompA]
813	2827981	16545062	2007-08-25 12:32	cloning and expression of Chlamydia trachomatis inclusion membrane protein genes IncB and IncC in Escherichia coli.  [IncB, INcC]
813	2827981	16553875	2007-08-25 21:12	These findings provide the first genetic proof that TrpR acts as a negative regulator of transcription in C. trachomatis.
813	2827981	16824101	2007-08-25 15:01	ChlaDub1 and ChlaDub2 represent the first known bacterial deubiquitinating enzymes (DUBs) that possess both deubiquitinating and deneddylating activities.
813	2827981	16926431	2007-08-25 13:30	CT229 of Chlamydia trachomatis interacts with and recruits Rab4A to the inclusion membrane and therefore may play a role in regulating the intracellular trafficking or fusogenicity of the chlamydial inclusion.(CT229)
813	2827981	16936033	2007-08-25 15:04	results indicate RNAP containing sigma(28) is capable of recognizing some but not all E coli sigma(28)-dependent promoters & it can distinguish different promoter structures, preferentially activating promoters with upstream AT-rich sequences [sigma28]
813	2827981	17028176	2007-08-25 11:50	Results reveal a mechanism by which chlamydiae induce localized cytoskeletal changes by the translocated effector TARP (translocated actin recruiting phosphoprotein) during entry into host cells [TARP].
813	2827981	17116296	2007-08-25 12:24	chlamydial protease-like activity factor mediated anti-chlamydial immunity is highly dependent upon antigen-specific CD4(+) T cells[chlamydial protease-like activity factor]
813	2827981	17307941	2007-08-25 14:00	We found that expression of cHsp60-2 is responsive to iron deprivation in endometrial epitheliala cells in vitro. [Hsp60-2]
813	2827981	17360522	2007-08-25 21:11	LpxD is the N-acyltransferase of lipid A biosynthesis [LpxD for serovar B]
813	2827981	17532760	2008-03-10 15:03	A novel C. trachomatis antihost protein whose activity is relevant to chlamydial pathogenesis has been discovered.[CT847]
813	2827981	17604025	2007-09-22 12:36	chaperone activity may involve functional protease domain and that Chlamydia trachomatis HtrA functions as both a chaperone and protease at 37 degrees C[ HtrA ]
813	2827981	18165300	2008-05-17 10:07	Data show that CdsF is concentrated in the outer membrane of elementary bodies and is surface exposed as a component of an extracellular needle-like projection, and could serve as an efficacious target for anti-Chlamydia neutralizing antibodies[CdsF]
813	2827981	18358006	2008-05-31 10:29	Examination of the reactivities of three stable redox states of the Mn/Fe cluster of ribonucleotide reductase R2 subunit toward hydrogen peroxide (ribonucleotide reductase R2).
813	2827981	18422345	2008-06-14 10:24	F41A mutation increases the K(M) for UDP-3-O-(R-3-OHC14)-GlcN 30-fold, consistent with aromatic stacking of the corresponding F43 side chain against the uracil moiety of bound UDP-GlcNAc in the X-ray structure of Chlamydia trachomatis LpxD[LpxD]
813	2827981	18442471	2008-06-21 10:33	Tarp harbors a sequence similar to a Src and Abl kinase consensus target. (Tarp)
813	2827981	18489796	2008-07-26 10:12	cHSP60 and cHSP10 could affect mucosal immune function by increasing the release of IFN-gamma, IL-10 and TNF-alpha by cervical mononuclear cells. HSP60. HSP10.
817	3979058	16704984	2007-08-25 10:51	new information on the putative role of succinylated intermediates in arginine biosynthesis and on the evolution of transcarbamylases. (N-succinyl-L-ornithine transcarbamylase)
817	3979058	16757501	2007-08-25 12:29	data demonstrate that constitutive bmeB expression is prevalent in B. fragilis [bmeB]
817	3979058	16832728	2007-08-25 15:04	strains harboring bft-1 or bft-2 gene subtypes were able to induce histopathological alterations in intestine of a gnotobiotic mice model and it could explain the effect produced for the enterotoxin [bft-1, bft-2]
817	3979058	16879836	2007-08-25 10:13	Reconstructions from particles showed that GlnN has a double-ringed, dodecameric structure with a 6-fold dihedral space group (D6) symmetry and dimensions of 17.0 nm parallel with the 6-fold axis and 18.3 nm parallel with the 2-fold axes. [GlnN protein]
817	3979058	16907722	2007-08-25 21:17	Thiol peroxidase-scavengase, tps is similar to 'atypical 2-cysteine peroxidases' such as scavengase p20 and it demonstrated catalytic activity against t-butyl hydroperoxide and H2O2.[tps]
817	3979058	16926433	2007-08-25 13:30	Bacteroides fragilis toxin (BFT) binds specifically to intestinal epithelial cell lines in vitro in a polarized manner.
817	3979058	16988234	2007-08-25 10:48	C-terminal deletion mutants showed that deletion of only 2 amino acid residues at the C terminus significantly reduced BFT biological activity and deletion of eight or more amino acid residues obliterated BFT biologic activity. (BFT)
817	3979058	17097857	2007-08-25 21:21	The major determinant of carbapenem resistance in Bacteroides fragilis is production of CfiA metallo-beta-lactamase via activation of the cfiA gene by IS elements (higher level resistance) or by activation of its putative own promoter.[cfiA]
817	3979058	17600144	2007-11-10 10:19	Similarly, the P90E mutation in B. fragilis succinyl-L-ornithine transcarbamylase (equivalent to E92 in X. campestris N-acetyl-L-ornithine transcarbamylase) converts the SOTCase to AOTCase
817	3979058	17873045	2008-01-19 12:54	Results of this study showed that the anaerobic, opportunistic pathogen Bacteroides fragilis lacks the glutathione/glutaredoxin redox system and possesses an extensive number of putative thioredoxin (Trx) orthologs.[Trx]
817	3979058	18039760	2008-02-16 11:28	EPS expression is regulated at one level by the DNA invertase Tsr19, which is encoded by a gene immediately upstream of the EPS locus and inverts the EPS promoter, causing an on or off phenotype. [Tsr19]
817	3979058	18047569	2008-05-03 10:26	The oxyR mutants were more sensitive to oxidants in vitro and in vivo they were attenuated in an intra-abdominal abscess infection model.[OxyR]
817	3979058	18403231	2008-07-19 10:11	Pbp is a putative plasminogen binding protein expressed at the cell surface. [Pbp]
818	2827985	16740638	2007-08-25 14:09	biochemical properties, structural analysis, and phylogenetic relationships of RL5 [RL5 polyphenol oxidase]
818	2827985	17287210	2007-08-25 12:23	catalytic properties of BtMan2A are consistent with the flexible nutrient acquisition displayed by the colonic bacterium[BtMan2A]
818	2827985	18611383	2008-09-13 10:06	The structures of several SusD/oligosaccharide complexes reveal an inherent ligand recognition plasticity dominated by the three-dimensional conformation of the oligosaccharides rather than specific interactions with the composite sugars (SusD).
831	2827987	16923082	2007-08-25 21:17	GroEL expression was increased in the cell membrane-associated proteome when linoleic acid and conjugated linoleic acid were added. [GroEL protein]
837	2827989	15388936	2007-08-25 12:07	x-ray crystallographic analysis of dipeptidyl peptidase IV [dipeptidyl peptidase IV]
837	2827989	15469523	2007-08-25 14:51	molecular mechanisms of FimR regulation of fimA expression; gene expression analyses reveal a transcriptional cascade involving multiple steps, with FimR activating expression of the first gene of the cluster that encodes a key regulatory protein [FimR]
837	2827989	15731036	2007-08-25 14:49	degradation of PECAM-1 by gingipains contributes to increased vascular permeability and neutrophil flux at periodontal disease sites. [RgpA, Kgp]
837	2827989	15731048	2007-08-25 11:33	inactivate membrane tumor necrosis factor alpha [RgpA, RgpB, Kgp]
837	2827989	15748810	2007-08-25 15:06	these results indicate that activated gingipains attach to T cells and preferentially cleave CD2 and CD4 molecules, with potential to impair T cell responses at periodontal sites [RgpA], [Kgp]
837	2827989	15758230	2007-08-25 11:10	results suggest that UstA may play a significant role in oxidative stress responses in the bacterium [UstA]
837	2827989	15843583	2007-08-25 12:38	RgpB-stimulated neuropeptide expression in human dental pulp cells is mediated by a novel proteinase-activated receptor-2 (PAR-2) signaling pathway involving p38 MAPK and activated transcription factor-2 activation [RgpB]
837	2827989	16239522	2007-08-25 10:21	The role of hemagglutinin B (HagB) in adherence of P. gingivalis to human coronary artery endothelial cells is reported. [HagB]
837	2827989	16359325	2007-08-25 12:58	These results reveal a novel mechanism of platelet aggregation by P. gingivalis, involving Hgp44 adhesin but not Rgp proteinase [Rgp proteinase, Hgp44].
837	2827989	16428772	2007-08-25 14:12	Taken together, these results support a role for H95, H434, and the NPDL motif of the P. gingivalis HmuR protein in heme binding and utilization of serum hemoproteins and the HmuR YRAP motif in serum hemoprotein utilization. [HmuR]
837	2827989	16511231	2007-08-25 10:53	X-ray characterization of prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis
837	2827989	16549660	2007-08-25 12:32	results demonstrate that P. gingivalis sod is one of the OxyR regulons, suggesting that OxyR functions as an intracellular redox sensor rather than a peroxide sensor in this organism [sod, OxyR]
837	2827989	16735746	2007-08-25 13:33	Lys-gingipains with HA2 haemagglutinin domains may play a crucial role in haem-pigment formation by converting Fe(III)PPIX.OH monomers into [Fe(III)PPIX]2O and promoting their aggregation.[Kgp, RgpA, RgpB]
837	2827989	16790796	2007-08-25 13:32	Encodes a major manganese transporter required for protection of the bacterium from oxidative stress generated by atmospheric oxygen and H(2)O(2).  (FeoB2)
837	2827989	16832066	2007-08-25 15:04	characterize the structure and enzymatic activity of SerB653 and show that a SerB653 allelic replacement mutant of Porphyromonas gingivalis is deficient in internalization and persistence in gingival epithelial cells[phosphoserine phosphatase]
837	2827989	16907740	2007-08-25 21:17	Proteinaceous molecule(s) in oral streptococci may be responsible for regulation of Mfa1 expression in Porphyromonas gingivalis. [mfa1]
837	2827989	16914159	2007-08-25 10:12	Results describe the crystal structure of prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis [prolyl tripeptidyl aminopeptidase]
837	2827989	17020544	2007-08-25 11:50	Gene expression of uspA is upregulated during biofilm formation.
837	2827989	17220315	2007-08-25 13:58	The order in which proteinase genes contribute to the virulence of P. gingivalis in the murine periodontitis model is Kgp proteinase > or = RgpB proteinase >> RgpA proteinase. (Kgp proteinase)
837	2827989	17283109	2007-08-25 21:11	Both the ragA and ragB mutants were significantly less virulent than wild-type strains in a murine model of infection.[RagA, RagB]
837	2827989	17339349	2007-08-25 10:43	study showed that the Kgp proteinase of P. gingivalis W50 plays an important role in adherence to epithelial cells [Kgp]
837	2827989	17501928	2007-12-08 11:14	Results from gene expression and DNA-protein binding assays identified target genes that were either involved in transport functions or associated with oxidative stress, and indicated that RprY can act as an activator and a repressor.[RprY]
837	2827989	17526848	2007-11-10 10:20	FimE, as well as FimC and FimD encode minor components of the fimbriae and play critical roles in the adhesive activities of the mature FimA fimbriae in P. gingivalis.[FimA, fimC, fimD, fimE]
837	2827989	17913538	2008-01-12 11:10	We propose a novel role for arginine-specific gingipain A (RgpA) in induction of a proinflammatory event through protease-activated receptors(PAR)-mediated Weibel-Palade bodies exocytosis to ehnace endothelial responses. [RgpA]
837	2827989	17922109	2008-06-14 10:14	HmuY may be the first reported member of a new class of proteins in Porphyromonas involved in heme utilization, a function being exerted in conjunction with HmuR, an outer-membrane heme transporter.[HmuY and HmuR in strain A7436]
837	2827989	18053679	2008-06-14 10:34	HBP35 protein influences directly coaggregation but also the expression of other coaggregation factors. [HBP35]
837	2827989	18263730	2008-05-03 10:02	Inactivation of a putative O-antigen ligase (waaL) abolished the linkage of both the O antigen and APS to the lipid A core of O-LPS and A-LPS, respectively, suggesting that it has dual specificity for both.[waaL in strain W50]
851	2827993	16798738	2007-08-25 14:08	Results identify Tyt1 as the first bacterial NSS member consisting of only 11 TMs and shows that Tyt1 is a suitable model for the study of neurotransmitter:sodium symporter (NSS) dynamics and structure/function relationships of human NSSs [Tyt1}.
851	2827993	17142900	2007-08-25 10:45	X-ray structure; FadA exists in two forms: the intact form (pre-FadA), consisting of 129 amino acids, and the mature form (mFadA), which lacks an 18-residue signal sequence. The crystals belong to the hexagonal space group P6(1) or P6(5)[FadA].
851	2827993	17588948	2007-10-13 11:51	FadA from Fusobacterium nucleatum secreted and nonsecreted forms are used for functional oligomerization for attachment and invasion of host cells
851	2827993	18633282	2008-09-20 10:49	Fnu_GT displayed the highest glycosylation activity when UDP-galactose was used as a donor nucleotide-sugar and heptose or Nacetylglucosamine as an acceptor sugar. [GT]
851	2827993	18642853	2008-09-06 10:21	[fomA] Conformation and orientation of membrane-incorporated FomA demonstrate by selective interaction with phosphatidylcholine bilayer membranes that FomA is not trimeric, and is consistent with a monomeric beta-barrel of 14-16 strands.
876	3925350	16457621	2007-08-25 12:33	isolation of periplasmic superoxide dismutase gene and analysis of nucleotide sequence; characterization of the enzyme[superoxide dismutase]
876	3925350	17139522	2007-08-25 21:11	Two arsenite-inhibited forms of each of the aldehyde oxidoreductases from Desulfovibrio gigas and Desulfovibrio desulfuricans have been studied by X-ray crystallography and electron paramagnetic resonance (EPR) spectroscopy. (aldehyde oxidoreductase)
881	2827997	17139260	2007-08-25 21:11	The first structure of a cytochrome from this family, NrfH from Desulfovibrio vulgaris, which forms a stable complex with its electron partner, the cytochrome c nitrite reductase NrfA, is described.
881	2827997	17261542	2007-12-01 10:40	results show that the mutation of Leu122 in The FMN-binding protein changes midpoint potentials, dissociation constants for FMN, and dimer formation, indicating that this residue is important in the pairing subunit.[FMN-bp protein]
881	2827997	18355044	2008-05-31 10:29	The one-electron reduction (E sq/hq for FMNH (*)/FMNH (-)) difference can be best explained by the lower compensation of the side chain influence by the backbone influence in the D. vulgaris flavodoxin than in the C. beijerinckii flavodoxin (flavodoxin).
882	2793334	16621815	2007-08-25 21:12	Selenium inclusion in growth medium leds to increased formation of the periplasmic [NiFeSe]hydrogenase.
882	2793338	16621815	2007-08-25 21:12	Selenium inclusion in growth medium led to repression of the periplasmic [FeNi] hydrogenase
882	2793832	16285745	2007-08-25 10:56	study suggests that heme c in DcrA would primarily work as a sensor of redox and/or oxygen for chemotaxis
882	2794280	15895271	2007-08-25 14:38	features include redox-induced flipping of a peptide carbonyl that reversibly forms a H-bond to the his ligand to Fe1 of the diiron site, an intra-subunit proximal orientation of the rubredoxin-like and diiron domains, and an electron transfer pathway
882	2794328	17706667	2007-12-15 11:07	Results describe the crystal structures of HypE from Desulfovibrio vulgaris Hildenborough in the presence and in the absence of ATP at a resolution of 2.0 A and 2.6 A, respectively.
882	2795040	18457416	2008-06-14 10:23	CbiK(C) is likely to be the enzyme associated with cytoplasmic cobalamin biosynthesis, while the other, CbiK(P), is periplasmic located and possibly associated with an iron transport system
882	2795089	18457416	2008-06-14 10:23	CbiK(C) is likely to be the enzyme associated with cytoplasmic cobalamin biosynthesis, while the other, CbiK(P), is periplasmic located and possibly associated with an iron transport system
882	2795860	16866347	2007-08-25 14:07	Given the putative cytoplasmic localization of its hemerythrin-like oxygen-sensing domain, DcrH is proposed to serve a role in negative aerotaxis (anaerotaxis).
882	2795876	16519511	2007-08-25 14:11	Therefore, the CO-bound cyt c(3) may play a role in maintaining electron transport pathways on accumulation of toxic CO for its utilization.
882	2795966	15895271	2007-08-25 14:38	The characteristic combination of iron sites together with the redox-dependent iron toggling between protein ligands can account for the selectivity of rr for hydrogen peroxide over dioxygen
882	2795967	17630305	2007-10-27 10:36	Both the physiological and transcriptional data implicate a global regulatory role for Fur in the sulfate-reducing bacterium D. vulgaris.
882	2796326	18416566	2008-08-23 10:14	Lysine (78) of the dissimilatory sulfite reductase gamma-subunit is post-translationally modified by either trimethylation or acetylation.
882	2796522	18163882	2008-04-19 13:10	aptamer domains in thiM riboswitches from Desulfovibrio vulgaris, Erwinia carotovora and Rhodobacter spheroides with high similarity in their secondary structures can communicate with a broad variety of non-related expression domains by similar mechanisms
882	2827999	15736966	2007-08-25 11:16	It is proposed that Desulfovibrio vulgaris FprA functions as a scavenging nitric oxide reductase in vivo and that this activity protects D. vulgaris against anaerobic exposure to nitric oxide. [FprA]
882	2827999	16187073	2007-08-25 14:43	The role of the [NiFeSe] Hase, found to be the major Hase associated with the cytoplasmic membrane, was addressed.
882	2827999	17601576	2007-09-22 11:05	D. vulgaris nickel-iron-selenium hydrogenase is the first example of a bacterial lipoprotein translocated through the Tat pathway[nickel-iron-selenium hydrogenase]
915	2828001	16352852	2007-08-25 14:42	disruption of sucA affects growth in stationary phase in response to pH and in regards to activity of enzymes in the nitrification pathway [sucA]
915	2828001	16582494	2007-08-25 13:34	Cytochrome P460 from Nitrosomonas europaea, is a novel mono-heme protein containing an unusual cross-link between a conserved lysine and the porphyrin ring. (cytochrome p460)
915	2828001	16751567	2007-08-25 10:50	Global gene expression was compared between the Nitrosomonas europaea wild type and a nitrite reductase-deficient mutant using a genomic microarray (nitrite reductase)
915	2828001	17583915	2007-08-25 10:41	The crystal structure of cytochrome P460 reveals a proteinaceous link to heme involving a conserved lysine (cytochrome P460).
915	2828001	17608700	2007-12-22 12:50	Rh1 is an ammonia/methylammonium (MA) transporter.
915	2828001	18032606	2008-01-19 11:56	The structure of Nitrosomonas europaea homologue of human Rh50 proteins was solved at a resolution of 1.3 A.
915	2828001	18040042	2008-01-19 12:04	The first structure of an Rh family member, the Rh protein from the chemolithoautotrophic ammonia-oxidizing bacterium Nitrosomonas europaea, is reported.
915	2828001	18048911	2008-02-23 12:42	For efficient acquisition of Fe-loaded ferrioxamine, N. europaea needs both ferrioxamine transporters FoxA(1) and FoxA(2). FoxA(1) probably regulates its own production, and it controls the production of FoxA(2) as well. [FoxA2, FoxA1]
920	1450014	17909890	2007-12-29 11:08	The gene of ferredoxin was cloned, successfully expressed in Escherichia coli, and purified by one-step affinity chromatography. MS spectra confirmed that the iron-sulfur cluster was correctly inserted into the active site of the protein
920	2828003	15618623	2007-08-25 13:41	transcriptional level of sulfide:quinone oxidoreductase was 3-fold higher in sulfur-grown cells than in iron-grown cells. A model is proposed for the oxidation of reduced inorganic sulfur compounds in A. ferrooxidans (sulfide:quinone oxidoreductase)
920	2828003	16244438	2007-08-25 21:05	The F1-ATPase enzyme hydrolyzed ATP, GTP, and ITP, but neither UTP nor ADP; molecular masses of the alpha, beta, gamma, delta, and epsilon subunits of the F1 portion were deduced (F1-ATPase)
920	2828003	16271718	2007-08-25 14:42	Aminoacylation of tRNA(3)(Glu) might contribute to ensure protein synthesis upon high heme demand by an uncoupling of protein and heme biosynthesis.(tRNA(3)(Glu))
920	2828003	16604275	2007-08-25 13:34	structural model of high-potential iron-sulfur protein suggests that the role of proline residues is essential to stabilize the protein folding at very low pH [high-potential iron-sulfur protein ]
920	2828003	16830224	2007-08-25 10:13	Bacterial mercuric ion transporters such as MerC may be useful molecular tools for producing transgenic plants that hyperaccumulate divalent mercury (Hg2+) ion.
920	2828003	17360620	2007-08-25 10:42	Glu-tRNA synthetase (GluRS) plays a major role in regulating the cellular level of heme. [GluRs]
920	2828003	17470358	2007-08-25 13:24	IscA may function as a scaffold protein for the pre-assembly of Fe-S cluster and then transfer it to target proteins in A. ferrooxidans (IscA).
920	2828003	17660944	2008-02-02 11:12	The gene of IscS from A. ferrooxidans ATCC 23270 was cloned and expressed in Escherichia coli, the protein was purified by one-step affinity chromatography to homogeneity.[IscS]
920	2828003	17660945	2008-02-02 11:12	An iron-sulfur cluster assembly protein, IscU, is encoded by the operon iscSUA in Acidithiobacillus ferrooxidans. The gene of IscU was cloned and expressed in Escherichia coli and the protein was purified. [IscU]
920	2828003	18478280	2008-08-30 10:39	Sequence alignments of the transcriptional regulator AfeR, involved in quorum sensing (QS) in Acidithiobacillus ferrooxidans, revealed the presence of strictly or highly conserved residues located in the active site of these proteins.[AfeR]
944	3758889	16423831	2007-08-25 21:18	RIN2 connects Ras to Rab5 in the HGF-induced endocytosis of E-cadherin [RIN2]
944	3758889	16597588	2007-08-25 10:17	CUB domains have a critical role in a novel cargo-selective mechanism for apical sorting of a soluble ADAMTS protease (ADAMTS13) in polarized cells
948	3936710	18094110	2008-04-19 10:55	findings support the concept that changing Msp2 expression has little or no impact on clinical disease outcome in models of granulocytic anaplasmosis [msp2]
948	3936710	18285495	2008-05-10 10:13	These data are the first to confirm differential modification of any A. phagocytophilum MSP2(P44) paralog and the first to provide evidence for expression of truncated versions of such proteins.[MSP2]
971	2828007	17689155	2007-11-10 10:18	R290 & F31 provide catalytic power for hydrolysis of both substrates, native residues are more important for 4NPX than 4NPA as xylopyranose ring must undergo greater distortion than arabinofuranose ring[beta-D-xylosidase/alpha-L-arabinofuranosidase]
986	5129999	18281397	2008-05-03 13:10	Transposon insertions in sprB resulted in cells that were defective in gliding.[SprB in strain FJ1]
1053	4711971	18007033	2008-01-26 12:02	The complete structure (including H atoms) of photoactive yellow protein (PYP) has been determined through the application of joint X-ray (1.1 A) and neutron (2.5 A) structure refinement [PYP (H. halophila strain BN9626)]
1063	3759992	15977062	2007-08-25 13:08	REVIEW: structure and function of cytochrome c2 from Rhodobacter sphaeroides
1063	3759992	16622064	2007-08-25 14:10	role of cytochrome c(2), encoded by cycA, and cytochrome c(Y), encoded by cycY, in electron transfer to the nitrite reductase was investigated; results indicate c(2) is a major electron donor to nitrite reductase but c(Y) is probably not [cycA, cycY]
1063	3759992	16784239	2007-08-25 10:50	findings suggests that there is no direct blockage of DNA binding in the inactive state but rather that PrrA dimerization promotes a correct arrangement of two adjacent DNA-binding domains that recognizes specific DNA binding sequences [PrrA]
1063	3759992	16819830	2007-08-25 21:08	Subunit III creates a barrier that helps prevent protons from donors other than Asp-132 from directly accessing the internal waters of the D-pathway(cytochrome c oxidase subunit III)
1063	3759992	16828701	2007-08-25 14:08	mutant [S287R(cytb)/V135S(ISP)] from Rhodobacter sphaeroides to produce a highly active & more stable cytochrome bc(1) complex. The complex shows a 40% increase in electron transfer activity as compared to that of the wild type enzyme[cytochrome bc1]
1063	3759992	16852561	2007-08-25 14:07	structural alterations are proposed to be responsible for the transmission of the light signal in the BLUF domain [AppA]
1063	3759992	16885439	2007-08-25 13:31	identification of a second RpoH homolog, RpoH(II), in the alpha-proteobacterium Rhodobacter sphaeroides [RpoH(II)]
1063	3759992	16915353	2007-08-25 12:28	Redox properties of the photosynthetic gene repressor PpsR and the blue-light photoreceptor/antirepressor AppA from Rhodobacter sphaeroides have been characterized.[PpsR; AppA]
1063	3759992	17060620	2007-08-25 12:25	suggest a universal functional importance of the histidine-tyrosine cross-link in the mechanism of O(2) reduction by all heme-copper oxidases[cbb3-type cytochrome c oxidase]
1063	3759992	17223530	2007-08-25 13:26	These studies provide a detailed structure-function dissection of the role of hydrogen bonds in tuning the redox potentials of [2Fe-2S] clusters in Rieske [2Fe-2S] iron-sulfur protein. (Rieske [2Fe-2S] iron-sulfur protein)
1063	3759992	17399741	2007-08-25 21:02	Data suggest that light-dependent formation and breakage of the hydrogen bond between Gln63 and Trp104 are critical for the light-sensing mechanism of AppA [AppA].
1063	3759992	17685522	2007-10-13 12:36	this oxidized form of the enzyme oxidizes NO generating nitrate bound to T2 site generates by ET fron T2 to T1[nitrite reductase ]
1063	3759992	17711306	2007-11-10 10:19	The X-ray crystal structure of the AM149W mutant, determined to a resolution of 2.2 A, showed very little change in protein structure despite the absence of the bacteriopheophytin cofactor.[Bacteriopheophytin]
1063	3759992	17850796	2007-12-01 12:40	some bacterial Sco proteins may have biochemical properties that are distinct from those of mitochondrial Sco proteins[PrrC]
1063	3759992	18034796	2008-05-03 10:03	These findings suggest that the LH2 complex, specifically beta-glutamate-20 and the carotenoids' polar head group, contribute to the shaping of the photosynthetic membrane by specific interactions with surrounding lipid molecules.[pucA, pucB]
1063	3759992	18174148	2008-03-29 10:22	data show that R. sphaeroides cells lacking XoxF or CycB do not exhibit methanol-dependent oxygen uptake and lack the capacity to utilize methanol as a sole photosynthetic carbon source.[XoxF, CycB]
1063	3759992	18338855	2008-05-31 10:29	Molecular dynamics simulations on the catalytic subunit of the cbb 3-type oxidase model result in a conformational change of the active-site tyrosine, which may be related to different ligand-binding properties of the cbb 3-type oxidases[cbb3 oxidase]
1063	3759992	18393448	2008-06-07 10:29	electrogenic reactions in structural variants of cytochrome c oxidase in which residues in the second, K proton pathway of cytochrome c oxidase were modified [cytcO]
1076	2828011	16452170	2007-08-25 12:33	Heterologous expression of arsM from Rhodopseudomonas palustris was shown to confer As(III) resistance to an arsenic-sensitive strain of Escherichia coli.(ArsM)
1076	2828011	16631791	2007-08-25 11:55	Results describe the crystallization of the full-length protein HupR in the unphosphorylated state in two dimensions using the lipid monolayer technique [HupR]
1076	2828011	17640891	2007-09-15 12:40	determined the crystal structure at 2.2-A resolution of the chromophore binding domains of RpBphP3, covalently bound with chromophore biliverdin IXalpha[BphP3]
1085	3925363	16439368	2007-08-25 10:19	analysis of CooA DNA binding by UV resonance Raman spectroscopy [CooA]
1085	3925363	16724227	2007-08-25 12:30	These data afford a more complete understanding of how CooA utilizes the weak proline ligand to direct CO to the distal position, thus ensuring selective retention of the histidine ligand.(CooA)
1085	3925363	16822231	2007-08-25 10:50	The Form II Rubisco from R. rubrum has a low specificity for CO2 over O2, produces several by-products during catalysis, and does not bind inhibitors very tightly. rbcL.
1085	3925363	16866371	2007-08-25 10:49	The role of histidine-77 in the carbon monoxide-dependent activation of CooA and a possible activation mechanism involving collaborative movement of the heme and the amino residues at both sides of the heme plane are discussed.
1085	3925363	16889751	2007-08-25 14:06	We propose that proximal heme pocket residues of wild-type CooA have important role in stabilizing both active and inactive heme positions for its CO-sensing function[CO-sensing transcriptional activator]
1085	3925363	17337583	2007-08-25 10:42	findings show that for the uridylylation activity of R. rubrum GlnD, alpha-ketoglutarate is the main signal, whereas glutamine has no effect [GlnD]
1085	3925363	18266761	2008-05-10 10:13	The B820 homodimer is stabilized by both hydrophobic effects (entropy) and non-covalent bonds (enthalpy).(light-harvesting LH1 protein)
1092	2828013	17215361	2007-08-25 10:08	It was determined from the approximately 90 intermolecular distances that bacteriochlorophyll c molecules form piggyback-dimer-based parallel layers[bacteriochlorophyll c]
1097	2828015	15792807	2007-08-25 13:11	Methyltransferase, BchU, from Chlorobium tepidum was overexpressed, purifiied, and characterised.
1097	2828015	15893668	2007-08-25 12:45	Crystal structure of the RuBisCO-like protein (RLP) from Chlorobium tepidum was determined
1097	2828015	16294331	2007-08-25 13:38	The highly conserved gene in Chlorobium tepidum encodes ScpB--high resolution crystal structure of this protein.(ScpB)
1097	2828015	16511137	2007-08-25 11:57	X-ray diffraction study of BchU, a methyltransferase from Chlorobium tepidum involved in bacteriochlorophyll c biosynthesis
1097	2828015	16915355	2007-08-25 12:28	The interaction between the major chlorosome protein, CsmA, and the FMO protein in Chlorobium tepidum using surface plasmon resonance is reported.[FMO; CsmA]
1126	2828017	15528494	2007-08-25 15:02	results suggest that McyH functions as a microcystin exporter and is, in addition, intimately associated with the microcystin biosynthesis pathway [McyH]
1126	2828017	16343532	2007-08-25 21:03	crystal structures of the cyanotoxins, motuporin (nodularin-V) and dihydromicrocystin-LA bound to human protein phosphatase-1c [dihydromicrocystin-LA]
1126	2828017	16420359	2007-08-25 12:58	A lectin, microvirin (MVN), in M. aeruginosa PCC7806 that shares 33% identity with the potent anti-HIV protein cyanovirin-N from Nostoc ellipsosporum was discovered.
1126	2828017	17803924	2008-01-12 12:00	data indicate a rare eukaryote-to-prokaryote horizontal gene transfer has introduced ActM & PfnM sequences into the Microcystis lineage; both genes are actively expressed; a unique role in Microcystis cell stabilization for actin is proposed [ActM, PfnM]
1126	2828017	18281396	2008-05-03 13:10	Immunofluorescence microscopy detected MrpC at the cell surface, suggesting an involvement of the protein in cellular interactions in strain PCC 7806.[MrpC in strain PCC 7806]
1126	2828017	18599818	2008-09-20 10:42	Frequent horizontal gene transfer, point mutations and insertions/deletions contribute to variation in the mcyA/B/C gene cluster. [McyA,McyB, McyC]
1140	2828019	15213381	2007-08-25 11:17	crystallization and structure at 1.8 A resolution of DNA photolyase devoid of its 8-HDF chromophore (apophotolyase) [DNA photolyase]
1140	2828019	15550625	2007-08-25 13:45	temperature-compensated, robust circadian cycling of KaiC phosphorylation even without kaiBC messenger RNA accumulation under continuous dark conditions was demonstrated [KaiC]
1140	2828019	15576622	2007-08-25 12:07	crystal structure of DNA photolyase bound to duplex DNA that is bent by 50 degrees and comprises a synthetic cyclobutane pyrimidine dimer lesion [DNA photolyase]
1140	2828019	15775978	2007-08-25 21:24	LdpA is a component of the clock protein complex that senses the redox state of a cell.
1140	2828019	15831759	2007-08-25 21:22	reconstition of self-sustainable oscillation of KaiC phosphorylation in vitro by incubating KaiC with KaiA, KaiB and ATP
1140	2828019	16238617	2007-08-25 13:38	Results identify a novel component, NblC, which mediates phycobilisome degradation under nitrogen, sulphur and phosphorus starvation [NblC]
1140	2828019	16311758	2007-08-25 13:37	genetic analysis of glnN promoter region; non-canonical NtcA-binding motif is responsible for NtcA-dependent, nitrogen-responsive regulation of glnN; P(II) signalling protein has opposing effects on NtcA-dependent glnN expression [glnN]
1140	2828019	16451177	2007-08-25 10:19	SipA identified as a sensor histidine kinase non-bleaching sensor (NblS) interacting protein, at the ATP binding domain. [SipA, Nbls]
1140	2828019	16629668	2007-08-25 10:52	PsR domain of CikA negatively regulates histidine protein kinase activity in vivo and also serves as an interaction module to dock CikA at a specific subcellular location. [CikA]
1140	2828019	16861792	2007-08-25 13:31	Results suggest the involvement of DnaK3 in the translational process on the surface of the thylakoid membrane [DnaK3]
1140	2828019	16864644	2007-08-25 21:17	These results suggest that the dark-responsive gene expression of pex delays the circadian clock under daily light-dark cycles [Pex].
1140	2828019	17098741	2007-08-25 10:46	Pex from cyanobacterium Synechococcus elongatus PCC 7942 has an (alpha+beta) structure with a winged-helix motif and functions as a dimer; the subunit arrangement in the dimer is unique. Pex is a DNA-binding transcription factor[pex protein]
1140	2828019	17107658	2007-08-25 21:17	HtpG is involved in the regulation of tetrapyrrole biosynthesis through interacting with HemE protein[HtpG]
1140	2828019	17213638	2007-08-25 12:23	results suggest that DnaK2 and DnaJ2 are involved in RNA degradation through interaction with RNase E [DnaJ2 & DnaK2]
1140	2828019	17322191	2007-09-04 18:20	the results indicate that PipX interacts with NtcA to facilitate efficient acclimation of cyanobacteria to conditions of nitrogen limitation [PipX]
1140	2828019	17351044	2007-08-25 10:06	in the stress responses of three dnaK homologues (dnaK1, dnaK2, and dnaK3), only the dnaK2 gene was induced [nak1,dnak2, dnak3]
1140	2828019	17704220	2008-01-12 11:12	NtcA transcription factor regulattes expression of amtB after nitrogen deprivation. [NtcA]
1140	2828019	18004983	2008-06-14 10:14	Data provide genetic evidence of the antagonistic roles of NblR and SipA at regulation of the nblA gene, chlorosis and survival from stress is presented.[SipA], [NblS], [NblR] and [NblA]
1140	2828019	18391440	2008-08-02 10:27	Activation of NblR is independent of phosphorylation, if any, by a cognate histidine kinase
1140	3773504	17916691	2007-12-01 12:22	four forms of KaiC differing in their phosphorylation state appear in an ordered pattern arising from the intrinsic autokinase and autophosphatase rates of KaiC and their modulation by KaiA, one inhibits KaiA through interaction with KaiB
1140	3773504	17965725	2008-03-10 14:15	study found the robustness of the KaiC phosphorylation rhythm arises from the rapid synchronization of the phosphorylation state and reaction direction of KaiC proteins; synchronization is tightly linked with KaiC dephosphorylation
1140	3773504	18165308	2008-05-17 10:07	Data indicate that there was a positive correlation between activation of the kaiBC promoter and an increase in the KaiC phosphorylation ratio in three rhythmic conditions and the ratio is the main factor in the activation of kaiBC promoter.
1140	3773505	17916691	2007-12-01 12:22	four forms of KaiC differing in their phosphorylation state appear in an ordered pattern arising from the intrinsic autokinase and autophosphatase rates of KaiC and their modulation by KaiA, one inhibits KaiA through interaction with KaiB
1140	3773506	17916691	2007-12-01 12:22	four forms of KaiC differing in their phosphorylation state appear in an ordered pattern arising from the intrinsic autokinase and autophosphatase rates of KaiC and their modulation by KaiA, one inhibits KaiA through interaction with KaiB
1140	3773579	17203314	2007-08-25 10:09	Histidine residues in Synechococcus PCC7942 SmtA have a stabilising effect due to electrostatic interactions that impact on protein folding and metal cluster charge, and are involved in fine-tuning the reactivity of the bound metal ions.
1140	3774138	16920111	2007-08-25 10:48	Results describe new bacterial 6-Pyruvoyltetrahydropterin synthase (PTPS) orthologs, having either a single or dual domain structure and being responsible for tetrahydrobiopterin synthesis in vivo, thereby disclosing all the bacterial PTPS homologs.
1140	3774432	16451177	2006-10-05 18:31	Description of a novel protein, named SipA, that interacts with the ATP-binding domain of the NblS protein. In silico analysis suggests conservation and coevolution of both NblS and SipA in cyanobacteria. [SipA]
1140	3775245	16554052	2007-08-25 21:21	PsbU-mutant exhibits fast rates of degradation of the photosystem II core protein, D1, under sub-saturating as well as high-light conditions.
1148	951861	17541776	2007-12-29 12:01	Mutations at Thr-167, adjacent to the H motif of SphS, introduce elevated alkaline phosphatase activity in the presence of phosphate and an enhancement of alkaline phosphatase activity, when compared to the control strain, in phosphate-limiting media.
1148	951861	17927904	2008-01-12 12:50	The mutant lacking functional SphS and acetate kinase showed no detectable alkaline phosphatase activity under phosphate-limiting growth conditions.
1148	951870	16274634	2007-08-25 13:39	GUN4 reveals a novel hand-shaped fold for porphyrin binding.
1148	951878	16199557	2007-08-25 14:14	The open reading frame sll1213 encoding a fucose synthetase orthologue was deleted to probe the role of fucose and to determine the biological significance of myxoxanthophyll in Synechocystis sp. strain PCC 6803
1148	951890	16846223	2007-08-25 21:02	D1-Glu189 does not ligate the Mn(4) cluster during one or more of the S(0) --> S(1), S(1) --> S(2), and S(2) --> S(3) transitions of photosystem II.
1148	951890	17617168	2007-10-27 11:26	The synthesis of the D1 protein in vitro was inhibited by exogenous hydrogen peroxide, which was reversed by the addition of reduced forms of elongation factor G.
1148	951961	15716274	2006-10-25 15:45	KaiB antagonizes the action of KaiA on KaiC, and shares a sequence-homologous domain with the SasA kinase [KaiB]
1148	951973	16621843	2007-08-25 21:12	These results suggest that Slr0753 exports Cl(-) or a related anion, which is essential for PSII oxygen evolution.
1148	952054	17331473	2007-08-25 14:00	Synechocystis sp. PCC 6803 genome each encodes two isozymes for these five glycolytic genes, suggesting that each of the two isozymes is regulated by Sll1330 at the mRNA lev
1148	952097	15459199	2007-08-25 21:06	data indicate that in Synechocystis strain PCC 6803 K(+) uptake via KtrABE K(+) transporter plays a crucial role in the early phase of cell turgor regulation after hyperosmotic shock
1148	952137	15824118	2007-08-25 12:55	PsaK2-dependent state transition is essential for the growth of this cyanobacterium under high light condition
1148	952143	16364235	2007-08-25 15:01	Ycf37 plays a specific role in the preservation of photosystem I and the biogenesis of PSI trimers.
1148	952144	17516144	2007-11-10 11:57	This implies a role for PsbZ in the regulation of electron transfer, with implication for photoprotection.
1148	952152	15653792	2005-04-15 13:06	recombinant protein isolated from Synechocystis showed reversible photoconversion between green-absorbing form and blue-absorbing form.
1148	952159	18604500	2008-09-13 10:06	The hybrid kinase Sll0043 regulates phototaxis by suppressing the expression of pilA1 biosynthesis and pilT2.
1148	952202	18599843	2008-09-20 10:42	The Ser/Thr kinase encoded by sll0776 (spkD) is involved in the regulation of the pool of the TCA cycle metabolites.
1148	952218	16585762	2007-08-25 21:08	The product of the slr0788 gene is a nicotinamide-preferring phosphoribosyltransferase involved in the first step of the two-step non-deamidating utilization of nicotinamide (NMN shunt).
1148	952311	17159215	2007-08-25 14:02	it was determined that slr0388, encoding a hypothetical protein, is involved in natural transformation and phototactic motility; propose to designate this gene comF
1148	952326	18502765	2008-09-13 10:06	structural analysis of the cation-dependent O-methyltransferase slr0095 from the cyanobacterium Synechocystis sp. strain PCC 6803
1148	952337	18640098	2008-09-06 10:21	Overexpression of Synechocystis glucokinase in Arabidopsis gin2-1 mutants which are unresponsive to exogenously supplied glucose due to a mutation in HXK1 restored the ability of these transgenic plants to respond to exogenously supplied glucose.
1148	952373	17617168	2007-10-27 11:26	The synthesis of the D1 protein in vitro was inhibited by exogenous hydrogen peroxide, which was reversed by the addition of reduced forms of elongation factor G.
1148	952382	15596724	2006-05-04 11:52	Bicarbonate transporter, low affinity, Na+-dependent
1148	952382	15596724	2006-05-04 12:00	Encodes a low affinity but high flux bicarbonate transporter
1148	952415	15548534	2007-08-25 15:08	NdhL and Ssl1690 (NdhO) are found in NDH-1L and NDH-1M complexes of Synechocystis
1148	952443	18672807	2008-09-27 10:37	sll0886 gene is involved in controlling negative phototaxis of cyanobacteria at the level of photoreception and signal transduction and its role is mediated by the unidentified redundant gene whose function is suppressed by the prqRL17Q mutation.
1148	952560	15938613	2007-08-25 12:37	Structural details of the chromophore binding pocket in both far-red-absorbing and red-absorbing forms of phytochrome Cph1 are obtained using multidimensional heteronuclear solution-state nuclear magnetic resonance spectroscopy.
1148	952560	16689929	2007-08-25 12:30	Data describe chromophore-protein interactions in phytochrome Cph1 mutants from the cyanobacterium Synechocystis PCC6803.
1148	952628	16286465	2007-08-25 10:19	FtsH (slr0228) plays an important role in controlling the removal of PSII subunits from the thylakoid membrane and is not restricted to selective D1 turnover
1148	952628	17635189	2007-09-15 12:40	The FtsH2 (DeltaSlr0228) and Deg-G (DeltaSlr1204/DeltaSll1679/DeltaSll1427) protease mutants of Synechocystis sp. PCC 6803, were studied, to investigate the involvement of proteases in the processes of induction and degradation of the carbon complexes.
1148	952632	16411782	2007-08-25 14:12	role in reaction mechanism of photosystem I reduction
1148	952751	17921338	2008-04-05 11:14	early assembly partner for D1 and plays a functional role in stabilizing the binding of CP43 in the PSII holoenzyme
1148	952897	16547064	2007-08-25 21:01	accumulation of cyanophycin depends on the activation of the key enzyme of arginine biosynthesis, N-acetyl-L-glutamate kinase, by signal transduction protein PII
1148	952897	16549396	2007-08-25 12:32	Altered steady-state expression levels of glnA, glnN, amt1, gifA and gifB in the PII-deficient mutant suggest that Synechocystis sp. strain PCC 6803 has a mechanism for regulation of the subset of the NtcA-regulated genes related to ammonium assimilation.
1148	952923	17513482	2007-12-01 10:16	PSII from phosphatidylglycerol-depleted pgsA mutant cells sustained only approximately 50% of the oxygen-evolving activity compared to wild-type cells.
1148	952946	18604500	2008-09-13 10:06	The hybrid kinase Sll0043 regulates phototaxis by suppressing the expression of pilA1 biosynthesis and pilT2.
1148	953000	16829579	2007-08-25 10:13	redox potential of flavin generally defines the light sensitivity of flavin-binding photoreceptors
1148	953000	16952375	2007-08-25 13:29	Interaction between apoprotein and N(5) of flavin determines the photoreaction of the flavin-binding sensor PixD, a BLUF (sensor of blue light using FAD)-type blue light receptor protein.
1148	953000	16996275	2007-08-25 14:05	The receptor conformation of Slr1694 (dark adapted form Slr1694(r)) is transformed to the putative signalling state (light adapted form Slr1694(s)) with red-shifted absorption and decreased fluorescence efficiency by blue-light excitation
1148	953003	16585762	2007-08-25 21:08	The product of the slr1691 gene, a homolog of Escherichia coli gene nadE containing an additional nitrilase-like N-terminal domain, is a NAD synthetase capable of utilizing glutamine as an amide donor in vitro.
1148	953096	16905652	2007-08-25 10:49	The accumulation of pD1 in two reaction center assembly intermediates is dependent on Slr1471p.
1148	953192	15347679	2007-08-25 11:11	expression of the psbEFLJ operon is a prerequisite for D2 accumulation that is the key regulatory step for D1 accumulation and consecutive assembly of the PSII reaction center complex
1148	953196	16049785	2007-08-25 14:15	The effects of functional disruption on phycocyanin content is reported.
1148	953196	17468217	2007-10-06 11:58	CpcG2 is characterized by its C-terminal hydrophobic segment, which may anchor CpcG2-PBS to the thylakoid membrane or PSI complex.
1148	953196	18621684	2008-09-06 10:21	CcaS phosphorylates CcaR under green light and induces expression of cpcG2, leading to accumulation of CpcG2-phycobilisome as a chromatic acclimation system
1148	953393	18292340	2008-03-10 16:16	study reports three-dimensional structures of two proteins of previously unknown function, CcmL and OrfA (or CsoS4A), from the two known classes of carboxysomes, at resolutions of 2.4 and 2.15 angstroms
1148	953414	17616590	2007-10-20 10:19	We concluded that a single PDZ domain of HhoA plays a critical role in defining the protease activity and oligomerization state.
1148	953429	16868740	2007-08-25 15:00	Transcription of the heat-shock genes are regulated to various degrees by SigB, SigE and HrcA.
1148	953432	17166849	2007-08-25 12:24	Open reading frame ssr2998 seems to be structurally and functionally associated with the cytochrome b6f complex from Synechocystis and could be involved in regulation of electron transfer processes in Synechocystis sp. PCC 6803.
1148	953466	16142920	2007-08-25 10:20	PsbU is crucial for the stable architecture of the water-splitting system to optimize the efficiency of the oxygen evolution process
1148	953466	16363807	2007-08-25 11:58	Results are consistent with the assumption that PsbU stabilizes both energy transfer and electron transport in the phycobilisome-photosystem II assembly.
1148	953660	17929947	2008-01-12 11:10	A new view of the sequence of events occurring in the reaction catalyzed by magnesium chelatase.
1148	953676	17294699	2007-08-25 21:26	The hybrid sensory histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. strain PCC 6803 contains multiple sensory domains and a multi-step phosphorylation system.
1148	953677	17294699	2007-08-25 21:26	the two-component system Slr1759/Slr1760 has a function in the coordination of several metabolic activities which is in good agreement with the complex domain structure of Slr1759
1148	953713	15950240	2007-08-25 12:55	results indicate a third stage of membrane protein folding in which a cofactor binds to a pre-assembled transmembrane protein
1148	953738	16049785	2007-08-25 14:15	The effects of functional disruption on phycocyanin content is reported.
1148	953896	16585762	2007-08-25 21:08	The product of the sll1916 gene, a homolog of E. coli gene nadD, is a nicotinic acid mononucleotide-preferring adenylyltransferase. This gene is essential for survival
1148	954060	16705009	2007-08-25 14:09	DNA gel mobility shift assays showed that at least five regions in psaAB promoters were responsible for the binding of putative regulatory protein factors.
1148	954061	16705009	2007-08-25 14:09	DNA gel mobility shift assays showed that at least five regions in psaAB promoters were responsible for the binding of putative regulatory protein factors.
1148	954115	16777960	2007-08-25 10:50	Structure of a nitrate-specific receptor NrtA complexed with nitrate and determined to a resolution of 1.5 A was reported.
1148	954155	15882949	2007-08-25 21:22	Overexpression of ssr2061 from Synechocystis sp. PCC 6803 may provide protection to E. coli cells against oxidative stress mediated by H(2)O(2).
1148	954155	17239812	2007-08-25 12:22	oxidized Grx2061 could keep redox equilibrium with another probable Grx and be reduced by thioredoxin reductase; studies suggest Grx2061 in cyanobacteria plays an important role in redox network and its targets are as extensive as that in other organisms
1148	954158	15681848	2007-08-25 12:46	menB and rubA have roles in expression of FX, FA, and FB and plastoquinone or exchanged 9,10-anthraquinone
1148	954174	16842345	2007-08-25 13:31	Essential for growth at high temperatures. In cells growing autotrophically, sll1356 plays a more important role in glycogen digestion.
1148	954209	16842345	2007-08-25 13:31	when CO2-fixation and the supply of glucose are both limited, slr1367 is the key factor in glycogen metabolism; in cells growing autotrophically, sll1356 plays a more important role in glycogen digestion than slr1367
1148	954259	16075317	2007-08-25 10:57	results show that in autotrophically grown cells of the psbH deletion mutant, selective D1 turnover is inhibited and synthesis of CP47 becomes a limiting step in the PS II assembly
1148	954270	15518566	2007-08-25 13:42	The cytochrome c550 C550-H92M (His92 -> Met)substitution mutation does not prevent assembly of functional photosystem II (PSII) complex, although it does decrease accumulation of PSII in the thylakoid membranes and increases the PSII calcium requirement.
1148	954270	15835898	2007-08-25 11:16	Mutations in the residues engaging in hydrogen bond interactions with the heme propionate (Asn49) and the axial 6th ligand His92 (Pro93) resulted in small (12-20 mV), but reproducible, upshifts in midpoint redox potential.
1148	954404	16102913	2007-08-25 12:00	hox genes in Synechocystis PCC 6803 are transcribed as a single operon with the transcriptional regulator LexA binding in the promoter region, suggesting a role for LexA in the transcription regulation of the Synechocystis hox genes
1148	954404	16238629	2007-08-25 13:38	Data show that LexA acts not as a repressor but as a transcriptional activator, and that it is the first transcription factor identified for the expression of bidirectional hydrogenases in cyanobacteria.
1148	954404	18555801	2008-09-13 10:37	The Synechocystis LexA-orthologue binds as a dimer to 12 bp direct repeats in two target genes.
1148	954411	17910763	2008-02-09 11:09	The responses to Cd as an integrated "Yin Yang" reprogramming of the whole metabolism are controlled by the Slr1738 regulator.
1148	954413	16166530	2007-08-25 21:18	Signal transduction protein P(II) is dephosphorylated in Synechocystis sp. strain PCC 6803 by protein phosphatase PphA
1148	954434	15347679	2007-08-25 11:11	expression of the psbEFLJ operon is a prerequisite for D2 accumulation that is the key regulatory step for D1 accumulation and consecutive assembly of the PSII reaction center complex
1148	954446	18192382	2008-07-12 10:36	Analysis of the recombinant full-length and truncated ferrochelatase (FeCH) demonstrated that the C-terminal extension is critical for activity of the FeCH and that it is strictly required for oligomerization of this enzyme.
1148	954514	16113218	2007-08-25 15:01	results demonstrate that a transcriptional regulator, Sll1961, and its possible target proteins, including Sll1773, may be responsible for the regulation of photosystem stoichiometry in response to high light
1148	954571	15170383	2007-08-25 12:11	The drgA gene encodes soluble NAD(P)H:quinone oxidoreductase (NQR) which is mutated to Ins2 in the current study that lacks a functionally active protein product.
1148	954571	17025155	2007-08-25 12:25	The expression of genes drgA and slr1718 was repressed during cell incubation in the dark, but the addition of glucose led to a drastically enhanced expression both in the dark and after illumination of cells.
1148	954611	15848160	2007-08-25 14:38	IsiA protects cyanobacteria from photooxidative stress
1148	954611	16636284	2007-08-25 10:52	Results show that expression of IsiA is controlled by IsrR (iron stress-repressed RNA), a cis-encoded antisense RNA transcribed from the isiA noncoding strand.
1148	954611	17307930	2007-08-25 14:00	Data suggest that in cyanobacteria grown under iron starvation conditions, the blue light-induced nonphotochemical quenching involves the phycobilisome orange carotenoid protein-related energy dissipation mechanism and not IsiA.
1148	954611	17980697	2008-02-09 11:09	When time-resolved fluorescence of aggregated IsiA at room temperature is strongly quenched, unconnected IsiA provides photoprotection in all stages of iron deficiency, while unconnected to photosystem I.
1148	954619	17171466	2007-08-25 15:03	results establish that the phycobilisome degradation process and the expression of nblA take place in the absence of DspA and NblR-like under nitrogen starvation
1148	954640	15637065	2007-08-25 15:06	Ferrous KatG was rapidly converted by hydrogen peroxide in a two-phasic reaction.
1148	954640	17260948	2007-08-25 11:47	rapid kinetic and spectral analysis of the reactions of KatGs from three different sources (Synechocystis PCC 6803, Burkholderia pseudomallei, and Mycobacterium tuberculosis) with peroxoacetic acid and hydrogen peroxide
1148	954649	16453101	2007-08-25 10:54	sll1981 may code for a bifunctional enzyme protein having conserved domains for both L-myo-inositol 1-phosphate synthase (MIPS) and acetolactate synthase (ALS) activities.
1148	954656	15961161	2007-08-25 12:58	Structural and dynamic properties revealed by reconstitution with Zn-protoporphyrin IX
1148	954682	15459199	2007-08-25 21:06	data indicate that in Synechocystis strain PCC 6803 K(+) uptake via KtrABE K(+) transporter plays a crucial role in the early phase of cell turgor regulation after hyperosmotic shock
1148	954682	17921339	2008-04-05 11:14	presumably encodes a digalactosyldiacylglycerol synthase; disruption resulted in a mutant defective in digalactosyldiacylglycerol synthesis
1148	954683	15459199	2007-08-25 21:06	data indicate that in Synechocystis strain PCC 6803 K(+) uptake via KtrABE K(+) transporter plays a crucial role in the early phase of cell turgor regulation after hyperosmotic shock
1148	954686	16049783	2007-08-25 14:15	Using a peptide-directed antibody against this cyanobacterial PsbP-like protein (sll1418) it was shown that it was localized in the thylakoid membrane and associated with Photosystem II.
1148	954686	16049784	2007-08-25 14:15	results are consistent with the conclusion that PsbP is associated with approximately 3 of PS II centers, and may play a regulatory role in PS II
1148	954686	17516145	2007-11-10 11:57	data suggest a possible role of the PsbP-like protein in stabilisation of the charge separation in Photosystem II of cyanobacteria through interaction with the Mn cluster
1148	954803	15548534	2007-08-25 15:08	NdhL and Ssl1690 (NdhO) are found in NDH-1L and NDH-1M complexes of Synechocystis
1148	954875	17379735	2007-12-01 10:38	The expression of sll1242 was upregulated in Synechocystis sp. PCC 6803 after transfer from 30 to 15 degrees C at a photosynthetic photon flux density of 30 mumol photons m(-2) s(-1); sll1242, named ccr, may be required for cold acclimation in light.
1148	954888	17307930	2007-08-25 14:00	Data suggest that in cyanobacteria grown under iron starvation conditions, the blue light-induced nonphotochemical quenching involves the phycobilisome orange carotenoid protein-related energy dissipation mechanism and not IsiA.
1148	954964	15894798	2007-08-25 21:28	the PsaE subunit is not involved in NADP+ photoreduction
1148	954964	18164679	2008-05-10 10:04	Presence of the PsaE polypeptide at the reducing side of photosystem I has a function in avoidance of electron leakage to oxygen in the light and the resulting formation of toxic oxygen species.
1148	2828021	15328351	2007-08-25 22:21	PratA is a periplasmic tetratricopeptide repeat protein involved in biogenesis of photosystem II in Synechocystis sp. PCC 6803
1148	2828021	15333955	2007-08-25 21:03	D-ribulose 5-phosphate 3-epimerase catalyzes the epimerization of D-ribulose 5-phosphate and D-xylulose 5-phosphate--{newentry}
1148	2828021	15483753	2007-08-25 13:45	Under salt stress, hspA, groEL2 and dnaK2 were transcriptionally induced and greatly stabilized, indicating a transcriptional and post-transcriptional mechanism of acclimation to salt stress involving these heat-shock genes. [hspA],[groEL2],[dnaK2]
1148	2828021	15653792	2007-08-25 11:33	PixJ1 protein was overexpressed as a fusion with a poly-histidine tag (His-PixJ1); His-PixJ1 showed novel photoreversible conversion between a blue light-absorbing(Pb, lambdaAmax=425-435 nm) and a green light-absorbing form (Pg, lambdaAmax=535 nm) [PixJ1]
1148	2828021	15681848	2007-08-25 12:46	menB and rubA have roles in expression of FX, FA, and FB and plastoquinone or exchanged 9,10-anthraquinone [rubA]
1148	2828021	15699194	2007-08-25 13:11	results suggest that aquaporin-mediated shrinkage of the Synechocystis cells plays an important role in changes of gene expression in response to hyperosmotic stress [Aqpz]
1148	2828021	15774880	2007-08-25 13:09	Hik8 plays an important role in glucose metabolism and is necessary for heterotrophic growth. [Hik8]
1148	2828021	15821095	2007-08-25 21:22	structure analyzed by x-ray diffraction [apocarotenoid-15,15'-oxygenase]
1148	2828021	15944148	2007-08-25 15:01	results indicate that SigE functions in the transcriptional activation of sugar catabolic pathways in Synechocystis sp. PCC 6803 [SigE].
1148	2828021	15980195	2007-08-25 10:57	FesM, encoding a novel membrane iron-sulfur protein, is essential to cyclic electron flow in the cyanobacterium Synechococcus. (fesM protein)
1148	2828021	16049755	2007-08-25 14:15	the environmental regulation of the Synechocystis sp. PCC 6803 deg genes at the level of transcription and protein structures [degP, depQ, degS]
1148	2828021	16109709	2007-08-25 12:59	PamA has a role in the transcript control of genes for nitrogen and sugar metabolism in Synechocystis sp. PCC 6803
1148	2828021	16166530	2007-08-25 21:18	Signal transduction protein P(II) is dephosphorylated in Synechocystis sp. strain PCC 6803 by protein phosphatase PphA [PPHA]
1148	2828021	16411782	2007-08-25 14:12	role of cytochrome c6 in reaction mechanism of photosystem I reduction [cytochrome c6]
1148	2828021	16615917	2007-08-25 21:08	characterization and crystal structure of Synechocystis arogenate dehydrogenase
1148	2828021	16714404	2007-08-25 10:51	identification of the gene for monoglucosyldiacylglycerol (MGlcDG) synthase, which catalyzes the first step of galactolipid synthesis in cyanobacteria[MGlcDG synthase]
1148	2828021	16782089	2007-08-25 21:17	The crystal structure of the substrate-free form of PcyA from Synechocystis sp. PCC 6803 at 2.5 A resolution was determined.[PcyA]
1148	2828021	16836469	2007-08-25 11:53	Cytochrome c3 and [NiFe]-hydrogenase are linked to photosystem I to photoproduce hydrogn. [photosystem I]
1148	2828021	16868740	2007-08-25 15:00	Overall, we determined that transcription of the heat-shock genes are regulated to various degrees by SigB, SigE and HrcA. [SigB, SigE]
1148	2828021	16914546	2007-08-25 10:13	PfsR has a critical role in regulation of iron homeostasis and stress response
1148	2828021	16916897	2007-08-25 11:51	SpkA regulates the expression of putative pilA9-pilA10-pilA11-slr2018, pilA5-pilA6, and pilA1-pilA2 operons and is essential for the formation of thick pili.[SpkA]
1148	2828021	16981700	2007-08-25 10:12	Ala69Ser substitution on Synechocystis sp. PCC 6803 hemoglobin resulted in minor structural perturbations, but the response of the holoprotein to temperature-, urea-, and acid-induced denaturation was measurably affected. [Hemoglobin]
1148	2828021	17015670	2007-08-25 10:11	We find that cya1 and sycrp1 mutants are motile and phototactic but are impaired in one particular phase of phototaxis in comparison with wild-type Synechocystis sp.
1148	2828021	17035238	2007-08-25 10:46	PedR (Ssl0564) senses the activity of photosynthetic electron transport to achieve the photon flux density-dependent transcriptional regulation
1148	2828021	17134703	2007-08-25 14:04	Nuclear magnetic resonance (NMR) was used to map the binding sites on Synechocystis ferredoxin for ferredoxin-thioredoxin reductase.
1148	2828021	17148438	2007-08-25 10:10	FutA2 contributes to metal partitioning in the periplasm by sequestering ferric iron (Fe(III)), which limits aberrant Fe(III) associations with vital binding sites for other metals, including copper.
1148	2828021	17171466	2007-08-25 15:03	Results demonstrate that dspA and nblR-like do not exert a major control of phycobilisomes degradation in Synechocystis sp. PCC 6803. [dspA, NblR-like proteins}
1148	2828021	17294172	2007-08-25 14:01	This study identified the factor that binds the HLR1 upstream of the HL-inducible hliB gene in the cyanobacterium Synechocystis PCC 6803 as the RpaB (Slr0947) response regulator.[RpaB hliB proteins]
1148	2828021	17331074	2007-08-25 21:02	REsults describe a beta-1,4-glucanase-like protein (SsGlc) from Synechocystis PCC6803 and suggest that SsGlc functions in salt stress tolerance.
1148	2828021	17379215	2007-08-25 11:45	SigD and SigE interfere with each other's expression. (SigD) (SigE)
1148	2828021	17526840	2007-11-10 10:20	Expression of DnaK3 appears also to be as essential as expression of DnaK2, whereas the dnaK1 gene was deleted without resulting in any distorted phenotype.[DnaK1, DnaK2, DnaK3]
1148	2828021	17541776	2007-12-29 12:01	mutations into SphR show that Gly-225 and Trp-236, which are both conserved in SphR from cyanobacteria, are essential for activation of the Pho regulon under phosphate-limiting conditions.[SphR]
1148	2828021	17581127	2007-10-20 11:55	We analyse the mechanism underlying (GS)glutamine synthetase I reactivation and find that this process involves IF7 and IF17 proteolytic degradation. [GSI, IF7, I17]
1148	2828021	17616151	2007-09-22 12:36	Unique to these ABC zinc transporters, ZnuA has a highly charged and mobile loop that protrudes from the protein in the vicinity of the metal binding site that we had suggested might facilitate zinc acquisition.zua, synechocystis
1148	2828021	17827500	2007-12-15 12:45	The Fe/S protein SufR thus functions both as a transcriptional repressor of the sufBCDS operon and as an autoregulator of sufR.[sufR, sufBCDS]
1148	2828021	18039761	2008-02-16 10:28	This transcription factor, an AbrB-like protein functions as a regulator of hox gene expression. [AbrB]
1148	2828021	18252722	2008-06-21 10:34	There is a reduced level of ferric FutA2 in the periplasm of the DeltafutA1 mutant providing an explanation for its severe iron-uptake phenotype.[FutA2]
1148	2828021	18292340	2008-03-10 16:16	study reports three-dimensional structures of two proteins of previously unknown function, CcmL and OrfA (or CsoS4A), from the two known classes of carboxysomes, at resolutions of 2.4 and 2.15 angstroms [OrfA or CsoS4A]
1148	2828021	18469097	2008-08-09 10:44	Thus, CpcM is the methyltransferase that modifies the amide nitrogen of Asn71/72 of CpcB, ApcB, and ApcF.
1148	2828021	18485196	2008-07-19 10:40	The loss of phycocyanin-lyase function causes pleiotropic effects in Synechocystis sp. PCC 6803.[Phycocyanin lyase]
1148	2828021	18604500	2008-09-13 10:06	The hybrid kinase Sll0043 regulates phototaxis by suppressing the expression of pilA1 biosynthesis and pilT2. [pilA1]
1148	2828021	18621684	2008-09-06 10:21	CcaS phosphorylates CcaR under green light and induces expression of cpcG2, leading to accumulation of CpcG2-phycobilisome as a chromatic acclimation system[CcaS]
1148	2828021	18666550	2008-09-20 10:49	Mutation prqRL17Q changes the specificity of the PrqR repressor protein and thereby affects the regulation of phototaxis at the level of photoperception and signal transduction in cells.
1172	3758891	17371502	2007-08-25 12:21	The function of prpJ establishes a new control point for heterocyst maturation because it regulates the synthesis of only one of the two heterocyst glycolipids while other genes so far analysed regulate the synthesis of both heterocyst glycolipids.[Prpj]
1172	3758891	18556022	2008-07-26 10:32	crystal structure of the A. variabilis C503S/C565S phenylalanine ammonia lyase mutant; analysis in vitro of its kinetic properties, as well as its protease and thermal stabilities [phenylalanine ammonia lyase]
1219	2828023	15516600	2007-08-25 22:21	production of nickel superoxide dismutase requires cognate peptidase (SodX) [nickel superoxide dismutase (sodN)]
1245	3293029	16797542	2007-08-25 21:08	Therefore, Asp-196 is identified unambiguously as the catalytic nucleophile of sucrose phosphorylase, and its substitution by Ala forces the reaction to proceed via single nucleophilic displacement.  [Sucrose phosphorylase]
1245	3293029	17350620	2007-08-25 21:26	Replacements of Asp-295 by Asn (D295N) and Glu (D295E) decreased the catalytic center activity of sucrose phosphorylase to about 0.01% of the wild-type level (k(cat)=200s(-1)).(sucrose phosphorylase)
1245	3293029	17826770	2007-12-01 12:37	With a dissociation constant K(d) of 2.8x10(-9)M, this motif shows a very high affinity for isomaltohexaose and longer dextrans, supporting the proposed role of GBD in polymer formation[dextransucrase ]
1245	3293029	18048914	2008-02-23 12:42	Evidence was obtained concerning the anchoring function of c terminal region in cell-associated dextransucrase, a function which may be independent of its capacity to bind dextran. [DsrP]
1245	3293029	18414801	2008-09-13 10:16	The gene dexYG encoding the dextransucrase from an industrial strain of Leuconostoc mesenteroides 0326 was isolated.[dexYG]
1245	3293029	18467871	2008-08-09 10:44	Divalent cations such as Mg2+ and Mn2+, 6-bisphosphate and phosphoenolpyruvate increased the kinase activity of HPrK/P, but inorganic phosphate strongly inhibited it.[Hpr]
1247	2828025	16472556	2007-08-25 11:57	purified small heat shock protein, Lo18, interacts with liposomes, & increases molecular order of lipid bilayer in Oenococcus oeni membranes when temperature reaches 33.8 degrees [Lo18]
1255	2828029	16019271	2007-08-25 14:37	PedB, a bacterial immunity protein conferring immunity to a newly identified pediocin (pediocin PP-1), was crystallized and subjected to X-Ray Diffraction [PedB]
1265	2828031	16267281	2007-08-25 21:03	ScaE appears to play a role in anchoring the cellulosomal complex to the bacterial cell envelope via its interaction with ScaB. [scaE]
1270	3293178	18323637	2008-05-10 10:13	the binding site for the natural substrate farnesyl diphosphate and those for the intermediate allylic diphosphate, which contains the cis-prenyl unit, are different during the cis-prenyl chain elongation reaction.[undecaprenyl diphosphate synthase]
1280	2598266	15623960	2007-08-25 21:12	Detection of antiseptic- and disinfectant-resistance gene qacC in methicillin-resistant S. aureus in a single Japanese hospital.
1280	2598280	15504853	2007-08-25 10:24	low-level glycopeptide resistance of Staph aureus is likely due to instability of the genetic element, plasmid or transposon, carrying the vanA operon
1280	2610354	16449305	2007-08-25 14:41	Results indicated a separate evolution for plasmid- and chromosomally-encoded blaZ. Although a common gene pool seems to exist among staphylococci, exchange of blaZ between strains and species is judged to be an extremely rare event
1280	2828033	15292254	2007-08-25 11:34	crystal structure of the full-length HMG-CoA synthase was determined at 2.0-A resolution, representing the first structure of an HMG-CoA synthase from any organism [HMG-CoA synthase strain WCUH29]
1280	2828033	15321674	2007-08-25 13:49	The roles of HtrA-like serine surface proteases, htrA1 and htrA2, in the thermal stress response and and processing and/or degradation of extracellular proteins was investigated (HtrA1 and HtrA2).
1280	2828033	15321676	2007-08-25 13:49	Staphylococcal accessory regulator A (sarA) may play a role in the intrinsic multidrug resistance mechanism of S. aureus (sarA).
1280	2828033	15382235	2007-08-25 15:08	crystal structure of peptide deformylase in complex with actinonin, a naturally occurring antibacterial agent [peptide deformylase]
1280	2828033	15465043	2007-08-25 13:46	Results describe the structures of Aspergillus nidulans and Staphylococcus aureus dehydroquinate synthase (AnDHQS and SaDHQS), and compare ligand-induced conformational changes and mechanisms of domain closure between fungal and bacterial enzymes.
1280	2828033	15475351	2007-08-25 14:29	FhuD1 is a ferric hydroxamate-binding lipoprotein in Staphylococcus aureus
1280	2828033	15516560	2007-08-25 11:33	Bap binds Ca2+ with low affinity and that Ca2+ binding renders the protein noncompetent for biofilm formation and for intercellular adhesion [Bap (biofilm-associated protein)]by Staphylococci isolated from chronic mastitis [Bap strain V329]
1280	2828033	15516566	2007-08-25 11:33	AgrA binds to RNAIII and functions as a response regulator with recognition sites in the promoter regions of RNAIII and the agr locus [AgrA strain DB]
1280	2828033	15528666	2007-08-25 12:06	results indicate that spa expression is controlled by DNA supercoiling and suggest that the Arl sytem is involved in the control of spa expression by DNA supercoiling [spa, ArlS, ArlR]
1280	2828033	15548531	2007-08-25 15:08	a key finding of this study is that Staphylococcus aureus pantothenate kinase (CoaA) differs from all described previously pantothenate kinases in that it is refractory to feedback inhibition by CoA and/or its thioesters [CoaA]
1280	2828033	15616291	2007-08-25 14:49	MgrA overexpression and promoter region mutations result in a reduction in NorA expression [mgrA AND norA]
1280	2828033	15623960	2007-08-25 21:12	Detection of the antiseptic- and disinfectant-resistance genes qacA and qacB in methicillin-resistant S. aureus isolated during MRSA surveillance in a single hospital.[qacA, qacB]
1280	2828033	15644332	2007-08-25 12:03	staphostatin B structure compared to standard mechanism serine protease inhibitors [staphostatin B]
1280	2828033	15661005	2007-08-25 12:49	PBP2 recruited to the division site by binding to its transpeptidation substrate, which is localized at that place [PBP2, strain RN4220]
1280	2828033	15678100	2007-08-25 10:58	spa repression occurs not only at the transcriptional level but also by RNAIII-mediated inhibition of translation and degradation of the stable spa mRNA by the double-strand-specific endoribonuclease III (RNase III) [spa & endoribonuclease III & RNAIII]
1280	2828033	15716453	2007-08-25 13:10	The coordination of pbp2 with pbp4 and pbp2a (in MeSH) in ceftizoxime resistance and cell wall cross-linking.[pbp2a]
1280	2828033	15731040	2007-08-25 14:49	studies here have defined the nature of interaction of mgrA with other regulators such as agr, sarS, and sarT and its role in regulating hla and spa transcription within the virulence regulatory network of S. aureus[MgrA]
1280	2828033	15731082	2007-08-25 11:33	PIA expression is dependent on the genetic background of the strain as well as on strong inducing conditions in device-related infection model, such as those dominating in vivo. [PIA]
1280	2828033	15774883	2007-08-25 13:09	The regulatory role of MgrA in the expression of NorB and Tet38, two drug efflux pumps in S. aureus [MgrA, NorB, Tet38]
1280	2828033	15837383	2007-08-25 13:05	demonstrated that a putative glycoprotease (Gcp) is required for staphylococcal growth [gcp]
1280	2828033	15843987	2007-08-25 14:17	data indicates that ClpYQ plays only a secondary role in the degradation of non-native proteins in S. aureus [ClpY, ClpQ]
1280	2828033	15845485	2007-08-25 21:13	results show that Pls is a virulence factor for septic arthritis and sepsis [Pls]
1280	2828033	15870453	2007-08-25 14:24	cloning and identification of the gene, azo1, encoding a novel aerobic tetrameric FMN-dependent azoreductase [Azo1]
1280	2828033	15916614	2007-08-25 12:36	results indicate that cidC is involved in the generation of acetic acid that contributes to the cell death and lysis that occurs in high-glucose stationary phase cultures [cidC, pyruvate oxidase]
1280	2828033	15941988	2007-08-25 11:20	identification of sae as an important regulator of the staphylococcal adhesins Eap and Emp, which is capable of modulating their expression under different environmental conditions [sae, Eap, Emp]
1280	2828033	15987898	2007-08-25 11:30	Structural model and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus (FAbH).
1280	2828033	16023209	2007-08-25 11:31	SEG and SEI co-express, differently interact with MHC class II, stimulate different subsets of T-cells, which indicate complementary superantigenic activity and suggest an important advantage to staphylococcal strains in producing them both.(SEG)(SEI)
1280	2828033	16045623	2007-08-25 21:06	ClfA promotes platelet activation in fibrinogen dependent and independent pathways with the latter requiring IGG and complement deposition [ClfA, clumping factor A]
1280	2828033	16109930	2007-08-25 11:25	the cidR gene product functions as a transcriptional activator of cidABC transcription in response to acetic acid accumulation in the growth medium [CidR]
1280	2828033	16113270	2007-08-25 21:18	strains carrying seb and selp produced SEB but not SElP, suggesting the inactivation of the selp locus in S. aureus strains with a particular se gene constitution (SElP = staphylococcal enterotoxin-like toxin P)
1280	2828033	16113817	2007-08-25 13:39	ClfA(221-550) is a fibrinogen-binding segment of Staphylococcus aureus clumping factor A that disrupts fibrinogen function [from isolate 30326]
1280	2828033	16145104	2007-08-25 15:04	role of penicillin Binding protein 2a in oxacillin resistance, and discovery of functionally impaired form of PBP2a with a novel amino acid substitution [PBP2a]
1280	2828033	16151171	2007-08-25 11:25	roles in copper homeostasis and oxidative stress response [mco, multicopper oxidase]
1280	2828033	16177293	2007-08-25 11:25	TRAP is a master regulator of staphylococcal pathogenesis.(TRAP)
1280	2828033	16177891	2007-08-25 14:43	DsbA is a membrane localised lipoprotein, supporting a role in disulfide bond formation. The persistence of the protein throughout the growth cycle despite its predominant transcription during exponential growth phase suggested a long half-life[DsbA]
1280	2828033	16227199	2007-08-25 14:42	role of the N terminus in the assembly of alpha-hemolysin [alpha-hemolysin]
1280	2828033	16262792	2007-08-25 11:25	purification and characterization of a 32 kDa N-acetylmuramyl-L-alanine amidase designated Sle1; findings suggest Sle1 is involved in cell separation [Sle1]
1280	2828033	16267314	2007-08-25 12:35	results demonstrated that the YhcSR regulatory system is indispensable for S. aureus growth in culture [YhcS, YhcR]
1280	2828033	16269153	2007-08-25 10:56	crystal structure in three crystal forms at different pH values [LytM]
1280	2828033	16299297	2007-08-25 14:14	dltA and mprF mutations in Staphylococcus aureus increased in vitro susceptibility to platelet microbicidal protein 1 and significantly attenuated virulence. (dltA)(mprF)
1280	2828033	16299304	2007-08-25 14:14	To assess the roles of ClpX and ClpP within the sar/agr regulatory network, deletions in clpX and clpP were combined with mutations in these genes. (ClpX) (ClpP)
1280	2828033	16352822	2007-08-25 14:42	SigB regulates transcription of virulence factors in SCVs (Staphylococus aureus small-colony variant) from cystic fibrosis patients [SigB]
1280	2828033	16359330	2007-08-25 12:58	Data suggest that the fibrinogen/fibronectin-binding proteins FnBPA and FnBPB are major platelet-activating factors on the surface of S. aureus, and act through FcgammaRIIa and GPIIb/IIIa [FnBPA, FnBPB].
1280	2828033	16406068	2007-08-25 11:58	Data describe the contribution that individual metal ligands of the alpha5 sensing site of S. aureus CzrA make to metal ion binding affinity, coordination geometry, and allosteric negative regulation of DNA operator/promoter region binding
1280	2828033	16415880	2007-08-25 11:59	cocrystal structure reveals the basis for both sequence and structure specificity in the interactions of TadA with RNA, and it additionally provides insight into the active site architecture that promotes efficient hydrolytic deamination [TadA]
1280	2828033	16428756	2007-08-25 14:12	Small colony variants (SCVs) of Staphylococcus aureus as well as hemB- and menD-deficient mutants of S. aureus are greatly reduced in virulence in the C. elegans infection model. [HemB, MenD]
1280	2828033	16451174	2007-08-25 10:19	first report of a temperature-sensitive dnaA mutant in S. aureus, and the results show that DnaA is required for the initiation of chromosomal replication and for the regulation of synchrony in the bacterial cells [DnaA]
1280	2828033	16455801	2007-08-25 11:23	2.6 A-resolution x-ray crystal structure of the dimeric winged helix SarA protein was reported.
1280	2828033	16513734	2007-08-25 13:35	findings support the conclusion that FhuC functions with FhuB, FhuG, and FhuD1 or FhuD2 to transport iron(III)-hydroxamates and is the "genetically unlinked" ABC-ATPase that functions with SirA, SirB, and SirC to transport iron(III)-staphylobactin [FhuC]
1280	2828033	16514164	2007-08-25 13:36	Derepression of PerR by HOCl is dependent on the level of SOD and protects exponentially arrested cells against HOCl stress.[PerR, SOD]
1280	2828033	16522365	2007-08-25 21:18	in spite of the preferential location of the binding epitopes within triple helical regions in some collagens there is a striking specificity of Eap binding to different collagen types [Eap]
1280	2828033	16530010	2007-08-25 10:53	Complementation experiments with sigB on a plasmid reduced expression of proteases and alpha-hemolysin dramatically, indicating that the high production of these exoproteins was associated with sigmaB deficiency. [SigB]
1280	2828033	16547040	2007-08-25 21:01	role of the conserved Glu100 of S. aureus MGT (equivalent to the proposed catalytic Glu233 of E. coli PBP1b) by site-directed mutagenesis [monofunctional glycosyltransferase]
1280	2828033	16547042	2007-08-25 21:01	observations suggest that the role of murF exceeds its primary function in peptidoglycan biosynthesis and may also be involved in the control of cell division
1280	2828033	16547047	2007-08-25 21:01	The role of SarA in the regulation of virulence factor expression in S. aureus is reported.[SarA]
1280	2828033	16582476	2007-08-25 13:34	The dimeric repressor MecI regulates the mecA gene that encodes the penicillin-binding protein PBP-2a in methicillin-resistant Staphylococcus aureus(MecI)
1280	2828033	16632608	2007-08-25 13:33	MoaA binds 5'-GTP with high affinity and interacts through its C-terminal [4Fe-4S] cluster with the guanine N1 and N2 atoms, in a yet uncharacterized binding mode [MoaA]
1280	2828033	16640587	2007-08-25 10:51	ClfA inhibited phagocytosis in the absence of fibrinogen, and showed enhanced inhibition in the presence of fibrinogen.
1280	2828033	16689803	2007-08-25 11:55	Data show that SarR (a member of the SarA protein family) in part regulates agr expression by direct binding to the agr intergenic promoter region as determined by gel shift and DNase I footprinting assays [SarR].
1280	2828033	16782383	2007-08-25 21:17	results suggest that LukM/F'-PV may constitute a particular virulence attribute of mastitis-causing S. aureus strains [LukM, LukF'-PV]
1280	2828033	16782403	2007-08-25 13:33	Apart from an apparent direct positive effect of mgrA on sspA & aur transcription, these genes were mainly controlled through repression by sarA & rot, which seemed to occur via binding of SarA & Rot to the aur & sspA promoters, respectively[sarA, rot]
1280	2828033	16794307	2007-08-25 13:32	assembly of LukS and LukF into the pore-complex occurs in lipid rafts in human polymorphonuclear leukocytes and that LukF can bind to LukS, which had already bound to lipid rafts, to assemble into hetero-oligomers [LukS and LukF]
1280	2828033	16801432	2007-08-25 11:53	it is concluded that expression of the Cfr rRNA methyltransferase confers a PhLOPSA resistance phenotype (resistance to five chemically distinct classes of antimicrobials: Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A [Cfr]
1280	2828033	16861653	2007-08-25 13:31	Our results indicate that activation of the SaeRS system may be required for S. aureus to adhere to and invade epithelial cells. [SaeR, SaeS]
1280	2828033	16861682	2007-08-25 13:31	examined the potential of the YjeQ protein as a virulence determinant [YjeQ]
1280	2828033	16861688	2007-08-25 13:31	role in Staphylococcus aureus fitness and resistance to antioxidants and neutrophil killing [staphyloxanthin]
1280	2828033	16879652	2007-08-25 10:13	RNAIII regulates the synthesis of Rot, by blocking its translation; it is proposed that the RNAIII-rot mRNA interaction plays a key role in agr regulation of staphylococcal virulence [rot]
1280	2828033	16923071	2007-08-25 21:17	findings show that the vraS/vraR regulatory system plays a crucial role in allowing MRSA to respond to beta-lactams by regulation of a gene target other than the known effectors of methicillin resistance [VraS, VraR]
1280	2828033	16943773	2007-08-25 12:28	3.0 A crystal structure of a bacterial ABC transporter (Sav1866) from Staphylococcus aureus [Sav1866]
1280	2828033	16980961	2007-08-25 13:29	The study reveals that in Staphylococcus aureus, MgrA adopts a similar mechanism but uses it to globally regulate different defensive pathways.
1280	2828033	16981688	2007-08-25 10:12	crystal structure of S. aureus CoADR has been solved using multiwavelength anomalous dispersion data and refined at a resolution of 1.54 A [coenzyme A-disulfide reductase]
1280	2828033	16984414	2007-08-25 21:08	cells surviving an attack by alpha toxin can be induced to proliferate via recruitment of an EGFR-dependent signalling pathway (alpha-toxin)
1280	2828033	16984420	2007-08-25 21:08	results indicate that exported alpha-toxin inhibits the adhesion and internalization of S. aureus by interfering with integrin-mediated pathogen-host cell interactions (S. aureus WCUH29 alpha-tox; hla gene)
1280	2828033	17005987	2007-08-25 10:48	results indicate that, in contrast to NCTC 8325 derivatives, agr plays a limited role in overall regulation of gene expression in UAMS-1, when compared with sarA [agr, sarA]
1280	2828033	17005991	2007-08-25 10:48	Collectively, the results suggest that arlR positively regulates capsule production at the transcriptional level primarily through an mgrA-dependent pathway.[arlR, mgrA]
1280	2828033	17012781	2007-08-25 21:08	The structures of unliganded monophosphate kinase (GMK) and GMK complexed with GMP at 1.9 A resolution (GMK).
1280	2828033	17021255	2007-08-25 12:26	S. aureus FnBPA produces attachment sites that promote bacterial movements but subvert actin- and Rab5 reorganization during invasion.[FnBPA]
1280	2828033	17041042	2007-08-25 13:22	IsdB-mediated scavenging of iron from hemoglobin represents an important virulence strategy for S. aureus replication in host tissues and for the establishment of persistent staphylococcal infections. [IsdB]
1280	2828033	17041853	2007-08-25 13:28	Regulation of Staphylococcus aureus alpha-toxin gene (hla) expression by agr, sarA, and sae [hla]
1280	2828033	17198402	2007-08-25 12:23	SrrAB regulates RNAIII, tst, spa, icaR, and icaA in a clinical isolate of S. aureus, MN8 (SrrA and SrrB).
1280	2828033	17209021	2007-08-25 21:16	Three genes in glycolipid synthesis and lipotheichoic acid anchoring were identified:  alpha-phosphoglucomutase (PgcA) and UTP:alpha-glucose 1-phosphate uridyltransferase (GtaB)and LtaA (lipoteichoic acid protein A), [PgcA, GtaB, LtaA]
1280	2828033	17234914	2007-08-25 10:07	findings show that Panton-Valentine leukocidin is sufficient to cause pneumonia & that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted & cell wall-anchored staphylococcal proteins [LukS,LukF]
1280	2828033	17302800	2007-08-25 10:07	The study suggests that Fibronectin binding protein A (FnBPA) binds to fibrinogen and elastin in a similar manner, amino acid sequence divergence of 26.5% occurred between the A domains of FnBPA from strains 8325-4 and P1. [FnBPA protein]
1280	2828033	17303126	2007-08-25 10:07	crystal structure of Sav1866 in complex with adenosine-5'-(beta,gamma-imido)triphosphate (AMP-PNP) at 3.4A resolution and comparison with the previously determined structure of Sav1866 with bound ADP
1280	2828033	17328763	2007-08-25 13:25	results support the previous report that isaA expression is regulated by YycF, and also suggest that IsaA is probably involved in bacterial proliferation by residing on the cell wall [IsaA]
1280	2828033	17340193	2007-09-04 16:21	menstrual toxic shock syndrome patients may be incapable of generating TSST-1 neutralizing antibodies
1280	2828033	17347437	2007-08-25 11:46	2.8 angstrom structure of penicillin binding protein 2, a bifunctional cell-wall cross-linking enzyme, including its transpeptidase and GT domains, both unliganded and complexed with the substrate analog moenomycin [PBP2]
1280	2828033	17359518	2007-08-25 13:24	Interaction of alpha-toxin with alpha5beta1-integrin and overproduction of TNF-alpha may contribute to destruction of epithelial cells during S. aureus infection.
1280	2828033	17368484	2007-08-25 10:06	The active site proline in thioredoxin determines the driving potential for substrate reduction (Sa_Trx)
1280	2828033	17416657	2007-08-25 13:59	Study shows that protein A, the ligand of immunoglobulin, is unevenly distributed over the staphylococcal surface; upon removal with trypsin, newly synthesized polypeptide is deposited at two to four discrete foci. [protein A]
1280	2828033	17438053	2007-08-25 13:23	Transient nature of MupA polymorphism accounts for transient loss of high level mupirocin resistance. [MupA]
1280	2828033	17464068	2007-12-01 10:13	The data indicate that the expression of rot transcription is significantly repressed only by SarA. [rot]
1280	2828033	17467042	2008-03-15 11:58	the antithrombotic effect of ClfA221-550 may result from the blockade of fibrinogen gamma chain C-terminal functions, in mediating platelet aggregation and fibrin clot formation.[Clumping factor A, Staphylococcus aureus}
1280	2828033	17502406	2007-10-20 11:56	GraRS, the 2 component regulatory system regulates vancomycin intermediate resistance phenotype by interactions with VraFG ABC transporter. [GraR, GraS]
1280	2828033	17526828	2007-11-10 10:20	The absence of Bap correlated with increased adherence to fibrinogen and fibronectin.[Bap protein]
1280	2828033	17551788	2007-10-13 11:06	Constructed tatC-deficient mutants from distinct parent strains showed the same patterns of exoproteins compared with those of parent strains; it seems that the Tat pathway does not play a major role in the secretion system of S. aureus.[tatC]
1280	2828033	17555436	2007-08-25 13:58	Linezolid resistance in a methicillin-resistant Staphylococcus aureus hospital strain from Colombia is determined by the cfr gene whose product, Cfr methyltransferase, modifies adenosine at position 2503 in 23S rRNA in the large ribosomal subunit. [Cfr]
1280	2828033	17576674	2007-08-25 13:23	NMR solution structure of MecI complexed to a operator sequence provides insights for the repression and induction mechanisms of bacterial resistance to beta-lactams (MecI).
1280	2828033	17583736	2007-09-22 12:36	Crystal structures of Mevalonate diphosphate decarboxylase (MDD) from T. brucei (TbMDD, at 1.8 A resolution) and S. aureus (SaMDD, each diffracting to 2.3 A resolution) have been determined[mevalonate diphosphate decarboxylase ]
1280	2828033	17584179	2007-10-13 11:51	the monomer orthorhombic Sau3AI/E64A crystal is in space group C2221 with unit cell parameters (69.44, 197.60, 191.46, 90, 90, 90) and contains two molecules in one asymmetric unit[Sau3AI endonuclease]
1280	2828033	17585782	2007-08-25 21:25	Data supports a catalytic mechanism in which the reduced flavin coenzyme mediates a single electron transfer to and from the IPP substrate during catalysis by type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IDI-2).
1280	2828033	17608791	2007-09-15 12:40	Cloning and purification of the two known S. aureus signal peptidases, SpsA and SpsB, demonstrated that only SpsB catalysed type I signal peptidase activity in vitro.
1280	2828033	17640274	2007-10-27 10:33	The ypfP gene responsible for biosynthesis of a glycolipid found in LTA was deleted in Staphylococcus aureus SA113, causing 87% reduction of the LTA content.[ypfP, autolysin]
1280	2828033	17675373	2007-12-01 13:07	An isaA sceD mutant is attenuated for virulence, while SceD is essential for nasal colonization in cotton rats, thus demonstrating the importance of cell wall dynamics in host-pathogen interactions.[isaA, sceD]
1280	2828033	17697253	2008-05-24 10:26	results demonstrate that SrrAB is a major activator of ica expression and polysaccharide intercellular adhesin production in anaerobic environments, where it contributes to the protection of S. aureus against non-oxidative defence mechanisms [SrrA, SrrB]
1280	2828033	17703424	2007-10-13 12:36	As the length of the ClfA repeat region increased, binding of acapsular S. aureus to fibrinogen-coated microtiter plates was enhanced; by contrast, encapsulated S. aureus expressing the full-length ClfA were poorly adherent.[ClfA]
1280	2828033	17827301	2008-01-19 12:04	This study showed that WalKR positively controls autolytic activity.[WalK; WalkR]
1280	2828033	17848512	2007-12-01 12:40	the three-dimensional structure of the complex of SSL7 with Fc of human IgA1 at 3.2 A resolution (SSL7).
1280	2828033	17980412	2008-03-10 13:39	findings show that S aureus products have various effects on mucosal tissues: surface protein A induces mast cell degranulation, whereas enterotoxin B induces the release of cytokines, with a T(H)2-skewed pattern in nasal polyps.[SEB, protein A]
1280	2828033	17981965	2008-02-02 10:18	Affinity purification of proteins binding to the rot promoter fragment, followed by N-terminal protein sequencing, identified the SarA and SarR proteins.[SarA and SarR in strain GP269]
1280	2828033	17988649	2008-03-22 10:18	The effects of ceramide incorporation in supported bilayers prepared from ternary lipid mixtures which have small nanoscale domains have been examined using atomic force and fluorescence microscopy.[SMase]
1280	2828033	18007038	2007-12-22 10:18	MenB consists of 2 subunits & a crystallographic threefold axis of symmetry generates a hexamer.  MenB displays crotonase-family fold with distinct N- & C-terminal domains & a flexible segment of structure around the active site.[MenB]
1280	2828033	18007049	2007-12-22 10:18	SaDsbA crystals diffract to a resolution limit of 2.1 A and belong to the hexagonal space group P6(5) or P6(1), with unit-cell parameters a = b = 72.1, c = 92.1 A and one molecule in the asymmetric unit (64% solvent content)[DsbA]
1280	2828033	18048940	2008-02-23 12:42	The expression of copA and copZ was inducible by copper and to some extent by ferric and lead ions. The cysteine residues in the CXXC metal-binding motif in CopA are involved in copper binding and play an important role in copper transport. [CopA, CopZ]
1280	2828033	18063809	2008-02-16 12:56	fibrinogen and IgG binding to ClfA is essential for aggregate formation under arterial shear conditions and may explain why S. aureus is the major cause of infective endocarditis [C1fA]
1280	2828033	18070966	2008-05-03 10:57	This strain is the first clinical isolate of MRSA for which the genetic base for high-level resistance has been clarified. It is connected to a LytH mutation caused by IS1182 insertion. [LytH]
1280	2828033	18084043	2008-06-28 10:23	These results suggest that His343 of S. aureus MurC is essential for high-affinity binding to L-alanine both in vitro and in vivo and provide experimental evidence supporting the structural information of MurC ligase.[MurC]
1280	2828033	18092812	2008-03-10 13:38	The crystal structures of non-thiocarboxylated MPT synthase from Staphylococcus aureus in its apo form and in complex with precursor Z, is presented.[MPT synthase]
1280	2828033	18174341	2008-03-22 10:18	Collectively, the data implicated the importance of sae in the rot-mediated repression of hla in S. aureus. [rot, hla in strain RN4220]
1280	2828033	18195060	2008-09-06 10:35	Mutants resulting from an rplB-to-rplV gene conversion-like event is specific to selection of telithromycin resistance in staphylococcus aureus. [rplB, rplV]
1280	2828033	18199287	2008-06-21 10:24	In Staphylococcus aureus V8 strain, data showed that glutamyl endopeptidase I (GluV8) Ser237 was essential for proteolytic activity, and Val69 was indispensable for the cleavage by thermolysin and was involved in the proteolytic reaction itself [GluV8]
1280	2828033	18201720	2008-03-22 12:54	The spontaneous reversible unfolding and refolding of staphylococcal nuclease under native conditions was studied by a kinetic native-state hydrogen exchange (HX) method.[SNase]
1280	2828033	18239412	2008-05-24 10:35	This study shows that this variation of biofilm formation in S. aureus is deduced by the role of sigB, not agr and sarA. [SigB]
1280	2828033	18276850	2008-03-22 12:01	determineation of the crystal structures of S. aureus dehydrosqualene synthase (CrtM) at 1.58 angstrom resolution; structural similarity to human squalene synthase found [dehydrosqualene synthase]
1280	2828033	18297087	2008-03-29 11:17	The crystal structures at 2.8-A resolution of full-length PC from Staphylococcus aureus and the C-terminal region (missing only the BC domain) of human PC, is reported.[Pyruvate carboxylase]
1280	2828033	18326495	2008-06-21 10:15	The signal transduction mechanism of the VraSR system, is reported.[VraR, VraS]
1280	2828033	18335995	2008-05-31 10:29	triclosan, 5-ethyl-2-phenoxyphenol (EPP), and 5-chloro-2-phenoxyphenol (CPP) are all nanomolar slow-onset inhibitors of saFabI[FabI]
1280	2828033	18347047	2008-05-10 10:13	Deletion of ccpA, coding for the catabolite control protein A (CcpA), abolished the capacity of SA113 to form a biofilm under static and flow conditions, while still allowing primary attachment to polystyrene surfaces.[CcpA in strain SA113]
1280	2828033	18375547	2008-07-12 10:06	data identify a novel S. aureus biofilm phenotype promoted by FnBPA and FnBPB which is apparently independent of the known ligand-binding activities of these proteins[FnBPA, FnBPB]
1280	2828033	18375951	2008-07-19 10:22	model contradicts the previously proposed mechanism of binding predicted by the x-ray crystal structure of SrtA[ sortase A]
1280	2828033	18385434	2008-07-26 10:26	Two mutations were identified in katA from S. aureus UCN61,a methicillin-susceptible catalase-negative strain isolated from an arterial leg ulcer, including one leading to a substitution of key histidine 58 by a tyrosine. [katA]
1280	2828033	18391032	2008-07-19 10:11	We describe the first detection of cfr-mediated linezolid resistance in Staphylococcus aureus and Staphylococcus epidermidis recovered from human infection cases monitored during the 2007 LEADER Program in the US. [cfr]
1280	2828033	18448121	2008-06-14 10:23	Results describe SplB protease catalytic activity and reveal that the enzyme possesses exquisite specificity and only cleaves efficiently after the sequence Trp-Glu-Leu-Gln.
1280	2828033	18510563	2008-08-02 10:23	Nuclease A [nuc1] and thermonuclease [nuc2] are two thermostable nucleases, coesiting and encoded by two different genes. [nuc1, nuc2]
1280	2828033	18518949	2008-07-12 10:32	findings show that graRS deletion considerably alters bacterial surface charge, increases susceptibility to killing by human neutrophils or the defense peptide LL-37 & attenuates virulence of S. aureus in a mouse infection model [GraR, GraS]
1280	2828033	18534123	2008-07-26 10:32	The femA regulating gene probably lies in the 250 bp upstream sequence in methicillin-resistant Staphylococcus aureus and high-level expression is essential for high-level methicillin resistance.
1280	2828033	18547145	2008-10-04 10:39	The crystal structures of the phosphorylated and unphosphorylated states of the tyrosine kinase CapB together with the activator domain of its cognate transmembrane modulator CapA (CapB).
1280	2828033	18556787	2008-08-30 10:16	We were able to create mutants in either of the putative ribitol phosphate polymerases (encoded by tarK and tarL) without affecting teichoic acid levels in the S. aureus cell wall.[TarK and TarL in strain RN4220]
1280	2828033	18576947	2008-08-02 10:35	Staphylococcal accessory regulator (sarR) acts as a stimulator of aur (aureolysin) and sspA (serine protease) transcription, and does not require sarA [sarR, aur, sspA]
1280	2828033	18588752	2008-08-02 10:35	there were no differences in enterotoxin genes between S. aureus strains isolated from controls compared with nasal polyposis patients.
1280	2828033	18611377	2008-09-13 10:06	Two distinctive features of DkgB are a structural Mg2+ site and an associated Asp*water*Mg2+ network that extends toward the active site locale (DgkB).
1280	2828033	18643935	2008-09-27 10:43	S. aureus differentially regulates IsdG and IsdI in response to alterations in iron and haem availability during infection. [IsdI, IsdG]
1280	3978608	16801425	2007-08-25 11:53	data suggest that qacA-encoded thrombin-induced platelet microbicidal protein 1 (tPMP-1)resistance results from the impact of a specific transporter upon membrane structure or function unrelated to PMF (Proton Motive Force)-dependent peptide efflux.
1280	3978608	16958854	2007-08-25 21:21	Of the 10 prolines in the transmembrane regions, no single proline mutation, including those at conserved positions, significantly disrupted QacA protein expression or QacA-mediated resistance to all representative substrates.
1280	3978608	18223078	2008-07-12 10:26	Results demonstrat novel functional associations between amino acid positions on opposite sides of the membrane and in distal N- and C-terminal regions of the QacA protein.
1282	2828035	15255185	2007-08-25 21:25	cysteine protease (Ecp) and a downstream gene coding for a putative inhibitor of the protease form an operon which resembles that of staphopain A in S. aureus. The protease was detected on the cell surface and culture media during growth [Ecp]
1282	2828035	15731082	2007-08-25 11:33	PIA expression elevated and less vulnerable to environmental conditions than in Staph aureus in device-realated infection model [PIA].
1282	2828035	16151151	2007-08-25 11:25	stability of established biofilms depends on sigma(B) activity,however, the slow decay of biofilms under conditions of nutrient limitation reveal its use as an energy-storage molecule to be unlikely. [SigB]
1282	2828035	17449620	2007-08-25 21:23	Disrupting the hemB biosynthetic gene in S. epidermidis resulted in an small-colony variant (SCV) phenotype.[hemB]
1282	2828035	17496953	2007-08-25 13:23	The production of polysaccharide intercellular adhesin (PIA) in Staphylococcus epidermidis is regulated indepently by both sigma B and staphylococcal accessory regulator A (SarA). [polysaccharide intercellular adhesin, sigmaB, sarA]
1282	2828035	17661294	2007-12-01 12:56	The smallest deletion 10-bp long conferring constitutive resistance in the translational attenuator of erm(A) in a naturally occurring S. epidermidis strain of human origin.
1282	2828035	17890122	2008-01-19 10:24	clpP influenced initial attachment of bacteria on the plastic surface, the first step of biofilm formation.[ClpP]
1282	2828035	18208836	2008-04-05 12:04	Result suggest that a 28 bp core segment of the ica operator is implicated in the cooperative binding of two IcaR dimers on opposite sides of the duplex DNA (IcaR).
1282	2828035	18426874	2008-07-12 10:23	SdrG is expressed early during infection in response to specific host environmental cues present in the bloodstream. [SdrG]
1282	2828035	18454346	2008-09-13 10:06	RecA is involved in genetic deletions and rearrangement of the icaADBC operon of Staphylococcus epidermidis.[recA]
1282	2828035	18502872	2008-08-16 10:16	Therefore, GdpS affects biofilm formation through a novel c-di-GMP-independent mechanism involving increased icaADBC mRNA levels and exopolysaccharide biosynthesis.[GdpS in strain CSF41498]
1292	2648466	16009508	2007-08-25 12:36	Deletion of the third transmembrane helix resulted in loss of immunity but did not affect the binding activity.
1296	2828041	16166526	2007-08-25 21:18	The protein product of the S. sciuri mecA can efficiently participate in cell wall biosynthesis and build a cell wall using the cell wall precursors characteristic of the S. aureus host [MECA]
1296	2828041	18024515	2008-02-02 11:09	The protein product of pbpD was identified as PBP4 with a molecular mass of 84 kDa, one of the six penicillin binding proteins present. [pbpD]
1299	2828043	15162484	2007-08-25 13:06	NMR structure of nudix hydrolase DR0079 [nudix hydrolase]
1299	2828043	15333634	2007-08-25 10:31	RNA ligase (DraRnl) from the radiation-resistant bacterium; DraRnl seals 3'-OH/5'-PO4 RNA nicks in either a duplex RNA or an RNA: DNA hybrid, but it cannot seal 3'-OH/5'-PO4 DNA nicks [DraRnl]
1299	2828043	15448166	2007-08-25 12:50	HucR is a participant in the intrinsic resistance of D. radiodurans to high levels of oxidative stress [HucR]
1299	2828043	15458422	2007-08-25 14:51	plays critical role in radiation-induced non-homologous end-joining repair mechanism [PprA strain KH311]
1299	2828043	15733849	2007-08-25 15:05	molecular cloning and characterization of amylosucrase
1299	2828043	15784255	2007-08-25 12:44	1.1A resolution crystal structure of MTHase [maltooligosyltrehalose trehalohydrolase]
1299	2828043	16292304	2007-08-25 14:42	three-dimensional structure of the chromophore-binding domain of Deinococcus radiodurans phytochrome assembled with its chromophore biliverdin in the Pr ground state [phytochrome]
1299	2828043	16322580	2007-08-25 10:55	crystal structures of WrbA from Deinococcus radiodurans and the complexes with flavin mononucleotide [WrbA]
1299	2828043	16368685	2007-08-25 14:37	Results report the 1.75-A crystal structure of Deinococcus radiodurans topoisomerase IB (DraTopIB), a prototype of the bacterial clade [topoisomerase IB].
1299	2828043	16406432	2007-08-25 10:19	PprA protein recognizes and bind to double-stranded DNA carrying strand breaks, and visualizes radiation-induced DNA strand breaks in mammalian cultured cells.
1299	2828043	16514151	2007-08-25 13:36	MBD (MerR metal-binding domain) expressed on the cell surface and in the cytosol afforded improved survival from Hg(II) exposure [MerR]
1299	2828043	16582477	2007-08-25 13:34	Molecular structure is compared with that in E coli, and is found to be essentially the same (manganese superoxide dismutase)
1299	2828043	16615167	2007-08-25 10:16	helicase and three HRDC domains are necessary for RecQ functions in Deinococcus radiodurans, while three HRDC domains have a synergistic effect on the whole function
1299	2828043	16750221	2007-08-25 11:54	the transcriptional regulator HucR from Deinococcus radiodurans has a repressor preconfigured for DNA binding
1299	2828043	16828801	2007-08-25 11:52	Presence of an N-terminal metal-binding site suggests that it may define an iron-exit channel responsible for the continuous release of iron from the protein core.  [Dps-1]
1299	2828043	17128988	2007-08-25 12:25	activities are likely to be relevant to the action of bacterial SSB proteins in double-strand break repair, acting at the frayed ends created by ionizing radiation[SSB protein]
1299	2828043	17204483	2007-08-25 12:23	Mutational analysis of 15 residues of the N domain of RNA ligase identified Lys26, Gln31 and Arg79 as key constituents for enzyme activity (RNA ligase).
1299	2828043	17331944	2007-08-25 11:45	Deinococcus radiodurans Dps-1 N-terminal extensions mediate DNA major groove interactions as well as assembly of the dodecamer
1299	2828043	17419762	2007-08-25 10:41	Disruption of the recD gene of D. radiodurans resulted in a remarkably increased sensitivity to hydrogen peroxide but had no apparent effect on the resistance to gamma and UV radiation.[RecD]
1299	2828043	17581636	2007-12-01 11:24	suggest a possible mechanism for Deinococcus radiodurans RecR and RecO recognition of stalled replication forks[ RecR and RecO ]
1299	2828043	17847097	2008-04-19 13:12	the crystal structure of DR1281 from Deinococcus radiodurans.
1299	2828043	18192276	2008-06-21 10:15	The data show that a number of contacts contribute to the unique photochromicity of Phy-type photoreceptors.[Bphp]
1299	2828043	18389309	2008-08-16 10:16	Inactivation of the pentose phosphate pathway decreases resistance to DNA damaging agents and increases mutation frequency in mutS1 mutant. [mutS1]
1299	2828043	18411208	2008-06-14 10:23	The results suggest the unusual electrostatic surface features of the RecQ Helicase and RNaseD C-terminal domain may be important for inter-domain interactions that regulate structure-specific DNA binding(RecQ).
1299	2828043	18668125	2008-09-13 10:45	The crystal structure of the RecD2 helicase from Deinococcus radiodurans at 2.2-A resolution, is presented.[RecD2, SF1B]
1302	5602367	18237743	2008-03-29 11:16	The crystal structure of GcnA, an N-acetyl-beta-D-glucosaminidase from Streptococcus gordonii, was solved by multiple wavelength anomalous dispersion phasing using crystals of selenomethionine-substituted protein.[GcnA]
1302	5602367	18380804	2008-09-13 10:16	These findings indicate that S. gordonii Hsa specifically binds to GPA and band 3, alpha2-3-linked sialic acid membrane glycoproteins.[Hsa in strain Challis DL1]
1302	5602367	18462386	2008-08-02 10:40	These results suggest that, in S. gordonii, mutations in glmM appear to influence bacterial cell growth and morphology, biofilm formation, and sensitivity to penicillins.[GlmM in strain DL1]
1302	5602367	18474648	2008-07-12 10:32	Mfa1-interacting interface of sspB antigen encompasses both the KKVQDLLKK and NITVK motif and suggest that the adherence of P. gingivalis to streptococci is driven by a protein-protein interaction domain as in the eukaryotic NR box. [sspB]
1307	2828045	15629953	2007-08-25 13:10	In this study, the dipeptidyl peptidase IV (DPP IV) of the swine pathogen Streptococcus suis was cloned, overexpressed in Escherichia coli, and characterized. [dipeptidyl peptidase IV]
1307	2828045	16091046	2007-08-25 14:43	By deleting and ectopically overexpressing Dpr was shown that Dpr affects cellular iron homeostasis.
1307	2828045	16368985	2007-08-25 11:23	Novel C-terminally anchored surface antigen one (Sao) of Streptococcus suis type 2 was identified; immunization protocol with Sao mainly induces a T helper type 2(Th2)-like immune response [Sao]
1307	2828045	16997323	2007-08-25 14:05	These results indicate an intrinsic flexibility in the active site of Dpr that may be important for the catalytic reaction and subsequent nucleation events [Dpr]
1307	2828045	17057090	2007-08-25 11:49	Serum opacity factor represents a novel virulence determinant of Streptoccus suis serotype 2.  (OFS, SOF, serum opacity factor)
1307	2828045	17854470	2007-12-29 10:19	It was found that there are three allelic variants of sao gene, namely sao-S, sao-M, and sao-L based on the different lengths of the genes (approximately 1.5, approximately 1.7, and approximately 2.0 kb, respectively).
1307	2828045	18474639	2008-08-09 10:44	the DeltadltA mutant was attenuated in both the CD1 mouse and porcine models of infection, probably reflecting a decreased ability to escape immune clearance mechanisms and an impaired capacity to move across host barriers.[dltA in strain 31533]
1308	2828047	15919090	2007-08-25 11:06	quaternary structure and function of LacS [LacS]
1309	2828049	15472313	2007-08-25 14:25	various expression levels of glucosyltransferase isozymes are associated with the ability of distinct Streptococcus mutans genotypes to grow as biofilms [GtfB, GtfC]
1309	2828049	15501816	2007-08-25 14:50	role for enolase in S. mutans attachment, clearance, or breach of the bloodstream barrier [alpha-enolase]
1309	2828049	16039152	2007-08-25 12:19	results indicate that S. mutans BrpA is associated with virulence in blood, due to its correlation to phagocytosis susceptibility and platelet aggregation properties [BrpA]
1309	2828049	16091037	2007-08-25 11:26	A novel regulatory pathway for mutacin I gene expression involves luxS and irvA, a putative transcription repressor (mutacin I, luxS and irvA)
1309	2828049	16177372	2007-08-25 21:14	HtrA plays an important role in the biogenesis of extracellular proteins including surface associated glycolytic enzymes and in biofilm formation of S. mutans.( HtrA )
1309	2828049	16442486	2007-08-25 13:36	results suggest that S. mutans PAc may be associated with phagocytosis susceptibility to human polymorphonuclear leukocytes, with approximately 7% of S. mutans clinical isolates possible high-risk strains for the development of bacteremia
1309	2828049	16563343	2007-08-25 14:11	Comparative study of the amino acid sequence of S. mutans 47 kDa wall-associated protein A (WapA) revealed a collagen-binding domain at the N-terminal region (WapA).
1309	2828049	16626493	2007-08-25 10:52	results show that the amino acid sequence of mutacin H-29B is identical to the already known mutacin II (J-T8) over the first 24 residues [mutacin H-29B]
1309	2828049	16707667	2007-08-25 10:16	EIIAB(Man) of S. mutans has a key regulatory role in energy metabolism; loss of EII(Glc) was shown to have a significant impact on the proteome and to affect the expression of a known virulence factor (EIIABMan AND EIIGlc)
1309	2828049	16861645	2007-08-25 12:28	These results suggest that Frp is a novel pleiotropic effector of multiple cellular functions and is involved in the modulation of exopolysaccharide synthesis, sucrose-dependent biofilm formation, and competence development.[Frp]
1309	2828049	16907725	2007-08-25 21:17	Study demonstrates that mutacin I gene regulation can be divided into two pathways: that dependent on irvA (an inducible repressor) and irvA-independent.[mutacin I, irvA]
1309	2828049	16985295	2007-08-25 11:51	Single gene product, automutanolysin, produces two bacteriolytic enzymes; disruption of the aml gene in S. mutans results in the formation of a longer bacterial cell chain length suggesting Aml is involved in S. mutans cell separation. [Aml protein]
1309	2828049	17166223	2007-08-25 15:03	data are consistent with a role for GbpA in facilitating development of biofilms harboring taller microcolonies via binding to alpha-1,6-linkages within glucan [GbpA]
1309	2828049	17229063	2007-08-25 21:01	variation in comC among 36 clinical strains of S. mutans collected from geographically diverse sources is reported [comC]
1309	2828049	17714452	2007-12-08 12:43	Two genes, designated as relP and relQ, encoding novel enzymes that are directly involved in (p)ppGpp synthesis, are identified.[RelP, RelQ]
1309	2828049	17720789	2008-01-12 12:51	In Strep. mutans, lactoylglutathione lyase is involved in the detoxification of methylglyoxal. [lactoylglutathione lyase]
1309	2828049	18255096	2008-03-29 12:11	Based on the enzyme-regulator complex structure observed in this study, an allosteric mechanism for dCD regulation, is proposed.[dCD]
1309	2828049	18395742	2008-05-03 10:27	corresponding residues of alpha-1,6-hydrolyzing enzymes participate in the determination of the substrate specificity of these enzymes[dextran glucosidase ]
1311	2828051	15501744	2007-08-25 21:06	FbsA promotes the adherence of S. agalactiae to epithelial cells but does not mediate the bacterial invasion of host cells. [FbsA]
1311	2828051	15731068	2007-08-25 11:33	identified novel LPXTG anchored surface antigen containing leucine-rich repeat (LRR) motifs that elicits protective immunity [LrrG]
1311	2828051	15980341	2007-08-25 10:57	Lnu(C) confers resistance to lincomycin by adenylylation of lincomycin [Lnu(C)]
1311	2828051	16173392	2007-08-25 13:08	scaAB gene encoding for putative adherence and aggregation factor was cloned and sequenced; its inactivation increased the tendency of Streptococcus agalactiae to aggregation.
1311	2828051	16344483	2007-08-25 13:02	C5a peptidase binding to integrins by the Arg-Gly-Asp motifs may stabilize conformational changes required for substrate binding [C5a peptidase]
1311	2828051	16513739	2007-08-25 13:35	data suggest that a minimum intracellular concentration of the delta subunit of RNA polymerase is necessary for this organism to cause disease [RNA polymerase delta subunit]
1311	2828051	16514156	2007-08-25 13:36	These results demonstrate considerable genetic diversity of the bac (C protein beta-antigen}gene and upstream regions of invasive and noninvasive GBS, which may contribute to the variability of bac expression levels among strains [Bac]
1311	2828051	16549667	2007-08-25 21:27	gene encoding Srr-2 located within a putative accessory secretory locus that included secY2 & secA2 homologues; results indicate the restriction digest pattern III-3/ST-17 lineage expresses Srr-2 & is highly virulent in model of neonatal sepsis [Srr-2]
1311	2828051	16773378	2007-11-10 12:03	study shows that CAMP factor binds to GPI-anchored proteins, and that this interaction involves the carbohydrate core of the GPI-anchor
1311	2828051	16824100	2007-08-25 15:01	In frame deletion showed that GBS80 is a major component protein of the antigenic pilus-like structures in Streptococcus agalactiae.
1311	2828051	16988238	2007-08-25 10:48	RovS specifically binds to the promoter regions of fbsA. (RovS)
1311	2828051	16989973	2007-08-25 15:04	To our knowledge, this is the 1st report of erm(T) in GBS, the 2nd bacterial species from humans in which the erm(T) gene has been identified, and the 3rd erm gene to be found in inducibly clindamycin resistant GBS.[erm(T)]
1311	2828051	17042502	2007-08-25 13:28	FbsA-induced Fbg aggregates consist of thicker fibers organized in a cage-like structure[FbsA--fibrinogen-binding protein expressed ]
1311	2828051	17086430	2007-12-01 12:08	results of the present study support the conclusion that CAMP factor does not bind to immunoglobulin IgG [CAMP factor]
1311	2828051	17577061	2007-09-04 17:50	study concludes that a chromosomally integrated, composite transposon is associated with ermB-type macrolide resistance in GBS [ErmB]
1311	2828051	17709412	2007-12-01 11:49	Deletion of the srr-1 gene in the genome of S. agalactiae revealed that this gene plays a role in bacterial binding to human K4 and that it is involved in adherence to epithelial HEp-2 cells.[Srr-1]
1311	2828051	18313373	2008-07-12 10:36	These results are consistent with the hypothesis that ScpB binds to a motif created by the juxtaposition of multiple Fn molecules.[ScpB]
1311	2828051	18541657	2008-08-09 10:11	sortases are responsible for polymerization of the pilus structure, while SrtA is required to covalently attach it to the cell wall, utilizing ancillary pilus subunit GBS150 as the anchor protein.[SrtA and SrtC in strain 515]
1313	3979060	15909201	2007-08-25 14:48	the lack of PspC significantly enhances the susceptibility of S. pneumoniae to both bactericidal activity and secretory response by the microglial cells.[PspC]
1313	3979060	16368990	2007-08-25 11:23	data suggest that potD is involved in pneumococcal polyamine transport and is important for pathogenesis within various infection models [potD]
1313	3979060	16820692	2007-08-25 14:07	The raffinose-binding protein component of this system shares strong sequence homology with the multiple sugar metabolism substrate-binding protein from Streptococcus mutans. (RafE protein) (newentry)
1313	3979060	16968223	2007-08-25 14:06	adr as the structural gene of the pneumococcal peptidoglycan O-acetylase was identified. (adr)
1313	3979060	17020554	2007-08-25 11:50	Surface expression of PspC was analysed in pneumococcal isolates of different pathological sources. [PspC]
1313	3979060	17098735	2007-08-25 10:46	S. pneumoniae directly sheds syndecan-1 ectodomains through the action of ZmpC
1313	3979060	17098892	2007-08-25 13:27	DivIVA in S. pneumoniae seems to be primarily involved in the formation and maturation of the cell poles [DivIVA]
1313	3979060	17187076	2007-08-25 21:16	structure-function studies of previously uncharacterized glycogen-binding modules in the surface-anchored pullulanase SpuA; multivalent binding to glycogen leads to a strong interaction with alveolar type II cells in mouse lung tissue [SpuA]
1313	3979060	17220305	2007-08-25 11:48	Ply, PspA, and PspC expression resulted in C3 degradation in vitro and in vivo.[Ply, PspA, PspC]
1313	3979060	17235642	2007-08-25 11:48	of 174 S. pneumoniae isolates, 76 (44%) had alterations in all of the three genes examined (pbp1a, pbp2b, and pbp2x), 81 (47%) had alterations in one or two of the genes, and 17 (10%) had no alterations [pbp1a, pbp2b, pbp2x]
1313	3979060	17308305	2007-08-25 10:43	define the membrane architecture and the critical active site residues in the PlsY family of bacterial acyltransferases[acylphosphate:glycerol-3-phosphate acyltransferase]
1313	3979060	17442969	2007-08-25 10:05	The acquisition of factor H by pneumococci via PspC occurs via two contact sites located in SCR8-11 and SCR19-20, and factor H attached to the surface of the pneumococcus promotes adhesion to both host epithelial and endothelial cells.(PcpC)
1313	3979060	17483548	2007-09-22 12:37	In tetracycline-susceptible pneumococci with erm(B)-mediated erythromycin resistance, the erm(B) gene is carried on a variety of Tn916-related genetic elements either lacking tet(M) or, more often, carrying an unexpressed tet(M) gene. [ErmB]
1313	3979060	17494718	2007-08-25 10:41	A serotype 1 Streptococcus pneumoniae strain isolated by blood culture from a woman with pneumonia was found to harbor insertion sequence (IS) 1515 in the pneumolysin gene, abolishing pneumolysin expression.
1313	3979060	17509154	2007-08-25 10:41	isolation and characterization of the alanine racemase gene [alanine racemase]
1313	3979060	17543335	2007-08-25 10:05	specific electrostatic interactions observed in the crystal structure represent major associations between PspA and lactoferrin[Pneumococcal surface protein A]
1313	3979060	17562771	2007-09-08 10:48	While various adherence mechanisms have been characterized for pneumococci, the specific interaction of PspC with complement factor H represents a novel mechanism that tethers pneumococci to host tissues.[PspC protein]
1313	3979060	17626173	2008-01-26 11:13	characteristics of four optochin-resistant (Opt(r)) Streptococcus pneumoniae isolates from Brazil; all four Opt(r) isolates presented mutations in the nucleotide sequence coding for the c subunit of F(0)F(1) ATPase [atpC]
1313	3979060	17631628	2007-10-20 11:55	We conclude that a suicide gene of pneumococcus is spxB, which induces an apoptosis-like death in pneumococci and confers a selective advantage in nasopharyngeal cocolonization. [SpxB]
1313	3979060	17640279	2007-10-27 10:33	Upstream of czcD a gene was identified, encoding a novel TetR family regulator, SczA, that is responsible for the metal ion-dependent activation of czcD expression.[SczA, czcD]
1313	3979060	17660411	2007-12-01 11:04	CpsA expression under ambient oxygen concentrations correlates with serotype-specific invasiveness and is inversely associated with the prevalence of serotype-specific carriage.[cpsA]
1313	3979060	17673230	2007-10-20 11:07	rRNA structures that are required for efficient methylation by RlmA(II) [RlmA]
1313	3979060	17721684	2007-12-08 11:54	examined susceptibility to erythromycin and distribution of macrolide-resistance genes, mefA and ermB in S. pneumoniae isolates from upper respiratory tracts of children in 4 cities in the Sapporo district, Hokkaido prefecture, Japan [mefA and ermB]
1313	3979060	17848373	2008-01-05 15:15	The effects of multiple antibiotics on pneumolysin synthesis in Streptococcus pneumoniae were compared.[pneumolysin]
1313	3979060	17850254	2008-03-29 11:18	Data suggest that RrgA is central in pilus-mediated adherence and disease, even in the absence of polymeric pilus production [RrgA]
1313	3979060	17956621	2008-01-19 12:32	pneumolysin may be a particularly potent pneumococcal virulence factor in the setting of cirrhosis.[Pneumolysin from ATCC6303 strain]
1313	3979060	18056269	2008-05-03 12:15	Telithromycin resistance is shown to be conferred by a deletion in erm(B) gene that increases rRNA methylation. [erm(B)]
1313	3979060	18086214	2008-05-17 10:33	These data strongly suggest that Sp0928 encodes the S. pneumoniae type II signal peptidase (Lsp).[Sp0928 in strain 0100993]
1313	3979060	18160523	2008-09-06 10:05	Variable penicillin resistance determinants were found in PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. [PBP2x, PBP 2b, PBP1a]
1313	3979060	18234221	2008-04-26 11:18	study analyzed in vitro and in vivo properties of penicillin-binding protein 2x (PBP2x )variants from cefotaxime-resistant laboratory mutants and a clinical isolate[PBP2x]
1313	3979060	18285489	2008-07-12 10:16	In erm(B)-positive tetracycline-resistant pneumococci, Tn6003 was the least common erm(B)-carrying Tn916-related element and Tn6002 the most common. [ermB]
1313	3979060	18321242	2008-07-12 10:36	Results describe the structure, ligand recognition and mechanism of sulfonamide resistance of dihydropteroate synthase (DHPS) from Streptococcus pneumoniae [DHPS].
1313	3979060	18379252	2008-05-03 12:16	A young mouse model is established for complicated pneumococcal pneumonia. This model proved that allelic variation of zmpB affects the virulence of S. pneumoniae.[zmpB]
1313	3979060	18388990	2008-05-24 10:05	We demonstrated that 2 genetic loci, SP_2170 (AdcB, zinc ABC transporter) and SP_0157 (hypothetical protein), were involved in adherence to A549 cells.[SP_2170 and SP_0157 in strain 820047]
1313	3979060	18443093	2008-07-12 10:32	It was determined that the pilus locus is down-regulated by preexisting networks designed for adhesion and cation transport/response and that its regulation occurs through RlrA. [RlrA]
1313	3979060	18449503	2008-06-14 10:23	Transcription of dnaK and groEL operons in Streptococcus pneumoniae in regulated by HrcA and calcium.
1313	3979060	18535636	2008-09-13 10:06	Sequence analysis revealed that most penicillin-nonsusceptible S. pneumoniae isolates (penicillin MIC > or = 1.5 microg/mL and cefotaxime MIC > or = 2 microg/mL) shared identical PBP2b, PBP2x, and PBP1a amino acid profiles.[PBP2b, PBP2x, PBP1a]
1314	2828055	15458415	2007-08-25 14:51	phage-encoded streptodornase identified through mass spectroscopy, nucleotide sequence, cloning and expression [Sda1 strain M1T1]
1314	2828055	15489420	2007-08-25 14:38	global regulatory factor that contributes to growth phase-dependent synthesis of proteins associated with secondary metabolism and oxidative and thermal stress responses [Streptococcus pyogenes NZ131 (serotype M49), Rgg]
1314	2828055	15516573	2007-08-25 11:33	two genotypes of prtF2 (a fibronectin binding protein), pfbp and fbaB, are described [prtF2]
1314	2828055	15563518	2007-08-25 13:45	the mef(A) gene is carried on different chromosomal genetic elements depending on whether the isolates are susceptible or resistant to tetracycline[mefA]
1314	2828055	15574492	2007-08-25 13:44	crystal structure of the catalytically inactive mutant IdeS-C94S by x-ray crystallography at 1.9-A resolution {IdeS]
1314	2828055	15581366	2007-08-25 22:20	Newly discovered protease IdeS (IgG-degrading enzyme of S. pyogenes, also known as Mac-1-like protein) seems to be atypical cysteine protease with strict specificity for IgG cleavage due to an exosite recognizing the CH2 domain in IgG Fc fragment. [IdeS]
1314	2828055	15616324	2007-08-25 14:49	ciprofloxacin resistance due to point mutations in topoisomerase IV subunit C encoded by parC, mainly replacement of serine-79 by alanine. [ParC]
1314	2828055	15647274	2007-08-25 21:22	Data show that the recombinant Scl protein p176 promotes adhesion and spreading of human lung fibroblast cells through an alpha2beta1 integrin-mediated interaction [sc1]
1314	2828055	15705635	2007-08-25 14:28	The efflux of telithromcyin from S. pyogenes, resulting in reduced activity, is related to the presence of the mef(A) gene.
1314	2828055	15772148	2007-08-25 12:59	A comparison different mef(A) elements of Streptococcus pyogenes for a possible chimeric genetic nature, i.e. a transposon inserted into a prophage. [MefA]
1314	2828055	15773976	2007-08-25 14:48	data indicate that human Fibrinogen bound to Streptococcus pyogenes M5 protein promotes phagocytosis resistance by inhibiting complement deposition via the classical pathway [M5 protein]
1314	2828055	15792638	2007-08-25 13:11	The present study investigated an association between the presence of the prtF2 gene and internalisation efficiency in group A streptococci isolated from patients with invasive disease. [prtF2]
1314	2828055	15882414	2007-08-25 11:05	findings suggest CovR regulation of the covR promoter (Pcov) is direct; CovR was sufficient to mediate repression of Pcov; this repression was enhanced by phosphorylation of the protein [CovR]
1314	2828055	15980381	2007-08-25 10:57	prtF1 is associated with erythromycin resistance [prtF1]
1314	2828055	16045611	2007-08-25 21:06	study presents evidence for a novel protease-protease inhibitor couple, SpeB-Spi, in the Streptococcus pyogenes[cysteine protease SpeB] [Spi]
1314	2828055	16045622	2007-08-25 21:06	MsmR positively regulates FCT region genes including Nra and cytolysin-mediated translocation system genes [MsmR]
1314	2828055	16059700	2007-08-25 12:01	SpeB could cause the mitochondria damage to the polymorphonuclear cells, preventing immune clearance at an early infectious stage (SpeB)
1314	2828055	16113291	2007-08-25 21:18	controls iron homeostasis and has a role in disease production (MtsR - Mts repressor)
1314	2828055	16174772	2007-08-25 14:34	CovR is sufficient to repress transcription from the sag promoter (CovR)
1314	2828055	16177295	2007-08-25 11:25	The prevention of the cell surface export of SDH affects the virulence properties of group A Streptococcus (GAS).
1314	2828055	16177331	2007-08-25 21:14	NADase enhance S.pyogenes virulence in vivo. (NADase)
1314	2828055	16233902	2007-08-25 15:04	crystal structure of delta1-pyrroline-5-carboxylate (P5CR) determined at 2.0 angstroms [P5CR]
1314	2828055	16237270	2007-08-25 11:25	allelic diversity of streptococcal DNase B (sdaB) gene was investigated in 83 strains with 14 emm genotypes; distribution of each allele was generally emm genotype-specific [DNase B (sdaB)]
1314	2828055	16272396	2007-08-25 11:59	required for virulence in zebrazfish and role in iron acquisition pathway both in vitro and in vivo [SiuG]
1314	2828055	16352823	2007-08-25 14:42	RscA is a member of the MDR1 family of ABC transporters, is required for growth of GAS at 40 degrees and is repressed by CovR [RscA][CovR]
1314	2828055	16359315	2007-08-25 12:58	data indicate that binding of human plasma proteins plays an important role in determining the location of opsonic and non-opsonic epitopes in streptococcal M5 protein [M5 protein]
1314	2828055	16369006	2007-08-25 11:23	Seroconversion of IdeS in patients with pharyngotonsillitis and erysipelas leads to inactivation of enzyme activity, supporting the view that the enzyme plays an important role during streptococcal infection [IdeS]
1314	2828055	16407233	2007-08-25 14:12	findings show that serum opacity factor (SOF) interacts with HDL in human blood by binding to apoA-I and apoA-II and causing the release of HDL lipid cargo, which coalesces to form lipid droplets, resulting in opacification [SOF]
1314	2828055	16487973	2007-08-25 14:11	Results describe a eukaryotic-type signaling system in group A Streptococcus, including a eukaryotic-type Ser/Thr kinase (SP-STK) and phosphatase (SP-STP) and their endogenous substrate histone-like protein (SP-HLP) [SP-STK, SP-STK].
1314	2828055	16488874	2007-08-25 12:33	DNase Sda1 is both necessary and sufficient to promote Group A Streptococcus neutrophil resistance and virulence in a murine model of necrotizing fasciitis. [Sda1]
1314	2828055	16531115	2007-08-25 13:35	CodY protein identified as a pleiotropic transcription regulator with global features [CodY]
1314	2828055	16703511	2007-08-25 10:16	the high virulence of the type M3-f strain is associated with the decreased binding of type M3-f CsrR to its target sequences [CsrR]
1314	2828055	16822869	2007-08-25 13:31	study shows for the first time that residues Arg101, Arg114, His102, and His115 in both the a1 and a2 repeat domains of PAM can mediate high affinity plasminogen binding [PAM]
1314	2828055	16929299	2007-08-25 10:48	signal sequence of M protein promotes secretion at the division septum, whereas that of PrtF preferentially promotes secretion at the old pole [M protein; PrtF]
1314	2828055	16963575	2007-08-25 10:48	phosphorylated CovR represses transcription of rivR directly by binding to conserved sequences located downstream from the promoter to block procession of RNA polymerase [CovR]
1314	2828055	16977314	2007-08-25 11:51	ScpC represents a novel GAS virulence factor functioning to directly inactivate a key element of the host innate immune response.[ScpC]
1314	2828055	17012384	2007-08-25 13:29	Here, we describe a novel plasminogen-binding M protein, the plasminogen-binding group A streptococcal M protein (PAM)-related protein (Prp). [Prp]
1314	2828055	17015662	2007-08-25 10:10	The results provide further evidence that Rgg contributes to growth phase-dependent gene regulation in strain NZ131.[Rgg]
1314	2828055	17042787	2007-08-25 13:28	These data establish that cytolysin-mediated translocation is discriminatory, and that NAD glycohydrolase is a multidomain protein that plays an active role in its translocation. [NAD glycohydrolase]
1314	2828055	17142758	2007-08-25 21:16	analyzed the SpeC-Vbeta2.1 interaction by mutating all SpeC residues that make contact with Vbeta2.1 and determined the energetic and functional consequences of these mutations [SpeC]
1314	2828055	17159372	2007-08-25 12:24	results support the involvement of NAPlr in inflammatory cell accumulation in glomerular tufts and functional abnormality of glomerular microvasculature such as hyperpermeability [NAP1r]
1314	2828055	17187076	2007-08-25 21:16	structure-function studies of previously uncharacterized glycogen-binding modules in the surface-anchored pullulanase PulA; multivalent binding to glycogen leads to a strong interaction with alveolar type II cells in mouse lung tissue [PulA]
1314	2828055	17238919	2007-08-25 13:26	silC and silCR form a novel regulatory circuit that controls the streptococcal invasion locus transcription [SILC, SILCR]
1314	2828055	17238923	2007-08-25 11:47	data suggest that PerR has a greater impact on the transcriptome than can be predicted by its binding sites and that pmtA functions to link metal homeostasis and oxidative stress responses[pmtA]
1314	2828055	17303463	2007-08-25 10:43	We conclude that DRS (distantly related to SIC[streptococcal inhibitor of complement]) shares several of the properties of SIC, and therefore can be considered an important virulence factor of M12 GAS and an aid to colonization of the host mucosae.
1314	2828055	17510253	2007-08-25 12:20	The results obtained by quantitative real-time PCR using the M49 strain NZ131 showed that CodY influenced Streptococcus pyogenes gene activity in a dynamic fashion, with differential responses detected for 26 genes.[CodY protein]
1314	2828055	17608796	2007-09-15 11:08	This study is the first to characterize global gene regulation by a group A Streptococcus two-component system in response to a specific environmental stimulus.[CsrR, CsrS]
1314	2828055	17632528	2007-10-20 11:55	describe how bacteriophage-encoded group A Streptococcus DNase (Sda1), which facilitates the pathogen's escape from neutrophil extracellular traps, serves as a selective force for control of virulence regulatory sensor kinase mutation[ Sda1 ]
1314	2828055	17658548	2007-10-20 11:55	crystal structures of GluR from Streptococcus pyogenes in both inhibitor-free and inhibitor-bound forms [MurI or glutamate racemase]
1314	2828055	17660410	2007-12-01 11:04	In this study, the addition of M1 protein to human blood or purified peripheral blood mononuclear cells led to a dose-dependent increase of pro-coagulant activity, which was mediated by an upregulation of tissue factor on monocytes. [M1 protein]
1314	2828055	17662041	2008-05-24 10:17	study reports that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation [M1 protein]
1314	2828055	17900297	2008-03-10 14:59	Soluble M1 protein is a novel streptococcal superantigen, which contributes to the excessive T cell activation and hyperinflammatory response seen in severe invasive streptococcal infections.
1314	2828055	17993527	2008-02-02 10:18	Heterologous expression in Escherichia coli showed that SipA2, along with the pilus backbone protein T3 and the sortase SrtC2, is required for polymerization of the T3 protein.[SipA in strain GAS AM3]
1314	2828055	18039665	2008-02-16 10:20	The data revealed that, in Plasminogen, the species specificity of VEK-30 binding in human and mice is entirely dictated by two lysine residues.[PAM protein]
1314	2828055	18072207	2008-03-10 13:38	HtrA plays an indirect role in the maturation of cysteine protease SpeB.[HtrA, SpeB]
1314	2828055	18093091	2008-05-17 10:34	we have identified a functional interaction between Scl1 and plasma FH, which may contribute to GAS evasion of complement-mediated opsonization and phagocytosis.[Scl1 in strain MGAS6169]
1314	2828055	18093092	2008-05-17 10:34	protein H and M1 protein of the highly pathogenic S. pyogenes AP1 strain bind full-length beta(2)GPI and prevent its processing into antibacterial peptides.[protein H and M1 in strain AP1]
1314	2828055	18174338	2008-03-22 10:18	These results suggest a novel SPE B mechanism, one which degrades serum C3 and enables GAS to resist complement damage and opsonophagocytosis. [SpeB in strain A20]
1314	2828055	18179387	2008-02-23 11:31	Our data indicate that horizontal transfer of SSA by lysogenic phages among GAS can occur across the M-type barrier; these data also provide further support for the hypothesis that toxigenic conversion can occur via lysogeny between species. [SSA]
1314	2828055	18310340	2008-05-17 10:24	1)Rgg is identified as a novel sensoregulator of streptococcal H2O2 resistance.(rgg) 2) ahpCF operon knockouts demonstrated that the gene products decompose H2O2 and protect GAS against peroxide stress. (ahpC)(ahpF)
1314	2828055	18329243	2008-07-19 10:22	SPEA and SMEZ does not had effect on global protein expression and on transcription of genes encoding the secreted exoproteins.[SPEA, SMEZ]
1314	2828055	18347035	2008-07-12 10:36	In this report Nra activates pilus gene transcription and MsmR represses nra and pilus gene transcription [Nra], MsmR]
1314	2828055	18477635	2008-07-26 10:32	Stimulation of the delta(2) (ParA) ATPase activity and its polymerization on DNA required ability of omega(2) (ParB) to bind parS DNA and its N-terminus (ParA and ParB).
1314	2828055	18490458	2008-08-09 10:30	the findings provide in vivo support of the hypothesis that SpeB-mediated inactivation of LL-37 at the streptococcal surface represents a bacterial resistance mechanism at the infected tissue site in patients with severe GAS tissue infections.[SpeB]
1314	2828055	18522500	2008-08-30 10:39	Streptococcal pyrogenic exotoxin B (SPE B) potentially causes immunosuppression by cleaving human S-adenosylhomocysteine hydrolase (AdoHcyase).
1314	2828055	18533265	2008-09-06 10:14	IgG and 1/2Fc binding to the streptococcal surface was studied and correlated to IdeS activity.[IdeS]
1314	2828055	18541662	2008-10-04 10:39	These data indicate that Dpr provides protection from hydrogen peroxide stress by preventing the Fenton reaction, and Dpr was identified as a novel stress protein that protects against several stresses in group A streptococci.[Dpr in strai A-20]
1314	2828055	18573900	2008-10-04 10:06	challenge with the ScpC mutant that does not degrade IL-8 resulted in more severe systemic disease with higher bacteremia levels and mortality than did challenge with the wild-type strain.[ScpC in strain S291]
1314	3355465	16740123	2007-08-25 21:03	The urea dependence of the circular dichroism at 222 nm strongly suggests that folded monomers of beta recombinase represent the unfolding intermediate.
1314	6155857	18180360	2008-09-06 10:25	A plasmid carrying the erm(T) methylase gene, was identified as the genetic basis of macrolide and inducible clindamycin resistance in 23 invasive GAS isolates with no know macrolde resistance determinants.
1351	2828057	15159583	2007-08-25 11:07	Crystallization and preliminary crystallographic analysis of an Enterococcus faecalis repressor protein, CylR2
1351	2828057	15272159	2007-08-25 13:46	crystal structure of catalase [catalase]
1351	2828057	15618522	2007-08-25 21:15	enterococci use CylL(L)'' to actively probe the environment for target cells, and when target cells are detected, allows the organism to express high levels of cytolysin in response [CylL(L) strain FA2-2]
1351	2828057	15633107	2007-08-25 12:06	important for virulence as well as stress response, and anti-Gls24 immune rabbit serum shows protection against E. faecalis infection in a mouse peritonitis model. [Gls24]
1351	2828057	15731060	2007-08-25 11:33	results indicate that gelatinase is important for the successful in vitro translocation of E. faecalis across human enterocyte-like T84 cells [GelE]
1351	2828057	15870448	2007-08-25 14:24	results indicate that DivIVA is a speceis specific essential gene involved in cell division, cell growth and chromosome segregation [DivIVA]
1351	2828057	15980063	2007-08-25 12:02	Enterococcus faecalis FabN and FabZ protein domain swapping localizes the structural determinants for isomerase activity [FabN]
1351	2828057	15980374	2007-08-25 10:57	development of high-level resistance to penicillins and imipenem depends on point mutations of PBP4 at positions 520 and 605 [PBP4]
1351	2828057	15995198	2007-08-25 11:06	PrgY may sequester or inactivate cCF10 as it is released from the membrane. (cCF10)
1351	2828057	16216443	2007-08-25 12:58	HypR acts as a transcriptional activator, especially during oxidative stress, and appears to be an important virulence factor [HypR]
1351	2828057	16239583	2007-08-25 21:12	results indicate that gls24 is important in the pathogenesis of enterococcal endocarditis [gls24]
1351	2828057	16514144	2007-08-25 21:18	pIP501 tra operon is negatively autoregulated at the transcriptional level by the conjugative DNA relaxase TraA. [TrA]
1351	2828057	16547051	2007-08-25 21:01	The role of CroR as a direct transcriptional activator of the salB expression in E. faecalis is reported.[CroR; SalB]
1351	2828057	16585749	2007-08-25 14:11	results show that the FsrABC system positively & negatively regulates expression of numerous genes between late exponential phase & early stationary phase; also the FsrABC system regulon is independent of the expression of gelE and sprE[FsrA, FsrB, FsrC]
1351	2828057	16926389	2007-08-25 13:30	Increased Ace expression correlated with increased collagen and laminin adhesion. (Ace)
1351	2828057	17071762	2007-08-25 13:28	The effect of siamycin I on the metabolism of fsrC, fsrA, and gelE-sprE transcripts and the subsequent production of gelatinase biosynthesis-activating pheromone is reported.[gelE; sprE; fsrA; fsrC]
1351	2828057	17077496	2007-08-25 21:11	Phosphopantetheine adenylyltransferase is an essential enzyme in the coenzyme A biosynthetic pathway has been cysstallized and the X-ray diffraction data were collected. [phosphopantetheine adenylyltransferase]
1351	2828057	17128980	2007-08-25 12:25	overall reaction rate of HMG-CoA synthase was increased 140-fold[HMG-CoA synthase]
1351	2828057	17261598	2007-08-25 10:07	E. faecalis GelE hydrolyzed C3a and also mediated the degradation of C3b, thereby inhibiting opsonization and the formation of the membrane attack complex resultant from the activation of the complement cascade triggered by C3 activation.[GelE]
1351	2828057	17360674	2007-08-25 10:06	PrkC, a one-component signaling protein containing a eukaryotic-type Ser/Thr kinase domain, modulates inherent antimicrobial resistance and intestinal persistence of E. faecalis. [PrkC]
1351	2828057	17428434	2007-08-25 13:24	we report the crystal structure of the AzoA from E. faecalis determined at 2.07 A resolution with bound FMN ligand[AzoA]
1351	2828057	17434998	2007-08-25 15:03	Gel retardation assays showed that the CroR regulator binds specifically to the glnQHMP promoter.[CroR]
1351	2828057	17557326	2007-10-06 12:39	study describes the crystal structure of ACE19 and compares it with CNA19 crystal structure; present modeling studies presented to localize the collagen-like peptide interactions with ACE19 [ACE protein]
1351	2828057	17586623	2007-10-13 10:19	An ebpR deletion (DeltaebpR) mutant was found to have reduced ebpABC expression with loss of pilus production and a defect in primary adherence with, as a consequence, reduced biofilm formation.[ebpR]
1351	2828057	17620355	2007-10-13 11:06	Surface protein ElrA has a role in the E. faecalis infectious process in vivo and may contribute to E. faecalis virulence by stimulating the host inflammatory response. (ElrA)
1351	2828057	17785473	2007-12-01 12:12	EF_0783 is currently involved in the lysozyme resistance of E. faecalis, peptidoglycan O acetylation and de-N-acetylation are not the main mechanisms conferring high levels of lysozyme resistance to E. faecalis.[EF0783]
1351	2828057	17785477	2007-12-01 12:12	Deletion of bps had a major effect on virulence in murine UTIs; deletion of srtA from OG1RF from a bps mutant had a pronounced effect on biofilm, suggesting that Bps and/or the proteins it anchors may compensate for the loss of SrtA function.[ArtA,Bps]
1351	2828057	17971082	2008-02-16 10:02	the thiol peroxidase (Tpx) deletion mutant showed attenuated virulence in a mouse peritonitis model.[Tpx in strai JH2-2]
1351	2828057	18026911	2008-06-07 10:42	the high-resolution solution structure of the 15.4 kDa homodimer CylR2, the regulator of cytolysin production from Enterococcus faecalis
1351	2828057	18388125	2008-09-27 10:28	DivIVA self-interacts and forms a 10-12 multimeric complex (DivIVA).
1351	2828057	18391442	2008-08-02 10:27	indicate that together with KPR, D-ManDH constitutes a new family of D-2-hydroxyacid dehydrogenases that act on C3-branched 2-ketoacid substrates with various specificities for coenzymes and substrates [D-mandelate dehydrogenase]
1351	2828057	18409053	2008-07-12 10:16	Results showed distinct characteristics in mutation patterns of ermB and ermA.
1351	2828057	18426870	2008-07-12 10:23	these results indicate that the regulator Ers (PrfA-like transcriptional regulator) has a pleiotropic effect, especially in the cellular metabolism and virulence of E. faecalis. [Ers]
1351	2828057	18641135	2008-09-27 10:43	A stem-loop sequestering the Fst ribosome binding site is required for translational repression.
1351	3119706	17697106	2007-12-08 12:43	This gene allows E. faecalis to survive tetracycline.
1351	3267197	15469521	2007-08-25 14:51	Results describe a new model for the mechanism used by PrgX for regulation of the prgQ promoter, PrgX autoregulation, and Qa RNA processing.
1351	3267197	16339309	2007-08-25 11:24	pheromone binding destabilizes PrgX tetramers, opening a 70-bp pCF10 DNA loop required for conjugation repression
1351	3267223	15995198	2007-08-25 11:06	PrgY may sequester or inactivate cCF10 as it is released from the membrane (cCF10)
1351	3267223	18083822	2008-07-12 10:16	Results showed that amino acid residues 125 to 241 of PrgY are required for specific recognition of cCF10 and that PrgY recognizes determinants within the heptapeptide cCF10 sequence, supporting a direct interaction between PrgY and mature cCF10.
1352	3293180	16144833	2007-08-25 12:35	Ldt(fm) is a novel peptidoglycan cross-linking enzyme for a beta-lactam-resistant transpeptidation pathway [Ldt(fm)]
1352	3293180	16700712	2007-10-13 10:08	E. faecium blood culture-derived isolates harbouring esp had a significantly higher ability to acquire the vanA gene cluster in vitro when compared with esp- isolates [esp]
1352	3293180	17113270	2007-08-25 10:45	Point mutations in penicillin-binding protein 5 (PBP5) and the levels of PBP5 expression were found to be significantly associated with ampicillin resistance. [PBP5]
1352	3293180	17118984	2007-08-25 10:09	study demonstrates that Esp expression on the surface of E. faecium (i) varies consistently between strains, (ii) is growth condition dependent, and (iii) is quantitatively correlated with initial adherence and biofilm formation [esp]
1352	3293180	17244806	2007-08-25 10:07	the C-terminal region of the pbp5 gene was highly polymorphic among the AmpR and AmpS isolates of animal origin; there seemed to be a correlation between specific changes located at positions close to the active site of PBP5 and the ampicillin MIC [pbp5]
1352	3293180	18409053	2008-07-12 10:16	Results showed distinct characteristics in mutation patterns of ermB and ermA.
1352	3293180	18591236	2008-10-04 10:06	The authors show with a rat endocarditis model that TX0082 Deltaacm::cat is highly attenuated versus wild-type TX0082.[Acm in strain TX0082]
1352	6385877	18511120	2008-09-06 10:14	The third completely sequenced enterococcal vanA plasmid from a Norwegian poultry farm previously exposed to animal growth promoter avoparcin provides information on the diversity of the extrachromosomal gene pool of E. faecium.
1358	1113455	17480057	2007-08-25 13:59	the C-terminal domain of LctM is responsible for cyclization, the zinc ligands are critical for cyclization, and dehydration takes place independently from the cyclization activity
1358	1113455	18570437	2008-08-02 10:35	Conserved Glu that is conserved in many class II lantibiotics, including those not belonging to the lacticin 481 subgroup, is not essential for antimicrobial activity of lacticin 481.
1358	1450207	15901696	2007-08-25 15:05	a reverse transcriptase activity might be involved in the phage resistance activity of AbiK.
1358	2828059	15629931	2007-08-25 13:10	study showed that thioredoxin reductase is not essential in L. lactis and that its inactivation triggers induction of several mechanisms acting at the membrane and metabolic levels [trxB1 strain MG1363]
1358	2828059	15699193	2007-08-25 13:11	DR2 (direct repeat 2) is the CmbR binding site within the metC promoter in Lactococcus lactis [CmbR, metC]
1358	2828059	15812026	2007-08-25 21:28	observations demonstrate that enterocin P is secreted by the Sec translocase [SecA]
1358	2828059	15819895	2007-08-25 12:37	comparison of the structure of X-PDAP from Lactococcus lactis (PepX) with its human counterpart DPP-IV [pepX]
1358	2828059	16091047	2007-08-25 13:04	The crystal structure of DpsA and DpsB reveals the presence of an N-terminal helix that is required for DNA binding (DpsA and DpsB).
1358	2828059	16339304	2007-08-25 11:24	identification of an enzyme, LtnJ, that is responsible for the conversion of dehydroalanine to D-alanine in lacticin 3147 [LtnJ]
1358	2828059	16401093	2007-08-25 21:23	The LmrCD heterodimer of the lactococcal ABC-multidrug transporter contains two structurally and functionally distinct nucleotide-binding domains (NBDs). (LmrC, LmrD)
1358	2828059	16513740	2007-08-25 13:35	two distinct functional domains of the CluA protein were defined in this work; the first domain is involved in cell binding specificity, and the Tra domain is probably involved in the formation of the DNA transport machinery [CluA]
1358	2828059	16624811	2007-08-25 11:56	charge-stabilizing role for Lys-D48 during reduction of FMN by dihydroorotate, establish a common mechanism of flavin reduction in the single FMN-containing A-type and the complex multicenter B-type DHOD enzymes [DHODB]
1358	2828059	16672481	2007-08-25 21:27	description, purification, structural analysis, and characterization of a novel two-peptide bacteriocin, named lactococcin Q, produced by L. lactis QU 4[Lactococcin Qalpha, Qbeta]
1358	2828059	16844687	2007-08-25 10:14	Species-specific C-terminal anionic tails of the cystathionine beta-synthase module in OpuA tune the ionic sensitivity of the transporter.  [OpuA]
1358	2828059	16879641	2007-08-25 11:52	the heterodimeric multidrug resistance ABC transporter LmrCD is a major determinant of both acquired and intrinsic drug resistance of L. lactis.[LmrC; LmrD]
1358	2828059	16990434	2007-08-25 13:29	A detailed characterization of the metal ion-fluoride complex bound to the enzyme active site in solution, which reveals the molecular mechanism for fluoride inhibition of beta-phosphoglucomutase, is presented.[beta-phosphoglucomutase]
1358	2828059	17159206	2007-08-25 14:02	results show that the C terminus of NisI is involved in specific interaction with nisin, and that it confers specificity for the NisI immunity lipoprotein [NisI]
1358	2828059	17222187	2007-08-25 15:03	Crystal structures of recombinant Lactococcus lactis 6-phosphogluconate dehydrogenase (LlPDH) in complex with substrate, cofactor, product and inhibitors have been determined (LlPDH).
1358	2828059	17302438	2007-08-25 21:00	investigation of the molecular dynamics of the 64 kDa ABC multidrug efflux pump LmrA; experiments provide insight into the molecular dynamics of a full-length ABC transporter during the catalytic cycle [LmrA]
1358	2828059	17341096	2007-08-25 21:07	findings show that the oxidation of dihydroorate by the class 1A dihydroorotate dehydrogenase is concerted and the active site cysteine acts as a classic general base[dihydroorotate dehydrogenase]
1358	2828059	17530171	2007-08-25 12:20	phosphatidylethanolamine is required to generate the structural intermediates induced by ionization of carboxylic residues in LmrP (LmrP)
1358	2828059	17587868	2007-09-08 11:50	Using a homology model to guide mutagenesis of LmrP, two separate proton translocation pathways were found, each involving membrane-embedded carboxylate residues.[LmrP]
1358	2828059	17603047	2007-09-22 11:06	At high osmolarity, an elevated cytoplasmic ionic strength would dissociate BusR from busAp, resulting in the osmotic induction of the busA operon[busA and BusR ]
1358	2828059	17690480	2007-12-22 11:10	amino acid sequence and activity against gram positive bacteria and temperature stability of a novel bacteriocin (lacticin Z)
1358	2828059	17993533	2008-02-02 10:18	This suggests that LmrR is a drug-dependent transcriptional regulator of lmrCD expression.[LmrR in strain NZ9000]
1358	2828059	18187052	2008-05-17 10:07	The three-dimensional structures of the two peptides LcnG-alpha (39 residues) and LcnG-beta(35 residues), that constitute the two-peptide bacteriocin lactococcin G (LcnG) have been determined.(LcnG-alpha) (LcnG-beta)
1358	2828059	18648072	2008-09-13 10:45	These data reveal that Ll.LtrB can trans-splice efficiently when fragmented at various locations throughout its structure.(LtrB)
1359	1113514	17474995	2007-08-25 10:42	results indicate that exposure of an anchored cell wall proteinase PrtP, and not its proteolytic activity, is responsible for greater cell hydrophobicity and adhesion
1359	2828061	15629923	2007-08-25 13:10	demonstrate that CodY interacts directly with a region upstream of the promoter of its major target known so far, the opp system; results indicate that multiple molecules of CodY interact with this promoter [CodY, oppD]
1359	2828061	16585736	2007-08-25 12:32	The presented transport data are consistent with a uniport mechanism for riboflavin translocation and provide the first detailed molecular and functional analysis of a bacterial protein, RibU, involved in riboflavin transport.[RibU]
1360	3125810	17215903	2007-08-25 13:26	these strains produced two additional bacteriocins (LsbA and LsbB) with genes responsible for their production and immunity located on the small rolling circle-replicating plasmid pMN5
1360	3125811	17215903	2007-08-25 13:26	these strains produced two additional bacteriocins (LsbA and LsbB) with genes responsible for their production and immunity located on the small rolling circle-replicating plasmid pMN5
1360	3293182	16917523	2007-08-25 11:51	results suggest that Pip is an integral membrane protein that is not anchored to the cell wall and that the multiple-membrane-spanning region is required for productive phage infection but not phage inactivation [Pip]
1360	3293182	17012392	2007-08-25 13:29	Northern analysis revealed that nisI mRNA was present under conditions when no nisA transcription was occurring, suggesting an internal promoter within the nisin operon that helps establish nisin immunity prior to induction of the operon.  [NisI]
1360	3293182	17215903	2007-08-25 13:26	In Lactococcus lactis subsp. lactis isolated from homemade cheese structural genes for bacteriocin lactococcin B were located on large plasmids [lactococcin b]
1360	3293182	18078973	2008-04-26 11:18	We show that lactococcal abortive infection protein (AbiP) is a protein anchored to the membrane by an N-terminal membrane-spanning domain and binds nucleic acids. [AbiP]
1390	5469284	18523007	2008-06-28 10:22	These results provide kinetic evidence that the formation of specific structure need not be slowed down by any significant free energy barrier during the course of a very fast protein folding reaction.[barstar]
1392	2828065	15870458	2007-08-25 14:24	electron microscopy and genetic analysis of crystallization domain of Sap S-layer protein [Sap S-layer protein]
1392	2828065	16045616	2007-08-25 21:06	findings suggest that CapD catalyses the capsule anchoring reaction to peptidoglycan. [CapD]
1392	2828065	16103125	2007-08-25 13:39	PlyL is a Bacillus anthracis prophage endolysin
1392	2828065	16138311	2007-08-25 12:36	Crystal structure of PurE (BA0288) at 1.8 A resolution [PurE]
1392	2828065	16357526	2007-08-25 12:35	studies suggest that proteasomes and potassium control LT-induced mitochondrial dysfunction and membrane perturbation, key events in LT killing [lethal toxin]
1392	2828065	16428776	2007-08-25 14:12	Induces ketotifen sensitive vascular leakage event which is the most rapid in vivo or in vitro LT-mediated effect reported to date.  Bacillus anthracis lethal toxin [LT]
1392	2828065	17339348	2007-08-25 10:43	We report that Edema Toxin (ET) sensitizes DBA/2J mice to Lethal Toxin (LT); study using highly purified ET and LT demonstrates how the components of anthrax toxin can work together to increase lethality [edema toxin]
1392	2828065	17644587	2007-10-20 12:41	BclB membrane glycoprotein plays a key role in the formation and maintenance of the exosporium structure in B. anthracis. [BclB]
1392	2828065	17990888	2008-01-05 15:14	identification of a glmS active-site mutation of a conserved guanine that abolishes catalysis without perturbing coenzyme binding [glmS]
1392	2828065	18048936	2008-02-23 12:42	We show that in B. anthracis the relA gene is responsible for the synthesis of (p)ppGpp and the stringent down-regulation of stable RNA synthesis upon starvation for the essential amino acids isoleucine, leucine and valine. [RelA]
1392	2828065	18188181	2008-04-05 10:18	The structure of the ternary complex between the Bacillus anthracis UDP-GlcNAc 2-epimerase, its substrate UDP-GlcNAc and the reaction intermediate UDP, showed direct interactions between UDP and its substrate.[UDP-GlcNAc 2-epimerase]
1392	2828065	18190531	2008-06-21 10:15	Data provides the first evidence for Spo0B of B. anthracis as an enzyme with histidine kinase and ATPase activities, which may have important roles to play in sporulation and pathogenesis. New Gene[Spo0B]
1392	2828065	18378720	2008-07-19 10:11	Only the murA1 gene and not the murA2 gene is required for the normal cellular growth of Bacillus anthracis. [MurA1, MurA2]
1392	2828065	18539743	2008-08-16 10:44	The results indicate that the loss of ResDE-controlled respiratory capacity does not affect the synthesis of anthrax toxin.[ResD and ResE in strain 34F2]
1392	2828065	18625239	2008-09-20 10:28	The crystal structure of UK from Bacillus anthracis (BA1797) in complex with ATP at 2.82 A resolution, is reported.[UMP kinase]
1396	2828067	15113834	2007-08-25 12:53	hydrolysis and starch binding of beta amylase from Bacillus cereus [beta amylase; var mycoides]
1396	2828067	15528656	2007-08-25 15:02	a new B. cereus gene, hlyIIR, which is located immediately downstream of hlyII and regulates hlyII expression, is reported [HlyIIR]
1396	2828067	15583149	2007-08-25 13:11	cloning of the Nhe enterotoxin(NheA, NheB, NheC); all three componenents required for biological activity; maximum cytotoxic activity was obtained when the molar ratio between NheA : NheB : His6-NheC was 10:10:1 [NheA, NheB, NheC]
1396	2828067	15640177	2007-08-25 14:49	nonribosomal peptide synthetase gene responsible for cereulide production in emetic Bacillus cereus identifeid and partially characterized [cereulide peptide synthetase (ces)]
1396	2828067	15699205	2007-08-25 13:11	identifed and characterized the iron-responsive regulator Fur from B. cereus and demonstrate that it plays a key role in the virulence of this human pathogennce [Fur]
1396	2828067	16049914	2007-08-25 14:15	trtiary structure of peptide deformylase consists of a mixed alpha + beta topology
1396	2828067	16192570	2007-08-25 14:42	Although Bacillus cereus DNA topoisomerase I and IIIalpha have different biochemical activity, they both are able to substitute for the loss of Escherichia coli topoisomerase III (DNA topoisomerase I and DNA topoisomerase IIIalpha).
1396	2828067	16380268	2007-08-25 11:24	results presented here show for the first time that two types of human cells are sensitive to HlyII action [HYLII]
1396	2828067	16451187	2007-08-25 10:19	a new bacteriocin produced simultaneously with cerein 7A by Bacillus cereus Bc7 was purified and sequenced [Cerein 7B]
1396	2828067	16468998	2007-08-25 21:27	AlkC and AlkD thus define novel families of alkylbase DNA glycosylases within a new protein superfamily [ALKC, ALKD]
1396	2828067	16952956	2007-08-25 13:30	the ResDE system was found to exert major control on both fermentative growth and enterotoxin expression, and it is concluded that the ResDE system of B. cereus should be considered an anaerobic redox regulator.[ResD, ResE]
1396	2828067	17097673	2007-08-25 21:21	HlyIIR forms a tight dimer with a fold and overall architecture similar to the TetR family of repressors.[HylIIR]
1396	2828067	17324372	2007-08-25 11:46	Subtle changes in steric and electronic properties in the substrate binding site of PC-PLC(Bc) are responsible for the significant changes in substrate selectivity.
1396	2828067	17346714	2007-08-25 13:24	Two HlyIIR dimers were found to bind to native operator independently with Kd level in the nanomolar range. The minimal HlyIIR binding site was identified as a half of the long DNA perfect inverted repeat.(hlyIIR)
1396	2828067	17395642	2007-08-25 13:24	B. cereus AlkD and AlkC are members of a new and uncharacterized structural superfamily of DNA glycosylases with an alpha-alpha superhelix fold (AlkD and AlkC).
1396	2828067	17521361	2007-09-08 10:48	The function of the two distinct MnSODs of Bacillus cereus 905 appears to be essential in colonization of wheat rhizosphere.[sodA-1, sodA-2]
1396	2828067	17988649	2008-03-22 10:18	The effects of ceramide incorporation in supported bilayers prepared from ternary lipid mixtures which have small nanoscale domains have been examined using atomic force and fluorescence microscopy.[SMase]
1396	2828067	18065609	2008-03-10 14:57	Beta-lactamase type I is reported for the first time to occur in the sporulated form in a penicillin-resistant Bacillus cereus 5/B line (ATCC 13061). [beta-lactamase I]
1396	2828067	18175317	2008-05-03 10:27	study reports the crystal structure of B component of hemolysin (39 kDa), HBL-B [HBL-B]
1396	2828067	18214442	2008-09-27 10:07	CodY represses production of an unknown protease and is involved in biofilm formation. [codY]
1396	2828067	18310016	2008-05-03 12:45	we show that Nhe has haemolytic activity against erythrocytes from a variety of species.[Nhe in strain NVH 0075/95]
1396	2828067	18323609	2008-05-03 10:27	crystals belonged to the tetragonal space group P4(1)2(1)2, with unit-cell parameters a = b = 92.7, c = 242.9 A and four molecules in the asymmetric unit[N-acetylglucosamine deacetylase ]
1396	2828067	18535631	2008-09-13 10:06	The succinate:menaquinone-7 reductase of B. cereus consists of a 65-kDa flavoprotein (SdhA), a 29-kDa iron-sulphur protein (SdhB), and a 19-kDa subunit containing 2 b-type cytochromes (SdhC). [Sdha, SdhB, SdhC]
1396	2828067	18585735	2008-07-26 10:32	AlkD utilizes a novel strategy to manipulate DNA in its search for alkylpurine bases[ AlkD]
1396	2828067	18641133	2008-09-27 10:43	GerN, but not GerT, is required for all germination responses that involve the GerI germinant receptor. [GerT, GerN]
1396	2828067	18706426	2008-10-04 10:13	These results provide structural and functional insights into the dimerization mechanism and substrate specificity of Bacillus cereus OMT2 [OMT2].
1402	2828069	16328988	2007-08-25 21:18	A gene (apr 46) encoding a protease was cloned from Bacillus licheniformis RSP-09-37 and functionally expressed in E. coli. N-terminal sequencing suggests that Apr 46 alkaline protease is identical to a B. licheniformis RSP-09-37 protease.
1402	2828069	16525847	2007-08-25 10:54	release of the calcium ion significantly affected the movements of loops 1, 2, and 3, as shown by essential dynamics. These movements differ with temperature and affect dramatically the activity of the enzyme, as observed by thermoinactivation studies.
1402	2828069	18427806	2008-09-13 10:06	The purified protease revealed temperature optima of 50 degrees C and pH optima of 10.0 and was classified as serine protease based on its complete inhibition with phenyl methyl sulfonyl fluoride.[Apr46]
1402	2828069	18483737	2008-10-04 10:28	CYP102A7 was active towards medium-chain fatty acids but showed a strong preference for saturated over unsaturated fatty acids. [YrhJ]
1404	2828071	15555585	2007-08-25 10:27	the FMN domain of P450 BM3 was found to form an anionic FMN semiquinone, which is kinetically trapped by a slow protonation event [p450 BM3]
1404	2828071	15558816	2007-08-25 12:50	isolation and functional alanysis of comEA, a DNA uptake protein [comEA]
1404	2828071	15677446	2007-08-25 10:23	Data show that bacillolysin MA (BL-MA)affects blood coagulation and fibrinolysis systems and can be used to produce angiostatin-like plasminogen fragments and active serine proteases of human plasma [BL-MA].
1404	2828071	15710617	2007-08-25 13:41	Mutation of tryptophan-1046 in the isolated FAD domain and diflavin reductase domains of flavocytochrome P450 BM3 effects a remarkable switch in coenzyme preference. (flavocytochrome P450 BM3)
1404	2828071	15758224	2007-08-25 11:10	harbors two recA genes, both being damage-inducible and functional in DNA repair [RecA]
1404	2828071	15773986	2007-08-25 14:48	interacts with RNA polymerase to inhibit transcription [CcpA]
1404	2828071	15880388	2007-08-25 10:58	The structural and dynamical properties of the heme domain of monooxygenase P450 BM-3 in water and dimethylsulfoxide solutions were studied.
1404	2828071	16199582	2007-08-25 14:14	data indicate that germination protease (GPR) is an atypical aspartic acid protease[GPR]
1404	2828071	16214136	2007-08-25 10:56	Flavocytochrome P450 BM3 fatty acid hydroxylase specific activity decreases sharply at low enzyme concentrations,which is consistent with separation of active dimer into inactive monomer.(flavocytochrome P450 BM3)
1404	2828071	17077084	2007-08-25 13:28	spectroscopic characterization of P450 BM3 mutants [P450 BM3]
1404	2828071	17376479	2007-08-25 13:59	Stabilization of closed conformation and bolstering of cross contacts between CcpA and its corepressor, HPr-Ser46-P, provide a molecular explanation for how adjunct corepressors G6P and FBP enhance interaction between CcpA-(HPr-Ser46-P) and DNA.(CcpA)
1404	2828071	17434971	2007-08-25 15:03	An approximate 6-kb region of the 165-kb plasmid was found to harbor a tricistronic receptor operon, gerU, and a monocistronic receptor component, gerVB.[gerU, gerVB]
1404	2828071	17500051	2007-08-25 13:59	present the crystal structure of full-length apo CcpA at 2.5 A resolution from B. megaterium[CcpA]
1404	2828071	17587680	2007-09-29 11:22	BMerP can act as a bio-adsorbent compartmentalizing the toxic mercuric ion on the cell membrane and enhancing resistance.(MerP or BMerP)
1404	2828071	17608626	2008-01-05 16:35	novel levansucrase was identified; crucial amino acid residues responsible for product specificity and catalysis were identified[levansucrase]
1404	2828071	17996858	2008-04-05 13:00	Four CYP102A1 mutants containing missense mutations, formed the same drug (clozapine, diclofenac and acetaminophen) metabolites as human and rat liver microsomes, but with an activity up to 70-fold higher compared to human enzymes. (cytochrome P450 BM3)
1404	2828071	18004886	2008-02-16 12:56	interactions of amino acid side chains with hydrophobic pocket near R47, as revealed by crystal structure determination of N-palmitoyl-l-methionine bound to heme domain of P450BM-3, appears to be responsible for increasing affinity of substrates[P450BM-3]
1404	2828071	18020460	2008-05-31 10:15	Data show that CYP102A1 oxidation of acyl homoserine lactones represents an important new mechanism of quorum quenching [CYP102A1]
1404	2828071	18298086	2008-05-31 10:05	crystal structure of N-(12-imidazoloyldodecanoyl)-leucine inhibitor bound to heme domain of P450BM-3 reveals that mode of interaction of leucine group with enzyme is different from that previously observed for acyl amino acid substrates[P450BM-3]
1404	2828071	18556815	2008-07-12 10:32	biochemical properties, including substrate specificity, optimal pH and temperature values for the cyclization reaction, enzyme stability and structural characterization was studied [cyclodextrin glucanotransferase ]
1408	2828075	15625326	2007-08-25 11:10	biochemical analysis of recombinant APRP [APRP]
1408	2828075	15769599	2007-08-25 14:25	expression, purification, crystallization, X-ray analysis and phasing of the acetyl xylan esterase from Bacillus pumilus [acetyl xylan esterase]
1408	2828075	18071642	2008-04-26 12:11	The enzyme released arabinose from oat spelt xylan.[AraB in strain ARA]
1421	3759994	17400775	2007-08-25 13:23	The results confirmed the presence of a glucokinase-encoding gene, glcK, and on the bacterial chromosome and expression of glucokinase during vegetative growth of B. sphaericus strains.[glucokinase]
1421	3759994	17638580	2008-05-10 10:28	High-resolution images for sbpA lipid monolayer crystals were obtained by cryoelectron microscopy. A projection map of sbpA at 7 angstroms resolution was calculated.
1421	3759994	17646596	2007-12-29 10:20	Both Cry48Aa1 and Cry49Aa1 components are necessary for pathogenicity, indicating an unprecedented interaction to generate mosquitocidal toxicity. (crystal protein components Cry48Aa1 and Cry49Aa1)
1422	3759996	16511150	2007-08-25 11:57	preliminary X-ray analysis of pyruvate kinase [pyruvate kinase]
1422	3759996	16511233	2007-08-25 10:53	crystallographic analysis of a family 43 beta-D-xylosidase from Geobacillus stearothermophilus T-6, XynB3 [XynB3]
1422	3759996	17559872	2007-09-22 12:20	Results describe distinct, characteristic differences in the thermodynamic signatures of tryptophan binding by trp RNA-binding attenuation protein (TRAP) from two different bacterial species, Bacillus subtilis and Bacillus stearothermophilus .
1422	3759996	17642511	2007-09-22 12:36	structure of intracellular xylanase 6 was compared with the highly homologous extracellular xylanase XT6[intracellular xylanase ]
1422	3759996	17644609	2008-03-29 12:14	C-terminal truncation forms of the S-layer protein SbsC and the secondary cell wall polymer (SCWP) confirmed the exclusive responsibility of the N-terminal region comprising amino acids 31-270 for SCWP binding [SbsC]
1422	3759996	18158267	2008-03-22 10:18	In the 3.2 A structure of UvrA, the nucleotide-binding sites are formed in an intramolecular fashion & are not at the dimer interface. It has 2 unique domains, one of which interacts with UvrB, and 3 zinc modules.[UvrA]
1422	3759996	18247578	2008-06-07 10:29	The mRNA and rRNA fragments bind L10(L12) 4 with similar affinity ( approximately 10 (8) M (-1)), but fluorescence binding studies show that a nearby protein in the ribosome, L11, enhances L10(L12) 4 binding approximately 100-fold [L10, L12 and L11]
1422	3759996	18319246	2008-06-21 10:05	the binding of D-tyrosine weakens the affinity with which ATP binds to the functional subunit in tyrosyl-tRNA synthetase [tyrosyl-tRNA synthetase]
1422	3759996	18319247	2008-06-21 10:05	Single turnover kinetics for the aminoacylation of tRNA(Tyr) by D-tyrosine were monitored using stopped-flow fluorescence spectroscopy [Tyrosyl-tRNA synthetase]
1423	2828077	15044948	2007-08-25 10:32	Data show that SpoIIQ dynamically localizes to the sporulation septum, tracks the engulfing mother cell membrane, assembles into helical arcs around the forespore and is finally degraded [SpoIIQ,strain PY79]
1423	2828077	15213402	2007-08-25 11:17	crystal structure [yczA protein or Anti-TRAP protein]
1423	2828077	15272169	2007-08-25 13:46	crystal structure of methylmalonate-semialdehyde dehydrogenase from Bacillus subtilis [methylmalonate-semialdehyde dehydrogenase]
1423	2828077	15272301	2007-08-25 21:10	Data show that MreB, Mbl and MreBH form helical filaments underneath the cell membrane, the pattern of which is distinct for each protein [MreB] [Mbl][MreBH]
1423	2828077	15341727	2007-08-25 11:35	Results describe the crystal structure of the 6-phospho-alpha-glucosidase GlvA in complex with its ligands to 2.05 angstrom resolution [GlvA]
1423	2828077	15363790	2007-08-25 13:12	crystal structure of the YckF protein from Bacillus subtilis was determined with MAD phasing and refined at 1.95A resolution [YckF]
1423	2828077	15374645	2007-08-25 10:28	the spa-box has a role in in subtilin-responsive promoter controlled autoregulation of subtilin biosynthesis [subtilin]
1423	2828077	15458638	2007-08-25 14:51	The crystal structure of the full-length B. subtilis Hsp33 in the reduced form was reported (Hsp33).
1423	2828077	15468321	2007-08-25 11:33	Crystal structure of putative ribosomal N-acetyltransferase, YdaF [YdaF]
1423	2828077	15489457	2007-08-25 13:06	A base substitution, T to A at the +4 position, detected in the spontaneous mutant resulted in the stabilization of bmr3 mRNA and in a multidrug resistance phenotype [bmr3]
1423	2828077	15528654	2007-08-25 15:02	proposed that the expression of the levansucrase operon is modulated by a positive autogenous mechanism; this feedback loop requires transcripts of levB, the second gene of the operon [levB]
1423	2828077	15544802	2007-08-25 11:10	Data suggest that ligand binding induced a conformational change in the transmembrane domain of McpB dimers that acts as an excitation signal that is likely propagated within the cytoplasmic region [McpB strain O13545]
1423	2828077	15576792	2007-08-25 10:59	the production of a-type terminal oxidases is the basis for the role of ResD in Pho induction [ResD]
1423	2828077	15583164	2007-08-25 13:11	GGT has a powerful exo-gamma-glutamyl hydrolase activity that participates in capsule gammaPGA degradation to supply stationary-phase cells with constituent glutamates [GGT strain NAFM5]
1423	2828077	15583392	2007-08-25 13:11	crystallographic characterization of BSAP, an extracellular aminopeptidase from Bacillus subtilis [BSAP]
1423	2828077	15588817	2007-08-25 21:27	TRAP binds to its RNA targets by first associating with one or more repeat at the 5' end of its binding site followed by wrapping the remainder of binding site around the protein in a 5' to 3' direction [TRAP]
1423	2828077	15628860	2007-08-25 12:49	Crystal structure has allowed for a detailed structure-function analysis of the active site (quercetin 2,3-dioxygenase)
1423	2828077	15649780	2007-08-25 21:23	Kinetic properties of B. subtilis IBTC-3 subtilisin in hydrolysis of ethyl esters of amino acid derivatives were compared with that of alkaline peptidase from Bacillus alcalophilus PB92 [IBTC-3 subtilisin]
1423	2828077	15654328	2007-08-25 12:02	the crystal structure of Bacillus subtilis RNase Z at 2.1 A resolution, and propose a mechanism for tRNA recognition and cleavage [RNase Z]
1423	2828077	15659156	2007-08-25 10:59	influences the Spo0J/Soj system of chromosome segregation [DivIB]
1423	2828077	15659166	2007-08-25 10:59	Spx directly activates trxA and -B transcription by interacting with the RNA polymerase alpha-subunit, but it does so only under an oxidized condition. [Spx]
1423	2828077	15659674	2007-08-25 21:28	Nearly half of pro-sigmaK was required for regulated intramembrane proteolysis of pro-sigmaK-GFP chimeras in sporulating B. subtilis. (pro-sigmaK)
1423	2828077	15663928	2007-08-25 22:21	results suggest that the transcription complex can interact with either uncharged or charged tRNA until it approaches the termination point, allowing maximal flexibility in monitoring the ratio of charged to uncharged tRNA [glyQ & gly S]
1423	2828077	15668000	2007-08-25 14:16	demonstrated that ribR is transcribed as part of a 10 kb ytmI-ytnM operon; role of the yrzC gene product as a negative regulator for the ytmI-ytnM operon [ribR, yrzC]
1423	2828077	15668014	2007-08-25 14:16	cloning, purification and preliminary biochemical characterization of the ywad gene product [Ywad]
1423	2828077	15686839	2007-08-25 14:49	novel germination gene induced by by high (100 MPa) and very high (600 MPa) pressure, by nutrients and by dodecylamine [YkvU]
1423	2828077	15687192	2007-08-25 14:49	PdaA could deacetylate the N-acetylmuramic acid residues of purified glycan strands derived from Bacillus subtilis peptidoglycan [PdaA]
1423	2828077	15687200	2007-08-25 13:10	propose that increases in level of Spo0A leads to an early phase of transcription in which genes playing auxiliary roles in development are turned on and a later phase in which genes playing a direct role in sporulation are activated [Spo0A strain PY79]
1423	2828077	15723536	2007-08-25 14:24	The structural identification of a disulfide switch demonstrates that BsSco has the capability to fill a redox role in cytochrome c oxidase) assembly. (bssco)
1423	2828077	15731457	2007-08-25 10:23	determined by NMR spectroscopy that Mistic forms a helical bundle with a surprisingly polar lipid-facing surface; experiments suggest that Mistic can be used for high-level production of other membrane proteins in their native conformations [Mistic]
1423	2828077	15743934	2007-08-25 10:59	measured levels of AT and TRAP and anthranilate synthase under different growth conditions; observed that the AT level increases upon tryptophan starvation and that this increase is associated with increased anthranilate synthase production [AT] [TRAP]
1423	2828077	15752199	2007-08-25 11:33	defined the localization requirements for the mother-cell membrane protein SpoIVFA, which anchors a signalling complex in the septal membrane on the mother cell side [SpoIVFA strain PY79]
1423	2828077	15758992	2007-08-25 22:20	crystal structure explains how the HutP and RNA interactions are regulated critically by the l-histidine and Mg2+ ion through the structural rearrangement [HutP]
1423	2828077	15849320	2007-08-25 21:24	RecN binds specifically to 3'-single-stranded DNA extensions in an ATP dependent manner and protects these regions from nuclease degradation (RecN).
1423	2828077	15866723	2007-08-25 14:15	This is the first report of a truncated bacterial globin endowed with peroxidase-like activity [yjbI, strain DB104]
1423	2828077	15869469	2007-08-25 21:12	The mono/bifunctional and metallo/non-metallo properties of B. subtilis DAHPS (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) using both the parent strain and the derivative 168 strain are reported.[DAHPS]
1423	2828077	15890195	2007-08-25 10:22	biochemical evidence for direct interaction of tRNA(Gly) with full-length in vitro transcribed glyQS leader RNA, and an initial view of structural modulations of both RNA partners within the complex [glyQS]
1423	2828077	15937167	2007-08-25 14:15	Multigene family repression by Spx in B. subtilis when sulfate is present as the sole sulfur source is reported. [Spx]
1423	2828077	15978076	2007-08-25 13:08	investigated the contributions of sigma(E) and SpoIIE's protein structures, expression and the genetic asymmetry that develops during chromosome translocation into the forespore on their abundance in each compartment [Sigma(E), SPOIIE]
1423	2828077	15978580	2007-08-25 13:05	By solving the crystal structure there was shown that YukD adopts a fold that is most closely related to ubiquitin, yet has the shortest C-terminal tail of all known ubiquitin-like proteins.
1423	2828077	15987505	2007-08-25 14:44	a ScpA/ScpB sub-complex is directly recruited into the SMC complex; the activity of SMC could be regulated through binding and release of ScpA and ScpB, which has been shown to affect SMC ATPase activity
1423	2828077	15995641	2007-08-25 14:24	role for initiation of sporulation through regulation of spo0A expression. [cccA (cytochrome c550), spoOA]
1423	2828077	16008562	2007-08-25 10:22	Lys197 and Arg199 of Ribose-Phosphate Pyrophosphokinase are important in stabilization of the transition state [Ribose-Phosphate Pyrophosphokinase]
1423	2828077	16024744	2007-08-25 13:39	RecU modulates RecA activities by promoting RecA-catalyzed DNA strand invasion and inhibiting RecA-mediated branch migration, by preventing RecA filament disassembly, and suggest a mechanism for the control of resolvasome assembly (RecU and RecA).
1423	2828077	16045613	2007-08-25 21:06	findings show that translesion synthesis is a bipartite dual polymerase process involving not only the Y-polymerases but also DNA polymerase I [Pol I][Pol Y1] [POl Y2]
1423	2828077	16061691	2007-08-25 10:56	RecN protein is recruited to a defined DNA double strand break repair centers and forms highly dynamic filamentous structures across the nucleoids
1423	2828077	16091051	2007-08-25 13:04	Identification of genes regulated by the quorum-sensing transcription factor ComA (ComA).
1423	2828077	16114880	2007-08-25 13:38	Hydrogen-bonding interactions that lead to precise positioning and deprotonation of the substrate are perturbed by mutations in urate oxidase (urate oxidase)
1423	2828077	16120674	2007-08-25 11:26	DnaA-mediated response, elicited by changes in DNA replication status, may be conserved [DnaA]
1423	2828077	16126221	2007-08-25 15:04	Data suggest that the loose dimer structure indicates that non-native interactions can mediate subunit association in nitric oxide synthase [nitric oxide synthase]
1423	2828077	16132829	2007-08-25 13:05	protein conformation of this protein studied by NMR in Bacillus subtilis. (VkuV)
1423	2828077	16154091	2007-08-25 15:01	The structure of the enzyme RecU was determined.(RecU)
1423	2828077	16163454	2007-08-25 14:43	UV-visible spectroscopy of SP lyases indicated that C141 does not participate in [4Fe-4S] formation and redox chemistry;in vivo SP lyase activity was abolished in mutants, indicating essential role for C141 in SP lyase activity [spore photoproduct lyase]
1423	2828077	16164558	2007-08-25 11:26	role of CcpN in the regulation of small RNA SR1 (CcpN)
1423	2828077	16166551	2007-08-25 13:39	A catabolite-responsive element (CRE), a binding site for the CcpA transcription factor, was identified within the sigL structural gene encoding sigma(L) in Bacillus subtilis[SIGL; CCPA]
1423	2828077	16192572	2007-08-25 14:42	A divalent metal ion binding pocket exists within the HutP protein that is important for mRNA recognition (HutP).
1423	2828077	16223496	2007-08-25 14:13	The dimeric AbrB domain shares a common fold with the addiction antidote MazE and the subunit of uncharacterized protein MraZ implicated in cell division and cell envelope formation. (AbrB)
1423	2828077	16234932	2007-08-25 10:57	structures of the CotA protein in the oxidised and reduced states and with the addition of peroxide and the inhibitor, azide [CotA]
1423	2828077	16249335	2007-08-25 12:35	crystal structure of the B. subtilis C-terminal domain of the alpha subunit of RNA polymerase bound to oxidized Spx (Spx)
1423	2828077	16267279	2007-08-25 21:03	data argue that a drop in ATP, rather than changes in GTP, proton motive force, or redox state, is the key to triggering nutritional stress activation of sigma(B)[SigmaB]
1423	2828077	16267287	2007-08-25 21:03	results indicate that CysK, besides its enzymatic role in cysteine biosynthesis, is a global negative regulator of genes involved in sulfur metabolism [CysK]
1423	2828077	16267299	2007-08-25 12:35	investigated the assembly and function of Tgl; results suggest that Tgl may be present at various levels within the spore coats and that its assembly is independent of its activity [Tgl]
1423	2828077	16306262	2007-08-25 10:55	x-ray structure of anti-TRAP at 2.8 angstroms resolution [anti-TRAP]
1423	2828077	16321932	2007-08-25 11:59	findings show CotO to be an important morphogenetic coat protein that shares some (although not all) of the functions of CotH [CotO]
1423	2828077	16321940	2007-08-25 11:59	results show an important function of three histidine residues for heme A synthase activity of CtaA [CtaA]
1423	2828077	16321961	2007-08-25 11:59	results show that multicopy senS enhances aprE expression by reducing the expression of scoC [senS, scoC]
1423	2828077	16352818	2007-08-25 14:42	alterations in Gerb receptors reduces interactions between different nutrient receptors in spore germination [GerB receptor]
1423	2828077	16352840	2007-08-25 14:42	results presented in this study support the hypothesis of a cooperative activity in vivo between the putative B. subtilis DEAD box RNA helicases CshA and CshB and the CSPs during the cold shock response [CshA, CshB, CspB]
1423	2828077	16363808	2007-08-25 11:58	The high-affinity binding of metals by BsSco is triggered by its redox state, and this property could be important for its function in vivo [Sco]
1423	2828077	16391148	2007-08-25 14:41	CotA shows strong bilirubin oxidase activity and markedly higher affinity for bilirubin than conventional bilirubin oxidase. This is the first characterization of bilirubin oxidase activity in a bacterial protein. [CotA]
1423	2828077	16411777	2007-08-25 14:12	Mn2+ might be the preferred cofactor for this enzyme and identifies QueD as a new member of the manganese dioxygenase family [QueD]
1423	2828077	16420366	2007-08-25 15:07	SepF is a new member of the Gram positive divisome, which interacts with FtsZ and is required for proper execution of septum. synthesis.[SepF][FtsZ]
1423	2828077	16426634	2007-08-25 11:58	Data provide structural insights at the molecular level into the transformation of UvrB into an active helicase [UvrB]
1423	2828077	16430687	2007-08-25 21:27	SpoIIIE might serve to couple the final step in cytokinesis, septal membrane fusion, to the completion of chromosome segregation.
1423	2828077	16430705	2007-08-25 21:27	Purified AseR and CzrA form complexes with derepressed promoters and sense zinc, arsenite, or copper ions in vivo.(AseR) (CzrA)
1423	2828077	16461910	2007-08-25 12:33	YabA regulates initiation through coupling with the elongation of replication.(YabA)
1423	2828077	16475182	2007-08-25 14:12	report the crystal structure of T1414 and compare it with structurally similar drug and DNA-binding proteins [yxaF or T1414]
1423	2828077	16511203	2007-08-25 10:53	X-ray characterization of the nitrile reductase QueF, a queuosine-biosynthesis enzyme [QueF]
1423	2828077	16522191	2007-08-25 21:18	Dihydroorotase was expressed soluble form in E. coli and purified [dihydroorotase]
1423	2828077	16541078	2007-08-25 10:53	PerR senses peroxides by metal-catalysed oxidation [PerR]
1423	2828077	16547045	2007-08-25 21:01	results demonstrate that GlnR and TnrA cross-regulate each other's expression and that there are differences in their DNA-binding specificities [GlnR & TnrA]
1423	2828077	16547058	2007-08-25 21:01	A stem-loop mutation between ccpA and motP in the Bacillus subtilis ccpA-motPS operon increased motPS transcription and membrane-associated MotPS levels, motility, and number of flagella/cell [ccpA, motP, motS]
1423	2828077	16547061	2007-08-25 21:01	alternative localization of two types of L31 ribosomal protein, RpmE and YtiA, is controlled by the intracellular concentration of zinc in Bacillus subtilis [RpmE, YtiA]
1423	2828077	16549676	2007-08-25 21:27	results of this study suggest that FtsL and EzrA synergistically regulate the FtsZ ring constriction [FtsL, EzrA, FtsZ]
1423	2828077	16585761	2007-08-25 21:08	localization of topoisomerases; both subunits of Topo IV were uniformly distributed throughout the nucleoids; Topo I and gyrase formed discrete accumulations, or foci, on the nucleoids in a large fraction of the cells [Topo I, Topo IV, Dna gyrase]
1423	2828077	16585774	2007-08-25 21:08	In this study, we present genetic evidence for participation of sigma(L) (sigma(54)) and the two sigma(L)-dependent transcriptional enhancers BkdR and YplP in the cold shock response of Bacillus subtilis JH642.[sigL]
1423	2828077	16677298	2007-08-25 10:52	Inactivating soj, spo0J or both led to a significant defect in separating replicated sister origins, such that the origins remain too close to be spatially resolved. (Soj) (Spo0J
1423	2828077	16677303	2007-08-25 10:52	The global DNA-remodelling activity of DnaD is the sum of three separate oligomerization and DNA-binding activities residing on two distinct but linked domains.
1423	2828077	16682782	2007-08-25 21:23	cloning, purification, crystallization and X-ray diffraction of glutamate-1-semialdehyde aminotransferase; X-ray diffraction studies yielded diffraction data to a resolution of 2.0 angstroms [glutamate-1-semialdehyde aminotransferase]
1423	2828077	16697411	2007-08-25 21:23	the 1.8A crystal structure of the fengycin thioesterase (FenTE) from Bacillus subtilis, which catalyses the regio- and stereoselective release and macrocyclization of the antibiotic fengycin [FenTE]
1423	2828077	16713562	2007-08-25 14:08	Results report the identification of the protein DisA (DNA integrity scanning protein, annotated YacK), which is required to delay the initiation of sporulation in response to chromosomal damage [DisA].
1423	2828077	16728958	2007-08-25 14:09	YlaC regulated by the YlaD redox state contributes to oxidative stress resistance in B. subtilis.
1423	2828077	16738132	2007-08-25 13:33	The role of Thr30 in activating TRAP to bind RNA (TRAP).
1423	2828077	16780573	2007-08-25 21:23	results show that different patterns of localization exist for DNA repair proteins, and that the B. subtilis SMC proteins RecN and SbcC play distinct roles in the repair of DNA damage [SbcC protein]
1423	2828077	16784238	2007-08-25 10:50	tertiary structure of the ligand-activated glmS ribozyme [glmS]
1423	2828077	16796679	2007-08-25 11:53	The essential role of only three cysteine residues (C227, C230, C235) at the C-terminus of B. subtilis Fnr for the transcriptional activation of the nitrate reductase operon (narGHJI) and nitrite extrusion protein gene (narK) promoters was revealed.
1423	2828077	16796683	2007-08-25 11:54	The Sda checkpoint co-ordinates early events of spore development, including the polar cell division, with successful completion of chromosome replication.(Sda)
1423	2828077	16816187	2007-08-25 21:26	LiaRS, responds to cell wall antibiotics that interfere with the undecaprenol cycle and to perturbation of the cytoplasmic membrane. [LiaRS protein](newentry)
1423	2828077	16816200	2007-08-25 21:26	Multiple Rap proteins and Phr peptides allows multiple physiological cues to be integrated into a regulatory network that modulates the timing and magnitude of the ComA response. (RAP AND PHR proteins)
1423	2828077	16819829	2007-08-25 21:08	On the basis of these results, a model for selective O2 sensing by HemAT was proposed.
1423	2828077	16829680	2007-08-25 10:13	Results present the first detailed characterization of catalytically active spore photoproduct lyase [spore photoproduct lyase; strain KI1152]
1423	2828077	16850297	2007-08-25 14:07	purification and characterization of an alpha-amylase from Bacillus subtilis KCC103; it displayed endolytic activity and formed maltooligosaccharides on hydrolysis of soluble starch at pH 4 and 7 [alpha-amylase]
1423	2828077	16861794	2007-08-25 11:52	suggested that YdbR plays a critical role, interacting with RNA substrates during translation at low temperature [YdbR]
1423	2828077	16885442	2007-08-25 13:31	additional roles for Spx in the control of gene expression during unperturbed, steady-state growth [spx]
1423	2828077	16888621	2007-08-25 10:13	By binding to the origins of replication, Spo0A prevents the initiation step of DNA replication of bacterial and phage genomes.[Spo0A]
1423	2828077	16894162	2007-08-25 10:49	Data show that YphC displays a major domain rearrangement associated with nucleotide binding.  ]YphC]
1423	2828077	16899079	2007-08-25 12:27	Clp protease activity modulates the sigmaW-mediated stress response to the cellular state.(Sigma W)
1423	2828077	16912897	2007-08-25 21:08	Iron transport mediated by siderophores in B. subtilis occurs through a transport process that is specific for the iron chelating moiety, with parallel pathways for catecholates and hydroxamates. (Hexadentate bacillibactin of B subtilis ATCC 6051)
1423	2828077	16935304	2007-08-25 10:48	The data show that multiple assembly forms are a general feature of lumazine synthases.
1423	2828077	16956971	2007-08-25 14:05	The structural consequences of the tight binding of CspB to thymidine-rich single-stranded DNA were investigated by NMR spectroscopy. (CspB).
1423	2828077	16978644	2007-08-25 10:12	Results describe the crystal structure of a dimeric pyridoxal kinase from Bacillus subtilis in complex with ADP to 2.8 A resolution [pyridoxal kinase].
1423	2828077	16990138	2007-08-25 13:29	We present experimental evidence for association between one RCK octameric ring and two KtrB membrane proteins. These results provide insights into the quaternary organization of the KtrAB transporter and its mechanism of activation [KtrAB]
1423	2828077	17055433	2007-08-25 14:04	identified a Bacillus subtilis mutant sigma(A) that is capable of specific binding and melting of the promoter DNA independently of core RNA polymerase sigma(A)
1423	2828077	17122346	2007-08-25 10:45	crystal structure uroporphyrinogen decarboxylase (UROD)has been determined at a 2.3 A resolution [UROD]
1423	2828077	17139259	2007-08-25 21:11	These results suggest that the dynamic polymerization of AlfA mediates plasmid separation during both growth and sporulation.
1423	2828077	17142911	2007-08-25 10:45	Native X-ray diffraction data from these crystals were collected to 2.2 A resolution on a home source. These crystals have unit-cell parameters a = b = 68.7, c = 211.5 A[YwfC]
1423	2828077	17194721	2007-08-25 12:24	Study applied a combination of NMR residual dipolar couplings & a domain-elongation strategy for measuring "motionally decoupled" relaxation data to characterize the structural dynamics of the P4 helix from Bacillus subtilis RNase P [RNase P]
1423	2828077	17198378	2007-08-25 12:23	the first X-ray crystal structure of ferrochelatase with iron (ferrochelatase).
1423	2828077	17223686	2007-08-25 13:26	Prodomain catalyzes late proline isomerizations needed to form metal site B. Effect in slowing folding is amplified because of instability of intermediate & apparent need for simultaneous isomerization of multiple prolines to create site B[subtilisin]
1423	2828077	17223687	2007-08-25 11:47	Antagonism between folding intermediate & native structure helps explain why prodomain is needed to stabilize folding intermediate as well as why unfolding of free subtilisin seldom occurs via intermediate[subtilisin]
1423	2828077	17284856	2007-08-25 21:26	accurate termination of translation is required for proper initiation of sporulation in the prfB gene--prfB gene {new entry}
1423	2828077	17294696	2007-08-25 21:26	beta-Mannanase has been isolated and cloned from Bacillus subtilis and expressed in Escherichia coli. [beta-mannanase]
1423	2828077	17302819	2007-10-27 11:45	regulation of pyrG expression; findings provide strong experimental support for the proposed reiterative transcription/antitermination mechanism and confirm that no trans-acting regulatory protein is required for pyrG regulation
1423	2828077	17303556	2007-08-25 10:43	provide novel insights into understanding the reaction mechanisms of the thioredoxin-arsenate reductase pathway[arsenate reductase]
1423	2828077	17305367	2007-08-25 11:46	Our results suggest that Trp302 and the C-terminal residues of SpaC are constituents of a hydrophobic cluster which is involved in stabilization of the catalytic center and binding of the subtilin precursor peptide.[lanthionine cyclase SpaC]
1423	2828077	17322317	2007-08-25 14:01	CcpA and ResD, along with the previously identified cydA regulator Rex (YdiH), affect the expression of the cydABCD operon [CcpA, ResD]
1423	2828077	17350039	2007-08-25 14:00	The data show that two Sda molecules bind to the base of the DHp dimerization domain of the KinA dimer, effecting an allosteric mode of inhibition involving transmission of the inhibitory signal.[KinA, Sda]
1423	2828077	17350627	2007-08-25 21:26	Using comparative NMR chemical shift analyses for hypersporulation mutants, we have confirmed these suppositions and isolated residues in Spo0F critical in sensor kinases discrimination. (Spo0F)
1423	2828077	17416649	2007-08-25 13:59	Study investigated the effects of smc mutations on global gene expression in B. subtilis using DNA microarrays and found that smc null mutation caused partial induction of the SOS response, including induction of the defective prophage PBSX.[SMC protein]
1423	2828077	17444678	2007-08-25 11:45	EPR evidence is consistent with the hypothesis that this Mn-binding site is located in the N-terminal domain, in agreement with predictions based on a recent X-ray structure of oxalate decarboxylase [oxalate decarboxylase]
1423	2828077	17502599	2007-08-25 15:03	Recovery of oxidized OhrR from Bacillus subtilis identifies three distinct S-thiolated species, including mixed disulfides with a novel 398-Da thiol, cysteine, and CoASH[OhrR]
1423	2828077	17555767	2007-11-10 11:57	these results indicate that the rate of TRAP binding to RNA is a crucial factor in TRAP's ability to control attenuation.
1423	2828077	17573175	2008-01-26 11:18	there are similarities, but also major differences, in the catalytic mechanism of GO and other flavooxidases also active on glycine and sarcosine and give insight into the mode of modulation of catalysis and substrate specificities [glycine oxidase]
1423	2828077	17576690	2007-08-25 13:23	The small regulatory RNA, SR1, inhibits translation initiation of ahrC mRNA by inducing structural changes between the ahrC SD sequence and the first complementary region G (SR1).
1423	2828077	17582436	2007-09-22 12:36	adduct also reveals a binding pocket specific to the diaminopimelic acid, the third residue of the peptidoglycan stem pentapeptide of B. subtilis. This pocket is specific for this class of penicillin-binding proteins[penicillin-binding protein 4a]
1423	2828077	17586624	2007-10-13 10:19	The data suggest a model in which ClpP facilitates the turnover of stress-generated factors, which persist in ClpP's absence to stimulate ongoing sigmaB activity.[ClpP]
1423	2828077	17586670	2007-10-20 10:20	Results suggest a physiological role of LDH for glucose consumption under fermentative conditions [LDH]
1423	2828077	17590234	2007-10-27 10:14	DegU appears to integrate environmental signals and co-ordinate multicellular behaviours that are subsequently manifested at different levels of DegU phosphorylation.
1423	2828077	17600142	2007-11-10 10:19	results suggest that Asp(69) interacts with His(68), that Arg(310) interacts with and orients the beta-carboxylate of Asp(69), and that His(68) must be protonated for adenylosuccinate lyase to be active (adenylosuccinate lyase).
1423	2828077	17617643	2007-09-15 10:22	Determination of the effects of amino acid substitutions on the ability of AraR to function in vivo and on the DNA-binding affinities in vitro (AraR).
1423	2828077	17640277	2007-10-27 10:33	These data indicate that RecG defines a new epistatic group (eta), RecG is required for proper chromosomal segregation and different avenues could process Holliday junctions.[RecG]
1423	2828077	17660290	2008-03-29 11:19	results indicate that the high sensitivity of the OhrR C15 residue to oxidation requires interactions with the opposed Tyr residues [OhrR]
1423	2828077	17660417	2007-12-01 11:04	Study shows that the LiaR-dependent liaI promoter is induced at the onset of stationary phase without addition of exogenous stresses.[LiaRS]
1423	2828077	17693499	2007-12-01 11:31	These results suggest that a role of negative feedback by sigma(K) RNA polymerase on early mother cell gene expression is to lower the level of SpoIIID late during sporulation in order to allow normal expression of genes in the sigma(K) regulon.[SpoIIID]
1423	2828077	17693500	2007-12-01 11:31	The Integrative and conjugative elements 1 ydcR (nicK) gene product is homologous to the pT181 family of plasmid DNA relaxases. [ydcR]
1423	2828077	17693505	2007-12-01 11:31	The spoIIIA locus is transcribed from two promoters, one at the start of the locus (P1(spoIIIA)) and the other within the locus (P2(spoIIIA)).[spoIIIA]
1423	2828077	17699634	2007-10-20 11:55	report the crystal structures of FlhF from Bacillus subtilis in complex with GTP and GMPPNP[ FlhF ]
1423	2828077	17720779	2008-01-12 12:51	gerT gene product (GerT) is a component of the spore coat, and its incorporation into the coat takes place in two stages. [gerT]
1423	2828077	17725565	2007-12-15 11:56	the FeuABC transporter is optimally expressed via Btr mediated transcription activation under conditions of iron starvation, when Fur-mediated repression is relieved, and in the presence of its cognate substrate.[Btr]
1423	2828077	17803910	2007-10-20 10:19	MgtE is a bacterial ATPase involved in Mg transport. Mg-bound M-box RNA's reside in 5'UTR of MgtE, regulating transription.
1423	2828077	17827297	2008-01-12 12:00	Inhibition of ClpXP by disulfide stress is due to structural changes to the N-terminal inc binding domain of ClpX[CLPXP]
1423	2828077	17873055	2008-01-12 10:20	EzrA has two distinct activities in vivo: (i) preventing aberrant FtsZ ring formation at cell poles through inhibition of de novo FtsZ assembly and (ii) maintaining proper FtsZ assembly dynamics within the medial FtsZ ring [EzrA, Ftsz]
1423	2828077	17881304	2007-12-01 13:11	Divergent energetic properties of CopZ apo- and holo-forms may be linked to conformational changes that facilitate copper transfer to the target. [CopZ copper chaperone]
1423	2828077	17905982	2007-12-29 10:19	A study evaluting the induction process of the BceAB genes in B. subtilis is reported.[BceAB]
1423	2828077	17921301	2007-12-29 10:18	Inactivation of the YydIJ transporter resulted in increased expression from the LiaR-dependent P(liaI) promoter only in the presence of the yydFGH genes.
1423	2828077	17921305	2007-12-29 10:18	The inactivation of the sigma(F)-directed csfB locus resulted in premature activation of sigma(G).[sigma F; csfB; sigma G]
1423	2828077	17929836	2008-01-12 11:10	A chemical mechanism for the enzyme-catalyzed reaction, and a chemical rationale for the observation of covalent catalysis.[QueF]
1423	2828077	17932047	2008-02-09 11:09	analysis of the structure of the dimeric KtrB membrane protein from Bacillus subtilis [KtrB]
1423	2828077	17999999	2008-02-16 10:59	Atomic force microscopy has confirmed that RecN binds to ssDNA regions and, in the presence of ATP, the interactions between individual ssDNA-RecN complexes favour inter-complex association and result in large nucleoprotein complexes (RecN).
1423	2828077	18001347	2008-02-16 11:34	Thus, the position of oriC after septation determines which cell will receive the chromosome and which will assemble SpoIIIE.[SpoIIIE]
1423	2828077	18045469	2008-03-22 12:55	Our data show that DprA/Smf acts downstream of the DNA uptake machinery, and support the idea that Smf protects incoming ssDNA, possibly in conjunction with RecA.[Smf in strain 79]
1423	2828077	18052200	2008-03-10 13:38	structural flexibility within the P protein ensemble may be important for proper RNase P holoenzyme assembly and/or catalysis[ribonuclease P]
1423	2828077	18053819	2008-04-05 11:12	basis for the pH-dependent thermostability of the Bacillus subtilis lipase (Lip A) using spectroscopic and X-ray crystallographic studies
1423	2828077	18077387	2008-02-02 10:18	Mutation of conserved arginine residues that map to the surface of Bacillus subtilis Soj caused only minimal effects on nucleotide-dependent dimerization but had dramatic effects on DNA binding (Soj)
1423	2828077	18084079	2008-02-02 10:18	The crystal structure of MnSOD was solved by molecular replacement with four dimers per asymmetric unit and refined to an R factor of 21.1% at 1.8 A resolution [sodA]
1423	2828077	18088595	2008-06-14 10:05	Acr3 has 10 transmembrane helices.[Acr3]
1423	2828077	18160039	2008-02-09 11:08	Support a model for DNA transport in which the transmembrane segments of SpoIIIE (Bacillus subtilis strain PY79) form linked DNA-conducting channels across the two lipid bilayers of the septum.
1423	2828077	18208527	2008-05-03 10:02	Gin allows sigma(F) to delay the switch to the late forespore transcription programme by preventing sigma(G) to take over before the cell has reached a critical stage of development.[sigmaG,sigmaF]
1423	2828077	18215122	2008-04-26 12:11	UV-visible and fluorescence spectroscopy indicate very different modes of Cu(I) binding below and above a level of 1 Cu(I) per protein, consistent with a major structural change occurring above 1 Cu(I) per CopAab[CopA]
1423	2828077	18230336	2008-03-15 12:51	thermostabilizing effect was confirmed by testing site-directed XynA variants[XynA]
1423	2828077	18239417	2008-05-24 10:35	The recombinant methionine sulfoxide reductase B, MsrB from Bacillus subtilis has been purified and crystallized by the hanging-drop vapor-diffusion method, and the functional and structural features of MsrB have been elucidated. [MsrB]
1423	2828077	18259064	2008-08-09 10:19	recombinant protein from Bacillus subtilis was overproduced in Escherichia coli and crystallized using the hanging-drop vapor-diffusion method from 25% PEG 600, 100 mM NaCl and sodium citrate buffer pH 5.5 at 291 K [queD protein]
1423	2828077	18284588	2008-06-07 10:07	MciZ is a previously unrecognized inhibitor of FtsZ that prevents inappropriate Z-ring formation during sporulation.[FtsZ, MciZ]
1423	2828077	18296515	2008-05-17 10:24	The binding of Spo0A to the spoIIG promoter stimulates promoter utilization by repositioning prebound RNA polymerase.(Spo0A).
1423	2828077	18307408	2008-07-12 10:16	Results characterize two mutants at the type 1 copper site of CotA laccase from Bacillus subtilis.
1423	2828077	18310427	2008-05-17 10:24	Osmotic down-shock experiments demonstrated that the MscL channel is the principal solute release system of B. subtilis, and strains with a gene disruption in mscL exhibited a severe survival defect upon an osmotic down-shock.[mscL in strain JH642]
1423	2828077	18321243	2008-07-12 10:36	Data show that the catalytic and helical domains of OpuAA are similar to those of MalK, but there are profound differences in the three-dimensional orientation of the accessory domain [OpuAA].
1423	2828077	18363800	2008-05-17 10:07	Depending on the oxidant, OhrR can be either reversibly oxidized or can instead function as a sacrificial regulator.(OhrR)
1423	2828077	18366639	2008-05-10 10:13	high-resolution structures of three levansucrase point mutants, D86A, D247A, and E342A, and that of raffinose-bound levansucrase-E342A.
1423	2828077	18384517	2008-05-17 10:33	These results pinpointed FabF[I108F] as responsible for the increased malonyl-CoA production, which in turn acts as an inducer of the fap regulon by impairing the binding of the FapR repressor to its DNA targets. (FabF)(FapR)
1423	2828077	18388975	2008-05-17 10:33	The native form of hydroxybenzoate decarboxylase is encoded by 3 genes yclBCD that we have renamed during this research as bsdBCD to align with existing nomenclature.[bsdB, bsdC, bsdD}
1423	2828077	18423489	2008-06-14 10:24	These results provide new insights into the role of the active site residues of ferrochelatase in controlling stereospecificity, distortion and metallation.
1423	2828077	18431750	2008-07-26 10:36	The solution nuclear magnetic resonance structure of B. subtilis YnzC is presented. [YnzC]
1423	2828077	18439896	2008-05-24 10:05	DisA, a protein that controls a Bacillus subtilis sporulation checkpoint in response to DNA double-strand breaks, was structurally and biochemically analyzed.(DisA)
1423	2828077	18441052	2008-06-21 10:05	The results of genetic experiments performed in B. subtilis support the cleavage of adenine riboswitch by RNase P in vivo and suggest that it induces the stabilization of pbuE mRNA under normal conditions.
1423	2828077	18445631	2008-06-28 10:22	HutP uses its dual RNA-binding surfaces to access two XAG-rich regions within the terminator RNA to mediate the destabilization process (HutP).
1423	2828077	18455734	2008-06-28 10:22	Data report the biochemical properties and crystal structure of BCman-GH26 enzyme from Bacillus subtilis [BCman].
1423	2828077	18455736	2008-06-28 10:22	Data show that thioredoxin A (TrxA) active-site mutants form mixed disulfide dimers that resemble enzyme-substrate reaction intermediates [TrxA].
1423	2828077	18465758	2008-08-16 10:37	soluble synthetic glycolipid is used to provide the first demonstration that TagF polymerizes glycerol phosphate directly on the product of TagB-teichoic acid lipid III [TagB]
1423	2828077	18487328	2008-08-09 10:30	Study identified residues critical for AcuA activity; changes at residues H177 and G187 completely inactivated AcuA and led to its rapid turnover while changes at residues R42 and T169 were less severe.[AcuA]
1423	2828077	18491386	2008-08-30 10:16	The crystal structure of B. subtilis QueC is described.[QueC]
1423	2828077	18502870	2008-08-16 10:16	the MerR-type transcriptional regulator Mta was found to activate both bacillibactin secretion and ymfE gene expression, exposing Mta as an additional regulatory member of the bacillibactin pathway.[Mta and ymfE in strain ATCC21332]
1423	2828077	18506095	2008-07-19 10:40	Results suggest that YabA can inhibit replication initiation through competitive inhibition of DnaD binding to DnaA (YabA and DnaA).
1423	2828077	18511073	2008-06-28 10:22	The effect of ligand-bound CcpN on the RNA polymerase might be due to a conformational switch that alters the interaction between the two proteins.[CcpN]
1423	2828077	18554327	2008-09-27 10:28	Crystal structures of C-CggR, the C-terminal effector-binding domain of CggR, both unliganded as well as in complex with the four ligands at resolutions between 1.65 and 1.80 A reveal unique ligand-specific structural changes in the binding site.(CGGR)
1423	2828077	18556788	2008-08-30 10:16	All of these results suggest that GerD is a lipoprotein associated with the dormant spore's inner membrane that may be released in some fashion from this membrane upon spore germination.[GerD in strain PS832]
1423	2828077	18566286	2008-07-12 10:32	study found an operon required for biofilm matrix synthesis also encoded an inhibitor of motility, EpsE; EpsE arrested flagellar rotation in a manner similar to that of a clutch [EpsE]
1423	2828077	18567662	2008-08-30 10:25	The authors demonstrate that OpuA is capable of importing the sulfobetaine dimethylsulfonioacetate (DMSA).[OpuAC in strain RMKB24]
1423	2828077	18567663	2008-08-30 10:25	Since sigD transcription is enhanced by SwrAA, this finding reveals that swrA expression is controlled by a positive feedback loop.[SwrAA in strain MH5636]
1423	2828077	18573177	2008-09-27 10:28	These data indicate that the FtsEX transporter is one of the top components in the hierarchy of factors required to initiate sporulation, and thus it is essential for establishing proper temporal activation of the process. (FtsE )(FtsX)
1423	2828077	18573182	2008-09-27 10:28	YvrI and YvrHa together recognize the oxdC promoter and activate transcription by core RNA polymerase.  (YvrI)(YvrHa)(oxdC) A yvrL deletion results in the upregulation of YvrI activity. (YvrL)
1423	2828077	18583577	2008-08-16 10:44	crystal structure of the 144-kilodalton Bacillus subtilis termination module SrfA-C was solved at 2.6 angstrom resolution [SrfA-C]
1423	2828077	18588855	2008-08-09 10:12	The solution structures of Bacillus subtilis Tpx in both the reduced and oxidized forms, the first pair of Tpx structures, were reported. (thiol peroxidase)
1423	2828077	18604506	2008-09-13 10:06	The activity of the enzyme was inhibited by Mg(2+), Ca(2+), EDTA and SDS, and enhanced by Fe(2+). [manA]
1423	2828077	18687074	2008-09-20 10:49	Spx transcription activation requires contact between the Spx/RNAP complex and upstream promoter DNA. [Spx]
1423	2828077	18691972	2008-09-06 10:21	SpoIVA harbors a Walker A box that is required for the proper deployment of the protein to the surface of the developing spore and proper assembly of the entire coat.[SpoIVA]
1428	2828079	15320864	2007-08-25 13:47	results show how modification of insect specificity can be achieved by manipulation of different parts of the toxin structure involved in different steps of the mode of action of B. thuringiensis toxins [Cry1Ca]
1428	2828079	15482853	2007-08-25 12:03	data indicate that immunogenic abilities to induce a significant mucosal IgG, and IgM Ab are not restricted to C-terminal half but N-terminal half itself could be involved [Cry1a AND Cry3A]
1428	2828079	15533304	2007-08-25 12:49	Cry1Ab toxin binding to aminopeptidase N and cadherin-like protein depends on its oligomeric structure; the two receptors interact sequentially with different structural species of the toxin leading to its efficient membrane insertion [Cry1Ab strain 407]
1428	2828079	15604796	2007-08-25 11:32	A new cry 1Ab-type gene, cry 1Ab17, was cloned from Bacillus thuringiensis WB9 by PCR. [cry1Ab]
1428	2828079	15705852	2007-08-25 14:38	Cry5B directly and specifically binds glycolipids in C. elegans; this binding is carbohydrate-dependent and relevant for toxin action in vivo [Cry5B]
1428	2828079	15811374	2007-08-25 12:37	crystal structure of Cry4Ba and functional implications [Cry4Ba]
1428	2828079	15963509	2007-08-25 11:30	Exposed loop alpha-8 of Cry11Aa toxin, located in domain II, is an important epitope involved in receptor interaction.
1428	2828079	16087890	2007-08-25 14:43	three-dimensional structure of the N-acyl-l-homoserine lactone hydrolase from Bacillus thuringiensis has been determined, by using single-wavelength anomalous dispersion phasing, to 1.6-angstroms resolution [N-acyl-l-homoserine lactone hydrolase]
1428	2828079	16168574	2007-08-25 14:15	identification, amino acid sequence and characterization of a novel sheep blowfly specific delta endotoxin [Cry47Aa]
1428	2828079	16204549	2007-08-25 12:35	A novel vip3-related gene 2,406 bp long and coding for a 91-kDa protein (801 amino acids) was identified and partially characterized. It exhibits between 61 and 62% similarity with Vip3A proteins but host range might be differrent [Vip3Ba1]
1428	2828079	16306686	2006-03-16 15:34	p29 crystal protein at the lower concentration induced cell death of Jurkat cells, accompanied by apoptosis-like cellular events with mitochondrial involvement(p29 crystal protein)
1428	2828079	16333339	2007-08-25 12:35	cloning, sequencing and characterization of cry9Ec1 from Bacillus thuringiensis serovar galleriae [cry9Ec1]
1428	2828079	16356469	2007-08-25 14:12	the highly conserved Asn(183) located in the middle of the transmembrane alpha5 of Cry4Ba plays a crucial role in toxicity and toxin oligomerisation in the lipid membranes (Cry4Ba)
1428	2828079	16391132	2007-08-25 14:41	role of Trp residues in the structure and function of Cry1Ab toxin [Cry1Ab]
1428	2828079	16400649	2007-08-25 21:23	the 26 kD nontoxic crystal protein from Bacillus thuringiensis demonstrates a remarkable structural similarity to beta-pore-forming toxins [26 kD protein]
1428	2828079	16756755	2007-08-25 10:15	results directly support the role of the alpha4-loop-alpha5 hairpin in membrane perturbation and pore formation of the full-length Cry4Ba toxin [Cry4Ba delta endotoxin]
1428	2828079	16809341	2007-08-25 14:07	Results show that parasporin-2 acts as a cytolysin that permeabilizes the plasma membrane with target cell specificity and subsequently induces cell decay [parasporin-2].
1428	2828079	16893170	2007-08-25 11:53	Cry1A toxins killed S2 cells expressing Heliothis virescens cadherin-like protein (HevCaLP), whereas Cry1Fa toxin did not suggesting that HevCaLP is a functional Cry1A but not Cry1Fa receptor.
1428	2828079	17087513	2007-08-25 21:07	It is proposed that at least alpha helices 4, 5, 6, and 7 and domain II partition in the midgut membranes of target insects, in support of an insertion model in which the whole protein translocates into the midgut membrane[Cry1Aa]
1428	2828079	17213187	2007-08-25 10:09	crystal structure of the W47A/W242A mutant of phosphatidylinositol-specific phospholipase C [PI-PLC]
1428	2828079	17309508	2007-08-25 12:22	first report of B. thuringiensis strains isolated from bryophytes, novel LLB6 harboring the new gene cry2Ac5; its expressed Cry2Ac5 protein revealed activity against Aedes and became a new member of B. thuringiensis toxins.[Cry2Ac5 protein]
1428	2828079	17382289	2007-08-25 10:42	Pore formation, as deduced from changes in membrane permeability induced by Cry1Ac during a 60-min incubation period, was strongly dose-dependent, but rapidly reached a maximum as toxin concentration was increased.[Cry1Ac]
1428	2828079	17394765	2007-08-25 11:46	The present study provides for the first time an insight into the highly conserved aromaticity of Tyr(249) and Phe(264) within helix 7 playing an important role in larvicidal activity of the Cry4Ba toxin.
1428	2828079	17537728	2007-09-22 10:49	the pre-pore oligomer and the toxin pore formation play a major role in the intoxication process of Cry1Ab toxin in insect larvae
1428	2828079	17657530	2007-09-22 12:36	Epizootic isolates of Bacillus thuringiensis crystals revealed a variety of number and type of cry genes; genes cry1I, cry2Ab, and cry9B were the most frequently observed.[Cry}
1428	2828079	17696320	2007-12-01 10:46	We determined the Cry1Ab toxin binding site in BT-R1 in the context of cadherin structural determinants. Our studies revealed a conserved structural motif for toxin binding that includes two distinct regions within the N- and C-termini of EC12.
1428	2828079	17714689	2007-12-01 11:04	Data showed a functional significance of the Cry3Aa-ADAM interaction in relation to this toxin mode of action: Cry3Aa
1428	2828079	17927913	2008-01-12 12:50	In vitro binding analysis to both histological midgut tissue sections and brush border membrane proteins revealed that the isolated Cry4Ba-domain II-III protein showed binding functionality comparable to the 65-kDa full-length active toxin: Cry4Ba
1428	2828079	17949406	2008-01-19 12:04	We found that recombinant Cry1A toxins retained their ability to induce serum and mucosal anti-Cry Ab as well as specific anti-DTB IgG, and IgA.
1428	2828079	17973088	2008-05-03 12:15	cry2Ab10 gene was cloned structure was constructed by homology modeling; insecticidal activity against Plutella xylostella was evaluated [Cry2AB10]
1428	2828079	18028391	2008-03-10 14:58	A new DNA sequence with 2 ORFs; cry5Ad sequence includes homology blocks 1-5, present in most B. thuringiensisdelta-endotoxins; C-terminal region of a Cry5Adelta-endotoxin is encoded by orf2-5Ad.[cry5Ad, orf2-5Ad]
1428	2828079	18048477	2008-04-19 12:45	analysis of domain I of Cry2A entomocidal toxin of Bacillus thuringiensis and protein engineering to enhance its toxicity [Cry2a]
1428	2828079	18230416	2008-05-31 10:17	Cry1Ab toxin produced by Bacillus thuringiensis exerts insecticidal action upon binding to BT-R(1), a cadherin receptor localized in the midgut epithelium of the tobacco hornworm Manduca sexta
1428	2828079	18248430	2008-05-10 10:22	The gene, designated cry1Ah1, encoded a protein with a molecular weight of 134 kDa and RT-PCR and Western blotting showed that Cry1Ah was expressed in the host strain BT8.[cryAH1]
1428	2828079	18345643	2008-05-31 10:29	disruption of helix B to allow enzyme dimerization is what leads to the activated PI-PLC conformation[phosphatidylinositol-specific phospholipase C]
1428	2828079	18407662	2008-06-07 10:18	AgCad1 is probably a Cry4Ba receptor[ Cry4Ba ]
1428	2828079	18446411	2008-08-16 10:25	Tzw1 is required for zwittermicin A biosynthesis in B. thuringiensis G03.[Tzw1]
1428	2828079	18457427	2008-06-14 10:23	domain II residue F371 has a vital role to play in membrane insertion [Cry1Ab]
1428	2828079	18523682	2008-07-12 10:32	Not toxic to Diadegma insulare, an important parasitoid of Plutella xylostella.  (Cry1C)
1428	5618795	18341579	2008-06-28 10:22	A new group of parasporal inclusions encoded by the S-layer gene of B. thuringiensis.
1430	2828081	15498557	2007-08-25 11:10	When Cry1Ac was pretreated with acetylgalactosamine it permeated the peritropic membrane of Bombyx much faster (cry1AC protein, bacillus sthuringiensis)
1430	2828081	15535584	2007-08-25 12:55	Cyt1A protein of Bacillus thuringiensis subsp. israelensis De Barjac was evaluated for its ability to suppress resistance to Bacillus sphaericus in Culex (Bacillus thuringiensis crystal proteins)
1430	2828081	16091772	2007-08-25 13:09	proteins different in N-terminal sequences from known delta-endotoxins and with antibacterial activity toward Micrococcus luteus and Streptomyces chrysomallus were isolated from entomocidal crystals of [Bti36, Bti34, Bti33]
1430	2828081	16255715	2007-08-25 10:20	results shows that GPI-ALP is an important receptor molecule involved in Cry11Aa interaction with midgut cells and toxicity to Ae. aegypti larvae [Cry11Aa]
1430	2828081	16339907	2007-08-25 10:19	Cyt1Aa synergizes or suppresses resistance to Cry11Aa toxin by functioning as a membrane-bound receptor[Cry11Aa and Cyt1Aa]
1430	2828081	16936025	2007-08-25 12:28	Taken together, these results indicate that B. thuringiensis harbors a new type of intracellular PHB depolymerase, PhaZ [PhaZ]
1430	2828081	17418824	2007-08-25 21:07	mutant Cyt1Ca caused instant arrest in biomass growth and decreased viability upon expression in Escherichia coli [Cyt1Ca]
1430	2828081	17682820	2008-01-12 11:12	purification and characterization of a novel leucine aminopeptidase; study shows that when it acts synergistically with endogenous proteases, it has only a minor role in the processing of Cyt1Aa into an active toxin [leucine aminopeptidase]
1430	5759849	17672866	2008-02-16 11:37	Cyt1Aa interacts with Cry11Aa and Cyt1Aa synergizes or suppresses resistance to Cry11Aa, by providing a binding site for Cry11Aa that will result in an efficient formation of Cry11Aa pre-pore that inserts into membranes and forms ionic pores.
1430	5759849	17927913	2008-01-12 12:50	In vitro binding analysis to both histological midgut tissue sections and brush border membrane proteins revealed that the isolated cry11AA (Cry4Ba)-domain II-III protein showed binding functionality comparable to the 65-kDa full-length active toxin.
1430	5759849	18223107	2008-07-26 10:06	The analysis of binding and pore formation in different midgut regions could be an effective method to study differences in the mode of action of Cry1Ac (Cry11Aa) toxin in different species.
1430	5759908	17672866	2008-02-16 11:37	Cyt1Aa interacts with Cry11Aa and Cyt1Aa synergizes or suppresses resistance to Cry11Aa, by providing a binding site for Cry11Aa that will result in an efficient formation of Cry11Aa pre-pore that inserts into membranes and forms ionic pores.
1430	5759927	18198178	2008-05-24 10:06	TubZ polymers have a capping mechanism that may be related to the GTP cap that produces dynamic instability of microtubules
1436	3293184	16885329	2007-08-25 13:31	Two novel crystal protein genes, cry30Ba and cry44Aa, were cloned and expressed in an acrystalliferous strain. Cry44Aa crystals were highly toxic to second-instar Culex pipiens pallens and Aedes aegypti. [Cry44Aa1, Cry30Ba]
1488	2828087	16927339	2007-08-25 10:12	Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum reveals a catalytic domain fold with a novel active site (ComB).
1488	2828087	17706598	2007-10-27 12:10	CYP152A2 is a fatty acid alpha-hydroxylase [CYP152A2]
1491	5220343	18084087	2008-02-02 10:18	crystral structure of HA3 [HA3]
1491	5220343	18093612	2008-04-05 10:19	Developed sandwich enzyme immunoassay to accurately quantify neurotoxin A, whatever the neurotoxin form.
1491	5220343	18242046	2008-07-19 10:11	The binding sites for gangliosides and phosphatidylethanolamine were identified in BoNT/C and BoNT/D. [BoNT/C, BoNT/D]
1491	5220343	18323610	2008-05-03 10:27	structure of the enzyme will help guide the design of novel therapeutics against the C. botulinum pathogen[dihydrodipicolinate synthase ]
1491	5220343	18369192	2008-05-24 10:05	Seven wild-type and ARTT loop-mutant structures of C3 exoenzyme of Clostridium botulinum free and bound to its true substrate, NAD, were presented. (C3 exoenzyme)
1496	2828089	15383161	2007-08-25 13:12	CdeA is the first multidrug efflux transporter of the MATE family identified in C. difficile
1496	2828089	15844079	2007-08-25 14:17	The isolation of C. difficile strains carrying the erythromycin ribosomal methylase B (ermB) genes in a teaching hospital is reported.[ermB]
1496	2828089	16054646	2007-08-25 11:26	structural analyisis of Clostridium difficile toxin B [tcdB]
1496	2828089	16157585	2007-08-25 10:56	The sugar donor specificity of C. difficile toxin B by site-directed mutagenesis is reported [toxin B]
1496	2828089	16344467	2007-08-25 13:02	determined a 1.85-A resolution crystal structure of a 127-aa fragment from the C terminus of the toxin A terminal repetitive domain [toxin A]
1496	2828089	16622409	2007-08-25 21:01	2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA[TcdA]
1496	2828089	16672625	2007-08-25 10:15	Gene is part of the pathogenicity locus, which also includes tcdC, a putative negative regulator of the toxin genes(TcdC protein)
1496	2828089	17027189	2007-08-25 15:03	Sensitivity and specificity examination of feces and isolates for toxin A and toxin B.[Clostrdium difficile toxins A AND B]
1496	2828089	17035492	2007-08-25 12:26	This result suggests that severe truncation of TcdC is responsible for the increased toxin production observed in strains belonging to the BI/NAP1 epidemic clone and that the 18-bp deletion is probably irrelevant to TcdC function [TcdC]
1496	2828089	17334356	2007-08-25 15:03	toxin B uses eukaryotic signals for induced autoproteolysis to deliver its toxic domain into the cytosol of target cells [toxin B]
1496	2828089	17639289	2008-03-15 12:56	In Clostridium difficile toxin A-induced enteritis Ras/MAPK cascade acts as the upstream signaling for AP-1 activation and IL-8 expression.
1496	2828089	17693508	2007-12-01 11:31	Cwp84 is a cysteine protease with degrading activity on fibronectin, laminin, and vitronectin, which was neutralized by the E64 inhibitor and specific antibodies.
1496	2828089	18070963	2008-05-03 10:57	In this study, the tet(W) gene region of a human clinical isolate of Clostridium difficile resistant to tetracycline was characterized. [tet(W)]
1496	2828089	18411291	2008-07-12 10:16	Human colonocyte gp96 serves as a plasma membrane binding protein that enhances cellular entry of TxA, participates in cellular signaling events in the inflammatory cascade, and facilitates cytotoxicity. {TxA]
1496	2828089	18435932	2008-07-12 10:42	Clostridium difficile (VP10463) toxin B interacts with high affinity with alpha-defensins. Defensins may provide a defense mechanism against some types of clostridial glucosylating cytotoxins.
1502	3897013	18078439	2008-05-03 10:03	These results indicate that CPB is both required and sufficient for type C disease isolate CN3685-induced enteric pathology, supporting a key role for this toxin in type C intestinal pathogenesis.
1502	6383107	18487333	2008-08-09 10:30	The results provide evidence that TcpH is located in the cell membrane, where it oligomerizes and interacts with TcpC to form part of the mating-pair formation complex, which is located at the cell poles and is closely associated with TcpF.
1513	2828093	17056064	2007-08-25 10:46	investigation of the oligomerisation of the receptor binding domain (H(C)) of tetanus toxin; possible mechanism for H(C) oligomerisation is proposed and discussion of how this may relate to toxicity [tetanus toxin]
1515	4835962	18084089	2008-02-02 10:18	the crystallization of CBM3b from cellobiohydrolase 9A is reported [CBM3b]
1515	4835962	18436237	2008-06-07 10:18	The crystal structure and biochemical properties of the N-terminal catalytic module (CtCes3-1) of CtCes3 is reported.
1520	5329690	18355044	2008-05-31 10:29	The one-electron reduction (E sq/hq for FMNH (*)/FMNH (-)) difference can be best explained by the lower compensation of the side chain influence by the backbone influence in the D. vulgaris flavodoxin than in the C. beijerinckii flavodoxin (flavodoxin).
1525	3925423	17937620	2008-01-05 15:44	SelA forms a homodecamer that has a ring-like structure with five bilobed wings, similar to the structure of the E. coli complex determined previously (SelA).
1525	3925423	18323607	2008-05-03 10:27	selenium substructure was solved using SHELX [RsbS]
1534	5183129	18323662	2008-05-10 10:13	showed NADH/NADPH diaphorase activity with 2,6-dichlorophenolindophenol and nitro blue tetrazolium; contained a tightly bound FMN molecule as a prosthetic group; an iron molecule was also detected[DiaA]
1579	2828097	15527978	2007-08-25 22:21	CdpA protein plays a role in cell-wall processing during the growth and cell-cell separation. [CdpA]
1579	2828097	17227458	2007-08-25 21:20	The genes encoding a heterodimeric enzyme, lacL and lacM, were cloned, and compared with other beta-galactosidases from lactobacilli (lacL and lacM).
1580	3759998	16842346	2007-08-25 13:31	These data suggest that L. brevis may interact with host cells directly through high affinity interactions with laminin and fibronectin predominantly, involving distinct regions of the SlpA protein. [SlpA]
1580	3759998	18323645	2008-05-10 10:13	catalyzed the reaction from 5'-hydroxyaverantin to 5'-oxoaverantin;the enzyme was cloned and sequenced [Lac-HAVN dehydrogenase]
1580	3759998	18460820	2008-08-02 10:40	the glutamate decarboxylase (GAD) gene from Lactobacillus brevis IFO12005 was cloned and expressed [glutamate decarboxylase]
1582	3293186	17693714	2007-12-01 10:46	findings strongly suggested a direct interaction of HPr or one of its phospho-derivatives with CspA and/or another, hitherto undetected cold shock protein in L. casei cold shock response [CspA]
1582	3293186	18232714	2008-05-10 10:32	mutagenesis study to identify structural elements of folylpolyglutamate synthetase that are directly responsible for the functional differences between the E. coli and the Lactobacillus casei enzymes [folylpolyglutamate synthetase]
1587	2828101	16125908	2007-08-25 15:04	UvrA contributes to acid and oxidative tolerance and possibly plays a role in survival at low pH under normal conditions [UvrA]
1590	2828103	15864550	2007-08-25 13:40	the ccl gene was co-transcribed with the arginine-repressed citrulline biosynthetic gene cluster; ccl gene is not essential [ccl]
1590	2828103	17056693	2007-08-25 11:49	The immunity protein of plantaricin 423 contains 109 amino acids and occurs within the putative operon containing plantaricin 423 encoded by plasmid pPLA4. [Plantaricin 423 immunity protein plaB]
1598	2828105	15691956	2007-08-25 12:38	role of Lsp and MsrB in the maintenance of these bacteria in gut ecosystems [Lsp, MsrB]
1598	2828105	15710400	2007-08-25 10:23	Ca2+ ions play an important structural role in the Lactobacillus reuteri 121 levansucrase (Lev) and inulosucrase (Inu) enzymes [Lev & Inu]
1598	2828105	15966745	2007-08-25 10:22	glucosidic linkage specificity was also observed in the oligosaccharide products synthesized by the different mutant reuteransucrase enzymes from (iso)maltose and sucrose [reuteransucrase]
1598	2828105	16911522	2007-08-25 14:06	Asn1134 is the main determinant of glucosidic bond product specificity in this reuteransucrase; mutations at this position greatly influenced the hydrolysis/transglycosylation ratio[reuteransucrase]
1599	2828107	15758227	2007-08-25 11:10	DNA-binding site of LasX identified in the lactocin S promoter region. [LasX]
1613	2828109	18487606	2008-09-06 10:24	"adaptation" of the nucleoside 2'-deoxyribosyltransferase activity to 2,3-dideoxyribosyl transfer requires an additional hydroxyl group on a key amino acid side chain of the protein [nucleoside 2'-deoxyribosyltransferase ]
1639	2828111	15528535	2007-08-25 15:02	SecA2 expression upregulated in the rough and revertant backgrounds compared to the parental smooth colony isolate
1639	2828111	15528669	2007-08-25 12:06	concluded that sigma(B) is essential for rapid induction of the tested stress-response and virulence genes under conditions typically encountered during gastrointestinal passage [sigma B; strain 10403S]
1639	2828111	15661014	2007-08-25 12:56	experiments demonstrated that iron availability regulates the svpA-srtB locus mediated by Fur [SvpA, SrtB]
1639	2828111	15699210	2007-08-25 13:11	transcription enhanced by Bkd substrates, but not by low temperature; this implies that Bkd is not the major cold-regulation point of BCFA synthesis. [Bkd (branched chain alpha keto acid dehydrogenase)]
1639	2828111	15845524	2007-08-25 14:24	mutant carrying a deletion in the ortholog of the Bacillus subtilis response regulator gene degU showed a clearly reduced virulence in mice, indicating that DegU is involved in the regulation of virulence-associated genes[DegU]
1639	2828111	15932974	2007-08-25 11:30	glutamate decarboxylase has a major role in the growth of Listeria monocytogenes at mildly acidic pHs (pH 5.1) [GadD1, glutamate decarboxylase]
1639	2828111	16102013	2007-08-25 11:26	hly 5' UTR plays a critical role in regulating expression of listeriolysin O during intracellular infection (hly).
1639	2828111	16113338	2007-08-25 21:18	ESAT-6 like protein is not required for Listeria virulence [ESAT-6 like protein]
1639	2828111	16118276	2007-08-25 11:25	Listeria monocytogenes phosphatidylinositol-specific phospholipase C has evolved as an important determinant of L. monocytogenes pathogenesis by absence of the beta-strand [phosphatidylinositol-specific phospholipase C ]
1639	2828111	16177371	2007-08-25 21:14	InlJ was identified as a new virulence factor among the proteins belonging to the internalin family in L. monocytogenes.(InlJ)
1639	2828111	16207905	2007-08-25 21:05	critical role for sigmaB in L. monocytogenes invasion into non-phagocytic cells, primarily mediated through control of inlA and inlB expression. [SigB]
1639	2828111	16213668	2007-08-25 12:35	findings show that the two L. monocytogenes operons encoding flagella-specific genes and the monocistronically transcribed flaA gene are positively regulated by DegU at 24 degrees C, but are not expressed at 37 degrees C [DegU]
1639	2828111	16237008	2007-08-25 11:24	findings show that lmo0422 is the actual thermal resistance regulator or effector while sigC provides a mechanism for temperature-dependent transcription of lmo0422 from P1 promoter [lmo0422, sigmaC]
1639	2828111	16352834	2007-08-25 14:42	CcpC interacts with the promoter regions of citB(Lm) (the gene that is likely to encode aconitase) and lmo0847 (encoding a possible glutamine transporter) and that citrate is a specific inhibitor of this interaction [CcpC]
1639	2828111	16391652	2007-08-25 11:23	Listeriolysin O (LLO) and phosphatidylinositol-specific phospholipase C(PI-PLC)enhance bacterial binding to epithelial cells Int407, with LLO being necessary and PI-PLC playing an accessory role.  [LLO][PI-PLC]
1639	2828111	16428730	2007-08-25 14:12	plays a critical role during the gastrointestinal stage of listeriosis in the guinea pig but is not important for systemic spread of the organism. [sigma b]
1639	2828111	16430699	2007-08-25 21:27	ActA accumulated more efficiently at younger, less inert poles, and proper polarization required an optimal balance between protein secretion and bacterial growth rates.
1639	2828111	16445760	2007-08-25 13:37	ActA allelic variation may contribute to reduced plaque size, ActA sequence alone determines phosphorylation, and sequence variation at ActA residue 498 does not contribute to ActA phosphorylation patterns or to differences in cell-to-cell spread. [ActA]
1639	2828111	16451184	2007-08-25 10:19	findings show in the LO28 strain, that the expression of MdrL is repressed at the transcriptional level, under standard growth conditions, by the product of a new gene ladR (lmo1408)[LadR, MdrL]
1639	2828111	16461909	2007-08-25 12:33	Oerproduced PrfA may strongly influence the synthesis of some amino acids, notably that of the branched amino acids. (PrfA)
1639	2828111	16499624	2007-08-25 10:17	Listeria adhesion protein (LAP) is identified as an acetaldehyde dehydrogenase homologue and its adhesion function to eukaryotic cells is confirmed in a recombinant E. coli strain; interaction of LAP to its receptor, Hsp60, is very specific [LAP]
1639	2828111	16681150	2007-08-25 10:52	p60 decreases hemolytic activity of listeriolysin, promotes adhesion and subsequent invasion of macrophages. [p60 protein]
1639	2828111	16735745	2007-08-25 13:33	SgB is primarily activated during environmental stress and the partially sigmaB-dependent P2prfA promoter region contributes the majority of prfA transcripts in both intra- and extracellular bacteria.[SigB, prfA]
1639	2828111	16838328	2007-08-25 14:07	crystal Listeria monocytogenes PGPase at 1.8 A resolution forms a homotetramer.  Each protomer contains an active site with Ca(2+) & Mg(2+) forming a hetero-binuclear center located in a hydrophilic cavity near surface[phosphatidylglycerophosphatase]
1639	2828111	16859495	2007-08-25 10:49	The data demonstrate that translational regulation of listeriolysin O is critical for L. monocytogenes pathogenesis.[LLO]
1639	2828111	16968229	2007-08-25 14:06	ResD is a central regulator of L. monocytogenes when present in the external environment. (ResD)
1639	2828111	17128979	2007-08-25 12:25	in L. monocytogenes HMG-CoA reductase histidine 143 and methionine 186 are present in the putative NAD(P)(H)-selective site[HMG-CoA reductase]
1639	2828111	17186524	2007-08-25 21:16	salt-bridge between Lys 114 and Asp 126 characteristic of L. innocua Dps is most likely abolished due to protonation of Asp 126[Dps]
1639	2828111	17222191	2007-08-25 15:03	role of listeriolysin O and the bacterial phospholipases PI-PLC and PC-PLC in cell-to-cell spread of L.monocytogenes[LLO, PI-PLC, PC-PLC]
1639	2828111	17244189	2007-12-15 10:51	induction of memory CD8+ T cells mediating long-term antibacterial protective immunity is dependent upon SecA2 expression inside the cytosol of host cells in vivo [SecA2]
1639	2828111	17419718	2008-02-16 12:59	LLO-induced release of Ca(2+) from intracellular stores occurs via at least two mechanisms: (i) activation of intracellular Ca(2+) channels and (ii) a Ca(2+) channels independent mechanism.
1639	2828111	17452473	2007-08-25 10:42	In vitro binding assays show that SH2-Bbeta binds ActA but not VASP; however, binding to ActA is greater in the presence of VASP.  VASP binds ActA at the surfaces of Listeria cells and enhances bacterial actin based motility. [ActA]
1639	2828111	17660431	2007-12-01 11:04	DNA sequencing of inlA for 40 L. monocytogenes isolates revealed 107 synonymous and 45 nonsynonymous substitutions. [inlA]
1639	2828111	17666069	2007-12-29 11:59	Complementation of mutant cs1 with a wild-type copy of lmo1078 restored its ability to grow at low temperature and high salt concentration, indicating that UDP-glucose pyrophosphorylase activity is important for cold and salt tolerance.(lmo1078)
1639	2828111	17715295	2007-10-20 11:07	Analysis of interface with E-cadherin to identify single amino acid substitutions in InlA that would potentially improve the overall quality of interaction and hence increase the weak binding affinity of the complex {In1A]
1639	2828111	17933929	2008-01-26 10:18	data demonstrate that interactions between CtsR and B play an important role in L. monocytogenes stress resistance and virulence.[SigB and CtsR in strain 10403S]
1639	2828111	17965207	2008-01-26 11:11	Data suggest that HrcA and sigma(B), as well as CtsR, form a regulatory network that contributes to the transcription of a number of L. monocytogenes genes.[HrcA, sigma B]
1639	2828111	18065622	2008-03-10 13:38	Proteomic and physiological data revealed the involvement of sigmaB in glycerol metabolism. [sigmaB]
1639	2828111	18202661	2008-03-10 13:37	studies reveal a role for LLO in promoting L. monocytogenes replication in vacuoles and suggest a mechanism by which this pathogen can establish persistent infection in host macrophages [Listeriolysin O]
1639	2828111	18226246	2008-03-15 12:51	Results detected 105 sigmaB-positively regulated genes and 111 genes which appeared to be under negative control of sigmaB and validated 36 sigmaB-positively regulated genes in vivo using a reporter gene fusion system: sigmaB
1639	2828111	18227172	2008-04-19 13:10	InlJ acts as a novel L. monocytogenes sortase-anchored adhesin specifically expressed during infection in vivo.[InlJ]
1639	2828111	18228097	2008-07-12 10:06	study provides the first experimental evidence that InlA and InlC2 are the in vivo induced or upregulated antigens for humoral immune responses that are common to listerial infection of various host species [In1A and In1C2]
1639	2828111	18262542	2008-03-29 13:04	four Ig domains form a bent, rather than a fully extended, conformation, and InlB(321) binds to Sema and the first Ig domain of Met[ InlB]
1639	2828111	18331468	2008-06-07 10:18	Inhibition of ROCK activity in human cell lines enhanced bacterial adhesion and entry in an InlF-independent manner,suggesting a host species or cell type-specific role for InlF. [InlF]
1639	2828111	18343406	2008-05-17 10:07	The crystal structure of the internalin domain of InlJ, a virulence-associated surface protein of Listeria monocytogenes, at 2.7-A resolution, was reported.
1639	2828111	18456805	2008-09-06 10:24	Data show that two-component system CesRK controls the transcription of several cell envelope-related genes and this may be viewed as an attempt by L. monocytogenes to protect itself against cell wall-acting antibiotics: [CesRK: cesR and cesK]
1639	2828111	18559424	2008-10-04 10:39	The glcV mutant was attenuated when it was inoculated orally into female A/J mice and failed to replicate efficiently in cultured mouse enterocytes.[glcV in strain F6214-1]
1639	2828111	18599819	2008-09-20 10:42	IspC is not important for cell division or separation but is essential for full virulence of L. monocytogenes in vivo. [IspC]
1642	2828113	17186524	2007-08-25 21:16	salt-bridge between Lys 114 and Asp 126 characteristic of L. innocua Dps is most likely abolished due to protonation of Asp 126[Dps]
1642	2828113	17616620	2007-10-27 12:55	The phosphotransferase system regulation domain (PRD)-containing activator, ManR, is required for glucose-controlled transcription of the mannose permease two (mpt) operon in Listeria innocua. [ManR]
1661	2828117	17906137	2007-12-01 11:24	this study we found that CbpA bound to almost all the collagen types tested but not to other proteins, and it displayed a propensity to interact with several collagenous peptides derived by CNBr cleavage of type I and II collagens.[CbpA]
1685	2828119	16321946	2007-08-25 11:59	findings show that ClgR, which in its purified form appears to exist as a dimer, requires a proteinaceous cofactor to assist in specific binding to a 30-bp region of the clpP promoter region [ClgR]
1685	2828119	17098914	2007-08-25 13:27	fndings suggest that the EII encoded by fruA is involved in fructose transport and that its expression is controlled by an antiterminator mechanism; biochemical studies demonstrated that FruA phosphorylates fructose at the C-6 position [FruA]
1685	2828119	17159201	2007-08-25 14:02	Cells co-expressing both abcA and abcB exhibited enhanced resistance levels to the antimicrobials nisin and polymyxin B. Furthermore, the drug extrusion activity in membrane vesicles was increased when both proteins were co-expressed [AbcA, AbcB]
1717	2828123	15667993	2007-08-25 14:16	The third domain of DtxR contains immunodominant epitopes and is required for full repressor activity in an Escherichia coli reporter system, but it is not required for binding to DNA in vitro. [DtxR]
1717	2828123	16239540	2007-08-25 10:21	low but significant levels of heme-specific transcriptional activity were observed at the hmuO promoter in the chrAS mutants, suggesting that an additional heme-dependent activator is involved in hmuO expression [hmuO & chrA & chrS]
1717	2828123	16352732	2007-08-25 14:42	binding site 1 (ancillary) is the first one to be occupied during metal ion activation, playing a critical role in stabilization of the diphtheria toxin repressor
1717	2828123	16585757	2007-08-25 14:11	transcription of dtxR and the sigB and galE genes located immediately upstream & downstream from dtxR; transcription at the dtxR locus is affected by environmental factors; dtxR can be cotranscribed with the genes that surround it [dtxR, sigB, galE]
1717	2828123	17353293	2007-08-25 12:21	ChrA-ChrS and HrrA-HrrS regulatory systems are critical for full hemoglobin-dependent activation at the hmuO promoter and are involved in the complex mechanism of the regulation of heme homeostasis. [HmuO]
1718	2828125	16040600	2007-08-25 14:15	Cg-emb deletion in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan core [emb; ubiA]
1718	2828125	16522631	2007-08-25 10:18	protein kinase G controls 2-oxoglutarate dehydrogenase activity via the phosphorylation status of the OdhI protein [OdhI]
1718	2828125	16901339	2007-08-25 10:49	cg0910 encodes the hitherto unknown essential L-histidinol-phosphate phosphatase (EC 3.1.3.15) in C. glutamicum. The identification of the hisN gene closed the last gap in histidine synthesis in the Actinobacteria. hisN.
1718	2828125	16912897	2007-08-25 21:08	For bacillibactin, neither chirality nor presence of an amino acid spacer affects the uptake and transport process, but alteration of the net charge and size of the molecule impedes the recognition.(Siderophore of C. glutamicum ATCC 14607)
1718	2828125	17293417	2007-08-25 11:47	in proteoliposomes, MtrB activity was stimulated by monovalent cations used by many osmosensors for the detection of hypertonicity.[MtrB]
1718	2828125	17308303	2007-08-25 10:43	NCgl2385 is essential for the production of mature trehalose mycolates and subsequent covalent attachment of mycolic acids onto the cell wall[NCgl2385]
1718	2828125	17350037	2007-08-25 14:00	The crystal structure of the regulatory subunit of aspartate kinase (AK) from Corynebacterium glutamicum at 1.58 A resolution in the Thr-binding form, is determined.[alpha2beta2-Aspartate kinase]
1718	2828125	17496102	2008-01-19 12:03	Results support the in vivo relevance of the PhoR-binding site within the phoRS promoter [RhoR]
1718	2828125	17693491	2007-12-01 11:31	Transport by PnuX was not energy dependent and had high apparent affinity for riboflavin (K(m) 11 microM).[PnuX]
1718	2828125	17714444	2007-12-08 12:43	These studies have identified a new mannosyltransferase, MptA, and they shed further light on the biosynthesis of lipomannan (LM) and lipoarabinomannan (LAM)in Corynebacterianeae.[MptA]
1718	2828125	18007046	2007-12-22 10:18	The crystal belongs to hexagonal space group P6(3)22, with unit-cell parameters a = b = 94.72, c = 359.68 A, gamma = 120 degrees. The asymmetric unit contains 2 molecules, corresponding to packing density of 2.65 A(3) Da(-1)[p-hydroxybenzoate hydroxylase]
1718	2828125	18051605	2008-02-02 11:09	these data suggest that cspA, cspB, and cspA2 perform functions related to cold shock as well as normal cellular physiology.[cspA, cspB, cspA2]
1718	2828125	18178556	2008-05-24 10:35	PimB is a new mannosyltransferase required for the synthesis of phosphatidylinositol mannosides and lipoarbinomannan [PimB]
1718	2828125	18234538	2008-08-02 10:27	The protein crystallizes in space group P2(1) with four molecules per asymmetric unit, which pack as 2 dimers[GTP-dependent PEP-carboxykinase]
1718	2828125	18296522	2008-05-17 10:24	DivIVA is required for cell elongation and the acquisition of a rod shape. (DivIVA)
1718	2828125	18310037	2008-05-03 10:57	The sigE and cseE genes were transcribed into a single transcript, and gene transcription was stimulated by heat; the SigE and CseE proteins interacted physically in vitro.[SigE and CseE in strain AS019]
1718	2828125	18355281	2008-06-14 10:34	The transcriptional regulators RamA, RamB and GlxR bind to the promoter region of the resuscitation promoting factor 2 (rpf2) gene.[RamA, RamB, GlxR, Rpf2]
1718	2828125	18566515	2008-09-06 10:34	The crystal structure of quinate dehydrogenase is presented that clearly prefers NAD+ as a cosubstrate and that demonstrates a higher catalytic efficiency for quinate rather than shikimate (quinate dehydrogenase).
1764	2828133	15908099	2007-08-25 11:30	Ma1120 is expressed to high levels as a functional adenylyl cyclase; maximally active in the presence of MnATP as substrate [Ma1120]
1764	2828133	16544254	2007-08-25 12:32	fadD2 is a regulator of M. avium invasion, and its effect is through Cdc42 [fadD2]
1764	2828133	17526707	2007-09-15 11:08	These results indicate that the fucosylation pathway in GPL biosynthesis is controlled by a combination of the mdhtA, merA, and gtfD genes.[mdhtA, merA, gtfD]
1764	2828133	18461657	2008-08-23 10:38	Demonstrate correlation between rpoB gene mutation in Mycobacterium avium subspecies paratuberculosis and clinical rifabutin and rifampicin resistance for treatment of Crohn's disease.
1765	2828135	15699203	2007-08-25 13:11	Point mutations in the DNA- and cNMP-binding domains of the homologue of the cAMP receptor protein (CRP) in Mycobacterium bovis BCG imply inactivation of a global regulator and strain attenuation [Rv3676]
1765	2828135	15882422	2007-08-25 11:05	data demonstrate that a mutation of sigK is responsible for decreased expression of MPB70 and MPB83 in low-producing BCG strains and provide clues into the role of Mycobacterium tuberculosis SigK [MPB70, MPB83, sigK]
1765	2828135	16533994	2007-08-25 21:03	an IS6110 insertion site in plcD [plcD]
1765	2828135	16828326	2007-08-25 14:08	These results suggest that the product of the sa5k gene (SA5K protein) has a role in both resistance of BCG to intracellular stress and in its adaptation to hypoxia.
1765	2828135	17252234	2007-08-25 13:25	results suggest that the Rv0679c protein exists as a tight complex with Lipoarabinomannan in M. tuberculosis/M. bovis BCG [Rv0679c]
1765	2828135	17652161	2007-12-01 11:34	These findings provide further support for the relevance of the LpdC-coronin-1 interaction in phagosome maturation arrest.[LpdC]
1765	2828135	18039558	2008-03-15 12:52	GnRH3-hinge-MVP peptide conjugated to heat shock protein 65 (hsp65, M.bovis) may be an efficacious vaccine against prostate cancer.
1765	2828135	18362135	2008-07-12 10:06	study determined that all BCG strains were defective for the induction of two dormancy genes: narK2 (Rv1737c) and narX (Rv1736c)[narK2, narX]
1765	2828135	18371202	2008-05-24 10:05	In M. bovis BCG, mRNA-parA levels decreased between the exponential and stationary phases and parB expression was higher than parA expression and remained unchanged along the growth curve.[ParA, ParB]
1765	2828135	18544159	2008-08-02 10:35	The MDP1 protein has a major impact on various growth characteristics of M. bovis BCG. [MDP1]
1769	2828137	15755201	2007-08-25 12:37	missense mutation at codon 516 in rpoB confers rifampin resistance [RpoB]
1769	2828137	15845477	2007-08-25 21:13	new immunomodulating protein identified in terms of activation of antigen-presenting cells and innate immunity [major membrane protein II, MMP-II]
1769	2828137	15919224	2007-08-25 11:06	observations reinforce the involvement of Hlp/LBP as an adhesin in mycobacterial infections and define its highly positive C-terminal region as the major adhesive domain of this protein [HLP/LBP]
1769	2828137	18070975	2008-05-03 10:57	We demonstrated that the gyrA mutations leading to G89C or A91V confer fluoroquinolone resistance whereas the gyrB mutation leading to D205N does not. [gyrA, gyrB]
1769	2828137	18544337	2008-08-02 10:35	Mycobacterium leprae trHbO could be involved in both H2O2 and (.)NO scavenging, protecting from nitrosative and oxidative stress, and sustaining mycobacterial respiration.
1772	4555927	17015450	2007-08-25 10:48	analysis of Asp75, Asp78, and Glu83 in GTP-dependent phosphoenolpyruvate carboxykinase from Mycobacterium smegmatis [PEPCK]
1772	4555927	17637345	2007-10-06 12:39	report the biochemical characterization and the atomic resolution structures of a soluble PPM phosphatase in complex with different ligands
1772	4555927	18083811	2008-07-12 10:16	Study proposed a model in which the transcription of pstSCAB is controlled by the two-component SenX3-RegX3 system, while phnDCE and phnF are subject to dual control by SenX3-RegX3 and Phn [PhnF]
1772	4555927	18156250	2008-05-17 10:07	Data show both ethidium bromide transport and normal cell surface properties require functional P55 and LprG, and that P55 requires the cell surface lipoprotein for normal function. New Gene: P55
1772	4555927	18373355	2008-06-14 10:24	positional isotope exchange analysis confirms that MshC catalyzes the formation of a kinetically competent cysteinyl-adenylate intermediate after the addition of ATP and cysteine [MshC]
1773	2828139	15159590	2007-08-25 11:07	X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis [alpha-IPMS]
1773	2828139	15557808	2007-08-25 11:10	NMR secondary structure determination of the 195-residue complex formed by the Mycobacterium tuberculosis proteins CFP-10 and ESAT-6 [CFP-10 & ESAT-6]
1773	2828139	15629142	2007-08-25 12:55	crystal structure of NAD kinase-NAD complex [NAD kinase]
1773	2828139	15659170	2007-08-25 10:59	Mpa is an ATPase whose enzymatic activity is necessary but not sufficient to protect against reactive nitrogen intermediates. [Mpa]
1773	2828139	15663922	2007-08-25 22:21	crystal structure of LeuB
1773	2828139	15701515	2007-08-25 21:09	crystal structure of AhpE, determined at 1.87 A resolution (R(cryst)=0.179, R(free)=0.210), reveals a compact single-domain protein with a thioredoxin fold [AhpE]
1773	2828139	15753209	2007-08-25 12:03	remnant mycobacterial catalase-peroxidase is one target of the adaptive immune response driving granulomatous inflammation in sarcoidosis [katG= catalase-peroxidase]
1773	2828139	15843027	2007-08-25 10:58	structure of the Mycobacterium tuberculosis UDP-galactopyranose mutase with FAD determined[UDP-galactopyranose mutase]
1773	2828139	15936994	2007-08-25 10:22	the putative movement of the alpha-helical sub-domain relative to the core sub-domain, until now only inferred from X-ray structures and modeling of PstB, is indeed a physiological phenomenon and is nucleotide dependent [PstB]
1773	2828139	15966722	2007-08-25 10:22	structural and functional analysis of CmtR [CmtR]
1773	2828139	16202156	2007-08-25 21:05	study demonstrates the presence of moaA3 gene, that is absent in M. tuberculosis H37Rv and H37Ra, in a large number of isolates from Kerala, India
1773	2828139	16262264	2007-08-25 14:42	Data describe the iron-sulfur cluster and its role in the mechanism of Mycobacterium tuberculosis APS reductase [APS reductase].
1773	2828139	16277343	2007-08-25 14:14	lumazine synthase is involved in the biosynthesis of riboflavin; an inhibitor would would Mycobacterium tuberculosis.(Lumazine synthase)
1773	2828139	16326705	2007-08-25 14:42	The structure of the ternary complex of mycothiol synthase with bound desacetylmycothiol and CoA was determined to 1.8 A resolution [shD, mycothiol synthase]
1773	2828139	16499927	2007-08-25 10:17	Results report the high-resolution crystal structure of the secreted dimeric chorismate mutase from Mycobacterium tuberculosis [chorismsate mutase].
1773	2828139	16511148	2007-08-25 11:57	preliminary crystallographic structure to 2.15 A resolution [EntD]
1773	2828139	16582482	2007-08-25 13:34	The crystal structure of the N-terminal domain of FadD28 at 2.35 angstroms resolution has been solved. (Fadd28)
1773	2828139	16595677	2007-08-25 13:58	identification and characterization of a novel arabinofuranosyltransferase AftA. The enzyme catalyzes the addition of the first key arabinofuranosyl residue from a sugar donor to the galactan domain of the cell wall [AftA protein]
1773	2828139	16672613	2007-08-25 10:15	Structure of the predicted protein encoded by open reading frame Rv3214 from the Mycobacterium tuberculosis, a phosphatase.
1773	2828139	16682410	2007-08-25 12:30	catalysis and struscture of this enzyme (thioredoxin peroxidase)
1773	2828139	16688782	2007-08-25 13:34	trHbN has evolved a dual-path mechanism for migration of O2 and NO to the heme, to achieve the most efficient NO detoxification [hemoglobin N]
1773	2828139	16769720	2007-08-25 10:50	Spectroscopic and kinetic studies of Mycobacterium tuberculosis 7-keto-8-aminopelargonic acid synthase
1773	2828139	16817899	2007-08-25 21:27	Here we show that Mstp, a mycobacterial Ser/Thr phosphatase, antagonizes Ser/Thr protein kinase-EmbR signaling by dephosphorylating Ser/Thr protein kinases, as well as EmbR, in vitro (Mstp).
1773	2828139	16834327	2007-08-25 15:04	Three crystal structures of shikimate kinase (SK) from Mycobacterium tuberculosis (MtSK), including apo-MtSK, a binary complex MtSK x SA, and the ternary complex of MtSK with SA and an ATP analogue, AMPPCP were presented. (shikimate kinase)
1773	2828139	16880544	2007-08-25 10:49	Rv2074 may be involved in the final step in the biosynthesis of pyridoxal 5'-phosphate (PLP; a vitamin B6). (Rv2074)
1773	2828139	16880560	2007-08-25 10:49	expressed in Escherichia coli, purified using standard chromatographic techniques and crystallized in two related crystal forms. (DapC--RV0858c)
1773	2828139	16885468	2007-08-25 13:31	Mycobacterium tuberculosis protein Rv2302 (80 residues; molecular mass of 8.6 kDa) has been characterized using nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopy [Rv2302]
1773	2828139	16885473	2007-08-25 13:31	Rv2719c is DNA damage inducible independently of RecA [Rv2719c]
1773	2828139	17020913	2007-08-25 21:26	MurI binds to GyrA subunit and this interaction prevents gyrase from accessing the DNA substrate, thereby inhibiting all its catalytic reactions (MurI).
1773	2828139	17140384	2007-08-25 21:26	Equilibrium denaturation of streptomycin adenylyltransferase (SMATase) has been studied by CD spectroscopy, fluorescence emission spectroscopy, and binding of the hydrophobic dye 1-anilino-8-naphthalene sulfonic acid.
1773	2828139	17143269	2007-08-25 14:03	We identify a new copper-specific repressor(CsoR) of a copper-sensitive operon(cso)in Mycobacterium tuberculosis representative of a large previously uncharacterized family of proteins(DUF156). Potential roles of CsoR in pathogenesis are discussed.[CsoR]
1773	2828139	17374883	2007-08-25 13:24	The vaccine potential of an M. tuberculosis strain with a mutation at cysH is reported.[cysH]
1773	2828139	17428787	2007-08-25 15:03	MT2282 (Rv2224c) and its adjacent paralogous gene MT2281 (Rv2223c) are named caeA and caeB respectively, for carboxylesterase A and B [caeA and caeB]
1773	2828139	17584180	2007-08-25 10:41	A combination of bioinformatics analysis, enzyme kinetics and substrate-specificity characterization revealed that MptpB exhibits both dual-specificity protein phosphatase activity and, importantly, phosphoinositide phosphatase activity.
1773	2828139	17599915	2007-12-01 10:16	analysis of cadmium sensing by winged helix repressor CmtR by NMR [CmtR]
1773	2828139	17657598	2007-12-01 10:15	Recombinant Mycobacterium tuberculosis antigen 85B was delivered to macrophages and elicited CD4 T-cell hybridoma activation.
1773	2828139	17714444	2007-12-08 12:43	These studies have identified a new mannosyltransferase, MptA, and they shed further light on the biosynthesis of lipomannan (LM) and lipoarabinomannan (LAM)in Corynebacterianeae.[MptA]
1773	2828139	18006503	2008-02-16 10:29	These data proved that despite their synteny and high similarity umaA and MSMEG0913 are not functionally orthologous.[UmaA]
1773	2828139	18031532	2008-03-10 16:16	These data indicate a role for PknF in biofilm formation, possibly associated with alterations in glycopeptidolipid composition.[PknF]
1773	2828139	18062777	2008-04-26 11:18	The three-dimensional structure of the enzyme dihydrodipicolinate synthase (KEGG entry Rv2753c, EC 4.2.1.52) from Mycobacterium tuberculosis (Mtb-DHDPS) was determined and refined at 2.28 A (1 A=0.1 nm) resolution. [dapA]
1773	2828139	18068389	2008-04-19 11:50	Therefore fadB4 is part of the family of genes whose expression serves to regulate the virulence of M. tuberculosis within the host.[fadB4 in strain MT103]
1773	2828139	18212020	2008-05-24 10:06	molecular dynamics (MD) simulation on the MscL of Mycobacterium tuberculosis embedded in a palmitoyloleoylphosphatidylethanolamine membrane [MscL]
1773	2828139	18266005	2008-06-20 12:32	The role of multinucleated giant cells may thus be different from epithelioid cells by virtue of higher MPT64, more TGF-beta, and reduced caspase 3 which may contribute towards persistence of infection [MPT64].
1773	2828139	18399868	2008-08-02 10:27	MTB12, in combination with 38-kDa Ag, can be used to increase the accuracy of pulmonary tuberculosis diagnosis [MTB12 and 38-kDa antigens].
1773	2828139	18420147	2008-06-28 10:22	Crystal structures of M. tuberculosis FabH (mtFabH) show the substrate binding site to be a buried, extended L-shaped channel with only a single solvent access portal. [FabH]
1773	2828139	18685700	2008-09-20 10:49	EspR (also known as Rv3849) is a key regulator of ESX-1 that is required for secretion and virulence in mice [EspR]
1833	2828141	18031290	2008-03-22 10:18	cloning and biochemical characterization [3-Keto-5alpha-steroid Delta(1)-dehydrogenase; kstD3]
1833	2828141	18183391	2008-05-10 10:22	A gene encoding a putrescine oxidase (PuORh, EC 1.4.3.10) was identified from the genome of Rhodococcus erythropolis NCIMB 11540.[PuORh]
1833	2828141	18192419	2008-04-05 12:59	Rhodococcus qsdA-encoded enzyme defines a novel class of large-spectrum quorum-quenching lactonases. [qsdA]
1833	2828141	18388476	2008-07-12 10:06	The amidase was found to exhibit a higher degree of activity when used with midchain substrates than with short-chain ones.[amidase]
1901	5332655	17729280	2008-04-19 12:46	mutational study of amino acids situated at 306 of deacetoxycephalsoporin C synthase has provided a better understanding of the significance of specific amino acid residues at this position which can improve its ring-expansion activity.
1901	5332655	17877708	2008-03-29 12:13	molecular characterization of the areB gene, encoding S. clavuligerus IclR-like protein, its binding to the cognate AREccaR sequence & its pleiotropic effects in S. clavuligerus, including leuCD expression & clavulanic acid & cephamycin C synthesis [AreB]
1902	2828143	15265863	2007-08-25 11:27	crystal structure of 1,3,6,8-tetrahydroxynaphthlene synthase (THNS) [THNS]
1902	2828143	15458634	2007-08-25 14:51	Crystall structure of polyketide ketoreductase (actIII) with its bound cofactor, NADP+, was determined (actIII).
1902	2828143	15615709	2007-08-25 11:17	the Streptomyces developmental protein WhiD, a member of the WhiB family, binds a [4Fe-4S] cluster
1902	2828143	15629939	2007-08-25 13:10	experiments demonstrated that AbsA1 possesses both kinase and phosphatase activities that are specific for AbsA2 [AbsA1, AbsA2 strain C530]
1902	2828143	15629942	2007-08-25 13:10	bldC encodes a member of a previously unrecognized family of small (58- to 78-residue) DNA-binding proteins, related to the DNA-binding domains of the MerR family of transcriptional activators. [bldC]
1902	2828143	15632111	2007-08-25 11:44	VanK has a role in vancomycin resistance in Streptomyces coelicolor
1902	2828143	15752610	2007-08-25 13:40	structure and thermal stability of the first protein (enzyme I, EI) of the PTS in Streptomyces coelicolor is studied by using far-UV circular dichroism (CD) and Fourier transform infrared spectroscopy (FTIR) at pH 7.0 [enzyme I]
1902	2828143	15882427	2007-08-25 11:06	PhoP and its truncated DBD domain were found to bind with high affinity to an upstream region of the pstS and phoRP-phoU promoters close to the -35 sequence of each of these promoters [PhoP]
1902	2828143	15963991	2007-08-25 14:48	The wild-type H+-pyrophosphatase , but not a cysteine-less mutant, is reversibly inactivated by oxidation.
1902	2828143	16514143	2007-08-25 21:18	results strongly suggest that the enzyme responsible for RNA 3'-tail synthesis is polynucleotide phosphorylase (PNPase); moreover, this study shows that both PNPase and the product of SCO3896 are essential[PNPase, SCO3896]
1902	2828143	16553888	2007-08-25 14:11	Nur is a regulator of nickel homeostasis and antioxidative response in S. coelicolor. (Nur)
1902	2828143	16622059	2007-08-25 14:10	transcriptional regulation of macs1-fadD1; identification & characterization of a transcriptional activator, AcsR, whose role is to control growth-phase-dependent induction of the macs1-fadD1 operon by binding to an unusual operator [AcsR, macs1, fad1]
1902	2828143	16677297	2007-08-25 10:52	MreB is not essential for vegetative growth of S. coelicolor, but exerts its function in the formation of environmentally stable spores, and appears to primarily influence the assembly of the spore cell wall. (MreB)
1902	2828143	16816174	2007-08-25 21:26	Gene (devA) gene is required for proper development of Streptomyces coelicolor (DevA) (newentry)
1902	2828143	16819828	2007-08-25 21:08	The data show that the zinc site in RsrA is comprised of Cys11, His37, Cys41, and Cys44.(RsrA)
1902	2828143	16820862	2007-08-25 14:07	the core domain and active sites of FtsY and Ffh which are responsible for GTP hydrolysis, were identified; results indicated that Lys residue in the putative GTP binding loop was the crucial residue for the GTPase activity of NG domain [FtsY, Ffh]
1902	2828143	16859496	2007-08-25 10:49	Studies demonstrate that the increased levels of ribosome recycling factor(RRF) caused by the K88E mutation is responsible for an aberrant stationary-phase event: overproduction of antibiotic [RRF]
1902	2828143	16936034	2007-08-25 15:04	findings suggest that agl3R is one of a number of homologous proteins in Streptomyces that respond to nutritional and/or environmental signals to control genes that affect morphogenesis and antibiotic production [agl3R]
1902	2828143	16950922	2007-08-25 14:05	We conclude that NrdR is a widely conserved regulator of RNR genes, binding to specific sequence elements in the promoter region and thereby modulating transcription [NrdR]
1902	2828143	16980478	2007-08-25 10:48	Some crosses between pairs of recA null mutants generated no detectable recombinants, showing for the first time that conjugal recombination in S. coelicolor is recA mediated [recA]
1902	2828143	17227452	2007-08-25 21:20	The functional actVI-ORFA gene restored expression of actVI-ORF1, which encodes a key reductase in the actinorhodin tailoring step, in the mutant cells, indicating a possible regulatory role of ActVI-ORFA. [ActVI-ORFA]
1902	2828143	17322197	2007-09-04 18:20	results confirm that AsnO and HasP are required for the beta-hydroxylation and phosphorylation of the Asn residue within calcium-dependent antibiotic [hasP, asnO]
1902	2828143	17416659	2007-09-08 12:36	Zur, located downstream of the znuACB operon, encoding a putative zinc uptake transporter: Zur
1902	2828143	17464054	2007-12-01 10:13	cdaX or cchK) encoding MbtH-like proteins in Streptomyces coelicolor is required for biosynthesis of the peptide siderophore coelichelin and the calcium-dependent peptide antibiotic (CDA).[cdaX, cchK]
1902	2828143	17464055	2007-12-01 10:13	cloY is specifically required for the formation of the 3-amino-4,7-dihydroxy-coumarin moiety of the clorobiocin molecule.[cloY]
1902	2828143	17504091	2007-08-25 21:26	the N-terminus was dispensable for FtsY GTPase activity, and that the N-domain plays an essential role in the GTPase activity of the NG domain. In addition, the S.scoelicolor FtsY was able to restore function in an E. coli mutant.
1902	2828143	17614370	2007-09-22 10:19	The studies demonstrate that the subfamily partner CYP158A1, sharing 61% amino acid identity with CYP158A2, can catalyze the same flaviolin dimerization reactions, but it generates just two of the three isomers of biflaviolin that CYP158A2 produces.
1902	2828143	17635186	2007-09-15 12:40	S. coelicolor ParA provides scaffolding for proper distribution of ParB complexes and consequently controls synchronized segregation of several dozens of chromosomes, possibly mediating a segregation and septation checkpoint.[ParA]
1902	2828143	17640269	2007-10-27 10:33	These results suggested that the transcription of hppD is subject to coarse and fine control by a complex regulatory system.[hppD, HpdA, HpdR]
1902	2828143	17824926	2007-12-08 11:40	The septal localization of SffA was dependent on SmeA, suggesting that SmeA may act as an assembly factor for SffA and possibly other proteins required during spore maturation.
1902	2828143	17873868	2007-12-22 11:10	mutation in the N-terminal domain of germacradienol-geosmin synthase of a catalytically essential serine to alanine results in the conversion of farnesyl diphosphate to a mixture of sesquiterpenes [germacradienol-geosmin synthase ]
1902	2828143	17906150	2007-12-01 11:24	the phoA, phoC and phoD promoters showed clear differences in the modulation of their expression by PhoP.[PhoP]
1902	2828143	17926093	2008-03-29 13:05	Further transcriptional analysis on sporulation controlling genes, i.e., whiG, whiB, whiH, and prox, indicated that the regulation of sporulation by ftsY is likely to take effect through whiH.[FtsY and whiH in strain M145]
1902	2828143	17965158	2008-01-19 12:04	SCO1135 open reading frame identified by the insertion encodes a member of the TetR family of transcriptional regulators.[TetR]
1902	2828143	17993519	2008-02-02 10:18	in contrast to a previous postulate, Pol I and its paralog are not essential for replication of Streptomyces chromosomes.[PolA in strains 3454 and 3456]
1902	2828143	18187507	2008-03-22 12:54	A cooperative binding of PhoP initiated at conserved core direct repeats appears to be the mechanism involved in binding of several PhoP monomers to those complex operators (PhoP).
1902	2828143	18227241	2008-04-05 10:18	The chromosomal interruption of dasA resulted in a carbon-source-dependent vegetative arrest phenotype.[DasA]
1902	2828143	18310412	2008-05-24 10:05	the deletion of sco0958 produced a dramatic reduction in neutral lipid production, whereas the overexpression of this gene yielded a significant increase in de novo TAG biosynthesis.[sco0958 in strain M145]
1902	2828143	18390551	2008-09-06 10:05	prokaryotic homolog exhibits remarkable structural similarity to human formylglycine-generating enzyme, including the position of catalytic cysteine residues[ formylglycine-generating enzyme]
1902	2828143	18487344	2008-08-09 10:30	The paper reports that a cellulose synthase-like protein (CslA(Sc)) in Streptomyces has a function in hyphal tip growth and morphological differentiation.[CslA in strain M145]
1902	2828143	18511939	2008-09-27 10:17	Antibiotic pathway-specific activators are mediated through the pleiotropic transcriptional repressor DasR, the regulon of which also includes all N-acetylglucosamine-related catabolic genes.[DasR]
1902	2828143	18539734	2008-08-16 10:44	AbsB controls its own expression by sequentially and site specifically cleaving stem-loop segments of its polycistronic transcript.[AbsB in strain C120]
1902	2828143	18621902	2008-09-27 10:06	TrpRS1 is transcriptionally activated by indolmycin and confers resistance to indolmycin. [TrpRS1]
1916	2828145	15849419	2007-08-25 21:24	cpb1 took part in the regulation of chitinase expression in S. lividans[chitinase and cpb1]
1916	2828145	16150445	2007-08-25 11:25	Data suggest that the structure and stability of KcsA reconstituted into native-like membranes differ from those exhibited in detergent solution.
1916	2828145	16254447	2007-08-25 10:20	role of FtsY in protein secretion [FtsY]
1916	2828145	16301524	2007-08-25 22:21	KcsA channel inactivation can be described by a kinetic model in which pH(i) controls inactivation through pH-dependent activation [KcsA]
1916	2828145	16434244	2007-08-25 21:24	Conserved amino acids were mutated in order to investigate a functional role of these residues in catalysis.(acetylxylan esterase A)
1916	2828145	16549666	2007-08-25 21:27	The results presented here support the idea that ClpP1/P2 ensure post-translational control of ClgR regulon members, including ClgR itself.[ClpP1][ClpP2]
1916	2828145	16815844	2007-08-25 13:32	Sodium and potassium ions bind competitively to KcsA with distinct affinities and induce different conformations of the ion-bound protein.  (KcsA)
1916	2828145	17360526	2007-08-25 21:11	selectivity and gating functions of Streptomyces lividans KcsA [KcsA]
1916	2828145	17379717	2007-12-01 10:38	Study of the role of the Tat subunits in complex assembly and stability in the membrane and cytoplasm showed that TatB stabilizes TatC, driving Tat complex assembly is suggested for TatC and TatA is a translocator.[TatA, TatB, TatC protein]
1916	2828145	17693406	2007-11-10 11:55	the C-terminal domain of KcsA may contribute to the pH dependent opening of the potassium channel
1916	2828145	17877728	2007-12-08 12:50	A stem-loop structure on the sblA transcript plays a negative role in the regulation of sblA expression and might be involved in the regulation of the specific degradation of the sblA transcript.[sblA]
1916	2828145	17922011	2008-03-10 16:16	Results describe the structure and activity of full-length KcsA, a prototypical K+ channel, in its open, closed and intermediate states [KcsA].
1916	2828145	17922012	2008-03-10 16:16	Data show that in the KcsA potassium channel, the number and strength of hydrogen bonds between residues in the selectivity filter and pore helix determine the rate and extent of C-type inactivation, which can also be engineered in Kv1.2 channels.
1916	2828145	17974509	2008-03-10 15:46	solid-state NMR studies of the selectivity filter region of KcsA potassium channel[KcsA]
1916	2828145	18084741	2008-07-12 10:16	S-adenosylmethionine controls the expression of bldH through the TTA-codon control in translating bldH mRNA.[bldH]
1916	2828145	18419132	2008-06-14 10:24	effect of mutations of Thr75 in the S4 site of theKcsA K+ channel on the cation dependence of the thermal stability of the tetramer, a phenomenon that reflects the structural role of cations in the filter [KcsA]
1916	2828145	18633279	2008-09-20 10:49	XylR acts as a repressor in the S. lividans xylose operon and xylose isomerase(XylA) activity. [XylR, XylA]
1928	2828149	15321672	2007-08-25 13:49	The gene expression of the secreted endoglucanase EglS is growth phase-dependent (EglS).
1928	2828149	17526839	2007-11-10 10:20	srrX, srrA, srrB and srrC constitute a complex regulatory system for antibiotic production and morphological differentiation in S. rochei.[srrX, srrA, srrB, srrC]
1928	2828149	18083808	2008-07-12 10:16	Results confirmed the signaling pathway from srrX through srrA to srrY, leading to lankacidin and lankamycin production [srrY]
2021	3760012	16582491	2007-08-25 13:34	The crystals diffract to better than 2.3 angstroms resolution. (1,4-beta-D-glucan glucohydro)
2021	3760012	18402467	2008-06-07 10:18	number of interactions between the glucose units of the substrate and the aromatic residues in the enzyme active sites determines the point of cleavage in both enzymes[Cel9A]
2097	2828157	16184596	2007-08-25 14:23	NMR structure of MG354 [MG354]
2102	2828159	16166545	2007-08-25 21:18	function of L-alpha-glycerophosphate oxidase (GlpO) and the impact of the release of H2O2/ROS resulting from glycerol metabolism on cytotoxicity toward host cells [GlpO]
2102	2828159	16401080	2007-08-25 21:23	From analysis of the bi-substrate initial rate pattern, it is concluded that the deoxyadenosine kinase kinetic mechanism is of the Bi Bi sequential ordered type involving formation of a ternary complex, in which ATP and deoxyadenosine bind sequentially.
2104	2828161	15845487	2007-08-25 21:13	findings demonstrate that MPN372, a previously designated hypothetical protein, is surface exposed and mediates mycoplasma attachment to hSP-A [MPN372 strain B9 and S1]
2104	2828161	16104022	2007-08-25 10:21	Molecular model of 5,10-methenyltetrahydrofolate synthetase in the presence of substrates identify the critical binding site residues and their role in the enzymatic reaction (5,10-methenyltetrahydrofolate synthetase).
2104	2828161	17975088	2008-01-05 16:05	The attachment mediating region of the C-terminal part of P1 to receptors on HEp-2 cells was determined. [P1 protein]
2104	2828161	18411296	2008-07-12 10:16	In the present study, we determined that binding of M. pneumoniae EF-Tu (elongation factor Tu) to fibronectin is primarily mediated by the EF-Tu carboxyl region.[EF-tu]
2109	3758900	16493814	2007-08-25 21:18	organization of the M. synoviae vlhA gene locus and established that the vlhA gene transcript is monocistronic [vlhA]
2118	3293041	16585743	2007-08-25 12:32	the molecular structure of Gli349 resembles the symbol for an eighth note in music. It contains an oval foot 14 nm long in axis. From this foot extend three rods in tandem of 43, 20, and 20 nm, in that order. [Gli349]
2190	2828167	15014443	2007-08-25 13:20	NADH is bound in an extended conformation of sulfolactate dehydrogenase in each active site, in a manner that explains the pro-S specificity [sulfolactate dehydrogenase]
2190	2828167	15213409	2007-08-25 11:17	crystal structure of Methanococcus jannaschii 3,4-dihydroxy-2-butanone 4-phosphate synthase in complex with the substrate ribulose 5-phosphate at a dimetal centre at 1.7 A resolution [3,4-dihydroxy-2-butanone 4-phosphate synthase]
2190	2828167	15529746	2007-08-25 15:02	the oligomeric structure is loosened, resulting in stronger dynamics and in more accessible hydrophobic surfaces, properties leading to increased chaperone potency.(HSP 16.5)
2190	2828167	15614969	2007-08-25 14:28	X-ray analysis of Methanococcus jannaschii TATA box-binding protein (TBP) [TBP]
2190	2828167	16225889	2007-08-25 11:05	structure determined to 2.3 angstroms resolution; active site, coenzyme binding and specificity, and the dimerization interface are compared with that of bacterial ASADHs (aspartate-beta-semialdehyde dehydrogenase)
2190	2828167	16226256	2007-08-25 14:37	M. jannaschii ProRS is a homodimeric enzyme that is functionally asymmetric; only one of the two active sites at a time is able to form prolyl-adenylate, and only one tRNA molecule binds per dimer. (prolyl-tRNA synthetase)
2190	2828167	16286935	2007-08-25 11:59	Cbf5 and Nop10 complex cocrystal structure at 1.95-A resolution was reported. (Cbf5)(Nop10)
2190	2828167	16288921	2007-08-25 10:56	M.jannaschii PRPP synthase has been purified, characterised, crystallised, and the crystal structure determined. Substrate specificities and binding sites are described.(phosphoribosyl diphosphate synthase)
2190	2828167	16420352	2007-08-25 12:58	These results provide biochemical support to the hypothesis that Elp3 does indeed contain the Fe4S4 cluster.
2190	2828167	16540118	2007-08-25 21:21	Homodimeric Hmd reveals a unique architecture composed of one central and two identical peripheral globular units [Hmd]
2190	2828167	16601205	2007-08-25 13:35	The coiled-coil domain of the Nop56/58 core protein is dispensable for sRNP assembly but is critical for archaeal box C/D sRNP-guided nucleotide methylation
2190	2828167	17096428	2007-08-25 11:49	Functional M. jannaschii AroQ variants mutated at the N-terminal helix contained a smaller number of conserved residues & tolerated greater variability at individual sequence positions than those from E. coli.
2190	2828167	17263559	2007-08-25 13:26	Subunit H of the A1AO ATP synthase was analyzed by small-angle X-ray scattering in order to determine structure of this molecule; the protein is dimeric and has a boomerang-like shape, divided into two arms. [AtpH protein]
2190	2828167	17660283	2007-12-01 12:40	NflH and NflD are expressed constitutively and do not appear to be directly involved with nitrogen metabolism or detoxification of compounds such as cyanide or azide and were found to interact with each other.[NflD, NflH]
2190	2828167	17713928	2007-11-10 12:43	Three crystal structures of ADH synthase were determined in this work: a complex with fructose 1,6-bisphosphate, a complex with dihydroxyacetone phosphate and a native structure containing copurified ligands, modeled as DHAP and glycerol.[ADH synthase]
2190	2828167	18063795	2007-12-22 10:02	crystal structure of the transmembrane core domain of site-2 protease; the protease exhibits two distinct conformations in the crystals; structure reveals how zinc embedded in an integral membrane protein can catalyze peptide cleavage [S2P]
2190	2828167	18174226	2008-03-22 10:18	Identification of the ATP-binding site by in vitro and in vivo analysis of O-phosphoseryl-tRNA(Sec) kinase (PSTK) mutants (PSTK).
2190	2828167	18208838	2008-04-05 12:04	The structure of Nep1 reveals a fold which is very similar to the conserved core fold of the SPOUT-class methyltransferases but contains a novel extension of this common core fold (Nep1).
2190	2828167	18625008	2008-09-13 10:22	The interactions of the glucokinase/phosphofructokinase bifunctional enzyme with both sugar substrates were modeled using protein-ligand docking and restricted molecular dynamics (glucokinase/phosphofructokinase bifunctional enzyme).
2208	3760018	16675947	2007-08-25 21:03	Results report a 2.5 A resolution crystal structure of Methanosarcina barkeri seryl-tRNA synthetase and its complexes with ATP, serine and the nonhydrolysable seryl-adenylate analogue 5'-O-(N-serylsulfamoyl)adenosine [SerRS].
2208	3760018	18178739	2008-07-12 10:26	Both the delta mer and delta mtr mutants were able to grow on a combination of methanol plus acetate, but they did so by metabolic pathways that are clearly distinct from each other and from previously characterized methanogenic pathways [Mtr and Mer]
2209	2828169	17592110	2007-09-29 10:24	Crystal structures reveal that pyrrolysyl-tRNA synthetase, the last known synthetase that evolved for genetic code expansion, utilizes a deep hydrophobic pocket for recognition of the pyrrolysine side chain. (PylRS; pyrrolysyl-tRNA synthetase)
2209	2828169	18387634	2008-06-14 10:24	the carboxy-terminal catalytic fragment of Methanosarcina mazei pyrrolysyl-tRNA synthetase (PylRS) was analyzed by X-ray crystallography and site-directed mutagenesis.
2209	2828169	18559342	2008-09-20 10:28	Analysis of cognate and noncognate reactions by ATP/PP(i) and aminoacylation kinetics suggests that SepRS is able to discriminate against noncognate amino acids without need for a separate hydrolytic editing site [SepRS phosphoseryl-tRNA synthetase]
2234	2828173	15341724	2007-08-25 11:35	Results describe the X-ray crystal structure of Archaeoglobus fulgidus Rio2, with and without bound nucleotides, at 2.0 angstrom resolution [Rio2].
2234	2828173	15494391	2007-08-25 12:06	data support the presence of a unique transmembrane Cu(+) binding/translocation site constituted by Tyrosine-Asparagine in H7, Methionine and Serine in H8, and two Cysteine in H6 of Cu(+)-ATPases(CopA ATPase)
2234	2828173	15518563	2007-08-25 13:42	The crystal structure of A. fulgidus Rpp29 is described and the differences between the crystal and solution structures of the protein are reconciled and interpreted. (ribonuclease P protein Rpp29)
2234	2828173	15565169	2007-08-25 11:10	crystal structure of Piwi; conserved region around the C-terminus of the PIWI domain, required for siRNA binding to Piwi, may function as the receptor site for the 5' phosphate of siRNAs, thereby specifying the cleavage position of the target mRNA [Piwi]
2234	2828173	15788400	2007-08-25 21:05	reverse gyrase can mediate three distinct supercoiling reactions depending on the adenine nucleotide cofactor that is present in the reaction [reverse gyrase]
2234	2828173	15800628	2007-08-25 21:22	crystal structure of a Piwi protein from Archaeoglobus fulgidus (AfPiwi) in complex with a small interfering RNA (siRNA)-like duplex, which mimics the 5' end of a guide RNA strand bound to an overhanging target messenger RNA [Piwi]
2234	2828173	15800629	2007-08-25 21:22	crystal structure of Archaeoglobus fulgidus Piwi protein bound to double-stranded RNA, thereby identifying the binding pocket for guide-strand 5'-end recognition and providing insight into guide-strand-mediated messenger RNA target recognition [Piwi]
2234	2828173	16008568	2007-08-25 10:22	high-resolution crystal structures of Archaeoglobus fulgidus Rio1 in the presence and absence of bound nucleotides. [Rio1]
2234	2828173	16098517	2007-08-25 15:05	X-ray structure of the gamma-subunit of the dissimilatory sulfite reductase (DsrC) was determined at 1.12 and 2.1A resolution, in the two crystal forms named DsrC(nat) and DsrC(ox) the latter being cocrystallized with tert-butyl hydroperoxide [DsrC]
2234	2828173	16214888	2007-08-25 10:57	Results describe the crystal structure of the archaeal ammonium transporter Amt-1 from Archaeoglobus fulgidus [AMT-1]
2234	2828173	16377641	2007-08-25 11:23	Data report crystal structures of the citrate and sn-glycerol-1-phosphate (G1P) complexes of (S)-3-O-geranylgeranylglyceryl phosphate synthase from Archaeoglobus fulgidus (AfGGGPS) at 1.55 and 2.0 A resolution, respectively [GGGPS].
2234	2828173	16407212	2007-08-25 14:12	Data report several activities that reverse gyrase can efficiently mediate with a substoichiometric amount of enzyme [reverse gyrase].
2234	2828173	16414072	2007-08-25 10:18	Results describe the crystal structure of a pyruvate formate lyase (PFL2) from Archaeglobus fulgidus at 2.9 A resolution [PFL2].
2234	2828173	16511128	2007-08-25 11:57	crystallographic structure of Hjc resolvase from Archaeoglobus fulgidus
2234	2828173	16690865	2007-08-25 12:31	structure of a splicing endonuclease from Archaeglobus fulgidus bound with a bulge-helix-bulge RNA containing a noncleaved and a cleaved splice site detrermined at a resolution of 2.85 angstroms [splicing endonuclease]
2234	2828173	16731057	2007-08-25 13:33	analysis of the first archaeal L-aspartate dehydrogenase from the hyperthermophile Archaeoglobus fulgidus [L-aspartate dehydrogenase]
2234	2828173	16866373	2007-08-25 10:49	Reduction of superoxide by neelaredoxin (Nlr) involves the formation of a single transient, an iron-bound hydroperoxide, which immediately decays by a proton transfer step to form an iron-bound solvent species in acid-base equilibrium.(neelaredoxin)
2234	2828173	16963646	2007-08-25 21:26	the oligomeric state of the protein depends on the pH and presence of RNA
2234	2828173	17051158	2007-08-25 11:50	complete sequential snapshots of six complex structures of CCA-adding enzyme and four distinct RNA substrates with and without CTP (cytosine triphosphate) or ATP (adenosine triphosphate) [CCA-adding enzyme]
2234	2828173	17322901	2007-08-25 21:02	3.1 A crystal structure of a putative molybdate transporter (ModB2C2) from Archaeoglobus fulgidus in complex with its binding protein (ModA)[ModA & ModB & ModC]
2234	2828173	17558417	2007-09-15 12:40	apo and DNA-bound crystal structures of helicase Hel308 was determined (Hel308).
2234	2828173	17651440	2007-10-20 11:07	Data provide the first detailed description of substrate and coenzyme binding to L-aspartate dehydrogenase (L-aspDH) and of the molecular basis of the high thermostability of a hyperthermophilic L-aspDH [L-aspDH]
2234	2828173	17669425	2007-10-20 10:19	first crystal structure of the apo-F(420)-0:gamma-glutamyl ligase (CofE-AF) from Archaeoglobus fulgidus and its complex with GDP at 2.5 A and 1.35 A resolution, respectively [cofE]
2234	2828173	17951070	2008-05-10 10:04	Tubular crystals of CopA were obtained which displayed some diffraction. Negative-stain electron microscopy close-ups of the helical lattice are presented.
2234	2828173	18173131	2008-03-10 14:58	Role of transmembrane domain was shown in activation of LonB (LonB)
2234	2828173	18495940	2008-07-12 10:32	The data are consistent with a transient conformational change involving P295 of the tRNA-binding alpha-helix during or between one or more steps in CCA addition.[CCA]
2238	3293045	17451860	2007-12-08 12:43	The results highlight the role of anion-binding sites in protein adaptation to high salt conditions (malate dehydrogenase).
2242	3293190	15627399	2007-08-25 21:13	The structure of bacteriorhodopsin was considered by the file 1c3w and projections of sites of the proton movement pathway onto the normal to the purple membrane were measured [Bacteriorhodopsin]
2242	3293190	15919078	2007-08-25 12:45	first functional heterologous expression of SRII from H. salinarum provides the basis for studies with its cognate transducer HtrII to investigate the molecular processes involved in phototransduction as well as in chemotransduction
2242	3293190	16330046	2007-08-25 10:19	Using single-molecule force spectroscopy we characterized inter- and intramolecular interactions stabilizing structural segments of individual bacteriorhodopsin (BR) molecules assembled into trimers and dimers, and monomers [BR]
2242	3293190	16434052	2007-08-25 11:58	Results describe the controlled refolding of single bacteriorhodopsin proteins into the membrane [bacteriorhdopsin]
2242	3293190	16896523	2007-08-25 13:30	Gene encoding an extracellular protease, sptA, was cloned and characterized.
2242	3293190	17367807	2007-08-25 21:23	The results strongly suggest the presence of a regulation motif enclosed in helices C and D (Thr90-Pro91/Asp115) which drives properly the dynamics of helix C through a set of interactions. (bacteriorhodopsin)
2242	3293190	17406782	2007-12-08 10:04	Native form of the haloarchaeal ferredoxin (in high salt concentration) unfolds in low salt concentration via a hydrophobic collapsed form, which leads to a kinetic intermediate, which then unfolds further to the low salt form of the protein.
2242	3293190	17655327	2007-10-13 12:36	Kinetic and spectroscopic analysis of HtrI point mutants of Asn53 provides evidence that this residue is involved in the SRI and HRI interaction.(HtrI) (SRI)
2242	3293190	18422347	2008-06-14 10:24	heterogeneous branched model is more likely than one with separate linear sequences[ bacteriorhodopsin ]
2242	3293190	18422349	2008-06-14 10:24	most of the proton-charge displacement is connected with the step Ms-->bacteriorhodopsin
2242	3293190	18456840	2008-05-31 10:29	Light-induced coherent terahertz radiation from bacteriorhodopsin with femtosecond time resolution, was observed.[Bacteriorhodopsin]
2257	3760020	16452929	2007-08-25 10:54	Two molecules of NpSRII and two molecules of NpHtrII form a 2:2 complex in membranes as shown by electron paramagnetic resonance and X-ray structure analysis [SRII & HtrII]
2257	3760020	16981717	2007-08-25 12:19	The uptake of chloride, bromide, iodide, nitrate, and azide by anion-depleted blue halorhodopsin from Natronobacterium pharaonis has been followed by Fourier Transform Infrared Spectroscopy. [halorhodopsin]
2257	3760020	18199454	2008-03-22 12:02	A conformational change of the transducer HtrII upon photoexcitation of the associated photoreceptor sensory rhodopsin II (SRII) was investigated by monitoring the kinetics of volume changes and the diffusion coefficient (D) of the complex.[HtrII]
2261	2828177	15272158	2007-08-25 13:46	A neutron diffraction study has been carried out at 1.6 A resolution on a mutant rubredoxin from Pyrococcus furiosus [rubredoxin]
2261	2828177	15465052	2007-08-25 14:18	Results describe the structures of the free enzyme phosphoglucose isomerase and its complexes with the inhibitor, 5-phospho-d-arabinonate in the presence and absence of metal [phosphoglucose isomerase].
2261	2828177	15468318	2007-08-25 11:33	X-ray crystallography of rubrerythrin [rubrerythrin]
2261	2828177	16107254	2007-08-25 15:05	Data show that the dinuclear iron-oxo ferroxidase center of Pyrococcus furiosus ferritin is a stable prosthetic group with unexpectedly high reduction potentials [ferritin]
2261	2828177	16135241	2007-08-25 21:24	TrmB acts as a bifunctional transcriptional regulator acting on two different promoters and being differentially controlled by binding to different sugars
2261	2828177	16142893	2007-08-25 10:20	broad substrate specificity of this 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAH7PS), and various structural features indicate that, P. furiosus DAH7PS may be the contemporary protein closest to the ancestral type I enzyme [DAH7PS]
2261	2828177	16142902	2007-08-25 10:20	type-I methionyl aminopeptidases (MetAPs) can be selectively targeted over type-II MetAPs [type-II MetAPs]
2261	2828177	16243319	2007-08-25 12:58	To identify which cobalt site is tight-binding and which is loose-binding, site-directed mutagenesis was used to modify amino acid residues that participate in binding. (prolidase)
2261	2828177	16262689	2007-08-25 21:14	structural features of the hyperthermophilic endo-beta-1,3-glucanase from Pyrococcus furiosus were studied using circular dichroism, steady-state and time-resolved fluorescence spectroscopy and anisotropy[endo-beta-1,3-glucanase]
2261	2828177	16391048	2007-08-25 14:41	AdhD was purified and found to exhibit high thermostability, a broad substrate specificity, and high entantioselectiviity [AdhD]
2261	2828177	16436047	2007-08-25 12:34	results suggest that Hjm may be a functional counterpart of RecQ in Archaea, in which it is necessary for the maintenance of genome integrity, although the amino acid sequences are not conserved [Hjm helicase]
2261	2828177	16838833	2007-08-25 10:49	NMR structure of a 12-mer RNA derived from the helix 6 of SRP RNA from Pyrococcus furiosus, whose loop-closing base pair is U.G, was determined [SRP RNA]
2261	2828177	17035108	2007-08-25 10:46	The hydrophobicity of W229 may be critical to the transglycosylation activity of 4-alpha-glucanotransferase based on the enzyme's modeled tertiary structures (4-alpha-glucanotransferase).
2261	2828177	17053064	2007-08-25 21:26	even in the presence of only one of two specific pairs of RNase P proteins (Rpp), the RPR displays activity at lower substrate and magnesium concentrations
2261	2828177	17349953	2007-08-25 21:20	Mre11/Rad50 complexes from three organisms catalyze the reversible adenylate kinase reaction in vitro.[Rad50, Mre11]
2261	2828177	17357157	2007-08-25 21:23	different stabilization strategies could have been adopted among archaea[glycoside hydrolase]
2261	2828177	17434531	2007-08-25 15:03	Results describe the crystal structure of a protein from Pyrococcus furiosus, Phr, that represents the first characterized heat shock transcription factor in archaea [Phr].
2261	2828177	17496095	2007-09-15 11:54	This is the first experimental evidence that the PIP-box motif, located at the C termini of the archaeal DNA polymerases, is actually critical for PCNA binding to form a processive DNA-synthesizing complex.[DNA polymerase BI, DNA polymerase D, PCNA]
2261	2828177	17504099	2007-08-25 21:26	DNA polymerase from Pyrococcus furiosus was crystallized. crystal belongs to the space group C2 with unit cell parameters of a = 93.2 A, b = 124.9 A, c = 87.7 A, alpha = 90 degrees , beta = 109.7 degrees , and gamma = 90 degrees.[DNA polymerase B1]
2261	2828177	17504272	2007-08-25 12:21	Differential conformational changes of TrmB in response to binding the different sugars governs the ability of TrmB to interact with the promoter region and represents a simple mechanism for selecting the usage of one carbon source over the other. [TrmB]
2261	2828177	17587231	2007-10-27 11:36	TrmBL1 is a global sugar-sensing transcriptional regulator controlling the genes of transport systems and of sugar-metabolizing enzymes.(TrmBL1 )
2261	2828177	17965161	2008-01-19 12:04	Transcription fator B N-terminal region, containing conserved Zn ribbon and B-finger motifs, is important in promoter opening. [transcriptin factor b]
2261	2828177	17986447	2008-02-16 10:59	These results strongly suggest that the archaeal GINS is involved in both the initiation and elongation processes of DNA replication in P. furiosus, as observed in eukaryotic cells.[MCM helicase]
2261	2828177	18053245	2008-03-15 10:49	Chimeric hybrids derived from the rubredoxins of Pyrococcus furiosus (Pf) and Clostridium pasteurianum (Cp) provide a robust system for the characterization of protein conformational stability and dynamics in a differential mode. Rubredoxin]
2261	2828177	18154309	2008-03-10 14:58	MoaB catalyzes the adenylylation of molybdopterin (MPT) in a Mg and ATP-dependent way. Reaction velocity increased 20-fold from 20 to 80 C. Metal and nucleotide specificity for MPT adenylylation is well conserved between W and Mo cofactor synthesis: MoaB
2261	2828177	18156274	2008-05-17 10:07	Data concluded that the soluble hydrogenase from Pyrococcus furiosus is likely to function in the regeneration of NADPH and thus reuses the hydrogen produced by the membrane-bound hydrogenase in proton respiration [NiFe-hydrogenase I]
2277	4627242	17965169	2008-07-12 10:17	The serine racemase corresponding srr gene was cloned, and recombinant Srr was purified from Escherichia coli, and it showed that the highest racemase activity toward L-serine, followed by L-threonine, D-serine, and D-threonine [Srr]
2283	2828179	15710385	2007-08-25 10:23	A new subtype of archaeal Rieske ferredoxin (RFd) has been identified in the genome of the thermoacidophilic archaeon Acidianus ambivalens [Rieske]
2283	2828179	16303338	2007-08-25 11:59	We describe the crystallisation & preliminary structure determination of a NDH-2 that contains a covalently bound FAD. NDH-2 was crystallised using ammonium phosphate. The structure was solved by MIRAS using Pt & I derivatives[NADH:quinone oxidoreductase]
2283	2828179	16484493	2007-08-25 10:18	determination of the 1.7 angstrom-resolution structure of the sulfur oxygenase reductase [sulfur oxygenase reductase]
2283	2828179	17696500	2007-11-10 11:06	The combined spectroscopic approach illustrates how changes in the metalloprotein organization are intertwined with disassembly of the iron-sulfur centers, denoting the conformational interplay of the protein backbone with cofactors.[Ferredoxin]
2283	2828179	18312361	2008-06-14 10:34	The dihydrolipoamide dehydrogenase (DLDH) contains two identical subunits with a molecular mass of 45.4 kDa per monomer and it contains FAD as a prosthetic group and uses NAD+ as substrate.[DLDH]
2285	3758905	17337320	2007-08-25 10:42	the phosphotriesterase gene was cloned, the protein overexpressed in Escherichia coli, purified, and proven to have paraoxonase activity [phosphotriesterase]
2285	3758905	17692336	2007-12-15 12:46	Results demonstrate that the acid pH-dependence of protein stability in Sac7d and Sso7d is due to independent titration of acidic residues with pK(a) values perturbed primarily by hydrogen bonding of the side-chain to the backbone [Sac7d].
2287	2828181	15317021	2007-08-25 13:41	the role played by specific interactions connecting the two ends of the chain for the high thermal stability of Sso7d, and support for recent hypotheses on its folding mechanism emerged from site-directed mutagenesis studies [Sso7d]
2287	2828181	15469506	2007-08-25 15:08	Data describe LrpB, a novel DNA-binding protein from Sulfolobus solfataricus that binds cooperatively to three regularly spaced targets in its own control region [LrpB].
2287	2828181	15516590	2007-08-25 22:21	newly identified archael type phosphoenolpyruvate carboxylase, with its distinct properties, constitutes another example of the versatility of the enzymes of the central carbon metabolic pathways in the archaeal domain [phosphoenolpyruvate carboxylase]
2287	2828181	15591065	2007-08-25 11:20	the XPF endonuclease, which is dependent on the sliding clamp proliferating cell nuclear antigen for activity, represents an ancestral form of the XPF/Mus81 family, with key properties in common with both enzymes [XPF]
2287	2828181	15723526	2007-08-25 14:24	difference between the solution and crystal structures occurs in the putative DNA-binding helix-turn-helix motifs (Sso10a)
2287	2828181	15766258	2007-08-25 21:19	Observations of the crystalline structure of peptidyl-tRNA hydrolase clearly identify active site residues in the amino-part of alpha1 and in the beta3-beta4 loop as the basis of this enzyme's specificity. (spoVC; peptidyl-tRNA hydrolase)
2287	2828181	15819883	2007-08-25 12:37	molecular cloning and characterization of 5'-deoxy-5'-methylthio-adenosine phosphorylase II from Sulfolobus solfataricus [MTAPII]
2287	2828181	15846595	2007-08-25 14:38	residues W433 and E432 are important for glucoside- and galactoside-specificity [beta-glycosidase]
2287	2828181	15921693	2007-08-25 14:47	first steady-state kinetic characterisation of a junction-resolving enzyme; the Hje endonuclease from Sulfolobus solfataricus [Hje]
2287	2828181	16004869	2007-08-25 13:40	Alba2 dimerization with Alba1 provides a mechanism for control of DNA packaging [Alba1, Alba2]
2287	2828181	16223720	2007-08-25 10:56	characterization of the molecular basis of DNA binding and nucleotide incorporation by the thermostable archaeal DinB homologue (Dbh) DNA polymerase [Dbh]
2287	2828181	16401088	2007-08-25 21:23	archaeal replication protein A
2287	2828181	16414070	2007-08-25 13:36	Results describe the crystal structure of Sulfolobus solfataricus 5'-deoxy-5'-methylthioadenosine phosphorylase II (SsMTAPII) in complex with 5'-deoxy-5'-methylthioadenosine (MTA) and sulfate at 1.45A resolution [MTAPII].
2287	2828181	16490210	2007-08-25 11:57	Data suggest that Alba represents a formidable barrier to mini-chromosome maintenance (MCM) activity and further demonstrate that acetylation of Alba alleviates repression of MCM activity [alba]
2287	2828181	16511214	2007-08-25 10:53	X-ray diffraction analysis of the C-terminal domain of Ss-LrpB, a transcription regulator from Sulfolobus solfataricus
2287	2828181	16567425	2007-10-27 12:00	A possible evolutionary explanation for substrate promiscuity of dihydroxy-acid dehydratase is provided through amino acid sequence alignments of DHADs and 6-phosphogluconate dehydratases from archaea, bacteria and eukarya. (dihydroxy-acid dehydratase)
2287	2828181	16629677	2007-08-25 12:31	role in DNA rewinding, whether it leads to homoduplex or heteroduplex formation [Topoisomerase III, topo III]
2287	2828181	16794308	2007-08-25 13:32	kdgK gene was transcribed as polycistronic transcripts [2-keto-3-deoxy-D-gluconate (KDG) kinase]
2287	2828181	16945955	2007-08-25 12:27	The X-ray crystal structure of the Sulfolobus solfataricus PCNA1-PCNA2 heterodimer, bound to a single copy of the flap endonuclease FEN1(PCNA1, PCNA2, FEN1)
2287	2828181	17015653	2007-08-25 10:10	results indicate aMerR remains continuously DNA bound to protect and coordinate Hg(II)-responsive control over merHAI transcription.[MerR, merH, merA, merI]
2287	2828181	17173287	2007-08-25 21:16	substrate specificity of Sulfolobus solfataricus protein tyrosine phosphatase (PTP) is primarily localized at the phosphotyrosine, suggesting that this phosphatase may be a prototypical PTP[protein tyrosine phosphatase]
2287	2828181	17178749	2007-08-25 10:08	Analysis of the DNA-binding sequence specificity of the transcriptional regulator Ss-Lrp to a palindromic consensus box (Ss-Lrp).
2287	2828181	17259218	2007-08-25 10:44	Evidence for extensive regulatory inter-domain communication within the minichromosome maintenance protein MCM complex (minichromosome maintenance protein MCM).
2287	2828181	17329376	2007-08-25 12:21	RadA and members of the RecA protein family self-polymerize into left-handed helical filaments in vitro (RadA).
2287	2828181	17357157	2007-08-25 21:23	different stabilization strategies could have been adopted among archaea[glycoside hydrolase]
2287	2828181	17359995	2007-08-25 13:25	Hydrogen-deuterium exchange was used to explore the structure of the stable folding intermediates for indole-3-glycerol phosphate synthase from Sulfolobus solfataricus (sIGPS).[IGPS]
2287	2828181	17375926	2007-08-25 13:25	water-mediated and substrate-assisted mechanism takes specific advantage of the unique structural features of this low-fidelity lesion-bypass Y-family polymerase
2287	2828181	17434529	2007-08-25 15:03	Data show that sulfate acts as phosphate analog on the monomeric catalytic fragment of the CPx-ATPase CopB from Sulfolobus solfataricus [CopB-B].
2287	2828181	17608795	2007-09-15 11:08	The function in translation of the archaeal homologue (aIF2/5B) has been analysed in detail for the first time using a variety of in vitro assays.[IF2]
2287	2828181	17692336	2007-12-15 12:46	Results demonstrate that the acid pH-dependence of protein stability in Sac7d and Sso7d is due to independent titration of acidic residues with pK(a) values perturbed primarily by hydrogen bonding of the side-chain to the backbone [Sso7].
2287	2828181	17725324	2007-12-01 11:34	Dbh generates single-base deletion errors at an extremely high frequency by skipping over a template base that is part of a repetitive sequence.
2287	2828181	17761879	2007-09-15 10:22	the 3.4 angstrom-resolution structure of Cdc6/Orc1 heterodimer bound to origin DNA was dertermined [cdc6, orc1]
2287	2828181	17824633	2007-12-01 10:59	The putative ADH-2 (SSO0764) is integral to ethanol metabolism. [ADH2]
2287	2828181	17980144	2008-03-22 12:55	These data indicate that the wt GlcV NBD domain unfolds as a single domain protein, and that its stability is modified by mutations in the glutamate after the Walker B motif and by nucleotide binding.[GlcV]
2287	2828181	18000047	2008-01-05 16:05	release of Pi takes place after e/aIF2gamma has been informed of e/aIF1 dissociation by e/aIF2beta[initiation factor 2, alpha beta and gamma subunit ]
2287	2828181	18004773	2008-04-19 10:55	Solution structure of the beta-subunit of the translation initiation factor aIF2 from archaebacteria Sulfolobus solfataricus.
2287	2828181	18096617	2008-03-22 11:10	The Cren7 protein interacts with duplex DNA through a beta-sheet and a long flexible loop, presumably resulting in DNA distortions through intercalation of conserved hydrophobic residues into the DNA structure (Cren7).
2287	2828181	18174331	2008-07-19 10:11	The cytochrome P450 enzyme CYP119, its compound II derivative, and its nitrosyl complex were studied by iron K-edge x-ray absorption spectroscopy.(CYP119)
2287	2828181	18218710	2008-04-12 12:04	The structure of L40E is a three-stranded beta-sheet with a simple beta2beta1beta3 topology (L40E).
2287	2828181	18267970	2008-05-10 10:31	An open conformation of Sulfolobus solfataricus Rad54 homologue, is converted into a closed conformation after DNA binding (Rad54 homologue).
2287	2828181	18355316	2008-06-07 10:18	structure of the enzyme determined by homology modeling provides insight into the proteolytic analyses as well as into mechanisms of thermal stability[Pyrimidine-specific ribonucleoside hydrolase ]
2287	2828181	18417534	2008-06-28 10:22	Structural analysis of Mini-Chromosome Maintenance protein (MCM) highlights the essential role played by the zinc-binding domain in the interaction with nucleic acids (MCM).
2287	2828181	18448118	2008-06-14 10:23	Results describe the crystal structure of a novel 2-keto-3-deoxy-D-arabinonate dehydratase (KdaD), solved to 2.1 A resolution [KdaD].
2287	2828181	18451804	2008-06-21 10:05	In this work, the functional properties of the partially folded state of acylphosphatase accumulating during folding are investigated (acylphosphatase).
2287	2828181	18675278	2008-09-27 10:37	Results describe the crystal structure of the intact archaeal translation initiation factor 2, and demonstrate very high conformational flexibility in the alpha- and beta-subunits [eif2alpha, -beta].
2303	2828183	15893768	2007-08-25 12:45	crystal structures of tricorn interacting factor F3 in three different conformations at 2.3 A resolution [tricorn interacting factor F3
2303	2828183	16141198	2007-08-25 13:04	The crystal structure of LplA is reported [LplA]
2303	2828183	16500678	2007-08-25 13:36	expression of a predicted actin homolog of the thermophilic archaeon Thermoplasma acidophilum, Ta0583, and determination of its crystal structure at 2.1A resolution [Ta0583]
2303	2828183	16826545	2007-08-25 14:08	The solution structure of VAT-N derived in our laboratory using conventionally obtained NMR restraints shows the existence of two equally sized sub-domains, VAT-Nn and VAT-Nc, together forming a kidney-shaped overall structure. (VAT ATPase)
2303	2828183	16942780	2007-08-25 21:11	These data highlight the importance of the highly populated thermosome/ADP/Pi complex in the molecular mechanism.
2303	2828183	17019685	2007-08-25 10:11	Solution structure of TA0895, a MoaD homologue from Thermoplasma acidophilum
2303	2828183	17108356	2007-08-25 21:16	Substantial stimulation of MCM helicase activity by one of the T.acidophilum Cdc6 homologues (MCM helicase).
2303	2828183	17377985	2007-08-25 12:22	present the solution structure of TA0938 [TA0938]
2303	2828183	17889667	2007-11-10 10:18	The structure of Pelota from Thermoplasma acidophilum (Ta Pelota) was determined and the ribonuclease activity of Dom34/Pelota was investigated.[Pelota]
2336	2828187	15339930	2007-08-25 13:12	Data show that MiaB protein is a bifunctional system, involved in both thiolation and methylation of isopentenyl-adenosine (i(6)A) [MiaB].
2336	2828187	15548516	2007-08-25 15:08	MreB and actin display significantly different assembly properties despite high structural homology [MreB]
2336	2828187	15616586	2007-08-25 14:49	X-ray structure of TrmE; the structural and biochemical studies presented here suggest how TrmE most likely directly participates in at least the first step of the cmnm modification reaction in the anticodon loop of certain tRNAs [TrmE]
2336	2828187	15660995	2007-08-25 12:49	determined the crystal structure of the hetero-octameric (HisGS)4HisZ4 tmATPPRTase complex at 2.5 A resolution [HisGs, HIsZ]
2336	2828187	15701599	2007-08-25 21:09	Results describe the crystal structure of Thermotoga maritima tRNase Z at 2.6-A resolution, and present a docking model with tRNA that suggests how tRNase Z may recognize the substrate tRNAs [tRNAse Z].
2336	2828187	15849257	2007-08-25 21:24	biophysical analysis of how IGP synthase excludes water to optimize ammonia transfer [IGP synthase, PDB 1GPW]
2336	2828187	16094695	2007-08-25 10:21	domain orientation in free L11 shows limited similarity to that of ribosome-bound L11 in complex with elongation factor, EF-G [ribosomal protein L11]
2336	2828187	16113684	2007-08-25 13:39	the crystal structure at 3.85 A resolution of the RNA component of Thermotoga maritima ribonuclease P [ribonuclease P, RNA component]
2336	2828187	16137685	2007-08-25 12:36	Data describe the cloning, purification and characterization of HydE and HydG proteins from the thermophilic organism Thermotoga maritima [HydE and HydG].
2336	2828187	16167343	2007-08-25 12:35	Crystal structure of Hsp33 [Hsp33 or TM1394]
2336	2828187	16363810	2007-08-25 11:58	Data support the idea that interactions of the DNA duplex template arm with the RecG protein are the major sites of binding and production of translocation [RecG]
2336	2828187	16401086	2007-08-25 21:23	BglT employs a fully stepwise E1(cb) mechanism involving anionic transition states to catalyze the hydrolysis of glycosidic bonds, in contrast to all other currently characterized glycosidase families. (BglT, 6-phospho-beta-glucosidase)
2336	2828187	16403639	2007-08-25 13:03	evolutionarily related family of aldolases distinct from the N-acetylneuraminate lyase (NAL) family [2-keto-3-deoxy-6-phosphogluconate aldolase]
2336	2828187	16411890	2007-08-25 14:12	structural analysis of the complex reveals the presence of three binding-subsites, which explains why T. maritima invertase exhibits a higher affinity for raffinose than sucrose [invertase]
2336	2828187	16484367	2007-08-25 13:36	crystal structure of a soluble FtsH construct that is functional in caseinolytic and ATPase assays[FtsH]
2336	2828187	16495677	2007-08-25 13:36	endo-beta-1,4-D-galactanase gene of Thermotoga maritima was cloned and overexpressed in Escherichia coli [endo-beta-1,4-D-galactanase]
2336	2828187	16511117	2007-08-25 21:18	investigation of the crystal structure of inorganic polyphosphate/ATP-NAD kinase, PPNK_THEMA, a protein from Thermotoga maritima [PPNK_THEMA]
2336	2828187	16544291	2007-08-25 12:32	TM1367 crystal structure reveals unexpected similarities to members of the cyclophilin (peptidylprolyl isomerase) fold[ TM1367 ]
2336	2828187	16598263	2007-08-25 21:12	crystal structures of the full-length Thermotoga maritima CorA in an apparent closed state and its isolated cytoplasmic domain at 3.9 A and 1.85 A resolution, respectively [CorA]
2336	2828187	16611245	2007-08-25 14:10	the DnaA homolog (tmaDnaA) of Thermotoga maritima forms open complexes with the predicted origin region (tma-oriC) in vitro. TmaDnaA has a strong and specific affinity for ATP/ADP as well as for 12-mer repeating sequences within the tma-oriC [DnaA]
2336	2828187	16826544	2007-08-25 14:08	The NMR structures of the unphosphorylated Thermotoga maritima protein TM1442 at pH 4.8 and of the phosphorylated TM1442 (TM1442-P). at pH 7.0 are presented, and a functional interaction of TM1442 with TM0733 is characterized (TM1442)
2336	2828187	16857941	2007-08-25 11:53	determined a 2.9 angstrom resolution structure of CorA that reveals a pentameric cone-shaped protein; two potential regulatory metal binding sites are found in the N-terminal domain that bind both Mg2+ and Co2+ [CorA]
2336	2828187	16878985	2007-08-25 21:02	This work describes the first direct observation of the interaction between P1 and P4 domains in CheA. (CheA)
2336	2828187	16890956	2007-08-25 13:30	Results describe the structure of a histidine kinase (ThkA) complexed with a response regulator (TrrA) in the two-component regulatory system from hyperthermophile Thermotoga maritima [ThkA, TrrA].
2336	2828187	16916792	2007-08-25 11:51	Asp-52 and His-222 directly contribute the proton transfer of tRNase Z catalysis (tRNase Z).
2336	2828187	17144654	2007-08-25 12:25	The PLP synthase holoenzyme consists of two subunits. [Pyridoxal-5-phosphate synthase]
2336	2828187	17256761	2007-08-25 11:47	The crystal structure of TM1602 was determined to 2.3 A resolution using the MAD method. The final model includes a monomer (residues 3-174), one Ni2+ ion, one K+ ion, and 97 water molecules in the asymmetric unit [TM1602]
2336	2828187	17407781	2007-08-25 15:00	The structures of hTK1 and of the Thermotoga maritima thymidine kinase (TmTK) in complex with the bisubstrate inhibitor TP4A, is reported.
2336	2828187	17588774	2007-12-22 11:41	The crystal structure of a putative transcriptional regulator protein TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was determined by an unusual multi-wavelength anomalous dispersion method at 2.0
2336	2828187	17602502	2007-10-06 11:58	Thermodynamic properties calculated in the dynamic context of the protein structure provided new insight into the mechanism of glutamate dehydrogenase thermostabilization (glutamate dehydrogenase).
2336	2828187	17656578	2007-11-10 11:55	Rates of methionine formation in the presence and absence of TM0269 and S-adenosylmethionine demonstrate that both TM0269 and S-adenosylmethionine are required for reactivation of the inactive cob(II)alamin form of TM0268 (TM0268 and TM0269).
2336	2828187	18095710	2008-03-10 13:38	The conditions that regulate MreB's monomer-to-polymer assembly reaction, the critical concentrations of that reaction, the manner in which MreB uses nucleotides, its stability, and the structure of the assembled polymer, are characterized.[MreB]
2336	2828187	18216012	2008-05-24 10:05	ATP-DnaA-oriC unwinding element complexes specifically bound the upper strand of single-stranded DUE[DnaA]
2336	2828187	18272173	2008-03-29 12:11	functional switch of Tm HtrA is embedded in the sentinel of the helical lid in terms of substrate accessibility[High-temperature requirement A]
2336	2828187	18276588	2008-06-21 10:34	analysis of structure-function relationships and gating mechanisms in the CorA Mg2+ transport system [CorA]
2336	2828187	18323606	2008-05-03 10:27	recombinant protein, cloned from Thermotoga maritima genomic DNA, was overproduced in Esherichia coli and crystallized in 25%(v/v) PEG 4000, 100 mM NaCl and sodium citrate buffer pH 5.0 at 291 K [ folate-dependent tRNA methyltransferase]
2336	2828187	18515342	2008-08-16 10:16	HU bends DNA and constrains negative DNA supercoils in the presence of topoisomerase I (HU).
2336	2828187	18602113	2008-09-13 10:06	Data indicate that the flexible arm of tRNase Z is not essential for pre-tRNA binding but affects the cleavage site selection: [tRNase Z]
2371	2828189	16631787	2007-08-25 11:55	Results describe the crystal structure of the organic hydroperoxide resistance protein Ohr from Xylella fastidiosa in complex with polyethylene glycol [Ohr].
2371	2828189	17427811	2007-12-01 13:01	This study demonstrated that the pglA gene encodes a functional polygalacturonase; a mutant in pglA lost pathogenicity and was compromised in its ability to systemically colonize Vitis vinifera grapevines. [pglA gene]
2371	2828189	17693510	2007-12-01 11:31	A type I pilus mutant (fimA) moved six times faster (4.85 [SE, 0.27] microm min(-1)) and a pilY1 mutant moved three times slower (0.28 [SE, 0.03] microm min(-1)) than wild-type cells. [PilY1]
2371	2828189	17985115	2008-06-14 10:24	The rpoN mutant made more biofilm than the wild type strain and presented a cell-cell aggregative phenotype.[rpoN in strain J1a12]
2443	2693957	17455912	2007-08-25 13:23	Helix 3 of colicin E1 channel peptide is appressed to the surface of the bacterial outer membrane with its N-terminus more deeply buried within the interfacial region of the bilayer than its C-terminus.
2443	2693967	16299381	2007-08-25 12:34	analysis of the membrane-bound conformation of helix 1 in the colicin E1 channel domain
2443	2693967	17710646	2007-12-01 10:15	Results suggest that the peptides could be involved in the toroidal pore formation of colicin E1, notably by disturbing the lipids and facilitating the insertion of the other, more hydrophilic, helices that will form the pore.
2465	1263522	16403518	2007-08-25 13:03	Results describe the subcellular localization of SopA and SopB.
2465	1263547	16364910	2007-08-25 11:59	Data show that both the monomeric and the dimeric forms of the RepE initiator protein of F factor together promote pairing of incC-oriF sites by DNA looping.
2465	1263559	16403518	2007-08-25 13:03	Results describe the subcellular localization of SopA and SopB.
2465	1263567	17259615	2007-08-25 10:43	These results suggest that TraG may be translocated to the recipient cell, where it contacts the inner membrane, initiating transfer, a process that is blocked by TraS.
2465	1263588	17259615	2007-08-25 10:43	These results suggest that TraG may be translocated to the recipient cell, where it contacts the inner membrane, initiating transfer, a process that is blocked by TraS.
2504	2716946	17939681	2008-01-26 12:52	The structure of the RepA hexamer, in solution, differs considerably from the crystal structure of the enzyme. Both fluorescence energy transfer and analytical ultracentrifugation data indicate a significant conformational flexibility of the RepA hexamer
3055	2716961	18055611	2008-03-10 15:45	RBP40 binds to the psbD 5'UTR in a Nac2-dependent fashion both in vitro and in vivo
3055	2716979	17180456	2007-08-25 12:24	The level of the mature RNA for thie protein is determined more by the 3' UTR than the 5' UTR.
3055	2717000	15449953	2007-08-25 12:50	Substitution of alanine for threonine at position 739 of PsaA removes the hydrogen- bond donor to P700 but does not block incorporation of chlorophyll a' in Chlamydomonas reinhardtii photosystem I.
3055	2717021	16514563	2007-08-25 12:32	petD regulatory elements, and possibly the corresponding trans-acting factors, function via mechanisms highly specific and surprisingly sensitive to minor sequence changes
3055	2717040	17824672	2007-12-15 11:56	A variety of subtle interactions must be responsible for catalytic efficiency and CO2/O2 specificity of rbcL.
3055	2717040	17996019	2008-07-12 10:36	Results indicated that the two inverted repeats function as redundant mRNA stability determinants in the 3' UTR of rbcL.
3055	2717040	18072944	2008-04-26 10:24	C172S Rubisco showed a critical denaturation temperature approx
3055	5717125	18545969	2008-08-09 10:11	the candidate enzyme from Chlamydomonas reinhardtii with the highest similarity to the microsomal delta 12 desaturase of Chlorella vulgaris was isolated, and its function was verified by heterologous expression in yeast (Saccharomyces cerevisiae)
3055	5717182	18420590	2008-07-26 10:36	HEP2 might be required for de novo folding of HSP70B after transit peptide cleavage.
3055	5719874	18266760	2008-05-10 10:13	An association between CP12 and phosphoribulokinase (EC 2.7.1.19), glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.13) and aldolase was found.
3055	5720002	17711413	2007-12-22 12:50	data suggest that HSF1 is a key regulator of the stress response in Chlamydomonas
3055	5720015	18493046	2008-09-27 10:17	FER1 and FER2 encoding two ferritin complexes in Chlamydomonas reinhardtii chloroplasts are regulated by iron.
3055	5720109	18245275	2008-03-29 11:16	When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway.
3055	5720923	18420823	2008-05-24 10:05	A Chlamydomonas reinhardtii mutant defective in a Ser/Thr protein kinase (MUT9p), which phosphorylates histones H3 and H2A, shows deficiencies in the heritable repression of transgenes and transposons.
3055	5721101	18157907	2008-04-26 11:18	Chemical crosslinking, native gel electrophoresis, and epitope-tagged RSP3 proteins established that RSP3 forms a dimer.
3055	5722130	18385113	2008-06-21 10:14	These results reveal a complex genetic network that lies downstream of MAT3/RB and implicate protein sumoylation as an important step for cell-cycle progression in cells that are missing MAT3/RB.
3055	5722220	18420590	2008-07-26 10:36	HEP2 might be required for de novo folding of HSP70B after transit peptide cleavage.
3055	5723926	18055611	2008-03-10 15:45	RBP40 binds to the psbD 5'UTR in a Nac2-dependent fashion both in vitro and in vivo
3055	5724190	18421551	2008-09-20 10:43	The capability of cyclin-dependent kinases CDKA and CDKB from the green alga Chlamydomonas reinhardtii to complement a Saccharomyces cerevisiae cdc28 temperature-sensitive mutant, was investigated.
3055	5725497	18510927	2008-06-21 10:33	Gsm1/Gsp1 dyads share sequence homology with and are functionally related to KNOX/BELL dyads regulating stem-cell (meristem) specification in land plants.
3055	5725608	18202004	2008-05-31 10:29	The binding of zinc atoms to the N-terminal parts of CCM1, expressed as glutathione S-transferase fusion proteins, is reported.
3055	5726206	18245276	2008-03-29 11:16	This study proved the formate-producing activity of the putative Pfl1 enzyme by heterologous expression of the C. reinhardtii PFL1 cDNA in Escherichia coli and subsequent in vitro activity tests of the purified protein.
3055	5726868	18421551	2008-09-20 10:43	The capability of cyclin-dependent kinases CDKA and CDKB from the green alga Chlamydomonas reinhardtii to complement a Saccharomyces cerevisiae cdc28 temperature-sensitive mutant, was investigated.
3055	5727568	18487347	2008-08-30 10:39	The motility of oda2-t mutant is lower than that of the wild type and oda11 (lacking the alpha heavy chain) but higher than that of oda2 and oda4-s7.
3055	5727782	18573878	2008-09-13 10:06	The cloning of MCA1, the first pentatricopeptide repeat protein functionally identified in this organism, is reported.
3055	5729049	18077439	2008-01-12 11:59	Putative protein coded by MoT1 shows motifs specifically conserved in similar proteins and is probably involved in molybdate transport.
3055	5739187	17984324	2007-12-15 12:45	the CrPKD2 cation channel is involved in coupling flagellar adhesion at the beginning of mating to the increase in flagellar calcium required for subsequent steps in mating [PKD2]
3055	5739187	18024571	2008-03-10 14:58	data indicate that NIT2 is a central regulatory gene required for nitrate signaling on the Chlamydomonas NIA1 gene promoter and that intracellular nitrate is needed for NIT2 function and to modulate NIA1 transcript levels [NIT2]
3055	5739187	18055611	2008-03-10 15:45	RBP40 binds to the psbD 5'UTR in a Nac2-dependent fashion both in vitro and in vivo [RBP40]
3055	5739187	18157500	2008-06-20 14:35	A new Chlamydomonas reinhardtii flagellar mutant named tcp1 for twisted central pair in which central pair projections are missing and the central pair microtubules are twisted along the length of the flagellum is presented.[Tcp1]
3055	5739187	18326790	2008-09-06 10:05	data reveal the crucial regulatory role of SNRK2.1 in the signaling cascade critical for eliciting S deprivation responses [SNRK2.1]
3055	5739187	18510927	2008-06-21 10:33	Gsm1/Gsp1 dyads share sequence homology with and are functionally related to KNOX/BELL dyads regulating stem-cell (meristem) specification in land plants.[Gsm1]
3218	5951760	17921313	2008-04-26 13:06	study found that loss of RAD51 function in the moss Physcomitrella patens caused a significant vegetative phenotype, indicating an important function for RAD51 in this organism [RAD51]
3218	5951760	18460812	2008-08-02 10:40	PprecA2 partially complemented the recA mutation in Escherichia coli and was involved in the repair of chloroplast DNA in Physcomitrella patens [PprecA2]
3562	2715611	16569212	2007-08-25 12:33	short-chain plastoquinones stimulate O2*- production via a mechanism that involves electron transfer from Pheo- (pheophytin) to LP cyt b559 and subsequent auto-oxidation of LP cyt b559
3562	2715612	16569212	2007-08-25 12:33	short-chain plastoquinones stimulate O2*- production via a mechanism that involves electron transfer from Pheo- (pheophytin) to LP cyt b559 and subsequent auto-oxidation of LP cyt b559
3702	814572	17550895	2007-09-22 11:06	AtCCMA interacts with AtCcmB to form a novel mitochondrial ABC transporter involved in cytochrome c maturation in Arabidopsis
3702	814652	17889453	2007-12-01 10:13	The expression of RPL7B in Arabidopsis is reported.
3702	814654	17568770	2007-12-01 10:31	plausible mechanism of QSO2 action consists on the activation of root systems loading K(+) into xylem, but different from the SKOR channel, which is not required for QSO2 action
3702	814670	16055631	2007-08-25 14:44	Data suggest that auxin transport activity, in particular that of the PIN-FORMED1 (PIN1) and PIN4 proteins, is a major factor in the maintenance of auxin gradients.
3702	814670	17889649	2007-11-10 11:55	PP2A and PINOID both partially colocalize with PINs and act antagonistically on the phosphorylation state of their central hydrophilic loop, hence mediating PIN apical-basal polar targeting.
3702	814678	15659481	2005-09-28 08:05	PRETTY FEW SEEDS2 gene encodes a homeodomain transcription factor which affects either ovule patterning or differentiation [PFS2] [PRETTY FEW SEEDS2]
3702	814678	17652352	2007-11-10 11:07	Genetic interaction of the ER family and the WOX-family gene, PFS2, reveals their contribution to integument development through interrelated mechanisms.
3702	814686	15155881	2007-08-25 13:49	SLEEPY1 interacts directly with RGA and GA INSENSITIVE (GAI, a closely related DELLA protein) via their C-terminal GRAS domain
3702	814686	15161962	2007-08-25 13:02	SLY1 (the wild-type form) and sly1gar2-1 both confer substrate specificity on this complex via specific binding to the DELLA proteins, GAI and RGA
3702	814686	16034591	2007-08-25 11:26	We show that ga1-3 seeds lacking RGA, RGL1 and RGL2 or GAI, RGL1 and RGL2, confer GA-independent germination in the light but not in the darkness whilst ga1-3 seeds lacking GAI, RGA and RGL2 germinate both in the light and darkness.
3702	814686	17488236	2007-09-15 11:52	DELLA abundance is regulated during growth responses to neighbours in dense Arabidopsis stands. This occurs in a red:far red ratio-dependent manner in petioles, depends on gibberellin, and matches the induction kinetics of petiole elongation.
3702	814688	17041026	2007-08-25 21:11	The CRR3 gene (At2g01590) encodes a novel protein containing a putative plastid-targeting signal and a transmembrane domain and is localized to the membrane fraction of chloroplasts.
3702	814702	16897494	2007-08-25 13:31	Two 73 kD subunits of the AtCPSF complex appear to have special functions during flower development.
3702	814708	17082420	2007-08-25 21:17	findings provide functional proof that VIT1 mediates iron sequestration into vacuoles of seeds [VIT1]
3702	814714	15155880	2007-08-25 13:49	growth and development of the ahk2 ahk3 ahk4 triple mutant were markedly inhibited in various tissues and organs, including the roots and leaves in the vegetative growth phase and the influorescence meristem in the reproductive phase
3702	814714	15509853	2007-08-25 12:50	the diverse cytokinin compounds might have specific functions in the numerous cytokinin-regulated processes, which may depend in turn on different receptors and their associated signalling pathways
3702	814714	15923327	2007-08-25 21:24	The sugar effect in shoots of phosphate-starved plants was particularly enhanced in the cre1 ahk3 double mutant.
3702	814714	16357038	2007-08-25 12:34	findings imply that functional disturbance of AHK4 (a cytokinin receptor) affects other receptors & suggests that cytokinin receptors are needed for formation of auxin-transporting vascular tissues in the hypocotyl, but not in adventitious roots
3702	814714	16361392	2007-08-25 11:24	Results reveal partially redundant functions of the cytokinin receptors and prominent roles for the AHK2/AHK3, but not AHK4, receptor combination in quantitative control of organ growth in plants, with opposite regulatory functions in roots and shoots.
3702	814716	15860011	2005-11-22 09:04	XTH27 plays a role in the generation of tracheary elements in the rosette leaves of Arabidopsis. [AtXTH27]
3702	814722	15908607	2007-08-25 13:08	evidence that AtMAP65-1 and AtMAP65-6, two related proteins, may regulate microtubule organization in different manners
3702	814725	16813575	2007-03-05 16:52	SGR5 may be involved in an early event in shoot gravitropism such as gravity perception and/or a signaling process subsequent to amyloplast sedimentation as a putative transcription factor in gravity-perceptive cells. [SGR5]
3702	814725	18259878	2008-09-20 10:05	Loss of SGR5 regulatory activity affects starch accumulation in Arabidopsis shoot tissues and causes decreased sensitivity to gravity and diminished circumnutational movements.
3702	814729	15347782	2007-08-25 11:11	K(+) nutrition in salt overly sensitive1 (sos1) mutants
3702	814729	17023541	2007-08-25 13:29	Regulates several genes related to oxidative-stress tolerance.
3702	814729	17103013	2007-08-25 21:16	Truncation of the hydrophilic tail relieved the toxicity and proved that this protein is an excellent low-affinity K+ and Rb+ transporter.
3702	814729	17499048	2007-08-25 12:20	SOS2 family of protein kinases and their activators, the SOS3 family of calcium-binding proteins, function together; SOS2 is activated by Ca-SOS3 and subsequently phosphorylates ion transporter SOS1 to protect cellular ion homeostasis under salt stress
3702	814753	16829587	2007-08-25 10:13	it is reported that loss-of-function and gain-of-function mutations of the phytosulfokine receptor gene (AtPSKR1) alter cellular longevity and potential for growth without interfering with basic morphogenesis of plants
3702	814779	16478479	2007-08-25 10:54	crystal structure of the catalytic domain
3702	814786	16943276	2007-08-25 21:11	HVE/CAND1 gene acts upstream of ATHB-8 at least in higher order veins, in a pathway that involves AXR1, but not LOP1, PIN1, CVP1 or CVP2.
3702	814786	18550827	2008-07-19 10:40	The disruption of the CAND1-CUL1 interaction results in an increased abundance of assembled SCF(TIR1) complex; stabilization of the CAND1-CUL1 interaction diminishes SCF(TIR1) complex abundance.
3702	814800	17982713	2008-05-21 13:55	LOV domain of PLPA and PLPB functions as a blue light sensor, and suggest the applicability of these interactions to blue light-dependent switching in transcriptional regulation in yeast or other organisms [PLP]
3702	814811	16467298	2007-08-25 21:09	it is proposed that in A. thaliana, AtUTr1 is the UDP-glucose transporter involved in quality control in the endoplasmic reticulum
3702	814816	15908590	2007-08-25 13:08	Arabidopsis plantacyanin is expressed most highly in the inflorescence and, specifically, in the transmitting tract of the pistil.
3702	814823	15170492	2007-08-25 12:11	changes in PKS1 or PKS2 content may affect the total phytochrome A concentration
3702	814823	16777956	2007-08-25 10:50	PKS1 induction by a pulse of blue light is phytochrome A-dependent, suggesting that the PKS proteins may provide a molecular link between these two photoreceptor families.
3702	814823	18024556	2008-03-29 10:21	PKS1 positively affects root phototropism and both effects contribute to negative curvature in response to unilateral blue light.
3702	814863	18570649	2008-10-04 10:39	Data support that WRKY3 function as transcription factors and have a positive role in plant resistance to necrotrophic pathogens.
3702	814882	15308648	2005-01-31 14:53	UPS1 and UPS2 from Arabidopsis have roles in high affinity transport of uracil and 5-fluorouracil [UPS2]
3702	814885	17240087	2007-08-25 14:01	AtFBP7 is required for protein synthesis during temperature stress.
3702	814888	15308648	2005-01-31 11:39	UPS1 and UPS2 from Arabidopsis have roles in high affinity transport of uracil and 5-fluorouracil [UPS1]
3702	814896	15155883	2004-09-29 16:41	Observations suggest that SPR1 is involved in microtubule polymerization dynamics and/or guidance, which in turn influences touch-induced directional cell expansion and axial twisting. [SPIRAL1]
3702	814896	16478750	2007-08-25 12:33	these observations suggest that SPR1 and SP1Ls act redundantly in maintaining the cortical microtubule organization essential for anisotropic cell growth
3702	814898	15530395	2005-04-26 17:02	SEP4 contributes to the development of petals, stamens, carpels, sepals and plays an important role in meristem identity. [SEPALLATA4] [SEP4]
3702	814903	15317023	2007-08-25 13:41	crystal structure of At2g03760; it has high structural similarity to two human steroid sulfotransferases: human estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase
3702	814906	17251192	2007-08-25 14:01	GEK1 expression is capable of functionally compensating in E. coli for the absence of endogeneous d-Tyr- tRNA(Tyr) deacylase.
3702	814962	16792696	2007-01-08 13:49	The XERICO gene is involved in drought tolerance through regulation of ABA synthesis. [XERICO]
3702	814965	18441049	2008-06-21 10:05	RNase E participates in the initial endonucleolytic cleavage of the polyadenylation-stimulated RNA degradation process in the chloroplast, perhaps in collaboration with the two other chloroplast endonucleases, RNase J and CSP41.
3702	814965	18515828	2008-08-30 10:16	Loss of At2g04270 function resulted in the arrest of chloroplast development, loss of autotrophic growth, and reduced plastid ribosomal, psbA and rbcL RNA levels.
3702	814996	17616510	2008-01-12 11:13	encodes beta-ketoacyl-[acyl carrier protein] synthase(mtKAS), but mitochondrial protein lipoylation does not exclusively depend on the mtKAS pathway of lipoate biosynthesis in leaves and may occur independently of this pathway in roots
3702	814997	14630970	2008-03-28 15:40	IBR5 is an apparent MAP kinase phosphatase.  ibr5 mutants display reduced responses to auxin and abscisic acid (ABA).
3702	814997	18423007	2008-08-02 10:05	Data suggest that IBR5 is a phosphatase that promotes auxin responses, including auxin-inducible transcription, differently than the TIR1 auxin receptor and without destabilizing Aux/IAA repressor proteins.
3702	815035	15935985	2007-08-25 10:22	The preliminary X-ray analysis was undertaken. The crystal diffracted to 2.50 A resolution in-house and belongs to space group P2(1)
3702	815035	17264121	2007-08-25 21:20	A molecular model of WRKY1 protein-DNA complex from site-directed mutagenesis studies.
3702	815069	16107718	2005-12-01 11:04	AtPot1 (protection of telomeres 1) and AtPot2 are ubiquitously expressed at low levels in Arabidopsis. AtPot1 is essential for telomere length maintenance. [Atpot1]
3702	815085	15165191	2007-08-25 11:35	SGS2/SDE1 and SGS3 are needed for endogenous gene silencing from DNA viruses, and suggest that SGS2/SDE1 may reduce geminivirus symptoms by targeting viral mRNAs.
3702	815093	17287892	2007-07-02 14:11	These results suggest that AtGRP9 may be involved in lignin synthesis in response to salt stress as a result of its interaction with AtCAD5 in A. thaliana. [AtGRP9]
3702	815093	17287892	2007-06-12 10:57	Yeast two-hybrid analysis revealed that AtGRP9 interacted with AtCAD5, a major cinnamyl alcohol dehydrogenase (CAD) involved in lignin biosynthesis, for which tissue-specific distribution was comparable with that of AtGRP9. [AtGRP9]
3702	815111	17803955	2007-12-01 13:11	pgr5 mutant is affected in the redox poising of the chloroplast
3702	815111	17913767	2008-01-05 15:44	This study suggested that a balanced PGR5 level is required for efficient regulation of the rate of antimycin A-sensitive photosystem I cyclic electron transport.
3702	815111	18243102	2008-03-22 11:09	A complex containing PGRL1 and PGR5 is involved in the switch between linear and cyclic electron flow in Arabidopsis.
3702	815111	18388110	2008-07-12 10:06	These results suggest that the rate of PGR5-dependent photosystem I cyclic electron transport is high enough to balance the production ratio of ATP and NADPH during steady-state photosynthesis, consistently with the pgr5 mutant phenotype.
3702	815120	17437406	2007-08-25 13:23	The identification of ACO1, ACO2, and ACO3 in A. thaliana is reported, and it was demonstrated that, in plants, the cytosolic ACOs are not converted into iron regulatory proteins.
3702	815152	18467464	2008-09-20 10:16	inhibited by cyperin
3702	815160	16533544	2007-08-25 21:27	OPR3 was found to be induced by touch, wounding, methyl jasmonate, NaCl and CaCl(2) while ethylene and darkness had no effect.
3702	815160	16807820	2007-08-25 11:53	brassinosteroid-responsive gene
3702	815261	17692835	2008-01-05 14:54	analysis of secretory phospholipase A2-alpha from Arabidopsis thaliana
3702	815275	18287026	2008-05-03 13:10	Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis.
3702	815364	16107557	2007-08-25 14:15	Investigation of gene arrangements and the steady state transcripts of the mitochondrially encoded cox3 gene in three different ecotypes.
3702	815504	17701425	2008-03-15 12:54	Data shows that 14-3-3 proteins are physically present in the AtEm1 transcriptional complex in vivo and are required for the maintenance of the transcriptional complex in vitro.
3702	815657	16762032	2007-08-25 21:17	Exogenous auxin activates MGD3 expression during Phosphate starvation, whereas expression is repressed by cytokinin treatment in the root.
3702	815840	15361145	2007-08-25 12:59	Abh1 lesion affects several developmental processes, perhaps because the processing of certain mRNAs.
3702	815852	15842618	2005-10-26 14:08	CalS5 encodes a callose synthase which is responsible for the synthesis of callose deposited at the primary cell wall of meiocytes, tetrads and microspores, and the expression of this gene is essential for exine formation in pollen wall. [CalS5]
3702	815862	17600708	2008-01-05 15:16	study demonstrates that BAK1 and BKK1 (AtSERK4) have dual physiological roles: positively regulating a brassinosteroid (BR)-dependent plant growth pathway, and negatively regulating a BR-independent cell-death pathway
3702	815864	15447647	2005-02-14 10:54	We now find agd2-like defense response protein1 to be a key defense component that acts in multiple contexts and partially requires the PHYTOALEXIN DEFICIENT4 (PAD4) defense regulatory gene for its expression in response to infection. [ALD1]
3702	815864	18266921	2008-08-09 10:19	ALD1 is partially required for Pseudomonas syringae HopW1-1-induced disease resistance.
3702	815898	16533833	2007-08-25 21:03	Systems controlling cell death in animals and plants are not common in terms of mitochondrial fission.
3702	815907	16021502	2007-08-25 13:05	ANR1 expression in roots of hydroponically grown Arabidopsis plants was specifically regulated by changes in the N supply, being induced by N deprivation and rapidly repressed by N re-supply.
3702	815907	16339770	2007-08-25 10:19	There is evidence for a nitrate-dependent component of the ANR1 signalling pathway.
3702	815943	18346188	2008-10-06 15:46	LURP1 as an important component of the plant immune system and demonstrate its functional significance for SA-dependent defense pathways mediating R-proteintriggered and basal resistance to Hp. [LURP1]
3702	815949	15293050	2007-08-25 14:53	Expression in comparison to At2g19990; recommendation to change the annotation.
3702	815949	16048996	2007-08-25 21:09	Lipooligosaccharide and the lipid A and core oligosaccharides derived from it were all able to induce the defense-related gene PR1 in Arabidopsis and to prevent the hypersensitive response caused by avirulent bacteria.
3702	815955	15361146	2005-01-26 11:23	Sucrose transporter 8 encodes functional sucrose transporter and is expressed in floral tissue. [SUC8]
3702	815962	18436547	2008-06-28 10:22	Loss of AtVSR3 protein caused the accumulation of nitric oxide and hydrogen peroxide, signalling molecules implicated in the regulation of stomatal opening and closing.
3702	816012	16226259	2006-01-03 14:57	AtLip1 exhibits strong homology to lysosomal acid lipase and was found to drive the synthesis of an active TAG lipase when expressed in the baculovirus system. [AtLip1]
3702	816018	16891400	2007-03-07 15:25	Tic21 functions as part of the inner membrane protein-conducting channel and may be more important for later stages of leaf development. [Tic21] [CIA5]
3702	816018	17337631	2007-08-20 16:23	PIC1 functions in iron transport across the inner envelope of chloroplasts and hence in cellular metal homeostasis. [PIC1] [PERMEASE INCHLOROPLASTS1]
3702	816050	17517886	2007-09-22 11:34	AtATM1, AtATM2, and AtATM3 are a subfamily of Arabidopsis half-molecule ATP-binding cassette transporters implicated in iron homeostasis
3702	816074	18441215	2008-08-09 10:44	genetic data suggest that RBL, SQN, and, to a lesser extent, ULT1 also influence SUPERMAN activity
3702	816103	17298064	2007-08-25 12:22	The structures of AHb1 and AHb2, modeled on the basis of the homologous rice hemoglobin, exhibit a different cavity system that is fully compatible with the observed ligand binding kinetics
3702	816103	17555890	2007-09-29 12:22	Finding strongly supports the idea that AHb1 and AHb2 have distinct physiological functions.
3702	816136	15947783	2005-11-01 14:56	DRD1 is essential for RNA-directed de novo methylation and acts on different target promoters. [DRD1]
3702	816136	16724114	2007-06-27 11:22	DRD1 and Pol IVb establish a basal level of silencing that can potentially be reversed in euchromatin, and further reinforced in heterochromatin by other proteins that induce more stable modifications.[DRD1]
3702	816136	16741558	2007-08-25 14:08	DRD1, together with RNAi and histone methylation actively target developmentally important non-CG DNA methylation in arabidopsis.
3702	816149	15733873	2007-08-25 15:05	Arginine decarboxylase genes are required for production of polyamines that are essential for normal seed development in Arabidopsis
3702	816194	17978851	2008-05-10 10:22	AMS can target ASHR3 to chromatin and regulate genes involved in stamen development and function
3702	816218	17468208	2007-12-01 12:57	Leaf IDH activity reduced by 43% in mutant
3702	816232	15703056	2007-08-25 14:17	HSK overexpression had no effect on the level of soluble homoserine phosphate, methionine and threonine/me
3702	816235	17032064	2007-08-25 10:10	CPK6 functions in guard cell ion channel regulation and provide genetic evidence for calcium sensors that transduce stomatal ABA signaling.
3702	816238	18266921	2008-08-09 10:19	NIM1 is partially required for Pseudomonas syringae HopW1-1-induced disease resistance.
3702	816240	16040657	2007-08-25 21:04	CYP51A1 should be considered an expressed pseudogene.
3702	816241	16511115	2007-08-25 21:18	X-ray crystallographic structure of teh At2g17340 gene from Arabidopsis thaliana
3702	816248	17586656	2007-10-20 10:20	These data demonstrate that neither cytosolic nor mitochondrial NTRs are essential in plants.
3702	816271	15579666	2005-11-21 15:34	Serat3;1 and Serat3;2, were characterized with respect to their enzymatic properties, feedback inhibition by L-Cys, and subcellular localization. [Serat3;1]
3702	816271	16525754	2007-08-25 10:54	From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
3702	816278	17090544	2007-08-25 21:16	The protein kinase AT2G17700 could represent a subunit of a regulatory network involved in the cytosolic events of chloroplast protein import.
3702	816289	18222962	2008-05-31 10:27	findings suggest that VPS35, mainly VPS35b, is involved in sorting proteins to PSVs in seeds, possibly by recycling VSR from PVCs to the Golgi complex, and is also involved in plant growth and senescence in vegetative organs
3702	816291	18077346	2008-02-02 11:09	AHK1 plays important roles in plant growth because the ahk1 ahk2 ahk3 triple mutant showed further reduced growth.
3702	816291	18441212	2008-08-09 10:44	Since overexpression of ATHK1 results in increased water stress tolerance, our observations suggest a new top-down route to increasing drought resistance via receptor-mediated increases in sensing water status
3702	816305	15342527	2007-08-25 12:07	Ultrapetal1 negatively regulates WUSCHEL to establish floral meristem determinacy.
3702	816305	15952065	2007-08-25 13:10	results suggest that overexpression of WUS could trigger cell pluripotence and reestablish new meristems from differentiated tissues
3702	816305	15980263	2007-08-25 10:57	The homeobox gene WUSCHEL (WUS) is expressed in the organizing center underneath the stem cells and integrates regulatory information from several pathways to define the boundaries of the stem cell niche.
3702	816305	16372013	2007-08-25 10:18	data indicate that ARR genes might negatively influence meristem size and that their repression by WUS might be necessary for proper meristem function
3702	816305	16461579	2007-08-25 10:19	Detailed characterization of a semidominant roa allele revealed an essential role for the conserved C-terminal domain that mediates an interaction between WUS and two members of a small family of corepressor-like proteins in Arabidopsis.
3702	816305	16877025	2007-08-25 21:21	facilitates high cytokinin activity in the shoot apical meristem
3702	816305	17027956	2007-08-25 14:05	WUS expression is initiated very early during anther development in the precursor cells of the stomium and terminates just before the stomium cells enter terminal differentiation
3702	816305	17429400	2007-08-25 12:21	Importantly, both WOX5 and WUS maintain stem cells in either a root or shoot context.
3702	816330	17908155	2008-03-22 10:20	Data showed that expression of the MKK7 gene in wild-type plants is induced by pathogen infection. Reducing mRNA levels of MKK7 by antisense RNA expression not only compromises basal resistance, but also blocks the induction of SAR.
3702	816354	18047472	2008-04-12 11:12	Together these data suggest that ARL2 and ARG1 functionally link gravity sensation in the statocytes to auxin redistribution through the root cap.
3702	816394	15695459	2007-08-25 21:23	These results demonstrate roles for phytochromes in regulating both the elongation and gravitropic curvature of roots
3702	816394	15753105	2007-08-25 13:41	The expression of 35S:NtPHYB:GFP and 35S:AtPHYB:GFP complemented the tobacco hgl2 and Arabidopsis phyB-9 mutations, whereas the 35S:AtPHYD:GFP only rescued the hgl2 mutant.
3702	816394	15823535	2007-08-25 12:45	The nuclear-localization signal in the C-terminal PAS-related domain of phytochrome B is masked by interactions with the chromophore-attachment domains and unmasked by light-dependent conformational changes.
3702	816394	15965119	2007-08-25 13:40	Mesophyll phytochrome B suppressed the expression of a key flowering regulator, FLOWERING LOCUS T, in the vascular bundles of cotyledons.
3702	816394	17419844	2007-08-25 13:59	The extensive overlap in responses mediated by PHYA and PHYB is reported.
3702	816394	17545225	2008-01-05 15:45	ARR4 directly modulates the activity state of phyB.
3702	816394	17660358	2007-12-01 12:40	Photoconversion is not a prerequisite for phytochrome signaling.
3702	816394	17827270	2008-01-19 12:04	Photobiological and genetic evidence indicated that the photoactivated phytochrome molecule acts to induce PIF5 phosphorylation, phyA and phyB redundantly dominate this process.
3702	816394	18047474	2008-04-12 11:12	findings show that PIF4 and PIF5 act early in the phytochrome signaling pathways to promote the shade-avoidance response
3702	816394	18065691	2008-08-09 10:19	Data show that the phyB degradation in the Arabidopsis thaliana overexpressing PIF5 depends on a functional phyB binding motif in PIF5 and involves the 26S proteasome pathway.
3702	816394	18252845	2008-08-02 10:05	Data provide evidence that the mechanism by which PIFs operate on the phyB signaling pathway under prolonged red light is through maintaining low phyB protein levels, in an additive or synergistic manner.
3702	816394	18287016	2008-05-03 13:10	Amino acid polymorphisms in Arabidopsis phytochrome B cause differential responses to light.
3702	816394	18296722	2008-05-31 10:05	These data suggest that the second-phase decline in robustness of PIL1 derepression is an indirect consequence of the global developmental transition from the etiolated to the de-etiolated state.
3702	816394	18704165	2008-09-27 10:38	The N-terminal of phyB is involved in signal transfer and the C-terminal is responsible for light perception.
3702	816395	17674032	2008-02-09 11:11	AtXTH21 (At2g18800), an Arabidopsis XTH gene that mainly expresses in root and flower, exhibits different expression profiles from other XTH members under hormone treatment.
3702	816408	15310821	2007-08-25 11:11	LKP2, a nuclear protein, interacted not only with itself but also with other members of the family, LKP1 and FKF1.
3702	816413	17557075	2007-12-01 11:52	AHA1 is a distinct component of an abscisic acid-directed signaling pathway, and that dynamic downregulation of this pump during drought is an essential step in membrane depolarization to initiate stomatal closure
3702	816428	15498553	2005-01-31 14:00	AtHMA4 overexpressing lines displayed an increase in the zinc and cadmium content of shoots. [AtHMA4]
3702	816428	15733866	2005-09-02 15:20	Mutagenesis of the cysteine and glutamate residues from the N-ter degenerated heavy metal binding domain impaired the function of AtHMA4 [HMA4]
3702	816518	15293050	2007-08-25 14:53	Expression in comparison to At2g14610; recommendation to change the annotation.
3702	816519	16938844	2007-08-25 14:06	Small clones reveal non-cell-autonomous rescue of hbt mutant cells, indicating a previously unrecognized compensation mechanism for reduced activity of an anaphase-promoting complex/cyclosome component critical for cell cycle progression.
3702	816521	17071648	2007-08-25 10:09	The mutant phenotype associated with T-DNA insertions in the Arabidopsis gene AtCAF1, encoding the ortholog of the maize chloroplast splicing factor CAF1, was examined.
3702	816538	15448264	2007-08-25 12:50	negatively regulates chlorophyll biosynthesis
3702	816538	16359394	2006-04-28 17:18	PIF1 is degraded in red (R) and far-red (FR) light through the ubiquitin (ub)-26S proteasome pathway to optimize photomorphogenic development in Arabidopsis.[PIF1]
3702	816538	17449805	2007-10-06 11:58	PIL5 binds directly to GAI and RGA promoters but not to Giberellic and Abscisic metabolic gene promoters in arabidopsis.
3702	816538	18591656	2008-08-09 10:12	These data strongly suggest that PIF1 directly and indirectly regulates key genes involved in chlorophyll biosynthesis to optimize the greening process in Arabidopsis.
3702	816539	17873093	2008-05-21 12:37	Arabidopsis thaliana CLASP protein is a microtubule-associated protein that is involved in both cell division and cell expansion.[CLASP]
3702	816539	18042620	2008-03-22 11:10	findings show that AtCLASP is enriched at the plus ends of microtubules where it localizes behind the AtEB1b protein; AtCLASP is required for cell morphogenesis and cell division
3702	816545	17503073	2007-12-01 11:52	The psae1-3 psae2-1 double mutant totally lacked the E subunit of photosystem I but was still able to grow photoautotrophically.
3702	816549	17376810	2007-07-02 15:38	Study identified a novel mutant gene in Arabidopsis, ALE2, which is associated with various epidermal defects, including disorganization of epidermis-related tissues, defects in the leaf cuticle and the fusion of organs. [ALE2]
3702	816556	15863516	2006-05-02 11:56	KAM1/MUR3 is a novel component of the Golgi-mediated organization of actin functioning in proper endomembrane organization and cell elongation.[MUR3] [KAM1]
3702	816579	17533111	2007-08-25 10:40	GLK1 'regulon' encodes disease defense related proteins and confers resistance to Fusarium graminearum in Arabidopsis
3702	816580	16169895	2006-03-10 15:32	RPN1 activity is essential during embryogenesis, where it might participate in the destruction of a specific set of protein substrates.[RPN1a]
3702	816623	15516501	2005-02-01 14:49	The Thf1 gene product plays a crucial role in a dynamic process of vesicle-mediated thylakoid membrane biogenesis. [Thf1]
3702	816623	16582010	2007-08-25 10:53	THYLAKOID FORMATION1 (THF1) is demonstrated in vivo as a Galpha interaction partner that functions downstream of the plasma membrane-delimited heterotrimeric G-protein (GPA1) in a D-glucose signaling pathway.
3702	816642	18281507	2008-08-02 10:05	Study propose that FIO1 regulates period length in the Arabidopsis circadian clock in a close association with the central oscillator and that the circadian period can be controlled separately from amplitude and robustness.
3702	816648	16928193	2007-08-25 21:08	Isomerization and disulfide-reduction activities are independent functions of CYP20-3 that both are regulated by the redox state of its active centre.
3702	816705	17450127	2007-08-25 21:23	A. thaliana knockout lines defective in the glycine-rich RNA-binding protein GRP7 (also known as AtGRP7), a HopU1 substrate, were more susceptible than wild-type plants to P. syringae
3702	816705	17924945	2008-03-22 12:03	Data show that site-specific mutation of one conserved arginine to glutamine within the RNA recognition motif impairs binding of recombinant AtGRP7 to its pre-mRNA in vitro.
3702	816762	18298954	2008-05-17 10:24	CAMTA3 regulates the expression of a set of genes involved in biotic defense responses.
3702	816763	17905865	2008-01-19 10:52	This study reports on the characteristics of UBP3 and UBP4 in A. thaliana.
3702	816780	17450124	2007-07-02 16:37	GEM participates in the maintenance of the repressor histone H3K9 methylation status of root patterning genes, providing a link between cell division, fate and differentiation during Arabidopsis root development [GEM]
3702	816782	15501911	2007-08-25 14:50	Effect of expression in tobacco on plant shoot apical meristem development.
3702	816787	16679456	2007-08-25 11:56	The data provides genetic evidence for the role of AP1 in these interactions by showing that the floral phenotype in the ap1 agl24 svp triple mutant is significantly enhanced.
3702	816787	17322399	2007-08-25 14:01	SVP mediates the temperature-dependent functions of FCA and FVE within the thermosensory pathway.
3702	816787	17428825	2007-08-25 15:03	once AP1 is activated during the floral transition, it acts partly as a master repressor in floral meristems by directly suppressing the expression of flowering time genes SVP, AGL24 and SOC1, preventing continuation of the shoot developmental program
3702	816787	18453531	2008-08-02 10:05	Complementation tests showed that rice OsMADS22 and OsMADS47 are unable to reverse the flowering-time phenotypes of the svp and agl24 mutants in Arabidopsis.
3702	816795	16481352	2007-08-25 21:18	BRK1 is required for accumulation of SCAR1 protein in vivo, potentially explaining the apparently essential role of BRK1 in ARP2/3 complex function
3702	816795	16584883	2007-08-25 10:53	member of the "distorted group" of trichome morphology mutants and a critical WAVE-complex subunit that selectively stabilizes the Arp2/3 activator SCAR2
3702	816804	16287862	2007-08-25 12:34	H3 lysine 9 methylation is reduced in an suvh4 suvh6 double mutant
3702	816807	15155889	2007-08-25 13:49	role in the formation of endoplasmic reticulum bodies [NAI1]
3702	816808	17376163	2007-08-25 13:25	The function of PEROXISOMAL NAD-MALATE DEHYDROGENASE 1 and PEROXISOMAL NAD-MALATE DEHYDROGENASE 2 in fatty acid beta-oxidation and the glyoxylate cycle in Arabidopsis are reported.
3702	816812	15699063	2007-08-25 14:49	Expression in response to plant growth regulators and abiotic stress in roots and aerial parts as demonstrated by expression of the GUS reporter in A. thaliana.
3702	816829	17600138	2007-12-01 10:16	encodes an enzyme capable of synthesizing 1,2-disinapoyl-glucose from two molecules of sinapoyl-glucose
3702	816830	18490034	2008-09-13 10:26	1-O-sinapoyl-beta-glucose:l-malate sinapoyltransferase gene is embedded in a tandem cluster of five serine carboxypeptidase-like sinapoyltransferase genes
3702	816831	17600138	2007-12-01 12:40	encodes sinapoyl-glucose:anthocyanin acyltransferase, an enzyme that is required for the synthesis of the sinapoylated anthocyanins
3702	816832	17600138	2007-12-01 12:40	encodes an enzyme capable of synthesizing 1,2-disinapoyl-glucose from two molecules of sinapoyl-glucose
3702	816845	15286287	2007-08-25 14:18	AGP17 allows Agrobacterium rapidly to reduce the systemic acquired resistance response during the infection process.
3702	816847	16270029	2007-08-25 15:07	Mobilization of vacuolar iron (Fe) stores by AtNRAMP3 is crucial to support Arabidopsis early development until efficient systems for Fe acquisition from the soil take over.
3702	816870	16957776	2007-08-25 12:27	the spread of H3K27me3 contributes to the mitotic heritability of Polycomb-group (Pc-G) silencing, and that the loss of silencing caused by transposon insertions at plant Pc-G targets reflects impaired spreading.
3702	816870	17881378	2007-12-01 13:11	The Arabidopsis homologs of trithorax (ATX1) and enhancer of zeste (CLF) interact to control the expression of the flower homeotic gene AGAMOUS.
3702	816875	15749764	2007-08-25 14:38	Arabidopsis ICK1 blocks entry into mitosis but allows S-phase progression causing endoreplication, suggesting that plant CKIs act in a concentration-dependent manner and have an important function in cell proliferation as well as in cell cycle exit.
3702	816875	16766674	2007-08-25 11:54	ICK1/KRP1 localizes to different subnuclear domains, and is an unstable protein with its degradation mediated by at least two domains.
3702	816875	16845478	2007-08-25 21:02	Nuclear localization of ICK1 is regulated and suggests a possible role of ICK1 in regulating the cellular distribution of CDKA.
3702	816875	18005227	2008-05-24 10:05	The role of KRP1 in the plant cell cycle, and its degradation pathways, are reported.
3702	816878	17999646	2008-04-12 10:17	study describes initial functional characterization of XLG1, XLG2 & XZLG3 genes & reveals a role for XLG proteins in the regulation of root growth and seed germination by sugars and phytohormones
3702	816908	17873098	2008-06-06 16:00	These data suggest that BLH2/SAW1 and BLH4/SAW2 establish leaf shape by repressing growth in specific subdomains of the leaf at least in part by repressing expression of one or more of the KNOX genes. [SAW2]
3702	816946	16698900	2007-08-25 10:51	findings support a role for plastids in leaf morphogenesis and indicates that RpoTp is required for mesophyll cell proliferation
3702	816946	18084023	2008-03-10 15:45	evidence for nuclear-encoded RNA polymerases being represented by two phage-type RNA polymerases (RpoTp and RpoTmp) that have overlapping as well as gene-specific functions in the transcription of plastidial genes.
3702	816966	16000297	2007-08-25 11:26	first evidence for the presence of apoplastic calmodulin receptor-like binding proteins on the cell surface of Arabidopsis suspension-cultured cells
3702	816972	17291444	2007-08-25 12:23	Importance of serine residues required for dual-specificity Serine/threonine/tyrosine protein kinase activity.
3702	816985	16271867	2007-08-25 14:42	At2g24490 is the RPA2 gene, which plays an essential role in the maintenance of transcriptional gene silencing at specific loci in a DNA-methylation-independent manner.
3702	816985	16271868	2007-08-25 14:42	Arabidopsis RPA2 is a genetic link between transcriptional gene silencing, DNA repair, and DNA replication.
3702	816985	16326925	2007-08-25 14:42	Results suggest important roles for ROR1/RPA2A in epigenetic gene silencing and in the regulation of plant development.
3702	816993	17114354	2007-08-25 10:10	These results provide genetic evidence for the importance of WRKY11 and WRKY17 in plant defense.
3702	817014	16830178	2007-08-25 10:13	ARL1(AT2G24765) is associated with the localization of peripheral golgins to the plant Golgi apparatus.
3702	817016	16339850	2006-04-28 15:00	CONSTANS-LIKE3 (COL3)is a positive regulator of photomorphogenesis that acts downstream of COP1 and can function as a daylength-sensitive regulator of shoot branching. [COL3]
3702	817032	15702529	2005-12-12 13:53	three dimensional structure of At2g24940.1 as determined by NMR spectroscopy has a cytochrome b5 like fold.
3702	817039	16603654	2007-08-25 12:32	WRKY60 interacts both physically and functionally with WRKY40 and WRKY18 in a complex pattern of overlapping, antagonistic, and distinct roles in plant responses to different types of microbial pathogens.
3702	817055	16359393	2007-08-25 12:58	PKL is required continuously after germination to repress expression of PHERES1, a type I MADS box gene that is normally expressed during early embryogenesis in wild-type plants.
3702	817055	17892443	2008-03-10 13:41	PKL-dependent repression of embryonic gene expression extends to late-embryogenesis genes and is associated with changes in chromatin.
3702	817055	18539592	2008-10-04 10:39	PKL promotes hisone h3 methylation in both germinating seedlings and in adult plants but do not identify a connection between PKL-dependent expression and acetylation levels.
3702	817056	17132632	2007-08-25 14:03	ARR10 and ARR12play pivotal roles in the histidine kinase-dependent phosphorelay signaling in response to cytokinin in roots.
3702	817056	18037673	2008-05-24 10:35	The results of this study suggested that ARR1, ARR10 and ARR12 together play essential (or general) roles in cytokinin signal transduction.
3702	817087	17307926	2007-08-25 14:00	Data show that through control of EIN3/EIL1 levels, EBF1 and EBF2 fine-tune ethylene responses by repressing signaling in the absence of hormone, dampening signaling at high concentrations, and promoting rapid recovery after ethylene levels dissipate.
3702	817109	18003916	2008-02-21 16:52	Molybdate transporter, MOT1, is specific for molybdate and that the high affinity of MOT1 allows plants to obtain scarce Mo from soil. [MOT1]
3702	817109	18454190	2008-06-14 10:23	A deletion in the MOT1 promoter is strongly associated with low shoot Mo, occurring in seven of the accessions with the lowest shoot content of Mo.
3702	817112	18156294	2008-06-07 10:07	These findings strongly suggest that HCS1 is the only protein responsible for HCS activity in Arabidopsis cells, including the cytosolic, mitochondrial, and plastidial compartments.
3702	817129	16028112	2007-08-25 14:23	Aurora kinase AtAUR2 localized at the nuclear membrane in interphase and located in mitotic spindles during cell division.
3702	817134	16212608	2007-08-25 13:38	The function of ELF3 and ELF4 in their light-regulated expression associated with CCA1, LHY, and TOC1 as part of the central oscillator of the circadian clock in Arabidopsis is reported.
3702	817134	16258016	2007-08-25 11:59	We show that the effects of ZTL and ELF3 on circadian clock function and early photomorphogenesis are additive.
3702	817148	16682642	2006-10-13 18:38	RTE1 is a negative regulator of ethylene signaling and suggest that RTE1 plays an important role in ETR1 function [RTE1].
3702	817148	17644624	2008-01-12 11:12	Our results suggest specificity of the RTE1 function to ETR1 and that endomembranes may play a role in the ethylene signal transduction.
3702	817148	17999643	2008-04-12 10:17	we demonstrated the subcellular co-localization of RTE1 and ETR1. These findings support and enhance the genetic model that RTE1 plays a role in regulating ETR1.
3702	817154	16247555	2007-08-25 13:38	AtFtsH4 is an exclusively mitochondrial protein while AtFtsH11 is found in both chloroplasts and mitochondria.
3702	817155	16483133	2007-08-25 21:03	AtHsfA2 has role in linking heat shock with oxidative stress signals in Arabidopsis
3702	817155	17059409	2007-08-25 13:28	The results of this study indicate that HsfA2 is a key regulator in the induction of the defence system under several types of environmental stress.
3702	817155	17085506	2007-08-25 13:28	HsfA2 functions as a heat-inducible transactivator, sustains the expression of Hsp genes, and extends the duration of acquired thermotolerance in Arabidopsis.
3702	817157	16387852	2007-08-25 21:27	MAX1 is implicated in synthesis of the carotenoid-derived branch regulator(s) from the root, it likely links long-distance signaling with local control of bud outgrowth
3702	817170	15155892	2007-08-25 13:49	GCR1 may act as a negative regulator of GPA1-mediated abscisic acid responses in guard cells
3702	817170	15557100	2007-08-25 12:39	The effect of extracellular calmodulin on stomatal closure in GPA1 mutant Arabidopsis.
3702	817170	16415218	2007-08-25 10:19	G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 form all of or part of a signal transduction mechanism responsible for the light-mediated synthesis of phenylpyruvate and phenylalanine.
3702	817170	16582010	2007-08-25 10:53	THYLAKOID FORMATION1 (THF1) is demonstrated in vivo as a Galpha interaction partner that functions downstream of the plasma membrane-delimited heterotrimeric G-protein (GPA1) in a D-glucose signaling pathway.
3702	817170	17360436	2007-08-25 12:21	the Gbetagamma complex serves a signaling function in the ER independent of its function in the Galphabetagamma heterotrimer
3702	817170	17383830	2007-08-25 13:23	This research provides evidence of the functional association of alpha and beta with the gamma subunits in Arabidopsis, while also suggesting that plasma membrane localization may be critical for function of plant heterotrimeric G proteins.
3702	817170	17953540	2008-02-16 10:29	may participate in pollen germination through modulation of the hyperpolarization-activated Ca(2+) channel in the plasma membrane of pollen cells
3702	817170	18499742	2008-08-30 10:39	These results provided the first genetic evidence that G-protein- and brassinosteroid-mediated pathways may be converged to modulate cell proliferation in a cell/tissue-specific manner.
3702	817173	15998304	2007-08-25 11:20	This study suggests a putative function of ERECTA and heterotrimeric G protein (AGB1) in P. cucumerina perception.
3702	817173	16002616	2005-11-30 11:10	Three ERECTA-family leucine-rich repeat-receptor-like kinases (ER, ERL1,ERL2) together control stomatal patterning, with specific family members regulating specification of stomatal stem cell fate & differentiation of guard cells. [ER]
3702	817173	16007076	2007-08-25 14:23	ERECTA regulates transpiration efficiency
3702	817173	16126863	2007-08-25 12:44	Both genetic and cellular analyses indicate that auxin and the ER pathway regulate cell division and cell expansion in a largely independent but overlapping manner during elaboration of inflorescence architecture.
3702	817173	17652352	2007-11-10 12:44	ERL2 is haploinsufficient for maintaining female fertility in the absence of ER and ERL1.
3702	817175	16169966	2007-08-25 11:19	PEX2 and PEX10 are inserted into peroxisome membranes directly from the cytosol.
3702	817175	16923726	2007-08-25 11:52	AtPEX19-1 was shown to bind to the Arabidopsis peroxisomal membrane protein PEX10.
3702	817175	17215364	2007-08-25 10:08	inactivation of the RING finger domain in PEX10 has eliminated protein interaction required for attachment of peroxisomes to chloroplasts and movement of metabolites between peroxisomes and chloroplasts
3702	817182	18178770	2008-05-17 10:07	A previously uncharacterized Arabidopsis thaliana phosphatidylinositol-4-phosphate 5-kinase gene (PIP5K3) was identified and found to be expressed in the root cortex, epidermal cells, and root hairs.
3702	817182	18281506	2008-08-02 10:05	Results provide evidence that PIP5K3 is involved in localizing PtdIns(4,5)P2 to the elongating root hair apex and is a key regulator of the machinery that initiates and promotes root hair tip growth.
3702	817191	15951430	2007-08-25 13:08	To assess whether ferredoxin donates electrons directly to plastoquinone or via a Q-cycle in the cytochrome b(6)f complex in PSI cyclic electron transport, we characterized the activity of photosystem I cyclic electron transport in an Arabidopsis mutant.
3702	817195	18042043	2008-03-22 11:10	Identification of this gene in this plant by using functional complementation.
3702	817197	16297072	2006-02-22 15:31	PLP2 is a pathogen-inducible patatin-like lipid acyl hydrolase that can be exploited by pathogens to facilitate host colonization.[PLP2]
3702	817199	15299139	2007-08-25 11:08	Nozzle protein bound filamentous flower and yabby3. (nozzle protein) in Arabidopsis.
3702	817206	15734909	2007-08-25 10:59	Potassium transport and gene expression in A. thaliana deficient at this site.
3702	817206	16814720	2007-08-25 13:31	CIPK23 directly phosphorylates the K+ transporter AKT1
3702	817206	16895985	2007-08-25 13:30	Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2+)-dependent manner, connecting the Ca(2+) signal to K(+) uptake through activation of a K(+) channel.
3702	817230	15466218	2005-08-17 08:24	The gravitropism defective 2 (grv2) mutants of Arabidopsis show reduced shoot phototropism and gravitropism. [GRV2]
3702	817230	17259264	2007-08-25 10:44	KAM2/GRV2 is required for proper formation of the endosomes involving protein trafficking to the vacuoles and determination of growth axis of the embryo.
3702	817246	16839879	2007-08-25 12:29	Our results suggest a function for Cajal bodies as a center for the assembly of an AGO4/NRPD1b/siRNA complex, facilitating its function in RNA-directed gene silencing at target loci.
3702	817246	16998468	2007-08-25 14:06	AGO4 binds to small RNAs including small interfering RNAs (siRNAs) originating from transposable and repetitive elements, and cleaves target RNA transcripts
3702	817246	17785412	2007-11-10 12:44	AGO4 was partially compromised in the reception of silencing.
3702	817246	17993621	2008-03-10 13:39	OCP11 was cloned and shown that it encodes ARGONAUTE4 (AGO4), a component of the pathway that mediates the transcriptional gene silencing associated with small interfering RNAs that direct DNA methylation at specific loci.
3702	817246	18266474	2008-06-07 10:29	two classes of AGO4 bodies are structurally independent--disruption of one class does not affect the other--suggesting a dynamic regulation of AGO4 within two distinct nuclear compartments
3702	817247	15466219	2007-08-25 11:10	Transcription factor EIL1 is required for the second phase but not the first phase of growth inhibition by ethylene in Arabidopsis seedling hypocotyls.
3702	817247	17011517	2007-08-25 14:05	Light induced regulation of gene expression involves stabilization of EIL1 protein.
3702	817252	16222298	2007-08-25 12:00	SERRATE acts to coordinately regulate meristem activity and leaf axial patterning
3702	817252	16977334	2007-08-25 10:11	SE is a general regulator of miRNA levels affecting the processing of primary miRNA to miRNA.
3702	817252	17635222	2007-09-29 12:22	The se-1 mutation in the serrate gene dramatically affects both changes in the leaf development pattern and the response to reduced incident light; virtual plants helped to reveal the combined effects of the multiple changes induced by this mutation.
3702	817252	17675322	2008-02-09 12:03	we found that DCL1, HYL1 & SE formed bodies which localized in the nuclei; we were also able to locate the miRNA primary transcript on these bodies; it appears very likely that the observed DCL1-HYL1-SE nuclear body is involved in miRNA production
3702	817254	16212602	2007-08-25 13:38	role of DNA polymerase epsilon during gametophyte and seed development in A. thaliana, encoded by POL2a and POl2b, with a main regulatory subunit DPB2, is reported
3702	817257	18060348	2008-05-03 10:19	The competence of stomatal guard cells in V. faba to synthesize abscisic acid, using NCED3 and AAO3 from A. thaliana, is reported.
3702	817265	17626058	2007-11-01 17:37	LHW is nuclear-localized and is expressed in the root meristems, where we hypothesize it acts independently of other known root-patterning genes to promote the production of stele cells. [Lonesome Highway] [LHW]
3702	817267	16055633	2007-08-25 14:44	Data suggest that CLV3, CLE19 and CLE40 peptides represent the major active domain of the CLE proteins, which interact with an unknown cell identity-maintaining CLAVATA2 receptor complex in roots, leading to consumption of the root meristem.
3702	817267	16210497	2007-08-25 13:22	study provides evidence that CLV3 signaling in meristems mediates both cell fate specification and growth control through inhibition of cell division rate, as well as that the processes can be temporally uncoupled
3702	817267	16603652	2007-08-25 12:32	Increased CLV3 signaling restricts meristem growth and promotes allocation of peripheral meristem cells into organ primordia.
3702	817267	16751438	2007-08-25 10:50	The CLV3/ESR (CLE) motif is the functional region of the CLV3 protein and it acts independently of the adjacent sequences.
3702	817267	16902141	2007-08-25 11:52	structure of a modified peptide (MCLV3), derived from a conserved motif in the CLV3 sequence; synthetic MCLV3 induced shoot & root meristem consumption as cells differentiated into other organs; results suggest the functional peptide of CLV3 is MCLV3
3702	817267	18202283	2008-02-02 12:52	biochemical evidence shows that the CLV3 peptide directly binds the CLV1 ectodomain with a dissociation constant of 17.5 nM; results provide direct evidence that CLV3 and CLV1 function as a ligand-receptor pair involved in stem cell maintenance
3702	817267	18381924	2008-08-09 10:05	the novel receptor kinase CORYNE (CRN) and CLV2 act together, and in parallel with CLV1, to perceive the CLV3 signal
3702	817273	17410378	2007-11-08 15:09	NTL8 mediates salt-responsive flowering via FT in Arabidopsis.[NTL8]
3702	817273	18363782	2008-09-27 10:17	modulates gibberellic acid-mediated salt signaling in regulating seed germination
3702	817317	15165183	2007-08-25 11:35	RPP2A and RPP2B cooperate to specify Cala2 resistance by providing recognition or signalling functions lacked by either partner protein.
3702	817329	16415218	2007-08-25 13:37	G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 form all of or part of a signal transduction mechanism responsible for the light-mediated synthesis of phenylpyruvate and phenylalanine.
3702	817362	15539473	2005-09-30 14:34	We propose a new model for iron uptake in Arabidopsis where FRO2 and IRT1 are differentially regulated by FIT1 which encodes a putative transcription factor that regulates iron uptake responses in Arabidopsis thaliana [FIT1]
3702	817362	16117851	2006-05-01 14:18	AtbHLH29 encods a bHLH protein, which is a functional ortholog of the tomato FER gene which are proposed as transcriptional factors functioning in iron deficiency responses and iron uptake. [AtbHLH29]
3702	817362	17466530	2007-09-29 12:24	A proposed common name for At2g28160 in Arabidopsis, namely FIT=FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR, is discussed.
3702	817362	18268542	2008-07-19 10:22	ferric-chelate reductase FRO2 and ferrous-transporter IRT1 are the targets of the three transcription factors and the transcription of FRO2 and IRT1 is directly regulated by a complex of FIT/AtbHLH38 or FIT/AtbHLH39.
3702	817365	16861386	2007-08-25 21:03	CSD2 expression is fine-tuned by miR398-directed mRNA cleavage.
3702	817371	18088316	2008-05-28 13:48	Gene expression data suggests NCRK gene is highly expressed during tracheary differentiation, while RBK1 gene expression is upregulated by pathogen exposure and ethylene.[NCRK]
3702	817375	15833920	2007-08-25 12:45	SYD is recruited to the WUS promoter and is involved in regulation of the stem cell pool maintenance via direct transcriptional control of this master regulator.
3702	817375	16640604	2007-08-25 10:51	The N-terminal ATPase AT-hook-containing region of the SYD protein is responsible for its biological activity.
3702	817375	17293567	2007-08-25 14:01	Results describe overlapping functions for the two SWI/SNF ATPases, SPLAYED and BRAHMA, and indicate that these proteins exhibit remarkable regulatory specificity.
3702	817382	16006581	2007-08-25 14:22	In root, auxin and miR160 regulate the expression of ARF10 genes independently, generating a pattern consistent with root cap development.
3702	817382	17672844	2007-12-22 11:10	negative regulation of ARF10 by miR160 plays a critical role in seed germination and post-embryonic developmental programs
3702	817404	15952068	2005-11-18 15:03	Results suggest that AtRAD51B gene product is involved in the repair of double-strand DNA breaks via homologous recombination. [Rad51B]
3702	817429	16595657	2007-08-25 13:35	Alb3 has a role in insertion of a subset of the light-harvesting chlorophyll-binding proteins, while Alb4 is required for proper chloroplast biogenesis
3702	817435	17909855	2008-04-05 11:14	The functions of CYP710A1 and CYP710A4 in stigmasterol synthesis are reported.
3702	817439	16709189	2007-08-25 21:21	OEP16-L is expressed predominantly in leaves, is induced strongly by low-temperature stress and shows weak induction in response to osmotic stress, salicylic acid and exogenous ABA.
3702	817457	16543410	2007-08-25 14:10	CYP707A2 transcript levels increase from late-maturation to mature dry seed and plays a distinct role in seed development and postgermination growth.
3702	817484	16883480	2007-08-25 11:52	Two promoters of senescence-associated ARABIDOPSIS genes, SAG12 and SAG13, were used in tomato plants to express IPT that catalyzes the rate-limiting step in cytokinin biosynthesis.
3702	817513	18048325	2008-01-19 12:54	The results suggest that vitamin B1 biosynthesis in plants is in fact more similar to prokaryotic counterparts and that the THIC protein is likely to be the key regulatory protein in the pathway.
3702	817515	18353780	2008-09-30 14:00	ANTR1 is a thylakoid Na+-dependent phosphate transporter [ANTR1]
3702	817548	17507388	2007-10-13 10:03	The fatty acid composition of membrane lipids influences cell growth and mitochondrial respiration, in particular the expression and capacity of alternative oxidase, under cold stress in fad2 knockout and FDAD3 overexpressing cell lines
3702	817553	17630279	2007-12-13 15:08	These results demonstrate a key role for the AP2C1 phosphatase in regulating stress hormone levels, defense responses, and MAPK activities in Arabidopsis. [AP2C1]
3702	817562	17217463	2007-08-25 13:58	One mutant that suppresses snc1-mediated constitutive resistance is modifier of snc1 5 (mos5), which carries a 15-bp deletion in the C-terminus of UBA1.
3702	817564	18156133	2008-05-31 10:05	The role of FLX in the timing of flowers and the expression of other flowering-related proteins, including FRIGIDA and FLC, is reported.
3702	817575	17214894	2007-08-25 14:02	WRKY25 functions as a transcription factor with a role in SA-mediated defense responses to Pseudomonas syringae.
3702	817586	17483306	2007-10-20 12:43	These results suggest that PKS5 is part of a calcium-signaling pathway mediating PM H+ -ATPase regulation.
3702	817597	15894743	2005-11-21 10:50	These results indicate that HSI2 and related proteins are B3 domain-EAR motif active transcription repressors. [HSI2]
3702	817628	17573535	2007-10-20 10:20	These results lead to the conclusion that CYP71A13 catalyzes the conversion of indole acetaldoxime to indole-3-acetonitrile in camalexin synthesis and provide further support for the role of camalexin in resistance to A. brassicicola.
3702	817636	16538523	2007-06-27 13:54	AtGSTF9 and AtGSTU26 are two glutathione S-transferases from A. thaliana. AtGSTF9 is constitutively expressed and AtGSTU26 is induced by cold, stress, safener and herbicide treatments.[GSTF9]
3702	817646	15803409	2007-08-25 14:38	Results showed that the conserved Gly-Ala-Asp motif plays an important role in FtsH activity and characterization of the var2 alleles could help to identify the physiologically important domain of FtsH.
3702	817646	16449381	2007-08-25 15:01	A model has been proposed to explain the mechanism of var2 variegation, which suggests that threshold levels of FtsH complexes are required for green sector formation.
3702	817646	17449646	2007-10-06 11:52	The white sectors in var2 are made by viable cells that have plastids arrested in thylakoid formation.
3702	817646	18296449	2008-05-31 10:05	These results indicate that photo-oxidative stress by excess light is involved in the regulation of respiratory gene expression and the modulation of respiratory properties, especially the AOX up-regulation.
3702	817683	17085765	2007-06-29 13:51	results suggest that both AtAtg2 and AtAtg5 proteins are essential for autophagy whereas AtAtg9 protein contributes to, but is not essential for, autophagy in Arabidopsis root tip cells [Atg9]
3702	817684	15928083	2005-11-30 11:39	Down-regulation of AtCDT1a and AtCDT1b, members of the prereplication complex, is shown to alter both nuclear DNA replication and plastid division in Arabidopsis thaliana [CDT1a]
3702	817690	17823244	2007-12-01 10:48	in PARP2-deficient Arabidopsis plants, the observed abiotic stress resistance can also be explained by alterations in abscisic acid levels that facilitate the induction of a wide set of defense-related genes
3702	817698	17395793	2007-08-25 10:41	results show GUN1 & ABI4 are common to all 3 plastid-to-nucleus retrograde signaling pathways; model proposed in which indicators of aberrant plastid function are integrated upstream of GUN1 in plastids leading to ABI4-mediated repression of nuclear genes
3702	817721	16157865	2007-08-25 14:15	ATX1 is involved in methylating histone H3- lysine 4 of only a fraction of Arabidopsis nucleosomes.
3702	817721	17881378	2007-12-01 13:11	The Arabidopsis homologs of trithorax (ATX1) and enhancer of zeste (CLF) interact to control the expression of the flower homeotic gene AGAMOUS.
3702	817721	18375656	2008-08-02 10:27	Data show that ATX1 function in the epigenetic regulation of the floral repressor FLOWERING LOCUS C (FLC).
3702	817721	18375658	2008-08-02 10:27	Results show that ATX1 proteins methylate K4 of histone H3 and trimethylates it.
3702	817722	16889648	2006-11-29 18:09	SAD2 plays a specific role in nuclear transport in ABA signaling. [SAD2]
3702	817722	17993626	2008-03-10 13:39	Arabidopsis thaliana mutant sensitive to ABA and drought2 (sad2), which harbors a T-DNA insertion in an importin beta-like gene, is more tolerant to UV-B radiation than the wild type.
3702	817725	17259290	2007-08-25 10:44	At2g31690 plays a role in maintaining the structural integrity of chloroplasts by mobilizing the fatty acids of plastoglobular triacylglycerol.
3702	817744	18393624	2008-07-26 10:36	A role for poly(ADP-ribosyl)ation in plant defense responses was suggested initially by the upregulated expression of genes encoding NUDT7 and poly(ADP-ribose) glycohydrolase in multiple R-avr interactions.
3702	817749	16513816	2007-08-25 21:18	The CHX21 transporter plays a role in the regulation of xylem Na+ concentration and, consequently, Na+ accumulation in the leaf.
3702	817756	16990794	2007-08-25 10:11	The protective role of Rad50 protein on shortened telomeres results from its action in constraining recombination to sister chromatids and thus avoiding end-to-end interactions.
3702	817764	16162503	2007-08-25 13:04	At2g32040 has a role in regulating folate content of chloroplasts and 5-methyltetrahydrofolate but does not discernibly affect growth
3702	817819	15883832	2007-01-03 15:00	Localization of condensin subunit AtCAP-H and AtCAP-H2 is dynamically changed through the mitotic cell cycle.  AtCAP-H moves from cytoplasm to chromosomes at the beginning of mitosis and moves back to cytoplasm after cytokinesis. [AtCAP-H]
3702	817856	17332757	2007-08-21 08:05	AGO6 is important for the accumulation of specific heterochromatin-related siRNAs, and for DNA methylation and transcriptional gene silencing, this function is partly redundant with AGO4. [AGO6]
3702	817857	15155879	2007-08-25 13:49	accumulation of PIF3 in the nucleus in dark requires constitutive photomorphogenesis 1, a negative regulator of photomorphogenesis
3702	817857	15960622	2007-08-25 12:58	Arabidopiss SPA1 represses light signaling by modulating COP1-dependent degradation of HFR1 at a post-translational level.
3702	817857	16813572	2007-08-25 10:50	COP1 and SPA1 act in concert to form a functional E3 ubiquitin ligase complex and provide a molecular basis for understanding the structure-function relationship of SPA1.
3702	817857	16829591	2007-08-25 10:13	COP1 is a critical positive regulator of responses to low levels of UV-B.
3702	817857	18296627	2008-08-02 10:16	Results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness, thereby stabilizing CO, activating FT transcription, and inducing flowering.
3702	817857	18388858	2008-05-24 10:05	Contributes to day length perception by reducing the abundance of CONSTANS protein during the night, thereby delaying flowering under short days.
3702	817857	18722184	2008-09-20 10:49	phyA associations with FHY3 and FHY1 protect underphosphorylated phyA from being recognized by the COP1/SPA complex.
3702	817876	17728299	2008-02-06 14:04	Mutations within the 3-ketoacyl-CoA thiolase 2 (KAT2) gene interferes with the balance between silique development and the continued initiation of floral meristems. [KAT2]
3702	817876	18441338	2008-08-02 10:05	KAT2 as an essential component for the timely onset of leaf senescence in Arabidopsis.
3702	817894	18596113	2008-08-30 10:25	IAA28 overexpressing and knock-down lines showed no major morphological changes, whereas IAA13 and ARF2 overexpressing plants grew more slowly than the wild type.
3702	817912	18537822	2008-08-02 10:35	in A. thaliana, AtGLTP1 together with At1g21360 and At3g21260 constitute a small gene family orthologous to the mammalian glycosphingolipid transfer protein
3702	817919	18305006	2008-06-14 10:34	Arabidopsis CPL3 controls endoreduplication and flowering development in addition to trichrome and root hair formation.
3702	817943	16679417	2007-08-25 11:56	A previously identified Pi overaccumulator, pho2, is caused by a single nucleotide mutation resulting in early termination within the UBC24 gene.
3702	817943	16679424	2007-08-25 11:56	Map-based cloning identified PHO2 as At2g33770. miR399 and PHO2 are in a branch of the Pi-signaling network downstream of PHR1.
3702	817943	17643101	2007-09-22 12:36	IPS1 overexpression results in increased accumulation of the miR-399 target PHO2 mRNA and, concomitantly, in reduced shoot Pi content; engineering of IPS1 to be cleavable abolishes its inhibitory activity on miR-399.
3702	817948	16914499	2007-08-25 13:31	Results show that vegetative phase change in Arabidopsis is regulated by an increase in the expression of SPL3.
3702	817949	16730327	2007-08-25 10:15	Both BAC1 and BAC2 displayed highest affinity for arginine with similar Km and Vmax. However, BAC2 transported citrulline for which BAC1 had little or no affinity. Furthermore, BAC2 was less stereospecific than BAC1.
3702	817951	16291783	2007-08-25 21:24	Epistasis analysis between FES1, FRI and FRIGIDA-LIKE 1 (FRL1), indicates that these genes do not function in a linear pathway, but instead act cooperatively to promote the expression of FLC.
3702	817956	16199616	2007-08-25 14:14	Mutations in ETTIN were isolated as second site suppressors and found to ameliorate ectopic KANADI activity throughout the plant as well. Mutant phenotypes of ett are restricted to flowers.
3702	817956	16818444	2007-08-25 14:07	Mutations delay the expression of adult traits, demonstrating that these genes have non-redundant roles in shoot maturation.
3702	817958	15753038	2005-11-30 09:54	STIMPY (STIP; also called WOX9) is a homeobox gene required for the growth of the vegetative shoot apical meristem, in part by positively regulating WUSCHEL protein expression. [STIMPY] [STIP] [WOX9]
3702	817958	17706632	2008-01-12 12:51	Complete loss of STIP activity results in early embryonic arrest, most likely due to a failure in cell division.
3702	818002	17584741	2007-10-20 12:42	AtNIP2;1 is an anaerobic-induced gene that encodes a lactic acid transporter and may play a role in adaptation to lactic fermentation under anaerobic stress.
3702	818008	16563436	2007-08-25 10:53	At2g34450 protein is a nuclear protein, whereas the At5g23405 protein is found mainly in the cytoplasm
3702	818010	16244137	2007-08-25 21:05	Plants bearing T-DNA or Ds element insertions in either the structural gene for urease or in any of the three putative urease accessory genes AtureD, AtureF, and AtureG lacked the corresponding mRNAs and were defective in urease activity
3702	818013	16531502	2006-10-25 16:13	In arabidopsis, cyp710A family may encode P450s of sterol C-22 desaturases in different organisms. [cyp710A1]
3702	818013	17909855	2008-04-05 11:14	The functions of CYP710A1 and CYP710A4 in stigmasterol synthesis are reported.
3702	818030	15371311	2007-08-25 14:52	role in establishment of bilateral symmetry, as well as in the promotion of cotyledon outgrowth
3702	818030	15514156	2007-08-25 14:45	results show that a PINOID-dependent binary switch controls PIN polarity and mediates changes in auxin flow to create local gradients for patterning processes
3702	818030	16601102	2007-08-25 21:23	PDK1 is a potent enhancer of PID activity.
3702	818030	16731587	2007-08-25 10:15	Results suggest that PINOID positively regulates cellular auxin efflux, most likely by modulating the trafficking of PIN and/or some other molecular partners involved in auxin efflux.
3702	818030	17889649	2007-11-10 11:55	PP2A and PINOID both partially colocalize with PINs and act antagonistically on the phosphorylation state of their central hydrophilic loop, hence mediating PIN apical-basal polar targeting.
3702	818030	17913786	2008-01-19 11:42	MAB4/ENHANCER OF PINOID is involved in polar auxin transport in organogenesis
3702	818031	18325934	2008-05-31 10:29	This suggests that AtMRP2 is involved in vacuolar transport of chlorophyll catabolites.
3702	818033	17027491	2007-08-25 21:26	AIR9 has a role in the maturation of those cell plates successfully contacting the "programmed" cortical division site.
3702	818034	18657186	2008-10-04 10:35	generated site-specific mutants in ACD11 based on homologous GLTP residues required for glycolipid transfer. We show that these ACD11 mutant forms are impaired in their in vitro transfer activity of sphingolipids
3702	818036	15282547	2007-08-25 10:28	Pairing to the 5' portion of the small silencing RNA of PHAVOLUTA appears crucial regardless of the mode of post-transcriptional repression
3702	818036	15286295	2005-04-26 21:00	Class III HD-Zip genes required for root development [PHABULOSA (PHB)]
3702	818068	16244137	2006-02-23 09:24	AtUreD, AtUreF, and AtUreG are urease accessory proteins that are the core components for plant urease activation.  [AtUreD]
3702	818076	16377743	2007-08-25 11:23	The gene is expressed in all tissues but particularly in vascular tissues of leaves and stems and is suggested to be an arabinan alpha-1,5-arabinosyltransferase.
3702	818077	15368121	2005-01-31 12:57	encodes a putative regulator of the WAVE-HSPC300 complex, NAP125, combined with the phenotypic similarity between arp2/3 and grl mutants, provides evidence that the ARP2/3 complex is indeed regulated by the above mentioned pathway in Arabidopsis [gnarled]
3702	818077	15516496	2007-08-25 11:33	The multiple growth and developmental phenotypes of Atnap and Atpir mutants reveals these proteins are also required for a wider variety of cellular functions in addition to regulating trichome cell growth.
3702	818077	17041028	2007-08-25 21:11	AtNAP1;1 is a component of a regulatory mechanism that connects cell proliferation to cell growth and expansion during Arabidopsis leaf development.
3702	818083	16582009	2007-08-25 10:53	SUVH5 protein has histone methyltransferase activity in vitro and contributes to the maintenance of methylation of histone H3 at Lysine-9 and CMT3-mediated non-CG methylation in vivo.
3702	818088	16731582	2007-08-25 10:15	plays a role in root hair and pollen tube growth, most likely through the regulation of Arabidopsis ARF1 and ARF1-like protein U5 activity
3702	818102	18606144	2008-08-09 10:12	Key divisions in the early Arabidopsis embryo require POL and PLL1 phosphatases to establish the root stem cell organizer and vascular axis.
3702	818131	16377747	2007-08-25 11:23	MOR1 is important for the structure and function of preprophase bands and spindles.  MOR1 colocalizes along the entire length of microtubules at all stages of the cell cycle.
3702	818138	17172287	2007-08-25 14:02	The effects of mutations in ACX1 and ACX5 in A. thaliana on jasmonic acid synthesis are reported.
3702	818167	18055603	2008-03-10 15:45	The eostre phenotype is caused by misexpression of the homeodomain gene BEL1-like homeodomain 1 (BLH1) in the embryo sac.
3702	818174	16514015	2007-08-25 21:18	AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.
3702	818195	15870096	2005-11-29 14:13	Arabidopsis albino and pale green 10 (apg10) mutant exhibits pale green cotyledons; APG10 encodes BBMII isomerase which is directly involved in His biosynthesis.[APG10]
3702	818197	18284374	2008-07-12 10:16	Results describe the in vivo quantitative relationship between plastid division proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex.
3702	818199	16247556	2007-08-25 13:38	The redundancy of function among genes in the families of ABF3 and ABI5 in A. thaliana is reported.
3702	818199	18038114	2008-05-03 13:10	Results show that over-expression of ABI5 rendered phas expression ABA-independent in the presence of PvALF.
3702	818212	17698298	2007-10-27 11:03	SBE2.1 of Arabidopsis is different from other SBE gene families.
3702	818219	17881564	2007-11-01 17:09	HARDY is an Arabidopsis drought and salt tolerance gene [HARDY]
3702	818224	16624880	2007-08-25 10:52	Data suggest that a function of REPRESSOR OF SILENCING 1 (ROS1) and DEMETER is to initiate erasure of 5-meC through a base excision repair process and provide strong biochemical evidence for the existence of an active DNA demethylation pathway in plants.
3702	818224	16864782	2007-08-25 13:32	These results demonstrate that ROS1 is a 5-methylcytosine DNA glycosylase/lyase important for active DNA demethylation in Arabidopsis.
3702	818224	17208187	2007-08-25 13:26	CpXpG and CpXpX sites become heavily methylated in the ros1 mutant.
3702	818224	17951456	2008-04-05 11:13	ROS1 removes methylation that has multiple, independent origins, including de novo methylation directed by RDR2-dependent and -independent RNAi pathways.
3702	818232	15618414	2005-09-22 14:30	A new member of the proline transporter gene family, AtProT3, was isolated from Arabidopsis (Arabidopsis thaliana), and its properties were compared to AtProT1 and AtProT2. [AtProT3]
3702	818252	16214889	2007-08-25 10:57	Data support the hypothesis that 23-O-glucosylation of brassinolide is a function of UGT73C5 in planta, and that glucosylation regulates brassinosteroid activity.
3702	818262	16461581	2007-06-27 09:00	rax mutants show new phenotypes that are characterized by defects in lateral bud formation in overlapping zones along the shoot axis. RAX genes are partially redundant in function and allow a fine-tuning of secondary axis formation [RAX2]
3702	818264	16244155	2007-08-25 21:05	Our studies suggest that Sec22 and Memb11 are involved in anterograde protein trafficking at the ER-Golgi interface.
3702	818265	15908594	2007-08-25 13:08	The functional characterization of two closely related ABC (ATP-binding cassette) transporter genes, AtMDR1 and AtPGP1, in light and auxin responses.
3702	818265	16212599	2007-08-25 13:38	The localization, activity, substrate specificity and inhibitor sensitivity of AtPGP1 are reported.
3702	818265	16887800	2007-08-25 12:28	Immunophilin-like TWISTED DWARF1 modulates auxin efflux activities of Arabidopsis P-glycoprotein
3702	818265	18156217	2008-08-09 10:05	Data show that root hair cell-specific overexpression of auxin efflux transporter PGP1 decreased root hair elongation.
3702	818273	15807777	2007-08-25 11:31	AtSIG6 may act as a major general sigma factor in chloroplasts during early plant development.
3702	818273	16905663	2007-08-25 10:49	The developmental expression of Sig6 in plastids is reported.
3702	818280	18251883	2008-03-10 16:16	Data show rapid upregulation of PAL1, suggesting that an early induced, cell wall-based defence mechanism occurs in response to non-adapted bacteria and knockout of PAL1 permits increased leaf survival of non-host bacteria.
3702	818285	17322407	2007-08-25 14:01	Results suggest that IRREGULAR XYLEM9 (IRX9) is required for normal glucuronoxylan (GX)elongation and indicate roles for IRX8 and FRA8 in the synthesis of the glycosyl sequence at the GX reducing end.
3702	818298	17048257	2007-08-25 12:25	X-ray crystal structures of the conserved hypothetical proteins from Arabidopsis thaliana gene loci AT2g37210.
3702	818302	15618410	2007-08-25 14:50	Metabolic and growth alterations of A. thaliana with a knockout mutation of this site.
3702	818303	17766401	2007-12-22 10:03	Complexes containing R2R3 MYB and bHLH transcription factors regulate the expression of TTG2, which then regulates GL2 expression with complexes containing R2R3 MYB.
3702	818310	15659095	2005-09-21 12:34	The identification and expression of ALS3 gene, which encodes a transporter that is required for aluminum tolerance in Arabdiposis roots. [ALS3]
3702	818317	15722347	2007-08-25 12:38	C-terminal region of AtTIM17-2 is exposed on the outer surface of the outer mitochondrial membrane, is essential for protein import into mitochondria
3702	818336	17583520	2007-12-08 12:29	AtDof2.4 and AtDof5.8 might function in the early but different processes for vascular development
3702	818340	16243907	2007-08-25 22:21	Our data suggest that RS2/AS1 and HIRA mediate the epigenetic silencing of knox genes, possibly by modulating chromatin structure.
3702	818340	16699177	2007-08-25 12:30	RDR6, SGS3 and AGO7 act in the same pathway, which genetically interacts with the AS1-AS2 pathway for leaf development.
3702	818340	17592013	2007-10-13 12:37	AS1 patterns the Arabidopsis gynoecium by repressing BP.
3702	818340	18003921	2008-01-05 14:24	function of AS1 in responses to phytopathogens is independent of its AS2-associated role in development
3702	818340	18156293	2008-06-07 10:07	A previously unrecognized fundamental regulation by which AS1, AS2, and JAG act to define sepal and petal from their boundaries is reported.
3702	818340	18203921	2008-05-17 10:16	AS1 and AS2 form a repressor complex that binds directly to the regulatory motifs CWGTTD and KMKTTGAHW present at two sites in the promoters of the KNOX genes BREVIPEDICELLUS (BP) and KNAT2.
3702	818340	18409376	2008-06-07 10:18	results of studying new alleles of AS1 and AS2 support their role in control of class I KNOX genes and auxin transport.
3702	818345	15469493	2007-08-25 15:08	It was demonstrated that the septin-related domain is important for FHY1 to transmit phyA signals.
3702	818345	16244150	2007-08-25 21:05	PhyA is directly involved in mediating the light-triggered down-regulation of FHY1, and the dark accumulation of FHY1 requires functional pleiotropic Constitutive Photomorphogenic/De-Etiolated/Fusca proteins.
3702	818345	16332538	2007-08-25 21:12	Nuclear accumulation of the phytochrome A photoreceptor requires FHY1.
3702	818345	17566111	2007-08-25 10:41	Arabidopsis fhi/fhy1 double mutants reveal a distinct cytoplasmic action of phytochrome A.
3702	818383	18045813	2008-05-24 10:35	The isolation and characterization of transient defective exine 1 (tde1), an alleles of DET2, is reported.
3702	818390	16677815	2007-08-25 14:09	Biochemical characterization of the auxin-influx carrier AUX1 is presented.
3702	818390	16690816	2007-08-25 12:31	results show that AXR4 (At1g54990) a protein of the endoplasmic reticulum (ER)regulates localization of AUX1; findings indicate that the axr4 agravitropic phenotype is caused by defective AUX1 trafficking in the root epidermis
3702	818390	17084699	2007-08-25 12:25	Planar polarity in root tips studied and found that combinatorial action of the auxin influx carrier AUX1, ETHYLENE-INSENSITIVE2, and GNOM genes mediates the vector for coordinate hair positioning.
3702	818390	17114355	2007-08-25 10:10	AUX1 uses a novel trafficking pathway in plants that is distinct from PIN trafficking, providing an additional mechanism for the fine regulation of auxin transport.
3702	818390	17215297	2007-08-25 14:03	auxin signaling in the basal meristem triggers pericycle cells for lateral root initiation prior to the action of INDOLE-3-ACETIC ACID
3702	818395	15948832	2007-08-25 11:06	Null CAX1 mutants of Arabidopsis have most of the phenotypes associated with tolerance to serpentine soils, especially altered responses to calcium and magnesium.
3702	818395	15994298	2007-08-25 21:22	His338 has a role in metal transport activity in the Arabidopsis cation/H+ exchanger CAX1
3702	818395	16055687	2007-08-25 22:21	The functional roles of calcium exchanger 1 (CAX1), a vacuolar H+/Ca2+ transporter, and the closely related transporter CAX3 are reported.
3702	818395	17898422	2008-02-09 12:01	plants expressing activated CAX1 variants displayed hypersensitivity to ion imbalances, increased calcium accumulation, heightened concentrations of other minerals, and increased activity of tonoplast-enriched Ca(2+)/H(+) transport
3702	818402	17227548	2007-07-02 12:00	This study shows that the spatial and temporal expression patterns of PDX1.1 and PDX1.3, investigated at the transcript and protein level, largely overlap, but PDX1.3 is more abundant than PDX1.1. [PDX1.1]
3702	818408	15918887	2005-11-22 08:53	FAC1 is involved in early embryo development, most likely in providing sufficient ATP for embryo development to proceed beyond the zygote stage. [FAC1] [EMBRYONIC FACTOR 1]
3702	818408	16511144	2007-08-25 11:57	preliminary X-ray crystallographic structure of adenosine 5'-monophosphate deaminase
3702	818408	16543243	2007-08-25 13:35	analysis of the association between Arabidopsis FAC1 globular catalytic domain and intracellular membranes, with N-terminal transmembrane and disordered linker regions serving as the anchor and attachment to the globular catalytic domain
3702	818425	16006582	2005-11-23 17:18	ITB1 Encodes a Plant Scar/WAVE homolog called SCAR2. Loss of function of ITB1/SCAR2 leads to actin and microtubule defects. [IRREGULAR TRICHOME BRANCH1] [ITB1]
3702	818429	17059405	2007-08-25 13:28	Mmutations of WRKY33 gene encoding a WRKY transcription factor cause enhanced susceptibility to Botrytis cinerea and Alternaria brassicicola concomitant with reduced expression of the jasmonate-regulated plant defensin PDF1.2 gene.
3702	818429	17427812	2007-12-01 13:01	Study shows that a set of three WRKY-specific cis-acting DNA elements (W boxes) within the AtWRKY33 promoter is required for efficient pathogen- or PAMP-triggered gene activation.
3702	818436	15757661	2007-08-25 21:13	nsLTPs are a new family of CaM-binding proteins whose functions may be mediated by CaM signaling.
3702	818449	17189343	2007-06-29 16:17	CTP:PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE is a rate limiting enzyme in phosphatidylethanolamine biosynthesis and pect1 mutants exhibit embryonic and postembryonic defects. [PECT]
3702	818457	15161963	2007-08-25 13:06	results collectively suggest that AnnAt1 and AnnAt4 play important roles in osmotic stress and ABA signaling in a Ca2+-dependent manner
3702	818472	17923671	2007-12-15 11:56	A transcription factor AtNF-YB1, which acts through a previously undescribed mechanism to confer improved performance in Arabidopsis under drought conditions was identified.
3702	818530	17494768	2007-08-20 16:26	Expression of the Arabidopsis and poplar MTP11 cation diffusion facilitators in a manganese-hypersensitive yeast mutant restores manganese tolerance to wild-type levels.[MTP11]
3702	818530	17559518	2007-11-08 13:47	The role of MTP11 in manganese transport and tolerance in A. thaliana and in transgenic S. cerevisiae is reported. [AtMTP11]
3702	818532	17827269	2008-01-19 12:04	A study evaluating the function of PPL1 and PPL2, both members of the the PsbP gene family in Arabidopsis, is presented.
3702	818549	16339855	2006-04-27 15:19	BOTRYTIS-INDUCED KINASE1 (BIK1) modulates the signaling of cellular factors required for defense responses to pathogen infection and normal root hair growth, linking defense response regulation with that of growth and development.[BIK1]
3702	818558	16997900	2007-08-25 21:02	Activase levels have a role in the thermotolerance of photosynthesis in Arabidopsis.
3702	818558	17933901	2008-04-26 13:09	Results provide clear evidence that RCA is a major limiting factor in plant photosynthesis under moderately elevated temperatures and a potential target for genetic manipulation to improve crop plants productivity under heat stress conditions.
3702	818562	16720601	2007-08-25 14:09	Programmed cell death symptoms such as nuclear chromatin condensation, the presence of multivesicular bodies, and extensive degradation and disorganization of the grana stacks were observed in 10-week-old vtc1 leaves.
3702	818566	18060533	2008-05-03 13:09	Results show that down-regulation of P5CS1 occurred in 35S-P5CS1 leaves, leading to proline reduction, and, in turn, impaired bolting and stunted growth.
3702	818568	16702557	2007-08-25 13:33	cold stress responses in Arabidopsis are attenuated by a ubiquitination/proteasome pathway in which HOS1 mediates the degradation of the ICE1 protein
3702	818576	15618414	2007-08-25 14:50	AtProT1 expression was found in the phloem or phloem parenchyma cells throughout the whole plant, indicative of a role in long-distance transport of compatible solutes.
3702	818581	17220365	2007-08-25 14:01	A mutation within the coi1 gene impairs methyl jasmonate-induced stomatal closing, but not abscisic acid-induced stomatal closing.
3702	818588	17977154	2007-12-29 11:08	WRKY53 and HSPRO2[At2g4000] appear to function downstream of salicylic acid and to be negatively regulated by signaling through jasmonic acid and ethylene.
3702	818596	16212608	2007-08-25 13:38	The function of ELF3 and ELF4 in their light-regulated expression associated with CCA1, LHY, and TOC1 as part of the central oscillator of the circadian clock in Arabidopsis is reported.
3702	818596	17384164	2007-08-25 15:00	ELF4 is required to regulate the expression of CCA1 and TOC1 and can be considered a component of the central CCA1/LHY-TOC1 feedback loop in the plant circadian clock.
3702	818605	17609218	2008-06-06 15:00	AtSZF1 and AtSZF2 negatively regulate the expression of salt-responsive genes and play important roles in modulating the tolerance of Arabidopsis plants to salt stress. [AtSZF2]
3702	818608	16361514	2007-08-25 11:24	One possible function for ATEM6 in seed development is to buffer the water loss that occurs during embryo maturation.
3702	818614	15960620	2007-08-25 11:16	Double-mutant analysis showed that ABA-insensitive 4 (ABI4) is epistatic to AtLPP2 but ABA-insensitive 3 (ABI3) is not.
3702	818614	16098105	2007-08-25 14:15	Impaired responses to light, sugars, and abscisic acid in ABI mutants of A. thaliana.
3702	818614	16844907	2007-08-25 10:14	ABI4 functions as a repressor of lipid breakdown.
3702	818614	17395793	2007-08-25 10:41	results show GUN1 & ABI4 are common to all 3 plastid-to-nucleus retrograde signaling pathways; model proposed in which indicators of aberrant plastid function are integrated upstream of GUN1 in plastids leading to ABI4-mediated repression of nuclear genes
3702	818614	17427804	2007-12-01 13:01	Study defines abscisic acid(ABA)-induced resistance to L. maculans as a subset of the ABA responses regulated via ABI-1 and ABI4.
3702	818614	18363631	2008-09-20 10:16	The abi4 phenotype of Arabidopsis expressing tomator ASR1 is the result of competition between the foreign ASR1 and the endogenous ABI4 on specific promoter DNA sequences.
3702	818627	17716623	2007-12-01 12:56	Data suggest that DREB2C is a regulator of heat stress tolerance in Arabidopsis.
3702	818628	15341633	2007-08-25 14:52	A trans activator involved in cold acclimatization.
3702	818682	16596410	2007-08-25 21:23	DPE2 is not associated with the chloroplast in Arabidopsis thaliana.
3702	818682	16980562	2007-08-25 10:11	A comparison of ATPHS2 and DPE2 from A. thaliana with MalP and MalQ from E. coli is presented.
3702	818693	17224067	2007-08-25 11:47	Analysis of the double mutant null for both ETR1 and ERS1 in A. thaliana uncovered novel roles for the receptors not previously characterized.
3702	818694	17662035	2008-01-05 15:45	Salt stress induces a signaling cascade involving the processing of AtbZIP17, its translocation to the nucleus and the upregulation of salt stress genes.
3702	818705	18278441	2008-09-20 10:16	UBA2B (AT2G41060) encodes an hnRNP-type nuclear RNA-binding protein that functions in a novel wound signal transduction pathway.
3702	818706	15642716	2005-11-22 10:58	A leucine zipper transcription factor expressed during seed maturation. [EEL] [Enhanced Em Level]
3702	818713	15196054	2005-03-10 15:34	An AtCRK1 [Arabidopsis thaliana CDPK (Ca2+-dependent protein kinase)-related protein kinase 1] has been characterized molecularly and biochemically. [CRK1]
3702	818723	17516080	2007-12-01 12:09	up-regulated by iron deficiency in roots and leaves
3702	818735	17601823	2007-10-20 11:55	BOP1 and BOP2 act in cells adjacent to the lateral organ boundary to repress genes that confer meristem cell fate and induce genes that promote lateral organ fate and polarity.
3702	818735	18339677	2008-06-14 10:34	BOP1/BOP2 activity is required for multiple cell differentiation events in the proximal regions of inflorescence lateral organs.
3702	818741	17056758	2007-08-25 11:49	ERD15 is a novel mediator of stress-related ABA signaling in Arabidopsis.
3702	818764	17360591	2007-05-25 17:50	MIZ1 functions in the early phase of the hydrotropic response in Arabidopsis [MIZ1]
3702	818766	15292215	2007-08-25 21:14	Arabidopsis knock-out mutant showed growth inhibition and hypersensitivity to methyl viologen.
3702	818766	18625226	2008-09-20 10:28	NTRC and 2-Cys Prx are involved in the protection of at least the later part of the chlorophyll biosynthetic pathway; NTRC and 2-Cys Prx in vitro stimulate the aerobic cyclase step of this pathway.
3702	818802	15356005	2007-08-25 13:45	Results demonstrate the effects of calcium- and lipid-binding properties of the C2 and catalytic domains of plant phospholipase D (PLD) and provide insight into the mechanism by which calcium regulates PLD activity.
3702	818820	18278578	2008-09-20 10:16	SPL9 has a role in shoot maturation.
3702	818854	17384167	2007-08-25 15:00	COR15A encodes a small, plastid-targeted polypeptide that is processed to a mature form called Cor15am which localizes almost exclusively to the chloroplast stroma.
3702	818854	18540080	2008-08-30 10:16	indicate that Cor15am functions as a protectant against various stresses by preventing protein aggregation
3702	818862	17346265	2007-08-25 14:01	Results show that axillary shoot growth is controlled locally, at the node, by an SCF(MAX2), the action of which is enhanced by the mobile MAX signal.
3702	818862	17951458	2008-04-05 11:13	roles in red, far-red, and ultraviolet-A/blue light-signaling pathways
3702	818883	17145761	2007-08-25 21:16	Bisindolylmaleimide I abolishes the FGF2-mediated association of Shp2 tyrosine phosphatase with Frs2 and Gab1.
3702	818887	17948056	2008-03-06 13:01	PAR1 and PAR2 act in the nucleus to broadly control plant development, acting as negative regulators of a variety of the shade avoidance syndrome (SAS)responses. [PAR1]
3702	818903	16500988	2007-08-25 13:36	Overexpression of SHORT HYPOCOTYL UNDER BLUE1 enhanced the expression of PHYTOCHROME-INTERACTING FACTOR4 (PIF4) under red light.
3702	818903	18047474	2008-04-12 11:12	findings show that PIF4 and PIF5 act early in the phytochrome signaling pathways to promote the shade-avoidance response
3702	818903	18252845	2008-08-02 10:05	Data provide evidence that the mechanism by which PIF4 operate on the phyB signaling pathway under prolonged red light is through maintaining low phyB protein levels, in an additive or synergistic manner.
3702	818934	18441213	2008-08-09 10:44	molecular, physiological, and functional studies demonstrate that INT1 is a tonoplast-localized H(+)/inositol symporter that mediates the efflux of inositol that is generated during the degradation of inositol-containing compounds in the vacuolar lumen
3702	818937	16897469	2007-08-25 13:31	reaction catalyzed by Bio2 may be subject to biochemical constraints, and the apparent close connection with the mitochondrial Fe-S machinery may account for the reaction being retained within the organelle
3702	818941	16055629	2007-08-25 14:44	Data demonstrate the involvement of ETFQO in the catabolism of leucine in higher plants and imply a novel role for this protein in the chlorophyll degradation pathway activated during dark-induced senescence and sugar starvation.
3702	818942	17916737	2007-10-20 11:06	it is proposed that FCA and FPA regulate chromatin silencing of single and low-copy genes and interact in a locus-dependent manner with the canonical small interfering RNA-directed DNA methylation pathway to regulate common targets
3702	818978	17194764	2007-08-25 21:02	These results provide new insights into the molecular mechanism underlying formation of the Cys synthase complex and provide a structural basis for the biochemical regulation of Cys biosynthesis in plants.
3702	818978	18223034	2008-05-17 10:16	Null alleles of oastlA or oastlB alone showed that cytosolic OAS-TL A and plastid OAS-TL B were completely dispensable, although together they contributed 95% of total OAS-TL activity. oastlC plants also showed retarded growth.
3702	818982	15500467	2005-05-26 16:54	We have used ozone (O3) to generate reactive oxygen species in the apoplast of Arabidopsis thaliana and show that this treatment caused a transient activation of mitogen-activated protein kinase AtMPK6. [AtMPK6]
3702	818982	15539472	2007-08-25 12:03	Our identification of the first plant MAPK substrate reveals one mechanism by which MPK6/SIPK regulates plant stress responses and uncovers a signaling pathway that modulates the biosynthesis of ethylene in plants under stress.
3702	818982	17259259	2007-08-25 10:44	MPK6 is a key regulator of stomatal development and patterning.
3702	818982	17369371	2007-08-25 15:03	These results indicate that MAPK KINASE 3 (MKK3)-MAPK 6 (MPK6) unit plays a key role in jasmonic acid-dependent negative regulation of ATMYC2/JIN1 expression.
3702	818982	17519351	2007-09-04 18:35	MPK6 is involved in the regulation of flower and seed development.
3702	818982	17586809	2007-10-13 10:20	AtMKP2, a novel MKP protein in Arabidopsis, acts upon MPK3 and -6, and serves as a positive regulator of the cellular response to oxidant challenge
3702	818982	17630279	2007-12-01 11:49	These results demonstrate a key role for the AP2C1 phosphatase in regulating stress hormone levels, defense responses, and MAPK activities in Arabidopsis.
3702	818982	18005697	2007-12-15 11:56	The MAPKs MPK3 and MPK6 physically interact with HopAI1 indicating that they are direct targets of HopAI1.
3702	818982	18364464	2008-08-02 10:40	Results highlight an essential function of MPK6 in promoting cell division in the integument specifically during ovule development.
3702	818982	18378893	2008-06-14 10:24	the MPK3/MPK6 cascade regulates camalexin synthesis through transcriptional regulation of the biosynthetic genes after pathogen infection.
3702	818986	17085977	2007-08-25 11:49	isolation & characterization of UDP-glucose:salicylic acid glucosyltransferase1 (AtSGT1) gene; AtSGT1 was rapidly induced by exogenous SA & infection with Pseudomonas syringae, indicating pathogen-inducible AtSGT1 expression is an early disease response
3702	818986	18226820	2008-08-16 10:26	The reduced resistance by AtSGT1 overexpression results from a reduction in salicylic acid content, which is at least in part caused by increases in methyl salicylate 2-O-beta-D-glucoside and methyl salicylate levels at the expense of salicylic acid.
3702	819000	16624824	2007-08-25 13:34	OEP37 may constitute a novel peptide-sensitive ion channel in the outer envelope of plastids with function during embryogenesis and germination.
3702	819003	17698066	2007-10-20 10:19	AtITPK4 differs from other family members in that it does not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity; rather, it displays inositol 1,4,5,6-tetrakisphosphate and inositol 1,3,4,5-tetrakisphosphate isomerase activity.
3702	819018	17889453	2007-12-01 10:13	The expression of RPL7C in Arabidopsis is reported.
3702	819056	16293760	2005-12-07 14:59	PEN2 restricts pathogen entry of two ascomycete powdery mildew fungi that in nature colonize grass and pea species; the PEN2 glycosyl hydrolase localizes to peroxisomes and acts as a component of an inducible preinvasion resistance mechanism. [PEN2]
3702	819076	16709199	2006-10-13 18:35	CKB4, a CK2 regulatory subunit, is a component of the Arabidopsis circadian system. [CKB4]
3702	819076	17662034	2007-12-22 12:01	Oscillator dysfunction is responsible for the period defect of CKB4-ox plants that leads to clock dissonance with the environment and reduced sensitivity to day length.
3702	819084	17611796	2007-10-06 11:11	thiamin pyrophosphokinase activity provides the sole mechanism by which exogenous and de novo derived thiamin is converted to the enzyme cofactor Thiamin pyrophosphate
3702	819099	16434475	2006-03-16 16:00	ARABIDILLO-1 functions redundantly with Arabidillo-2 to promote lateral root development in Arabidopsis. [ARABIDILLO-1]
3702	819104	17329563	2007-08-25 12:22	role is proposed for chromatin remodeling in seed dormancy by H2B monoubiquitination through HUB1 and HUB2
3702	819104	17329565	2007-08-25 12:22	Data show that HUB1 is a functional homolog of the human and yeast BRE1 proteins, adn suggest that it mediates gene activation and cell cycle regulation through chromatin modifications.
3702	819107	15342640	2005-01-31 14:50	the sequential cleavages of beta-carotene by AtCCD7 and AtCCD8 may be initial steps in the synthesis of a carotenoid-derived signaling molecule necessary for the regulation lateral branching. [AtCCD7]
3702	819107	17092317	2007-08-25 11:49	Complementation analyses for HTD1 confirm that the defect in HTD1 is responsible for both high-tillering and dwarf phenotypes in the htd1 mutant; HTD1 is an ortholog of MAX3 in A. thaliana.
3702	819127	16714408	2007-08-25 10:51	AINTEGUMENTA acts in combination with FILAMENTOUS FLOWER to promote organ polarity by up-regulating the expression of the adaxial-specifying HD-ZIP gene PHABULOSA.
3702	819136	15923332	2005-11-21 11:01	AtRAD51C is essential for normal meiosis and is probably required for homologous synapsis.[AtRAD51C]
3702	819136	16169964	2007-08-25 11:19	Crossing of RAD51C mutant with wild-type plants showed defective male and female gametogeneses as evidenced by lack of seed production. Furthermore, meiosis was severely disturbed in the mutant.
3702	819139	15563616	2007-08-25 14:17	Functional cloning of the gene and biochemical characterization of the encoded enzyme.
3702	819143	15662426	2005-02-08 11:25	crr4 is among genes responsible for the specific RNA editing event in the chloroplast [CRR4]
3702	819143	17015439	2007-08-25 15:03	the pentatricopeptide repeat protein CRR4 is a sequence-specific RNA-binding protein that acts as a site recognition factor in plastid RNA editing
3702	819146	17521414	2007-10-13 11:06	Analyses of brassinosteroid profiles demonstrated that BEN1 is indeed responsible for regulating the levels of several brassinosteroids, including typhasterol, castasterone and brassinolide.
3702	819153	18055602	2008-06-06 15:01	The identification of a gene family that encodes small leucine zipper-containing proteins (LITTLE ZIPPER [ZPR] proteins) where the leucine zipper is similar to that found in REV, PHABULOSA, and PHAVOLUTA proteins, is reported. [Little Zipper]
3702	819157	16028112	2007-08-25 14:23	Aurora kinase AtAUR3 showed dot-like distribution on condensed chromosomes at prophase and then localized at the metaphase plate, and overexpression of AtAUR3 induces disassembly of spindle microtubules and alteration of orientation of cell division.
3702	819174	15618421	2005-11-17 10:50	Activation of SOC1 expression by FT and TSF in winter-annual flowering A. thaliana. [SOC1]
3702	819174	15695467	2007-08-25 21:23	FT regulates SOC1 expression, and SOC1 regulates LFY expression [SOC1]
3702	819174	16183837	2007-08-25 12:36	inactivation of FT caused down-regulation of SOC1 even in plants overexpressing CO, indicating that FT is required for SOC1 induction by CO
3702	819174	16623882	2007-08-25 11:55	SOC1 gene. MADS box proteins are thought to bind their DNA targets as dimers or higher-order multimers
3702	819174	17428825	2007-08-25 15:03	once AP1 is activated during the floral transition, it acts partly as a master repressor in floral meristems by directly suppressing the expression of flowering time genes SVP, AGL24 and SOC1, preventing continuation of the shoot developmental program
3702	819174	18339670	2008-06-14 10:34	during floral transition, a positive-feedback loop conferred by direct transcriptional regulation between AGL24 and SOC1 at the shoot apex integrates flowering signals
3702	819177	16040658	2007-08-25 21:04	AtPex16p (SSE1) is the only authentic plant peroxin homolog known to coexist at steady state within peroxisomes and ER; these data provide new insights in support of its ER-related, multifunctional roles in organelle biogenesis.
3702	819177	17431024	2007-08-25 21:23	The mechanism of protein trafficking of PEX16 through the endoplasmic reticulum to pre-existing peroxisomes is discussed.
3702	819184	17631528	2008-01-12 12:52	The loss of BAP2 function induces accelerated hypersensitive responses but does not compromise plant growth or confer enhanced resistance to virulent bacterial or oomycete pathogens.
3702	819185	16813577	2007-08-25 11:53	Mutations within the cpFtsY gene are associated with an inability to induce Fe(III) chelate reductase activity in response to iron deficiency.
3702	819185	17475780	2007-09-04 16:20	These results highlight intriguing differences between the classical and chloroplast SRP and SRP receptor GTPases, and help explain how the chloroplast SRP pathway can mediate efficient targeting of proteins to the thylakoid membrane.
3702	819185	18022392	2008-03-29 12:12	the crystal structure of chloroplast FtsY (cpFtsY) at 1.75 A resolution.
3702	819210	17293567	2007-08-25 14:01	Results describe overlapping functions for the two SWI/SNF ATPases, SPLAYED and BRAHMA, and indicate that these proteins exhibit remarkable regulatory specificity.
3702	819210	17825834	2007-12-22 11:40	characterization at the molecular and functional level, the carboxy-terminal part of Arabidopsis BRM. We have found three DNA-binding regions that bind various free DNA and nucleosomal probes with different specificity
3702	819210	18508955	2008-09-20 10:28	mediates the repression of seed storage proteins in leaf tissue
3702	819236	15998311	2007-08-25 11:20	This study suggests a role for TRIP-1 in the molecular mechanisms of brassinosteroid-regulated plant growth and development, possibly as a cytoplasmic substrate of the BRI1 receptor kinase.
3702	819242	15960622	2007-08-25 12:58	Repression of light signaling by Arabidopsis SPA1 likely involves post-translational regulation of HFR1 protein accumulation.
3702	819242	16709190	2007-08-25 21:21	SPA1 regulates circadian rhythms and flowering time in plants.
3702	819242	16813572	2007-08-25 10:50	COP1 and SPA1 act in concert to form a functional E3 ubiquitin ligase complex and provide a molecular basis for understanding the structure-function relationship of SPA1.
3702	819242	18722184	2008-09-20 10:49	phyA associations with FHY3 and FHY1 protect underphosphorylated phyA from being recognized by the COP1/SPA complex.
3702	819244	17220357	2007-08-25 14:01	FIN219 interacts with FIP1 to regulate cell elongation and flowering in response to light.
3702	819244	17291501	2007-08-25 13:25	analyzed the substrate specificity of recombinant JAR1 and determined whether it catalyzes the synthesis of mono- and dinucleoside polyphosphates
3702	819244	18247047	2008-08-30 10:17	Increase in jasmonic acid-isoleucine mediated by the JAR1 enzyme plays only a minor role in transcriptional modulation of genes induced by mechanical wounding.
3702	819249	15795220	2007-08-25 11:31	Deletion analyses of the CPC promoter revealed that hairless cell-specific transcription of the CPC gene required a 69 bp sequence, and a tandem repeat of this region was sufficient for its expression in epidermis.
3702	819249	16291794	2007-08-25 13:02	Intercellular CPC movement is mediated through plasmodesmata. Furthermore, the fusion of CPC to tandem-GFPs defined the capability of CPC to increase the size exclusion limit of plasmodesmata.
3702	819249	17644729	2007-12-01 12:56	The functional relationship of the R2R3-type MYB gene WEREWOLF (WER) and the R3-type MYB gene CAPRICE (CPC), was analyzed.
3702	819251	16449377	2007-08-25 15:01	CNGC3 functions in the non-selective uptake of monovalent cations in Arabidopsis root tissue.
3702	819252	16461580	2007-08-25 10:19	A 3-kb deletion fuses two cyclic nucleotide-gated ion channel (ATCNGC)-encoding genes, ATCNGC11 and ATCNGC12, to generate a novel chimeric gene, ATCNGC11/12.
3702	819253	16461580	2007-08-25 10:19	A 3-kb deletion fuses two cyclic nucleotide-gated ion channel (ATCNGC)-encoding genes, ATCNGC11 and ATCNGC12, to generate a novel chimeric gene, ATCNGC11/12.
3702	819262	17828375	2008-01-19 10:24	AtAIB functions as a transcription activator involved in the regulation of ABA signaling in Arabidopsis.
3702	819282	16472779	2006-04-28 16:32	AtCRK3 could specifically interact with and phosphorylate a cytosolic glutamine synthetase, AtGLN1;1, and possibly be involved in the control of nitrogen remobilization during leaf senescence. [AtCRK3]
3702	819290	17237351	2007-07-02 16:33	NST1 and NST3 redundantly regulate the secondary wall thickenings in interfascicular fiber of inflorescence stems and secondary xylem of hypocotyls in Arabidopsis without affecting the formation of cells destined to be woody tissues. [NST1]
3702	819290	17333250	2007-08-25 10:42	First line evidence demonstrating that SND1 and NST1 function redundantly in the regulation of secondary wall synthesis in fibers is presented.
3702	819292	15705949	2007-08-25 14:38	single prr7-3 or prr9-1 mutants exhibit modest period lengthening, but the prr7-3 prr9-1 double mutant shows dramatic and more than additive period lengthening in the light and becomes arrhythmic in constant darkness
3702	819292	15725665	2007-08-25 12:49	The APRR9 promoter contains at least two distinctive and separable regulatory cis-elements: an "L element" responsible for the light-induced expression, followed by an "R element" necessary for the fundamental rhythmic expression of the gene.
3702	819292	15767265	2007-08-25 12:37	PRR9/PRR7/PRR5 together act as period-controlling factors, and they play overlapping and distinctive roles close to (or within) the central oscillator in which the relative, PRR1/TOC1, plays an essential role
3702	819292	17504813	2007-10-13 12:37	The role of clock-associated genes PRR9, PRR7 and PRR5 are involved in activation of CONSTANS and CO-FLOWERING LOCUS T are reported.
3702	819292	17890242	2008-04-05 11:14	Data show that PRR9 polypeptides oscillate diurnally, and that they accumulate rapidly in response to light, and further suggest that the presence of PRR9 polypeptides is controlled through proteasome-mediated programmed degradation in the dark.
3702	819293	15653794	2005-09-22 14:57	we propose that AtMTP1 is localized in the vacuolar membrane and is involved in sequestration of excess Zn in the cytoplasm into vacuoles to maintain Zn homeostasis.[ATMTP1]
3702	819293	15946891	2005-11-10 14:00	The MTP1 protein of Arabidopsis thaliana belongs to a ubiquitous family of transition metal transporters that extrude metal ions from the cytoplasm (MTP1)
3702	819293	16038907	2005-09-22 14:59	RNA interference-mediated silencing of AtMTP1 causes Zn hypersensitivity and a reduction in Zn concentrations in vegetative plant tissues [MTP1]
3702	819293	18203721	2008-05-24 10:06	AtMTP1 functions as a Zn(2+)/H(+) antiporter in vacuoles and that a histidine-rich region is not essential for zinc transport
3702	819295	16109415	2007-08-25 12:59	demonstrated the exclusive localization of TMP14 in plant photosystem I (PSI); provided evidence that TMP14, designated PSI-P, is a novel subunit of this PS [PSI-P].
3702	819296	15516515	2007-08-25 11:33	This study demonstrated a light-entrained circadian clock regulates ethylene release from unstressed, wild-type Arabidopsis (Arabidopsis thaliana) seedlings, with a peak in the mid-subjective day.
3702	819296	15725674	2007-08-25 12:49	A functional interaction between the CCA1 clock component and one of the PRR family members, PRR5, by employing transgenic lines overexpressing both the CCA1 and PRR5 genes is reported.
3702	819296	16212608	2007-08-25 13:38	The function of ELF3 and ELF4 in their light-regulated expression associated with CCA1, LHY, and TOC1 as part of the central oscillator of the circadian clock in Arabidopsis is reported.
3702	819296	17483414	2007-09-29 10:26	TOC1 regulates the floral transition in a CCA1/LHY-dependent manner while CCA1/LHY functions upstream of TOC1 in regulating a photomorphogenic process.
3702	819296	17540692	2007-12-01 11:25	The linkages of TOC1, CCA1 and LHY genes and the canonical CO-FT flowering pathway were studied.
3702	819296	17873091	2008-01-19 12:54	This study suggests that the combination of light regulation of CCA1 transcription and CCA1 messenger RNA degradation is important for ensuring that the Arabidopsis circadian oscillator is accurately entrained by environmental changes.
3702	819296	18344319	2008-04-26 11:17	Regulation of CCA1 by organic N signals may represent a novel input mechanism for N-nutrients to affect plant circadian clock function.
3702	819296	18460819	2008-08-02 10:40	data suggests that CCA1 acts predominantly as a transcriptional repressor in nature
3702	819306	17079273	2007-08-25 11:50	POL and PLL1 are central players in regulating the balance between stem-cell maintenance and differentiation, and are the closest known factors to WUS regulation in the shoot meristem.
3702	819306	18606144	2008-08-09 10:12	Key divisions in the early Arabidopsis embryo require POL and PLL1 phosphatases to establish the root stem cell organizer and vascular axis.
3702	819311	16565297	2007-08-25 10:17	PIL1 is a direct target of phytochrome signaling and plays a key role in response to long-term shade in Arabidopsis.
3702	819311	16891401	2007-08-25 11:52	PIL1 is necessary for rapid light-induced expression of the photomorphogenesis- and circadian-related PSEUDO-RESPONSE REGULATOR9 gene, indicating a regulatory function in the early phy-induced transcriptional network.
3702	819311	18296722	2008-05-31 10:05	These data suggest that the second-phase decline in robustness of PIL1 derepression is an indirect consequence of the global developmental transition from the etiolated to the de-etiolated state.
3702	819314	17557805	2007-10-20 12:42	Mutations in Multidrug Resistance-Like1 (MDR1) reduced acropetal auxin transport in roots by 80% without affecting basipetal transport. Conversely, mutations in MDR4 blocked 50% of basipetal transport without affecting acropetal transport.
3702	819314	18156217	2008-08-09 10:05	Results suggest that PGP4 is an auxin efflux transporter in plants and that its trafficking to the plasma membrane involves both BFA-sensitive and -insensitive pathways.
3702	819329	16805739	2007-08-25 10:50	The generation of Arabidopsis thaliana plants that tolerate boron (B)-deficient conditions due to the overexpression of BOR1 is reported.
3702	819331	15466240	2005-04-27 09:31	GolS1 is a novel heat shock factor target gene, which is responsible for heat stress-dependent synthesis of raffinose in Arabidopsis.  [GolS1]
3702	819332	15569682	2007-08-25 12:59	a specific CaM isoform mediates salt-induced Ca2+ signaling through the activation of an MYB transcriptional activator, thereby resulting in salt tolerance in plants.
3702	819332	17031393	2007-08-25 12:26	MYB2 is involved in iron translocation from roots to shoots.
3702	819332	17686455	2007-10-20 11:54	Results demonstrate that the DNA-binding domain of AtMYB2 is inhibited by S-nitrosylation of Cys53 as a consequence of nitric oxide action.
3702	819351	16061502	2007-08-25 10:56	essential role of the intron present in the 5'-non-coding region of all known COX5c genes in directing the expression of these genes in plants.
3702	819356	17602786	2008-05-10 10:19	CKI-1 is involved in cytokinin perception and demonstrates the existence of a feedback loop altering cytokinin metabolism in response to the level of receptor abundance
3702	819358	18621669	2008-07-26 10:32	study presents 1.5 angstrom crystal structure of cpSRP43 characterized by a unique arrangement of chromodomains & ankyrin repeats; complex with the internal signal sequence of LHCPs reveals that cpSRP43 specifically recognizes a DPLG peptide motif
3702	819359	15923334	2007-08-25 10:21	The characterization of MYB12 as a flavonol-specific activator of flavonoid biosynthesis in A. thaliana is reported.
3702	819372	15592750	2007-08-25 11:34	Expression in response to nitrogen and phosphorus deprivation.
3702	819373	15710632	2007-08-25 13:41	The mechanism of the repression of AtMHX by its untranslated region is described.
3702	819383	16384903	2006-08-21 16:08	RFI2 encodes a protein with a C3H2C3-type zinc finger or RING domain and mediates phytochrome control of seedling deetiolation. [RFI2]
3702	819383	16709197	2006-10-13 13:35	RFI2 represses the expression of CONSTANS.  [RFI2]
3702	819386	17670748	2007-11-10 11:55	alternate transcription start sites of the GSTF8 promoter are used to confer differential tissue-specific and stress-responsive expression patterns as well as to target the same protein to two different subcellular localizations.
3702	819387	17216483	2007-08-25 21:16	Study reports the role of a previously uncharacterized GH3 gene family member, GH3.9, in root growth; unlike most other Group II family members, GH3.9 expression was repressed by low concentrations of exogenous indole acetic acid in seedlings.
3702	819410	16176934	2006-02-03 08:49	REC8 and SCC3 are necessary not only to maintain centromere cohesion at anaphase I, but also for the monopolar orientation of the kinetochores during the first meiotic division [AtSCC3]
3702	819411	15980260	2005-11-23 17:10	SLOW WALKER1 most likely plays a role in rRNA biogenesis that is essential for the progression of the mitotic division cycles during gametogenesis in plants. [SLOW WALKER1] [SWA1]
3702	819423	18430946	2008-06-28 10:22	The REF4 locus (At2g48110) was cloned by a combined map- and sequencing-based approach and was found to encode a large integral membrane protein that is unique to plants.
3702	819550	16113215	2006-02-02 08:25	ECT proteins, ECT1 and ECT2, are molecular components in the CBL-CIPK calcium signaling pathways. They contain a highly conserved 180-amino acid region, which is involved in mediating the nuclear localization of the ECT proteins.[ECT1]
3702	819563	17434987	2007-10-06 10:53	acts to reduce the concentration of extracellular nucleotides, highest expression in rapidly growing tissues and/or tissues that accumulate high auxin levels
3702	819564	16223486	2006-01-03 21:00	SIP1;1 is an aquaporin that when expressed in yeast gave water-channel activity. They are localized in ER of all tissues except dry seeds.
3702	819566	15564521	2007-08-25 14:25	findings suggest that AtGLR1.1 integrates and regulates the different aspects of C, N and water balance that are required for normal plant growth and development
3702	819579	16473894	2007-08-25 13:37	SECRET AGENT (SEC) functions in germination, rosette leaf growth, height of inflorescence stem, and the rate of production of rosette leaves.
3702	819583	17099079	2007-08-25 13:27	Spatial and temporal expression of ARR22 is discussed.
3702	819583	18625081	2008-10-04 10:28	Results favor the model that ARR22 acts as a phospho-histidine phosphatase on specific AHPs in the cytoplasm of Arabidopsis chalaza cells.
3702	819593	17020925	2007-08-25 21:26	A novel histone lysine methyltransferase specificity was demonstrated for SUVR4, in that monomethylated histone H3K9 is its preferred substrate in vitro.
3702	819602	16113209	2006-02-01 15:26	PEX12 is a peroxisomal protein in Arabidopsis and is essential for peroxisome biogenesis and plant development. [AtPEX12]
3702	819602	16813573	2007-03-06 09:36	APM2/PEX13 and APM4/PEX12 have roles in both PTS1- and PTS2-dependent protein transport on the peroxisomal membrane. [APM4] [PEX12]
3702	819608	17172352	2007-06-29 14:49	Seed-specific expression of feedback-insensitive Thr deaminase in both tha1 and tha2 Thr aldolase mutants greatly increases seed Ile content, suggesting that these two Thr catabolic enzymes compete for a common substrate pool.[THA2]
3702	819634	17224141	2007-08-25 11:48	AtSWP1 and AtCZS represent two main components of a co-repressor complex that fine tunes flowering and is unique to plants.
3702	819647	17468780	2007-11-08 13:24	SPC1 encodes a putative zeta-carotene desaturase (ZDS) in the carotenoid biosynthesis pathway and plays a crucial role in plant growth and development [SPC1]
3702	819660	17306301	2007-08-25 21:23	Toc64 is involved in preprotein translocation across the outer envelope at both sites of the membrane.
3702	819674	16709201	2007-06-27 12:00	AtGID1a, AtGID1b and AtGID1c function as GA receptors in Arabidopsis. [AtGID1a]
3702	819674	17194763	2007-06-29 14:19	GID1a, GID1b, GID1c are the predominant GA receptors in regulating GA growth response in Arabidopsis.  GA binding to GID1a promotes its interaction with DELLA proteins. [GID1a]
3702	819674	17521411	2007-09-08 11:34	The double knockout mutant atgid1a atgid1c showed a dwarf phenotype.  The stamens of the double knockout mutant atgid1a atgid1b were significantly shorter than those of the wild-type, and this leads to low fertility.
3702	819697	17964159	2008-01-26 10:18	AT3G05330 AtTAN is implicated as a component of a cortical guidance cue that remains behind when the preprophase band (PPB) is disassembled and directs the expanding phragmoplast to the former PPB site during cytokinesis.
3702	819730	16384909	2007-08-25 11:59	PLDzeta2 plays a role in regulating root development in response to nutrient limitation.
3702	819730	16617110	2007-08-25 12:31	pldz2 mutant is defective in the hydrolysis of phospholipids and has a reduced capacity to accumulate galactolipids under limiting Pi conditions
3702	819730	16891548	2007-08-25 10:12	Hydrolysis of phosphatidylcholine by PLD zetas during phosphorus starvation contributes to the supply of inorganic phosphorus in A. thaliana.
3702	819730	17259265	2007-08-25 10:44	PLDzeta2 and and its product, phosphatidic acid (PA) are required for the normal cycling of PIN2-containing vesicles as well as for function in auxin transport and distribution, and hence auxin responses.
3702	819730	18242181	2008-04-26 12:11	AtPLDzeta2 localizes to the tonoplast and the Nter regulatory domain is sufficient for its sorting. Under phosphate deprivation, AtPLDzeta2 remains located in the tonoplast but its distribution is uneven.
3702	819748	17478548	2007-11-01 17:18	Lon protease-like protein 4 (Lon4) targeted to both mitochondria, chloroplasts, and is also located in thylakoids.[Lon4]
3702	819757	15860016	2007-08-25 12:46	The expression of multiple RCI2a mutants in responset to ABA, DNA or NaCl, low temperature, or the stress induced expressio nof RD29A is reported.
3702	819757	16034593	2007-08-25 11:26	results suggest that RCI2A plays a role directly or indirectly for avoiding over-accumulation of excess Na+ and K+ ions in plants, and contributes to salt tolerance
3702	819772	17605754	2008-01-05 15:12	permits flexible modulation of growth in adverse and/or otherwise limiting environments
3702	819778	15632145	2005-06-16 10:10	PrxII F has a role in antioxidant defense and possibly in redox signaling in plant cells [AtPrxII F (Peroxiredoxin II F)]
3702	819783	18435919	2008-07-26 10:16	The data suggest that AtNIP7 can mediate AsIII transport and contributes to AsIII uptake in plants.
3702	819785	18450784	2008-08-09 10:30	We report that MUTE controls downstream events directing stomatal differentiation and that MUTE is required for the production of the structure evolutionarily related to stomata, the hydathode pore.
3702	819785	18453151	2008-07-26 10:16	regulates cell-cell interaction involved in stomatal development.
3702	819804	15528200	2005-08-24 14:48	molecular cloning and characterization of second prolyl 4-hydroxylase in Arabidopsis[At-P4H-2]
3702	819809	16784230	2007-08-25 10:50	interactions observed in DHQ-tartrate complex reveal conserved mode for substrate binding between plant & microbial DHQ dehydratase family. SDH-shikimate complex provides 1st direct evidence of role of active site residues in catalytic mechanism.
3702	819814	16286646	2006-02-06 09:12	Essential for haploid nuclear proliferation during megagametogenesis and cell expansion during the sporophytic phase of the plant life cycle [CHR11] [CHROMATIN REMODELING COMPLEX subunit 11]
3702	819826	15629119	2007-08-25 11:16	the conserved Glu, Lys, and Asn residues of the N-box contribute to coordinating Mg2+ in a position critical for formation of the PDK-MgATP-substrate ternary complex
3702	819827	17766401	2007-12-22 10:03	Complexes containing R2R3 MYB and bHLH transcription factors regulate the expression of TTG2, which then regulates GL2 expression with complexes containing R2R3 MYB.
3702	819832	15854662	2005-10-28 16:42	The Rab escort protein gene from Arbisopsis thaliana was cloned and characterized.[AtREP]
3702	819832	17140818	2007-08-25 12:24	We report the cloning and characterization of REP gene of Arabidopsis thaliana. Highest expression of REP mRNA was detected in leaves and flowers in contrast to stems and roots.
3702	819854	15581893	2007-08-25 11:27	functional differences between the peroxisomal acyl-CoA oxidases and the mitochondrial acyl-CoA dehydrogenases are attributed to structural differences in the FAD environments
3702	819865	17277896	2007-08-25 11:47	IBR3 encodes a putative acyl-CoA dehydrogenase that has a role in the oxidation of indole-3-butyric acid to indole-3-acetic acid.
3702	819870	16507084	2007-08-25 13:36	An exogenous supply of sucrose is required in mfp2 mutants for seedling establishment. Seed storage lipids are catabolized more slowly, long-chain acyl-CoA substrates accumulate, and there is an increase in peroxisome size in mfp2-1 mutants.
3702	819889	16212605	2007-08-25 13:38	Two closely related RPM1-interacting proteins, RIN2 and RIN3, are characterized in A. thaliana.
3702	819889	17397263	2007-08-25 10:42	AvrB is activated inside the host cell by nucleotide binding and subsequent phosphorylation and interacts with RIN4. Aactivated AvrB, bound to RIN4, is indirectly recognized by RPM1 to initiate plant immune system function.
3702	819899	18065557	2008-06-07 10:19	AtPAP15 may modulate ascorbic acid (AsA) levels by controlling the input of myoinositol into this branch of AsA biosynthesis in Arabidopsis.
3702	819925	16640601	2006-11-03 17:46	AtCHIP, an E3 ubiquitin liagase, functions upstream of protein phosphatase 2A in stress-responsive signal transduction pathways under conditions of low temperature or in the dark. [AtCHIP]
3702	819925	17714429	2007-12-22 12:31	The interaction of CHIP with FtsH1 in vitro, in normal and in CHIP-over-expressing plants is reported.
3702	819941	18245858	2008-06-21 10:24	These results indicate that ATG10 is essential for ATG12 conjugation and that the ATG12-ATG5 conjugate is necessary to form autophagic vesicles and for the timely progression of senescence and programmed cell death in plants.
3702	819945	16813573	2007-03-06 10:00	APM2/PEX13 and APM4/PEX12 have roles in both PTS1- and PTS2-dependent protein transport on the peroxisomal membrane. [APM2] [PEX13]
3702	819945	18160292	2008-03-29 10:22	AMC is strongly and transiently expressed in both male and female gametophytes during fertilization and functions in gametophytes as a peroxin essential for protein import into peroxisomes.
3702	819952	18218897	2008-03-05 16:11	Study identified a jmjC-domain gene, IBM1 (increase in bonsai methylation 1); ibm1 mutations induced a variety of developmental phenotypes, which depend on methylation of histone H3 at lysine 9 in addition to the ectopic cytosine methylation.  [IBM1]
3702	819979	16355224	2006-02-02 08:47	SCN1 is a RhoGTPase GDP dissociation inhibitor (AtRhoGDI1) that spatially restricts the sites of growth to a single point on the trichoblast [SCN1]
3702	819989	16965555	2007-08-25 13:30	MAP3Kepsilon2 is required for pollen viability in Arabidopsis.
3702	819992	17139246	2007-03-02 16:35	ATAB2 is a chloroplast A/U-rich RNA-binding protein that presumably functions as an activator of translation with at least two targets, one for each photosystem. [ATAB2]
3702	819995	17351051	2007-08-25 10:06	FRD3 effluxes citrate into the root vasculature, a process important for the translocation of iron to the leaves.
3702	820003	17710654	2007-12-01 10:15	Result show vacuolar H(+)-ATPase subunit isoforms VHA-a is regulated at transcript level.
3702	820020	16377759	2007-04-24 15:55	Arabidopsis RAPTOR1 (a TOR regulatory protein) interacts with the HEAT repeats of TOR and that RAPTOR1 regulates the activity of S6 kinase (S6K) in response to osmotic stress [S6K1]
3702	820032	15607746	2007-08-25 13:11	characterization of the two Arabidopsis orthologs of Raptor (AtRaptor1 and 2); AtRaptor1 is the most expressed isoform; mutation leads to seed abortion and to a complete arrest of embryo development at an early stage [AtRaptor1]
3702	820032	15845148	2007-08-25 11:06	Raptor1A Raptor1B double mutants show normal embryonic development but are unable to maintain post-embryonic meristem-driven growth.
3702	820032	16377759	2007-08-25 11:23	Arabidopsis RAPTOR1 (a TOR regulatory protein) interacts with the HEAT repeats of TOR and that RAPTOR1 regulates the activity of S6 kinase (S6K) in response to osmotic stress.
3702	820043	17850797	2007-12-01 12:40	location of the neoxanthin binding site in CP26 and CP29 was investigated by site-directed mutagenesis.
3702	820069	16897478	2007-08-25 13:31	The use of a maize Ds element in direct tagging of HY2 in A. thaliana is reported.
3702	820085	15486103	2007-08-25 14:28	TELOMERASE ACTIVATOR1 (TAC1) is overexpressed & induces telomerase in differentiated leaves without stimulating progression of the cell cycle; reducing endogenous auxin concentrations blocks this effect; TAC1 may increase other auxin responses [TAC1]
3702	820102	18222516	2008-05-24 10:05	Thus, Hsc70-3 and PABP2 are potentially integral components of the replicase complex and could have important roles to play in the regulation of potyviral RdRp functions.
3702	820118	15653809	2007-08-25 11:33	The purpose of the present study was to determine the subcellular localization of this novel plant enzyme. Immunogold electron-microscopic analysis showed the gold labels nearly exclusively in the peroxisomes. T
3702	820118	16201753	2007-08-25 21:05	structural analysis of the Mo(V) forms of sulfite oxidase from Arabidopsis thaliana
3702	820118	16407262	2007-08-25 12:34	Could be responsible for removing sulfite as a toxic metabolite, which might represent a means to protect the cell against excess of sulfite derived from SO2 gas in the atmosphere (acid rain) or during the decomposition of sulfur-containing amino acids.
3702	820118	17983221	2008-01-12 11:59	The isotropic hfi constant of 33S determined in these experiments was about 3 MHz, which demonstrates the presence of coordinated sulfate in the sulfite-reduced low-pH form of the plant enzyme.
3702	820121	17080642	2007-08-25 21:21	The drought tolerant alx8 mutant provides evidence for common steps in drought and high light stress response pathways.
3702	820128	15960618	2007-08-25 11:16	It was proposed that IQD1 to be novel nuclear factor that integrates intracellular Ca(2+) signals to fine-tune glucosinolate accumulation in response to biotic challenge.
3702	820128	16368012	2007-08-25 12:34	IQD proteins link calcium signaling pathways to the regulation of gene expression.
3702	820142	17693538	2008-01-05 14:21	Employing fluorescence correlation spectroscopy, it was shown that CDC48A hexamers are part of larger complexes.
3702	820151	17220200	2007-08-25 13:26	PIP5K9 interacts with CINV1 to negatively regulate sugar-mediated root cell elongation.
3702	820152	17643101	2007-09-22 12:36	IPS1 overexpression results in increased accumulation of the miR-399 target PHO2 mRNA and, concomitantly, in reduced shoot Pi content; engineering of IPS1 to be cleavable abolishes its inhibitory activity on miR-399.
3702	820162	18493721	2008-08-23 10:38	Results suggest that DML2 is required not only for removing DNA methylation marks from improperly-methylated cytosines, but also for maintenance of high methylation levels in properly targeted sites.
3702	820200	15728668	2005-06-16 10:28	ROXY1 is involved in flower development, probably by mediating post-translational modifications of target proteins (ROXY1)
3702	820200	18036205	2008-05-24 10:35	Two CC-type glutaredoxins ROXY1 and ROXY2 together control anther development in Arabidopsis thaliana.[ROXY2]
3702	820201	16040664	2007-08-25 21:04	An allelic series of six independent T-DNA mutations reveal a role for SEC8 in male gametophyte function.
3702	820202	17996704	2008-01-26 11:11	There is a close association of FCA and FLD in mediating H3K4 demethylation and thus transcriptional silencing of FLC.
3702	820202	18069938	2008-07-12 10:26	Data show that by repressing FLD activity through sumoylation, SIZ1 promoted FLC expression.
3702	820216	17298064	2007-08-25 12:22	The structures of AHb1 and AHb2, modeled on the basis of the homologous rice hemoglobin, exhibit a different cavity system that is fully compatible with the observed ligand binding kinetics
3702	820216	17555890	2007-09-29 12:22	Finding strongly supports the idea that AHb1 and AHb2 have distinct physiological functions.
3702	820243	18344421	2008-09-06 10:35	Arabinan-containing pectins are potential in vivo substrates.
3702	820249	18156219	2008-08-11 02:05	Data show that bZIP28 serves as a sensor/transducer in Arabidopsis to mediate ER stress responses related to unfolded protein response.
3702	820249	18634751	2008-08-23 10:10	N-terminal fragment of AtbZIP28 translocates to the nucleus in response to ER stress.
3702	820257	18467465	2008-09-20 10:16	The roots of Arabidopsis plants carrying T-DNA insertions in this putative MeIAA esterase gene displayed significantly decreased sensitivity to MeIAA compared with wild-type roots while remaining as sensitive to free IAA as wild-type roots.
3702	820263	18337490	2008-09-06 10:05	Reduced MnSOD affects mitochondrial redox balance and plant growth.
3702	820288	16292565	2007-08-25 14:42	When young, cold-induced tobacco seedlings were exposed to low-temperature (0.5, 2 or 3.5 degrees C) for up to 44 days, survival within independent cor15a-FAD7 transgenic lines (40.2-96%) was far superior to the wild type (6.7-10.2%).
3702	820288	16415067	2007-08-25 10:19	These results suggest that the ozone-induced expression of FAD7 gene requires SA, but not ethylene, JA, NPR1 and SID2.
3702	820292	17565971	2007-11-10 11:57	Electron microscopy of an elo mutant showed a hypotonic vacuole, alterations in the size of grana and starch grains in the chloroplasts, and the massive presence of Golgi vesicles in the cytoplasm.
3702	820297	17429400	2007-08-25 12:21	Importantly, both WOX5 and WUS maintain stem cells in either a root or shoot context.
3702	820314	16339800	2006-04-28 15:44	ABA-hypersensitive germination3 (AHG3)encodes AtPP2CA that functions as a negative regulator of the ABA-signaling pathway and plays a major role in ABA signaling in seed germination and early growth. [AHG3]
3702	820314	16361522	2006-04-28 16:07	The AtPP2CA protein phosphatase is a strong negative regulator of ABA signal transduction. [AtPP2CA]
3702	820316	17259262	2007-08-25 10:44	GPAT5 has a critical role in polyester biogenesis in seed coats and roots.
3702	820316	17496107	2007-12-01 12:14	GPAT5 expression correlated with production of both alpha- and beta-isomers of monoacylglycerols with C22 and C24 saturated acyl groups and the corresponding free fatty acids
3702	820317	15722475	2007-08-25 14:17	Consistent with functional redundancy, promoter-GUS fusions of MYB33 and MYB65 gave identical expression patterns in flowers (sepals, style, receptacle, anther filaments, and connective but not in anthers themselves), shoot apices, and root tips.
3702	820327	15155885	2007-08-25 13:49	spy-4 partially suppressed the reduced abundance of CONSTANS and FLOWERING LOCUS T RNA and the late flowering of gigantea mutant plants
3702	820327	15608330	2007-08-25 11:34	Our results demonstrate that SPY acts as both a repressor of GA responses and a positive regulator of cytokinin signaling. Hence, SPY may play a central role in the regulation of GA/cytokinin cross talk during plant development.
3702	820335	15773851	2007-08-25 14:48	BAS1 and SOB7 act redundantly with respect to light promotion of cotyledon expansion, repression of hypocotyl elongation and flowering time in addition to other phenotypes not regulated by light.
3702	820339	15961080	2007-08-25 12:58	DGDG is important for the stability of the PSI complex.
3702	820339	16930596	2007-08-25 21:11	Data show that cold acclimation of the Arabidopsis dgd1 mutant results in recovery from photosystem I-limited photosynthesis.
3702	820339	17080965	2007-08-25 21:21	The affected gene in atts02 was identified by positional cloning and encodes digalactosyldiacylglycerol synthase 1 (DGD1).
3702	820339	18208519	2008-05-10 10:32	The roles of DGD1 and DGD1 SUPPRESSOR 1 (DGS1) in the expression of nuclear genes encoding enzymes of the alternative galactoglycerolipid pathway are reported.[DGS1]
3702	820355	15342780	2005-09-07 15:38	SYP122 may have a general function in secretion and a role in cell wall deposition, while its homolog PEN1 appears to have a basal function in secretion and a specialized defense-related function [PEN1]
3702	820368	17569077	2007-12-01 12:08	molecular basis for the pds2 mutation is an in-frame 6 bp (2 aa) deletion in this gene
3702	820387	17507388	2007-10-13 10:03	The fatty acid composition of membrane lipids influences cell growth and mitochondrial respiration, in particular the expression and capacity of alternative oxidase, under cold stress in fad2 knockout and FDAD3 overexpressing cell lines
3702	820398	15681664	2007-08-25 11:06	BIG is required for pericycle cell activation to form LRP in both high and low phosphate conditions, but not for the low P-induced alterations in primary root growth, lateral root emergence, and root hair elongation.
3702	820398	17652113	2008-02-09 11:12	results suggest that CRM1/BIG controls the elongation of the pedicels and stem internodes through auxin action
3702	820405	15361142	2007-08-25 12:59	ABF2, an ABF subfamily member of bZIP proteins interacting with the ABA-responsive elements, is involved in Absicic ascid/stress responses. (bZIP) in arabidopsis.
3702	820408	16361519	2007-08-25 11:24	RBR restricts cell division early during leaf development when cell proliferation predominates, while it regulates endocycle occurrence at later stages.
3702	820408	16377572	2007-08-25 21:14	This research shows that if there is a local reduction of the Retinoblastoma-Related Gene (RBR) in the roots of Arabidopsis roots this increases the amount of stem cells without affecting the cell cycle.
3702	820408	17024182	2007-08-25 12:25	EBP1 is a conserved, dose-dependent regulator of cell growth that is connected to meristematic competence and cell proliferation via regulation of RBR1 level.
3702	820408	18064404	2008-05-03 12:17	Results show that confirmed that downregulation of AtRBR1 leads to a prolonged G2 phase and delayed activation of G2/M marker genes.
3702	820436	15688221	2007-08-25 14:51	AtTBP2 encodes a protein that binds plant telomeric DNA and induces DNA bending in vitro.
3702	820438	17494953	2007-09-15 11:05	The MAPK-EGR-1-HSP70 pathway regulates the cigarette smoke-induced inflammatory process.
3702	820458	17905859	2008-01-19 10:52	The characterization of the AAR3 gene is reported.
3702	820463	17142478	2007-08-25 13:27	The identification and characterization of SERRATED LEAVES AND EARLY FLOWERING (SEF) in A. thaliana and its interactions with other proteins, including ATARP6 and PIE1, are reported.
3702	820463	17470967	2007-08-25 21:20	Arabidopsis SWC6 (AtSWC6), SUPPRESSOR OF FRIGIDA 3 (SUF3) and PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1 (PIE1) are homologs of SWC6, ARP6 and SWR1 with roles in development, including floral repression through full activation of FLOWERING LOCUS C
3702	820472	15960623	2005-11-21 15:27	ASML2 functions as a transcriptional activator and regulates the expression of at least a subset of sugar-inducible genes. [ASML2]
3702	820499	16525754	2007-08-25 10:54	From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
3702	820506	17018031	2007-05-01 15:51	AtSPO11-1 and AtSPO11-2 genetically interact and function in meiotic recombination. [AtSPO11-1]
3702	820506	17965269	2008-04-26 10:23	Data show that the catalytically active tyrosine residues of SPO11-1 are required for meiotic double-strand break induction in Arabidopsis.
3702	820513	16117846	2007-09-03 02:03	GIP1 functions to enhance GBF DNA binding activity by acting as a potent nuclear chaperone or crowbar, and potentially regulates the multimeric state of GBFs, thereby contributing to bZIP-mediated gene regulation.
3702	820513	18178112	2008-08-09 10:30	The possible role of this protein during the nucleation process is discussed
3702	820530	17158604	2007-08-25 13:27	DCP2 interacts in vitro and in vivo with DCP1 and VARICOSE (VCS), an Arabidopsis homolog of human Hedls/Ge-1, suggesting that the three proteins operate as a decapping complex.
3702	820548	16113215	2006-02-02 09:00	ECT proteins, ECT1 and ECT2, are molecular components in the CBL-CIPK calcium signaling pathways. They contain a highly conserved 180-amino acid region, which is involved in mediating the nuclear localization of the ECT proteins. [ECT2]
3702	820555	16965555	2007-08-25 13:30	MAP3Kepsilon1 is required for the normal functioning of the plasma membrane in developing Arabidopsis pollen.
3702	820560	17889453	2007-12-01 10:13	The expression of RPL7D in Arabidopsis is reported.
3702	820582	15703058	2005-11-23 14:38	CYP90D1 is involved in brassinosteroid biosynthesis pathway. [CYP90D1]
3702	820582	17138693	2007-08-25 10:09	In vitro biochemical assays using insect cell-expressed proteins revealed that both CYP90C1 and CYP90D1 catalyze C-23 hydroxylation of various 22-hydroxylated Brassinosteroids with markedly different catalytic efficiencies.
3702	820591	16339783	2007-08-25 10:19	Enzyme activity measurements, quantitative RT-PCR, and T-DNA insertional mutagenesis have been used to determine that expression of AtcwINV1 is responsible for all induced cwINV activity in mechanically wounded leaves
3702	820591	17139091	2007-08-25 13:28	The structure of the Arabidopsis thaliana cell-wall invertase 1 (AtcwINV1; gene accession code At3g13790) is described at a resolution of 2.15 A.
3702	820591	17873089	2008-01-19 12:54	This study showed that a D239A mutant of INV1 acted as a 1-fructan exohydrolase, preferentially degrading 1-kestose.
3702	820591	17963237	2008-05-03 13:11	E203Q mutation introduced into the catalytic pocket triggers conformational changes that alter the wild type substrate binding.
3702	820591	18258263	2008-03-29 11:16	report on different X-ray crystal structures of Arabidopsis thaliana cell-wall invertase 1 (AtcwINV1) mutants with sucrose
3702	820600	15908600	2007-08-25 13:08	RHD3 may control epidermal CFR, root skewing, and waving on hard-agar surfaces by regulating the traffic of wall- or plasma membrane-associated determinants of anisotropic cell expansion.
3702	820602	17329564	2007-08-25 12:22	Data suggest that MYB26 functions in a regulatory role involved in determining endothecial cell development within the anther and acts upstream of the lignin biosynthesis pathway.
3702	820628	16720605	2007-08-25 14:09	Immediately after a dark/light shift of the flu mutant, singlet oxygen is generated within the plastids, activating several stress responses triggered by the Executer1 protein.
3702	820628	18182022	2008-05-24 10:26	The impact of the EXECUTER1 utation and the prevalence of enzymatic or non-enzymatic lipid peroxidation on the modes of singlet oxygen activity in flu mutant A. thaliana is reported.
3702	820639	16679459	2006-10-25 15:47	EPITHIOSPECIFIER MODIFIER1 (ESM1) epistatically represses nitrile formation and favors isothiocyanate production in combination with ESP. The glucosinolate hydrolysis profile change influenced by ESM1 is associated with insect resistance[ESM1]
3702	820639	17920088	2008-07-19 10:11	The Epithiospecifier modifier 1 gene controlled to produce significant levels of indol-3-acetonitrile formation.
3702	820643	17873090	2008-01-19 12:54	The action of SINAT2 may explain the recalcitrance of AtRAP2.2 protein levels to change by altering AtRAP2.2 transcription.
3702	820658	16460509	2006-08-23 09:00	wag1 and wag2 are protein kinases that negatively regulate root waving in Arabidopsis. [wag2]
3702	820667	18060348	2008-05-03 10:19	The competence of stomatal guard cells in V. faba to synthesize abscisic acid, using NCED3 and AAO3 from A. thaliana, is reported.
3702	820730	18278441	2008-09-20 10:16	UBA2C (AT3G15010) encodes an hnRNP-type nuclear RNA-binding protein that functions in a novel wound signal transduction pathway.
3702	820748	15500463	2007-08-25 21:23	The molecular basis for the activity of the protein.
3702	820748	17056621	2007-08-25 11:49	These results suggest that ESR2 plays a role in shoot regeneration through transcriptional regulation of CUC1.
3702	820748	18346190	2008-09-27 10:07	Regulation of axillary meristem formation by miR164 is mediated through CUC1 and CUC2, which in turn regulate LAS.
3702	820765	18304198	2008-08-09 10:30	Data demonstrated that Ppi2 is expressed in seedlings, cultured cells and flowers.
3702	820789	18427573	2008-08-16 10:25	The anac019 anac055 double mutant plants showed attenuated JA-induced VEGETATIVE STORAGE PROTEIN1 (VSP1) and LIPOXYGENASE2 (LOX2) expression, whereas transgenic plants overexpressing the two NAC genes showed enhanced JA-induced VSP1 and LOX2 expression.
3702	820790	16359384	2007-08-25 12:58	AtNAC2 may be a transcription factor incorporating the environmental and endogenous stimuli into the process of plant lateral root development.
3702	820793	17369427	2007-08-25 15:03	There are functional differences among the Aux/IAA gene family members MSG2, AXR2, and SLR.
3702	820809	18275854	2008-05-17 10:33	AtGRX4 may have important functions in plant growth and development under extreme environments.
3702	820816	16614222	2007-08-25 12:32	PLDalpha1 mediates the abscisic acid effects on stomata through interaction with a protein phosphatase 2C & a heterotrimeric GTP-binding protein
3702	820816	16949955	2007-08-25 10:12	PLDalpha1 plays a key role in freezing tolerance of Arabidopsis by modulating the cold-responsive genes and accumulation of osmolytes.
3702	820816	17261695	2007-08-25 10:07	Identification of PLDalpha-mediated events in response to progressive drought stress in Arabidopsis is reported.
3702	820816	17565616	2007-09-08 12:36	A high level of PLDalpha1 is detrimental to seed quality, and attenuation of PLDalpha1 expression has the potential to improve oil stability, seed quality and seed longevity.
3702	820816	17962199	2008-06-21 10:24	Report show that the presence of PLDalpha1 correlates with phospholipid hydrolysis in both freezing and post-freezing phases, suggesting a negative role for PLDalpha1 in freezing tolerance..
3702	820827	17573537	2007-12-01 10:46	essential for chloroplast NAD(P)H dehydrogenase-mediated nonphotochemical reduction of the plastoquinone pool in chlororespiratory electron transport
3702	820828	15579662	2007-08-25 11:10	Nonsense mutation at this site affects activity of the plastidial palmitoyl-monogalactosyldiacylglycerol Delta7-desaturase FAD5.
3702	820828	16698898	2007-08-25 10:51	The overall leaf fatty acid composition of S31 plants contained 31% 16:0 compared with 23% in fab1 and 17% in wild type. Biochemical and genetic analysis showed that S31 plants contain a new allele of fatty acid desaturation 5 (fad5), fad5-2.
3702	820830	15579662	2007-08-25 11:10	Lack of an effect of mutation at this site on the activity of the plastidial palmitoyl-monogalactosyldiacylglycerol Delta7-desaturase FAD5.
3702	820845	16331467	2007-08-25 10:20	MFP1 is expressed in both nuclei and chloroplasts.
3702	820860	16705405	2007-08-25 12:30	At3g16150 encodes a K+-dependent L-asparaginase with expression levels highest in sink tissues, especially in flowers and siliques, early in development.
3702	820870	15665250	2005-11-21 15:31	AtTIP2;1 and AtTIP2;3 can mediate the extracytosolic transport of methyl-NH2 and NH3 across the tonoplast membrane and may thus participate in vacuolar ammonium compartmentation. [TIP2;1]
3702	820883	18413999	2008-08-09 10:18	AHP4 negatively regulates thickening of the secondary cell wall of the anther endothecium, and provides new insight into the role of cytokinins in formation of secondary cell walls via the action of AHP4.
3702	820890	15919674	2005-11-09 15:00	PYK10 is a beta-glucosidase that is localized in ER bodies; PBP1 may act like a molecular chaperone that facilitates the correct polymerization of PYK10, when tissues are damaged and subcellular structures are destroyed by pests.[PBP1]
3702	820895	16708291	2007-08-25 12:30	The jasmonic acid signalling pathway, including the role of calcium metabolism, in A. thaliana is reported.
3702	820924	15238540	2005-05-25 17:52	ATL2 and other members of the ATL family are activated linking to the induction of this putative class of ubiquitin ligases to plant defense signaling pathways. [ATL2]
3702	820924	16557337	2007-08-25 12:32	The ATL protein comprising Ubiquitin Ligases that is one of a multigene family.
3702	820925	15883832	2007-01-03 14:11	Localization of condensin subunit AtCAP-H and AtCAP-H2 is dynamically changed through the mitotic cell cycle.  AtCAP-H2 localizes at the nuclear or chromosomal regions throughout the cell cycle. [AtCAP-H2]
3702	820932	16384909	2007-08-25 11:59	PLDzeta1 plays a role in regulating root development in response to nutrient limitation.
3702	820932	16891548	2007-08-25 10:12	Hydrolysis of phosphatidylcholine by PLD zetas during phosphorus starvation contributes to the supply of inorganic phosphorus in A. thaliana.
3702	820940	17202182	2007-08-25 21:11	arr1-1 mutation clearly affected the primary response in at least 17 genes, meaning that they respond primarily to cytokinins through the function of ARR1
3702	820940	18037673	2008-05-24 10:35	The results of this study suggested that ARR1, ARR10 and ARR12 together play essential (or general) roles in cytokinin signal transduction.
3702	820940	18502977	2008-09-20 10:05	Suppression of pleiotropic cytokinin activities by a dominant repressor version of a B-type ARR indicates that this protein family is involved in mediating most, if not all, of the cytokinin activities.
3702	820955	15326608	2007-08-25 21:24	The final solution of the structure of At3g16990 contains density that cannot be assigned to any amino acid or crystallization solution component.
3702	820960	18303110	2008-06-06 15:00	IPI plays a critical role in isoprenoid biosynthesis via the MVA pathway, and IPI is essential for the maintenance of appropriate levels of IPP and DMAPP in different subcellular compartments in plants. [IPI2]
3702	820960	18319397	2008-08-02 10:40	Each of Arabidopsis IPP2 and IPP1 isomerases is found in multiple but partially overlapping subcellular locations, and each can compensate for the loss of the other through partial redundancy in the cytosol.
3702	820961	15918885	2005-10-25 14:24	The identification of the HCF107 gene that is involved in the 5'-end processing/stability and/or translation of the psbH gene and in the translation of the psbB gene. [HCF107]
3702	820980	15326607	2007-08-25 21:24	The crystal structure of At3g17210 protein is best described as a dimer on a two-fold crystallographic axis.
3702	820999	16682350	2006-10-12 14:56	POK1 and POK2 participate in the spatial control of cytokinesis, perhaps via an interaction with the Arabidopsis TAN1 homolog, ATN. [POK1]
3702	821012	18178586	2008-06-03 15:02	Arabidopsis CRSH, localized in chloroplasts, is required for host plant fertilization.[CRSH]
3702	821016	16113215	2007-08-25 15:01	Two proteins containing the evolutionarily conserved C-terminal region (ECT1 and ECT2) may play a critical role in relaying the cytosolic Ca(2+) signals to the nucleus, thereby regulating gene expression.
3702	821016	17092313	2007-08-25 11:49	by alternative complex formation with either CBL1 or CBL9, the kinase CIPK1 represents a convergence point for abscisic acid-dependent and -independent stress responses.
3702	821027	17121469	2007-08-25 21:01	The data support the hypothesis that the opposite root system phenotypes of hy5 single and hy5 hyh double mutants represent the morphological response to a quantitative gradient in the same molecular process.
3702	821027	17929051	2008-07-26 10:16	important for high nitrate reductase expression in red light
3702	821027	18055587	2008-06-07 10:30	This research provides evidence that, in ultraviolet B (UV-B) signaling, UVR8, HY5, and HYH act together and demonstrates a new role for HYH in UV-B responses.
3702	821027	18203870	2008-07-26 10:06	HYH and PEX11b constitute a novel branch of the phyA-mediated light signaling cascade, which promotes peroxisome proliferation during seedling photomorphogenesis.
3702	821052	15842627	2007-08-25 10:58	Phosphatidylinositol phosphates were identified as essential regulators for the voltage-dependent and -independent activation of A. thaliana potassium channels expressed in X. laevis oocytes.
3702	821052	16623888	2007-08-25 11:55	The intracellular potassium sensing mechanism couples SKOR activity to potassium nutrition status in the 'source cells', establishing a supply-based unloading system for the regulation of potassium distribution.
3702	821052	16623889	2007-08-25 11:55	Mapping the SKOR sequence to the crystal structure of the voltage-dependent K+ channel suggests interaction between the S6 gating domain and the base of the pore helix, a prediction supported by mutations at this site.
3702	821052	18287042	2008-05-03 13:10	Single mutations in SKOR convert it from an outward K+ channel into an inward K+ channel.
3702	821053	15618630	2005-11-16 09:00	Result suggests that RLK902 and RKL1 may have common biochemical functions, especially signal transduction. They are involved in various stress conditions as mechanical wounding, treatment with salicylic acid, and pathogen infection. [RLK902]
3702	821055	17637675	2007-09-17 17:10	JAI3 and other JAZs are direct targets of the SCF(COI1) E3 ubiquitin ligase and jasmonate treatment induces their proteasome degradation [JAI3] [JAZ3]
3702	821081	17189342	2007-06-29 14:41	These data suggest that TPLATE functions in vesicle-trafficking events required for site-specific cell wall modifications during pollen germination and for anchoring of the cell plate to the mother wall at the correct cortical position.[TPLATE]
3702	821117	17284600	2007-08-25 10:08	Vacuolar glucose transporter 1 (AtVGT1) was localized to the vacuolar membrane. Analyses of Atvgt1 mutant lines indicate an important function of this vacuolar glucose transporter during developmental processes like seed germination and flowering
3702	821161	16249341	2006-02-07 14:53	A. thaliana Calmodulin (CaM)-like protein 15 (AtCaM15) interacts with the C terminus of AtNHX1, the most abundant vacuolar Na/H antiporter thereby modifying the Na/K selectivity of the antiporter and decreasing its Na/H exchange activity. [AtCaM15]
3702	821182	17195036	2007-08-25 21:02	TMAC2 acts in the nucleus and is an important negative regulator of abscisic acid and salt stress responses.
3702	821214	16699540	2007-08-25 10:52	BUD2, encoding an S-adenosylmethionine decarboxylase, is required for Arabidopsis growth and development.
3702	821233	17071651	2007-08-25 13:28	RGP1 is required during microspore development and pollen mitosis, either affecting cell division and/or vacuolar integrity.
3702	821240	18158146	2008-05-21 14:04	RPK1 and TOAD2 are primarily required to maintain central domain protoderm cell fate and the loss of this key embryonic cell type in mutant embryos results in defects in other regions of embryo including failure to initiate cotyledon primordia.[TOAD2]
3702	821243	15618226	2005-09-08 14:37	NPC4 plays an important role in the supply of both inorganic phosphate and diacylglycerol from membrane-localized phospholipids [NPC4]
3702	821248	16923726	2007-08-25 11:52	AtPEX19-1 was shown to bind to the Arabidopsis peroxisomal membrane protein PEX10. (AtPex19-1)
3702	821249	17163881	2007-01-23 15:00	At3g03480 encodes acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase (CHAT) which catalyzes the formation of (Z)-3-hexen-1-yl acetate from acetyl-CoA and (Z)-3-hexen-1-ol. [CHAT]
3702	821251	16034591	2007-08-25 11:26	We confirm that RGL2, one member of the DELLA family, encodes the predominant repressor of seed germination in Arabidopsis and show that the other DELLA genes GAI,RGA and RGL1 enhance the function of RGL2.
3702	821251	16167898	2007-08-25 12:35	role of conserved serine and threonine in GA signaling
3702	821251	17333251	2007-08-25 10:42	Four conserved tyrosine residues within the RGL2 protein are critical for gibberellin sensitivity in Arabidopsis.
3702	821251	17384169	2007-08-25 15:00	RGL2 disappearance is not a prerequisite for seed germination in the sly1 background.
3702	821254	17672843	2007-12-22 11:10	results suggest a novel role for AtNBS1 that is independent of AtATM-mediated signaling and functions in the very early stages of meiosis
3702	821259	17671505	2007-09-29 11:22	These studies uncover surprisingly pivotal roles of KIN10/11 in linking stress, sugar and developmental signals to globally regulate plant metabolism, energy balance, growth and survival
3702	821262	15630565	2007-08-25 14:49	NMR structure of calcium binding domain
3702	821279	17038516	2007-06-28 12:36	Results indicate that LONGIFOLIA1 (LNG1) and LNG2 are new components that regulate leaf morphology by positively promoting longitudinal polar cell elongation independently of ROT3 in Arabidopsis [LNG2].
3702	821287	17140415	2007-06-29 15:54	The Arabidopsis genome contains three genes for monofunctional aspartate kinases. AK2 and AK3 are inhibited only by lysine, and AK1 is inhibited in a synergistic manner by lysine and SAM. [AK3] [Aspartate kinase3]
3702	821292	16507086	2007-08-25 13:36	The transcript of the N-terminus region deleted form of CGS is insensitive to methionine application and its expression may be important for maintaining methionine metabolism even in the presence of a high level of methionine.
3702	821292	17720756	2008-01-05 16:06	The results of this study suggest that a metabolic effector, to date unidentified, can modulate CGS activity in vivo through an interaction with the N-terminal domain of the enzyme and that removal of this domain can suppress this regulation.
3702	821292	18184691	2008-06-28 10:23	These results show that S-adenosyl-L-methionine induces the stacking of ribosomes on CGS1 mRNA and that multiple mRNA degradation sites probably correspond to each stacked ribosome.
3702	821292	18285355	2008-05-31 10:27	CGS1 mRNA degradation involves a plant-specific mechanism.
3702	821293	17996018	2008-05-24 10:17	molecular cloning and functional analysis of the two unique C3 pyruvate, orthophosphate dikinase regulatory proteins, RP1 and RP2, in Arabidopsis thaliana are reported
3702	821300	16741077	2007-08-25 14:09	DCL4 and DCL2 exhibit specific, hierarchical antiviral activities; inhibition of DCL4 by a viral-encoded suppressor revealed the subordinate antiviral activity of DCL2
3702	821300	16810317	2007-08-25 12:30	DCL2 antagonizes the production of miRNAs and siRNAs by DCL1 in certain circumstances and can substitute for DCL4 when DCL4 activity is reduced or inhibited by viruses.
3702	821300	17592042	2007-09-04 17:50	Study shows that unidirectional (3-->5') transitivity requires the hierarchical and redundant functions of DCL4 and DCL2 acting downstream from RDR6 to produce 21- and 22-nt-long siRNAs, respectively.
3702	821300	18335032	2008-08-09 10:44	DCL2 plays an essential, as opposed to redundant, role in transitive silencing of transgenes and may play a more important role in silencing of viruses than currently thought
3702	821313	18395530	2008-09-27 10:28	Comparison of molecular masses of UGPases from root and leaf extracts revealed that the root protein was slightly larger, suggesting a post-translational modification.
3702	821327	16415216	2007-08-25 10:19	HAL3A is involved in coenzyme A biosynthesis and are therefore critical to early postgerminative growth.
3702	821383	16311517	2007-08-25 13:37	reported that AtMSH2 has a broad range of anti-recombination effects: it suppresses recombination between divergent direct repeats in somatic cells or between homologues from different ecotypes during meiosis
3702	821386	17307924	2008-05-01 15:43	BRANCHED1 (BRC1) plays a central role in the control of axillary bud development. BRC1 acts as a local integrator of the genetic pathways controlling branch outgrowth. [BRC1]
3702	821400	15990873	2007-08-25 10:22	MKS1 is required for full salicylic acid-dependent resistance in MAP kinase 4 mutants
3702	821400	17702678	2007-11-10 11:55	three of the twelve Ser-Pro serine residues (Ser72, Ser108, Ser120) are in the phosphorylated form.
3702	821404	15746155	2005-12-06 16:55	TONSOKU(TSK)/MGOUN3/BRUSHY1 of Arabidopsis thaliana encodes a nuclear leucine-glycine-aspargine (LGN) domain protein involved in genome maintenance; TSK is required during the cell cycle. [TSK]
3702	821404	16728410	2007-08-25 21:03	MGO3 is required for the correct transition to flowering and this may be mediated by histone acetylation and associated changes in FLC expression.
3702	821416	15525644	2005-03-11 09:21	Analysis of transport properties and expression in Arabidopsis indicate that AtPLT5 functions to transport a wide range of sugars into specific sink tissues in the plant [PLT5]
3702	821416	15598803	2005-11-29 15:22	AtPLT5 is a broad-spectrum H-symporter for linear polyols, such as sorbitol, xylitol, erythritol, or glycerol. It also catalyzes the transport of the cyclic polyol myo-inositol and of different hexoses and pentoses, including ribose[AtPLT5]
3702	821437	15525647	2005-05-27 17:57	the Arabidopsis HAF2 gene functions as a coactivator capable of integrating light signals and acetylating histones to activate light-induced gene transcription [HAF2]
3702	821437	17085686	2007-08-25 21:17	These results suggest that acetylation of specific histone Lys residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.
3702	821439	16682350	2006-10-12 15:00	POK1 and POK2 participate in the spatial control of cytokinesis, perhaps via an interaction with the Arabidopsis TAN1 homolog, ATN. [POK2]
3702	821449	15464981	2007-08-25 15:02	Results suggest that p22(ack1) and cyclin D1, which act antagonistically, are major rate-limiting factors for cell division in the leaf meristem [p22ack1]
3702	821449	15809079	2007-08-25 12:02	ACK1 acts as a cyclin dependent kinase inhibitor in Arabidopsis
3702	821451	15827031	2005-11-30 11:00	AtPrePI and AtPrePII are metalloproteases that degrade targeting peptides in mitochondria and chloroplasts.  AtPrePI showed a preference for the N-terminal amphiphilic α-helix and positively charged amino acid residues.
3702	821451	17081117	2007-08-25 21:21	AtPreP1 and AtPreP2 genes are differentially expressed in Arabidopsis
3702	821455	17227544	2007-06-29 16:46	findings point to an important role for Rad54 in homologous recombination repair in plants [Rad54]
3702	821455	18430956	2008-06-28 10:22	The trans-species compatibility of Rad54 functions, is reported.
3702	821456	17921316	2008-04-26 13:06	Data indicate that CYO1(At3g19220) has protein disulfide isomerase activity, and suggest that CYO1 has a chaperone-like activity required for thylakoid biogenesis in cotyledons
3702	821463	16299177	2007-08-25 12:35	CPK32 is an ABA signaling component that regulates the ABA-responsive gene expression via ABF4.
3702	821479	16633561	2007-08-25 15:04	determined the crystal structures of AtCAD5 in the apo-form and as a binary complex with NADP+, respectively, and modeled that of AtCAD4. The substrate-binding pockets of both AtCAD5 and AtCAD4 were also examined.
3702	821485	17530779	2007-09-04 17:33	The interaction of HAT3.1 with specific DNA binding by a homeodomain protein with histidine at position 51 was studied.
3702	821496	18508582	2008-10-06 16:17	In Arabidosis, there is high similarity of Bub3.1 and Bub3.2 sequences at the nucleotide level but Bub3.1 and not Bub3.2 showed increased expression during mitosis. Bub3.1 appeared to be essential during embryogenesis. [Bub3.1]
3702	821509	16170638	2007-06-27 10:34	ARC5, which encodes a cytosolic dynamin-like protein that is part of the chloroplast division machinery and arc mutants have large but fewer chloroplasts which have an effect on both the composition and structure of the photosynthetic apparatus. [ARC5]
3702	821514	18055610	2008-04-10 17:55	Both types of Rab5 members, ARA7 and RHA1 in Arabidopsis, are activated by a single Rab5 GEF, VPS9a. The activity of VPS9a is essential for various plant functions, such as cytokinesis, embryogenesis, and organ development. [VPS9a]
3702	821519	15994910	2007-08-25 11:06	Overproduction and repression of Dim/dwf1 resulted in contrasting phenotypes, with repressors mimicking the brd2 phenotype and overproducers having large stature with increased numbers of flowers and seeds.
3702	821519	16193053	2007-08-25 21:05	results provide direct proof that Ca2+/calmodulin-mediated signalling has a critical role in controlling the function of DWF1 [DWARF1]
3702	821565	15705955	2007-08-25 14:38	at the early stage of seed development, deltaVPE is involved in cell death of limited cell layers, the purpose of which is to form a seed coat
3702	821576	16818883	2006-10-13 18:29	TGD2 (TRIGALACTOSYLDIACYLGLYCEROL 2) gene represents the substrate-binding or regulatory component of a phosphatidic acid/lipid transport complex in the chloroplast inner envelope membrane. (TGD2)
3702	821576	16818883	2007-08-25 21:17	This protein is identical to Arabidopsis gene TRIGALACTOSYLDIACYLGLYCEROL 2 (TGD2).
3702	821576	17938172	2008-01-19 12:54	TGD3 is the missing ATPase component of a lipid transporter involving TGD1 and TGD2 required for the biosynthesis of ER-derived thylakoid lipids in Arabidopsis.
3702	821577	18053734	2008-07-19 10:22	Data show RNAi lines having reduced PYRB transcript and ATCase protein levels had delayed growth and development, produced smaller plants with reduced root to shoot biomass ratios, few flowers, smaller seeds with greatly reduced viability.
3702	821587	18158302	2008-03-22 10:18	Results indicate that AtRTL2 may use a dimeric mechanism to cleave double-stranded RNA.
3702	821593	18318687	2008-09-27 10:07	required for the formation of class I interference-sensitive crossovers
3702	821593	18379590	2008-08-09 10:19	Data indicate that AtMSH5 promotes homologous recombination through facilitating chiasma formation during prophase I in Arabidopsis.
3702	821601	16679419	2007-08-25 11:56	DDL is expressed in the root and shoot meristems and the reduced size of the root apical meristem in ddl plants suggests a role early in organ development.
3702	821601	18632581	2008-08-23 10:10	propose that DDL participates in miRNA biogenesis by facilitating DCL1 to access or recognize pri-miRNAs
3702	821604	17293437	2007-10-19 16:15	ENOD5-like protein that is GPI-anchored in the plasma membrane of phloem sieve elements.
3702	821607	15447649	2007-08-25 12:39	Sequence analysis and mass spectrometry suggest that NDR1 is localized to the PM via a C-terminal glycosylphosphatidyl-inositol (GPI) anchor.
3702	821607	17012600	2007-08-25 13:29	demonstrate that the RIN4-NDR1 interaction occurs on the cytoplasmically localized N-terminal portion of NDR1 and that this interaction is required for the activation of resistance signaling following infection by P. syringae
3702	821611	15995349	2005-11-01 14:31	identified a gene, designated NAN, encoding a basic helix-loop-helix (bHLH) transcription factor that regulates cell elongation and seed germination in plants[NAN]
3702	821622	15469499	2007-08-25 15:08	Used to demonstrate the feasibility of bimolecular fluorescence complementation in plants.
3702	821625	15466219	2007-08-25 11:10	Transcription factor EIN3 is required for the second phase but not the first phase of growth inhibition by ethylene in Arabidopsis seedling hypocotyls.
3702	821625	17011517	2007-08-25 14:05	Light induced regulation of gene expression involves stabilization of EIN3 protein.
3702	821625	17307926	2007-08-25 14:00	Data show that through control of EIN3/EIL1 levels, EBF1 and EBF2 fine-tune ethylene responses by repressing signaling in the absence of hormone, dampening signaling at high concentrations, and promoting rapid recovery after ethylene levels dissipate.
3702	821625	18273012	2008-03-22 10:17	The bifurcate and antagonistic CTR1 and MKK9 pathways are both critical in determining ethylene-signalling specificity through two MAPK phosphorylation sites with opposite effects on EIN3 stability
3702	821659	15711971	2005-09-22 10:39	Arabidopsis thaliana gene NADK-1 encodes a NAD(H) kinase that may contribute to the maintenance of redox status. [AtNADK-1]
3702	821671	16821193	2007-08-25 10:50	Upregulation of ACA8 and ACA9 in response to abscissic acid in A. thaliana seedlings is reported.
3702	821676	17259259	2007-08-25 10:44	MKK5 is a key regulator of stomatal development and patterning.
3702	821679	18307782	2008-09-27 10:43	The results of this study suggest that MRP6 is part of a cluster involved in metal tolerance, although additional functions in planta cannot be discarded.
3702	821705	18384742	2008-06-14 10:24	Fluorescence polarization studies demonstrate a specific interaction of ETR1 with the histidine-containing transfer protein AHP1, supporting the idea that a phosphorelay module is involved in ethylene signaling
3702	821717	18042724	2008-01-19 10:24	CERK1 plays a critical role in fungal microbe-associated molecular pattern perception in plants.
3702	821718	16887800	2007-08-25 12:28	Immunophilin-like TWISTED DWARF1 modulates auxin efflux activities of Arabidopsis P-glycoprotein
3702	821718	17045295	2007-08-25 10:47	the X-ray structure of the cytoplasmic portion of FKBP42 comprising both the FKBP-like domain and the TPR domain at 2.85 A resolution
3702	821732	16083885	2005-11-17 15:36	Substrate specificity of an Arabidopsis thaliana UDP-glycosyltransferase, UGT71B6. (UGT71B6)
3702	821732	16623908	2006-10-13 12:00	Overexpression of UGT71B6 leads to massive accumulation of abscisic acid glucose ester and reduced levels of the oxidative metabolites phaseic acid and dihydrophaseic acid, but has marginal effect on levels of free abscisic acid. [UGT71B6]
3702	821781	17012604	2007-08-25 21:08	FHY3 appears to be a novel gating factor, specifically in gating red light signaling to the clock during daytime
3702	821781	18033885	2007-12-08 10:03	study shows FHY3 & FAR1, which encode proteins related to Mutator-like transposases, act together to modulate phyA signaling by activating transcription of FHY1 & FHL
3702	821781	18722184	2008-09-20 10:49	phyA associations with FHY3 and FHY1 protect underphosphorylated phyA from being recognized by the COP1/SPA complex.
3702	821784	17971036	2008-04-12 13:03	isolation and characterization of the her1 mutant (encoding GABA-TP) altered in a specific response to E-2-hexenal; study shows that, as a consequence of the mutation in GABA-TP, her1 plants accumulate high GABA levels
3702	821800	17951454	2008-04-05 11:13	PMH1 and PMH2 (for PUTATIVE MITOCHONDRIAL RNA HELICASE), were analyzed and characterized in mitochondria of Arabidopsis
3702	821802	17951454	2008-04-05 11:13	PMH1 and PMH2 (for PUTATIVE MITOCHONDRIAL RNA HELICASE), were analyzed and characterized in mitochondria of Arabidopsis
3702	821806	16027972	2007-08-25 14:23	A 93 base pair portion necessary for induction was identified in the AtAOX1a promoter.
3702	821806	16299170	2007-08-25 12:35	AOX not only functions to prevent excess reactive oxygen species formation in whole tissues under stressful environmental conditions but also affects metabolism through more pervasive effects, including some that are extramitochondrial.
3702	821806	16299171	2007-08-25 12:35	a microarray study using an anti-sense line showed AOX1a influences outside mitochondria, particularly in chloroplasts and on several carbon metabolism pathways
3702	821806	16457775	2007-08-25 12:33	A variety of Cys(II) substitutions constitutively activated AtAOX1a, indicating that neither the catalytic site nor, unlike at Cys(I), charge repulsion is involved.
3702	821806	18296449	2008-05-31 10:05	These results indicate that photo-oxidative stress by excess light is involved in the regulation of respiratory gene expression and the modulation of respiratory properties, especially the AOX up-regulation.
3702	821806	18424626	2008-08-09 10:30	AOX1a plants have a greatly altered stress response even when mitochondria or the mitochondrial electron transport chain are not the primary target of the stress and that AOX1a plays a broad role in determining the normal redox balance in the cell
3702	821807	17496120	2007-07-03 21:01	TIC encodes a nucleus-acting clock regulator working close to the central oscillator.
3702	821836	16525894	2006-05-23 11:33	CEGEDUO (CEG, AtSFL61) is a novel negative regulator involved in the auxin-mediated lateral root production in Arabidopsis. [CEG] [AtSFL61]
3702	821839	16511118	2007-08-25 21:18	X-ray crystallographic analysis of At3g22680 from Arabidopsis thaliana
3702	821849	18057042	2008-03-29 11:17	The roles of TCX proteins in the observed range of phenotypes in tso1 mutants in A. thaliana are reported.
3702	821855	16028115	2007-08-25 14:23	Elip1 expression is differentially regulated in response to light or chilling stress with mechanisms active either at transcriptional and post-transcriptional level.
3702	821855	16778010	2007-08-25 14:08	Null mutations within the ELIP1 gene do not modify sensitivity to photoinhibition, photooxidation, or the ability to recover from light stress.
3702	821855	16829586	2007-08-25 10:13	we propose that the discrepancy between amounts of Elip transcripts and proteins in light stress-preadapted or senescent leaves is related to a presence of photoprotective anthocyanins or to lower chlorophyll availability, respectively
3702	821870	17892448	2008-01-26 12:53	exhibited significant expression in maturing seeds; results obtained outlined the importance of these plastidial pyruvate kinases for fatty acid synthesis and embryo development
3702	821879	17369427	2007-08-25 15:03	There are functional differences among the Aux/IAA gene family members MSG2, AXR2, and SLR.
3702	821891	17595158	2007-10-13 10:19	ETR2 is degraded by a proteasome-dependent pathway in response to ethylene binding
3702	821904	17015446	2007-08-25 15:04	myb15 mutant plants show increased tolerance to freezing stress whereas its overexpression reduces freezing tolerance
3702	821937	16399800	2007-08-25 15:04	The correlation between DNA damage accumulation and the subsequent occurrence of apoptotic nuclei in tso2 rnr2a (ribonucleotide reductase) double mutants suggests that plants can initiate programmed cell death upon sensing DNA damage.
3702	821947	17720869	2007-12-22 12:30	Kinesin-12 members serve as dynamic linkers of the plus ends of antiparallel microtubules in the phragmoplast.
3702	821960	15692015	2005-05-02 12:00	Results show that RNA polymerase IV (Pol IV, subunits NRPD1a and NRPD2) silences certain transposons and repetitive DNA in a short interfering RNA pathway involving RNA-dependent RNA polymerase 2 and Dicer-like 3(DCL3) [NRPD2]
3702	821960	15766525	2005-12-01 15:21	RNA Pol IV helps produce siRNAs that target de novo cytosine methylation events required for facultative heterochromatin formation and higher-order heterochromatin associations.
3702	821975	16698902	2007-08-25 10:51	Consistent with thioredoxin-regulated beta-amylase redox dependency, total beta-amylase activity in Arabidopsis chloroplasts was partially redox regulated and required reducing conditions for full activation.
3702	822000	18453151	2008-07-26 10:16	regulates cell-cell interaction involved in stomatal development.
3702	822008	16412079	2007-08-25 14:12	AtNCED6 is required for abscisic acid biosynthesis during seed development.
3702	822009	16055633	2007-08-25 14:44	Data suggest that CLV3, CLE19 and CLE40 peptides represent the major active domain of the CLE proteins, which interact with an unknown cell identity-maintaining CLAVATA2 receptor complex in roots, leading to consumption of the root meristem.
3702	822018	17026539	2007-08-25 12:26	The results of this study suggest an additive contribution of AMT1;1 and AMT1;3 to the overall ammonium uptake capacity in Arabidopsis roots under nitrogen-deficiency conditions.
3702	822024	17592123	2007-09-29 10:24	Syntaxin AtSYP132-dependent secretion is a component of multiple forms of defense against bacterial pathogens in plants.
3702	822041	16244138	2006-02-13 16:12	constitutive expression of MBF1c enhances the tolerance of transgenic plants to bacterial infection, heat and osmotic stress by perturbing the ethylene-response signal transduction pathway. [Multiprotein bridging factor1 protein] [MBF1c]
3702	822041	18201973	2008-05-24 10:06	the existence of a tightly coordinated heat stress-response network, involving trehalose-, SA-, and ethylene-signaling pathways, that is under the control of MBF1c.
3702	822061	15695450	2007-08-25 21:23	We suggest that LEC1 controls the expression of the SSP genes in a hierarchical manner, which involves ABI3 and FUS3.
3702	822061	15960620	2007-08-25 11:16	Double-mutant analysis showed that ABA-insensitive 4 (ABI4) is epistatic to AtLPP2 but ABA-insensitive 3 (ABI3) is not.
3702	822061	16463099	2007-08-25 14:12	The expression of ABI3- and/or ABA-responsive genes and cis-elements in the promoters are discussed
3702	822061	16531465	2007-08-25 21:18	ABI3 expression ceases following the completion of germination in both tomato and Arabidopsis seeds, suggesting that expression of this gene does not regulate germination.
3702	822061	17220197	2007-08-25 13:26	ABSCISIC ACID-INSENSITIVE3 (ABI3) regulates the developmental expression of HsfA9.
3702	822098	15546361	2007-08-25 14:45	These results indicate that the virulence activity of AvrRpt2 in Arabidopsis thaliana is likely to rely on the modification of host susceptibility factors other than, or in addition to, RIN4.
3702	822098	15749765	2007-08-25 14:38	In addition to characterizing the RPS2-RIN4 association in N. benthamiana, we have moved forward to show that the biological relevance of these amino acid changes is applicable in Arabidopsis as well.
3702	822098	16478045	2007-08-25 11:58	RIN4 was attached to the plasma membrane at its carboxyl terminus; RIN4 was cleaved by AvrRpt2 at two PxFGxW motifs.
3702	822098	17012600	2007-08-25 13:29	demonstrate that the RIN4-NDR1 interaction occurs on the cytoplasmically localized N-terminal portion of NDR1 and that this interaction is required for the activation of resistance signaling following infection by P. syringae
3702	822098	17397263	2007-08-25 10:42	AvrB is activated inside the host cell by nucleotide binding and subsequent phosphorylation and interacts with RIN4. Aactivated AvrB, bound to RIN4, is indirectly recognized by RPM1 to initiate plant immune system function.
3702	822105	16059719	2007-08-25 12:01	This study demonstrates a specific role for QUA1 in the development of vascular tissue in rapidly elongating inflorescence stems and supports a role of QUA1 in pectin and hemicellulose cell wall synthesis.
3702	822105	16263905	2007-08-25 11:59	These results show that perturbation of QUASIMODO 1-1 gene expression in calli resulted in alterations of homogalacturonan content and cell wall location.
3702	822119	17040918	2007-08-25 12:26	specific lipid signaling pathways converge on PTI1-2 via the PDK1-OXI1 axis
3702	822136	15994911	2005-11-21 10:18	Overexpression of AFH1 in pollen tubes has been shown previously to induce abnormal actin cable formation. AFH1 plays a central role in the initiation and organization of actin cables from the pool of actin monomers bound to profilin. [FORMIN1] [AFH1]
3702	822136	17027489	2007-08-25 21:26	AFH1 is a nonprocessive formin that moves from the barbed end to the side of an actin filament after the nucleation event.
3702	822136	17566111	2007-08-25 10:41	Arabidopsis fh1/fhy1 double mutants reveal a distinct cytoplasmic action of phytochrome A.
3702	822157	18193273	2008-07-26 10:16	Data show that CHUP1 as a linker between chloroplasts and the cytoskeleton, by interacting with actin and profilin.
3702	822169	17085685	2007-08-25 21:17	The crystallization and structure elucidation of Arabidopsis thaliana allene oxide cyclase 2 (AOC2), a key enzyme in the biosynthesis of jasmonates, is reported.
3702	822203	16507087	2007-06-27 08:59	Prx Q attaches to photosystem II and has a specific function distinct from 2-Cys peroxiredoxin in protecting photosynthetic apparatus. [Prx Q]
3702	822203	17054949	2007-08-25 10:10	findings show that the subcellular location of Prx Q is the lumen of the thylakoid membrane; levels of the Prx Q protein in thylakoid membranes were studied under different light conditions and oxidative stress
3702	822207	16714312	2007-08-25 10:51	RGS1 exerted its effects on plant responsiveness to ABA and drought tolerance largely through changing the expression either of genes responsible for ABA biosynthesis or of stress-responsive genes.
3702	822207	18541915	2008-07-19 10:40	This finding indicates that RGS1 is important in the dynamics of voltage-dependent activation of Kin current.
3702	822246	15941401	2007-08-25 11:06	The biological roles of a GR-RBP, designated atRZ-1a, in Arabidopsis thaliana under stress conditions are reported.
3702	822246	16608866	2007-08-25 12:31	These results strongly suggest that atRZ-1a plays a role as an RNA chaperone during the cold adaptation process.
3702	822246	17602187	2008-01-19 12:33	results suggest that atRZ-1a has a negative impact on seed germination & seedling growth of Arabidopsis under salt or dehydration stress conditions, & imply that atRZ-1a exerts its function by modulating expression of several genes under stress conditions
3702	822277	17854848	2008-05-10 10:23	GAPDH controls generation of H(2)O(2) by Bax and heat shock, which in turn suppresses cell death in yeast and plant cells
3702	822281	17824959	2007-12-15 12:45	NUDT13 protein is targeted to the mitochondria; this is the first description of a plant pyrophosphatase catalyzing the hydrolysis of long-chain diadenosine polyphosphates, molecules with multiple biological activities
3702	822286	16055688	2006-02-07 14:08	CCR-LIKE (CCL) and SENESCENCE ASSOCIATED GENE 1 transcripts are differentially regulated at the level of mRNA stability at different times of day and these mRNAs are targets of the mRNA degradation pathway. [CCL] [CCR-LIKE]
3702	822287	16702557	2007-08-25 13:33	cold stress responses in Arabidopsis are attenuated by a ubiquitination/proteasome pathway in which HOS1 mediates the degradation of the ICE1 protein
3702	822287	17416732	2007-10-06 11:59	Regulon genes repressed by siz1 did not affect expression of ICE1, which encodes a MYC transcription factor.
3702	822293	15516508	2007-08-25 11:33	In this study, it was shown that gibberellin (GA) hormone biosynthesis is regulated by LEC2 and FUS3 pathways.
3702	822293	15695463	2007-08-25 21:23	At2S3 activation by FUS3 was rapid but CRC induction by FUS3 with abscissic acid[ABA] and by ABA followed by presence of FUS3 took longer, suggesting involvement of an indirect mechanism requiring the synthesis of intermediate regulatory factor(s)
3702	822293	16034595	2007-08-25 11:26	Total repression of embryogenic potential was observed in double (lec1 lec2, lec1 fus3, lec2 fus3) and triple (fus3 lec1 lec2) mutants.
3702	822293	18038114	2008-05-03 13:10	Results show that Significant differences in histone modifications at the phas promoter were mediated by FUS3 and PvALF, suggesting that they function through different epigenetic mechanisms.
3702	822293	18343361	2008-05-24 10:05	FUS3 function is restricted to the acquisition of embryo-dependent seed dormancy, the determination of cotyledonary cell identity, and the synthesis and accumulation of storage compounds.
3702	822298	16766671	2007-08-25 11:54	PAD3 catalyzes the conversion of dihydrocamalexic acid to camalexin, the final step in camalexin biosynthesis.
3702	822298	17384165	2007-08-25 15:00	PHYTOALEXIN DEFICIENT3 (PAD3) is strongly up-regulated by both oligogalacturonides and Botrytis infection independently of salicylic acid, jasmonate, and ethylene.
3702	822312	15466232	2005-01-31 16:08	CDG1 gene may interfere with signal transduction of BR when overexpressed, but is not an essential factor for it in the wild type. [CDG1]
3702	822317	16481352	2007-08-25 21:18	BRK1 is required for accumulation of SCAR1 protein in vivo, potentially explaining the apparently essential role of BRK1 in ARP2/3 complex function
3702	822317	18424615	2008-08-09 10:30	Differences among SCARs in mRNA levels and the biochemical efficiency of ARP2/3 activation may explain the functional contributions of individual genes
3702	822318	16123132	2005-11-09 14:35	p33(TCP20), encoded by the Arabidopsis TCP20 gene, binds to the GCCCR element in the promoters of cyclin CYCB1;1 [TCP20]
3702	822349	17993547	2008-03-29 12:13	results suggest that loss of cytosolic G6PDH activity affects the metabolism of developing seeds by increasing carbon substrates for synthesis of storage compounds rather than by decreasing the NADPH supply specifically for fatty acid synthesis
3702	822350	15498773	2007-08-25 12:49	identified an Arabidopsis UBX domain-containing protein, PUX1, which functions to regulate the oligomeric structure of the Arabidopsis homolog of p97/CDC48, AtCDC48; results suggest a role for AtCDC48 and PUX1 in regulating plant growth [PUX1]
3702	822359	15563621	2007-08-25 14:17	An analysis of the expression of SDH2-1, SDH2-2, and SDH2-3 (not detected) in A. thaliana, including differential expression in plant organs.
3702	822359	16249327	2007-08-25 12:35	during germination the embryo-specific SDH2-3 is replaced by SDH2-1 or SDH2-2 in mitochondrial complex II
3702	822395	15854901	2007-08-25 14:15	Mutation in MER3 in Arabidopsis appears to be specific to recombination events resulting in interference-sensitive crossovers.
3702	822401	18541146	2008-07-26 10:32	ANAC019 and AtMYB3 specifically interact with the C-terminal region (640-967) of AtCPL1 containing two double-stranded RNA binding motifs.
3702	822402	17449810	2007-10-06 11:58	MDAR4 component of the ascorbate-dependent electron transfer system is necessary to detoxify hydrogen peroxide which escapes from the peroxisome.
3702	822415	17933793	2008-01-19 10:52	TRICHOMELESS1 can be recruited to the cis-acting regulatory elements of GLABRA1
3702	822415	18434419	2008-09-27 10:43	Data show that GL1 associates with TRANSPARENT TESTA GLABRA1 in vivo, forming a complex.
3702	822416	17351117	2007-08-20 16:13	These results suggest that Deg1 cooperates with the stroma-exposed proteases FtsH and Deg2 in degrading D1 protein during repair from photoinhibition by cleaving lumen-exposed regions of the protein.[Deg1]
3702	822484	17468262	2007-10-06 11:58	Expression in Arabidopsis resulted in enlarged endosomes with a reduced number of internal vesicles.
3702	822519	15908594	2005-11-18 16:12	The functional characterization of two closely related ABC (ATP-binding cassette) transporter genes, AtMDR1 and AtPGP1, in light and auxin responses. [AtMDR1]
3702	822519	17557805	2007-10-20 12:42	Mutations in Multidrug Resistance-Like1 (MDR1) reduced acropetal auxin transport in roots by 80% without affecting basipetal transport. Conversely, mutations in MDR4 blocked 50% of basipetal transport without affecting acropetal transport.
3702	822519	17557807	2007-10-20 12:42	Auxin levels established by MDR1-dependent acropetal transport control lateral root growth rate to influence root system architecture.
3702	822519	18156217	2008-08-09 10:05	Data show that root hair cell-specific overexpression of auxin efflux transporter PGP19 decreased root hair elongation.
3702	822566	15561775	2007-08-25 15:01	SRK2C is a positive regulator of drought tolerance in Arabidopsis roots.drought tolerance coincided with up-regulation of many stress-responsive genes, for example, RD29A, COR15A, and DREB1A/CBF3.
3702	822566	17671505	2007-09-29 11:22	These studies uncover surprisingly pivotal roles of KIN10/11 in linking stress, sugar and developmental signals to globally regulate plant metabolism, energy balance, growth and survival
3702	822623	17292360	2007-02-26 12:00	At3g29590 is a member of the AtBAHD family encoding the enzyme malonyl-CoA: anthocyanidin 5-O-glucoside-6″-O-malonyltransferase (At5MAT), responsible for synthesizing malonyl-modified anthocyanins in A. thaliana. [At5MAT]
3702	822623	17292360	2007-08-25 13:25	both in vivo and in vitro results define the activity of the At3g29590-encoded enzyme as an anthocyanin 5-O-glucoside-6''-O-malonyltransferase (At5MAT)
3702	822697	15849274	2007-08-25 21:24	Our observations suggest that COB, through its involvement in cellulose microfibril orientation, is an essential factor in highly anisotropic expansion during plant morphogenesis.
3702	822709	15821873	2007-08-25 14:24	investigated the temporal and spatial expression patterns of CYP85A1 and CYP85A2; both promoters of CYP85A1 and CYP85A2 showed maximum activity during the first week following germination, particularly in the vascular tissues
3702	822709	16024588	2005-12-01 12:25	CYP85A2 is a bifunctional enzyme that possesses BR C-6 oxidase (C-6 oxidation of brassinosteroids) and brassinolide (BL) synthase activity. It is thus a cytochrome P450 that mediates Baeyer-Villiger oxidation in plants. [CYP85A2]
3702	822833	18088315	2008-05-24 10:17	bZIP11 target processes are identified using transiently increased nuclear bZIP11 levels and genome-wide expression analysis; the effect of bZIP11 on ASN1 and GBF6 are reported.
3702	823150	16141450	2006-03-10 15:38	ARP6 acts in the nucleus to regulate plant development, and it does so through modulation of chromatin structure and the control of gene expression.[AtARP6]
3702	823150	16495307	2007-08-25 10:18	ESD1 encodes ATARP6, a putative component of chromatin remodelling that positively regulates FLC accumulation.
3702	823150	17142478	2007-08-25 13:27	The identification and characterization of SERRATED LEAVES AND EARLY FLOWERING (SEF) in A. thaliana and its interactions with other proteins, including ATARP6 and PIE1, are reported.
3702	823150	17470967	2007-08-25 21:20	Arabidopsis SWC6 (AtSWC6), SUPPRESSOR OF FRIGIDA 3 (SUF3) and PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1 (PIE1) are homologs of SWC6, ARP6 and SWR1 with roles in development, including floral repression through full activation of FLOWERING LOCUS C
3702	823170	18441211	2008-08-09 10:44	inhibition of the tonoplast-localized V-ATPase subunit isoform VHA-a3 does not impair cell expansion. By contrast, inhibition of the TGN-localized isoform VHA-a1 is sufficient to restrict cell expansion
3702	823190	16015335	2005-10-28 12:54	a transposase from Arabidopsis thaliana named DAYSLEEPER is essential for normal plant growth; it shares several characteristics with the hAT (hobo, Activator, Tam3) family of transposases [DAYSLEEPER]
3702	823287	17526749	2007-11-08 14:31	A SNF2 domain-containing protein (CLASSY1) that acts together with RDR2 and NRPD1a in the spread of transgene silencing and in the production of endogenous 24-nucleotide short interfering RNAs (siRNAs), is identified.[CLSY1]
3702	823396	15569152	2007-08-25 14:29	STUD/TETRASPORE/AtNACK2 appears to be an essential component of a MAP kinase cascade that promotes cytokinesis of plant cells.
3702	823405	16840699	2006-11-27 14:07	AtMIN7 is an immunity-associated protein which is the target for P. syringae virulence protein, HopM1; HopM1 mediates the destruction of AtMIN7 via the host proteasome [AtMIN7]
3702	823508	16798886	2007-08-25 21:21	Data show that small interfering RNAs and larger RNA fragments corresponding miRNA target genes accumulate in wild-type plants but not in ago1, the RNA-dependent RNA polymerase mutants rdr2 and rdr6, or the Dicer-like mutants dcl1 and dcl3.
3702	823508	17579240	2007-10-13 11:51	DICER-LIKE 1 and DICER-LIKE 3 are involved in the generation of small RNAs; mutants exhibit a delay in flowering.
3702	823508	17785412	2007-11-10 12:44	DCL3 is required for reception of long-distance mRNA silencing.
3702	823542	18266916	2008-08-16 10:16	ibo1-1 mutation, in which a conserved Glu residue in the activation loop is substituted by Arg, completely abolishes its kinase activity
3702	823585	17704213	2008-02-28 15:20	A WD40 domain cyclophilin, CYCLOPHILIN71 (CYP71), which functions in gene repression and organogenesis in Arabidopsis thaliana, is identified.[CYP71]
3702	823622	16113212	2006-02-01 11:52	PAO is involved in chlorophyll breakdown during leaf sensescence in A. thaliana.[PAO]
3702	823649	16531458	2007-08-25 21:18	The Arabidopsis gene At3g45130, designated LAS1, encodes a functional lanosterol synthase in plants.
3702	823651	16786299	2006-11-27 13:33	TCP16, a putative transcription factor, plays a crucial role in early processes in pollen development. [TCP16]
3702	823660	17041027	2007-06-29 11:00	Geminivirus Rep-interacting kinase 1, GRIK1 and GRIK2, interact with the geminivirus replication protein AL1 function by mediating one or more processes during early plant development and geminivirus infection by activating SNF1-related kinases.  [GRIK1]
3702	823706	15500467	2005-05-26 16:55	We have used ozone (O3) to generate reactive oxygen species in the apoplast of Arabidopsis thaliana and show that this treatment caused a transient activation of mitogen-activated protein kinase AtMPK3. [AtMPK3]
3702	823706	17259259	2007-08-25 10:44	MPK3 is a key regulator of stomatal development and patterning.
3702	823706	17286820	2007-08-25 10:43	These results provide clear evidence for the important role of MPK3 in the response to abscisic acid and hydrogen peroxide in guard cells.
3702	823706	17586809	2007-10-13 10:20	AtMKP2, a novel MKP protein in Arabidopsis, acts upon MPK3 and -6, and serves as a positive regulator of the cellular response to oxidant challenge
3702	823706	17947581	2007-11-10 12:43	study shows VIP1 is a direct target of Agrobacterium-induced MPK3; on phosphorylation by MPK3, VIP1 relocalizes to nucleus & regulates expression of PR1; MAPK-dependent phosphorylation of VIP1 is necessary for VIP1-mediated Agrobacterium T-DNA transfer
3702	823706	18005697	2007-12-15 11:56	The MAPKs MPK3 and MPK6 physically interact with HopAI1 indicating that they are direct targets of HopAI1.
3702	823706	18364464	2008-08-02 10:40	Results highlight an essential function of MPK3 in promoting cell division in the integument specifically during ovule development.
3702	823706	18378893	2008-06-14 10:24	the MPK3/MPK6 cascade regulates camalexin synthesis through transcriptional regulation of the biosynthetic genes after pathogen infection
3702	823721	15749755	2007-09-03 02:02	We conclude that phototropins promote plant growth by controlling and integrating a variety of responses that optimize photosynthetic performance under low photosynthetically active radiation in the natural environment.
3702	823721	16113208	2007-08-25 15:01	The interaction of JAC1 with PHOT1 and PHOT2 in chloroplast movement in A. thaliana is reported.
3702	823721	16150710	2007-08-25 14:43	LOV2 domain acts as a major light-regulated molecular switch of casein phosphorylation, & it acts as an attenuator of the light activation of the kinase by LOV2. LOV1 domain acts as an attenuator of the light activation of the kinase by LOV2.
3702	823721	16777956	2007-08-25 10:50	PKS1 interacts with PHOT1.
3702	823721	17085510	2007-08-25 13:28	The light, oxygen, or voltage domain (LOV2) of phot1 plays a major role in phototropism and leaf expansion.
3702	823721	17176396	2007-08-25 10:45	Phototropin-1 enhances performance under drought by mediating plastic increases in root growth efficiency near the soil surface.
3702	823721	17275025	2007-08-25 21:23	A two-step mechanism of the linker unfolding is proposed.
3702	823721	18183416	2008-07-26 10:16	exert a positive effect on phototropic curvature under long-term irradiation conditions. Specifically, in a phot1-deficient genetic background (phot1 mutant), curvature is reduced in the absence of cryptochromes.
3702	823721	18252844	2008-08-02 10:05	Data suggest that 5PTase13 antagonizes PHOT1-mediated effects on calcium signaling under blue light.
3702	823721	18378899	2008-06-14 10:24	autophosphorylation of Ser-851 is a primary step that mediates signaling between photochemical reaction and physiological events.
3702	823741	17329563	2007-08-25 12:22	role is proposed for chromatin remodeling in seed dormancy by H2B monoubiquitination through HUB1 and HUB2
3702	823752	17259181	2007-08-25 10:44	the EAR-domain of Cys2/His2-type zinc finger proteins plays a key role in the defense response of Arabidopsis to abiotic stresses
3702	823811	17008347	2007-08-25 10:47	This study showed that AtMBD5 becomes localized to the vicinity of chromosomes with the aid of AtRAN3 during cell division.
3702	823812	15688221	2007-08-25 14:51	AtTRP2 in Arabidopsis encodes a protein that binds plant telomeric DNA and induces DNA bending in vitro.
3702	823817	16006522	2005-11-03 08:55	LUX ARRHYTHMO (LUX) encodes a Myb domain protein essential for circadian rhythms.  [LUX]
3702	823817	16164597	2006-02-03 09:19	The PCL1 gene is the clock oscillator gene essential to the generation of clock oscillation in the higher plant. [PCL1]
3702	823827	15908591	2005-12-02 11:00	atTOC75-III of the Toc75 (translocon at the outer envelope membrane of chloroplasts, 75 kD) gene family is essential for plant viability, and is expressed at its highest level in young, rapidly expanding tissues
3702	823827	16275749	2007-08-25 14:13	SPase I converted Toc75 precursor to its mature form in vitro.
3702	823827	16435266	2007-08-25 12:34	Embryo development in the atToc75-III mutant, lacking the pore forming component of the translocase, was arrested extremely early at the two-cell stage.
3702	823850	16980562	2007-08-25 10:11	A comparison of ATPHS2 and DPE2 from A. thaliana with MalP and MalQ from E. coli is presented.
3702	823888	18088315	2008-05-24 10:17	bZIP11 target processes are identified using transiently increased nuclear bZIP11 levels and genome-wide expression analysis; the effect of bZIP11 on ASN1 and GBF6 are reported.
3702	823897	18203870	2008-07-26 10:06	Light induces proliferation of peroxisomes in Arabidopsis seedlings and PEX11b plays an important role in mediating this process.
3702	823899	16690168	2007-08-25 12:30	Atnos1 mutant plants show increased hypersensitivity to salt stress and methyl viologen (MV) treatment.
3702	823899	17030145	2007-08-25 14:04	The results of studies concerning the apparent function of ATNOS1 are reported and discussed.
3702	823899	17351048	2007-08-25 10:06	AtNOS1 is involved in salt tolerance in Arabidopsis.
3702	823901	15788395	2005-11-09 12:23	analysis of pigment-pigment interactions between nearest neighboring chromophores in Lhca4 antenna complex showed that the low energy spectral form originates from an interaction involving chlorophylls A5 and B5(Lhca4)
3702	823901	17968587	2008-07-26 10:26	target for STN7-dependent phosphorylation under extreme redox conditions
3702	823923	18281505	2008-08-02 10:05	Data find that antibodies directed against EB1 proteins colocalize with microtubules in roots, and that mutants with reduced expression from EB1A genes have roots that deviate toward the left on vertical or inclined plates.
3702	823924	17194767	2007-06-29 13:34	These findings suggest that MAG2 functions in the transport of storage protein precursors between the endoplasmic reticulum and Golgi complex in plants. [MAG2]
3702	823935	16926167	2007-08-25 21:17	Findings suggest that MAG1/VPS29 protein is involved in recycling a plant receptor for the efficient sorting of seed storage proteins
3702	823935	17889650	2007-11-10 11:55	VPS29 is required for endosome homeostasis, PIN protein cycling, and dynamic PIN1 repolarization during plant organ development.
3702	823948	18190525	2008-06-21 10:15	Data show that AtGALDH forms a flavin N5 sulfite adduct and that AtGALDH lacks the histidine involved in covalent FAD binding, but contains a leucine instead.
3702	823959	16258012	2007-08-25 11:59	Our results suggest that ROP10 negatively regulates ABA responses by specifically and differentially modulating the ABA sensitivity of a subset of genes including protein kinases and zinc-finger family proteins.
3702	823959	16805728	2007-08-25 10:50	The sequence requirements for association of Arabidopsis ROP9 AND ROP10 with the plasma membrane are reported.
3702	823964	15939664	2007-08-25 11:05	ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) and its interacting partner, PHYTOALEXIN DEFICIENT 4 (PAD4), constitute a regulatory hub that is essential for basal resistance to invasive biotrophic and hemi-biotrophic pathogens.
3702	823964	16040633	2007-08-25 14:15	Data show that EDS1 interacts in vivo with another protein, SENESCENCE-ASSOCIATED GENE101 (SAG101), and that interactions of EDS1 and its signaling partners are important for plant defense signal relay.
3702	823964	16531493	2007-08-25 21:18	There are salicylic-independent functions of FMO1 and NUDT7 in EDS1-conditioned disease resistance and cell death.
3702	823964	16790029	2007-08-25 12:30	Singlet oxygen activates a complex stress-response program with EDS1 playing a key role in initiating and modulating several of its steps.
3702	823964	16813576	2007-08-25 11:53	The susceptibility of A. thaliana plants to Alternaria brassicicola that induces defensive pathways via EDS1 and PAD4 is reported.
3702	823964	17725549	2007-12-22 11:10	A PHYTOALEXIN DEFICIENT4 (PAD4) mode of action that is uncoupled from EDS1 (ENHANCED DISEASE SUSCEPTIBILITY1) determines the extent of aphid feeding in the phloem.
3702	823964	18266921	2008-08-09 10:19	EDS1 is partially required for Pseudomonas syringae HopW1-1-induced disease resistance.
3702	823971	15649366	2007-08-25 14:28	DEL1 (EL3) is an important novel inhibitor of the endocycle and preserves the mitotic state of proliferating cells by suppressing transcription of genes that are required for cells to enter the DNA endoreduplication cycle.
3702	823975	15772150	2007-08-25 12:59	ATR and ATM dependency of the formation of gamma-H2AX histone foci in M-phase cells exposed to ionizing radiation
3702	823975	16166376	2007-08-25 15:01	ATM makes a distinct contribution to chromosome end protection and the maintenance of telomeric DNA.
3702	823975	17227549	2007-08-25 12:23	Study finds that hundreds of genes are upregulated in response to gamma-irradiation, and that the induction of virtually all of these genes is dependent on ATM, but not ATR.
3702	823975	17672843	2007-12-22 11:10	AtATM mutants produce reduced seed numbers, plants deficient in both AtATM and AtNBS1 are completely infertile
3702	823975	17989233	2008-01-12 11:59	findings suggest a dual role for ATM in regulating telomere size by promoting elongation of short telomeres and by preventing the accumulation of cells that harbor large telomere deletions
3702	823994	17220202	2007-07-02 16:21	BT2, a protein with BTB, TAZ, and calmodulin binding domains, is an essential component of the TAC1-mediated telomerase activation pathway. [BT2]
3702	824002	18467490	2008-06-21 10:33	BES1 recruits transcriptional regulators ELF6 and REF6 to regulate target gene expression and coordinate brassinosteroids responses with other developmental processes such as control of flowering time.
3702	824015	16007690	2007-08-25 21:09	The use several herbicide doses to determine the dominance level to six ALS-inhibiting herbicides in mutant A. thaliana is reported.
3702	824036	16311592	2007-08-25 13:37	CDC2A participates in the fertilization process of endosperm
3702	824036	16698944	2007-06-27 11:38	The balance between cell division and differentiation is regulated through the interaction between CDKA;1 and the antiphosphatase PAS2. [CDKA;1]
3702	824036	17369369	2007-08-25 15:03	The Arabidopsis thaliana Cdc2(+)/Cdc28 homolog CDKA;1 is also phosphorylated in the T-loop and that phosphorylation at the conserved Thr-161 residue is essential for its function.
3702	824036	17764501	2008-01-26 12:03	phosphorylation of T161 in Arabidopsis CDKA;1 is essential for cell division during male gametogenesis
3702	824039	18208516	2008-05-24 10:06	The roles of the LCB2a and LCB2b subunits in sphingolipid biosyntesis in A. thaliana were studied.
3702	824048	15659100	2005-11-17 12:00	The interaction of Tic110, Tic40 and Hsp93 in A. thaliana chloroplast protein transport is described. [Hsp93]
3702	824072	16284776	2007-05-01 14:51	AtPrx33 and Atprx34, two highly homologous Arabidopsis peroxidases, are involved in the reactions that promote cell elongation and this occurs most likely within cell walls. [AtPrx33]
3702	824073	16284776	2007-05-01 15:00	AtPrx33 and Atprx34, two highly homologous Arabidopsis peroxidases, are involved in the reactions that promote cell elongation which occurs most likely within cell walls. [AtPrx34]
3702	824086	18425128	2008-05-24 10:05	This finding implicates a putative chromosome architectural protein DMS3 that can potentially link nucleic acids in facilitating an RNAi-mediated epigenetic modification involving secondary siRNAs and spreading of DNA methylation.
3702	824112	16006579	2005-12-01 12:17	Arabidopsis RNA-Dependent RNA Polymerase (RDR6) gene regulates leaf development. [RDR6]
3702	824112	16682354	2007-08-25 12:30	A hypomorphic rdr6 mutant, which does not exhibit the leaf developmental defects observed in null mutants, accumulates wild-type TAS3 ta-siRNA levels but not TAS1 and TAS2 ta-siRNAs, suggesting that TAS3 is required for proper leaf development.
3702	824112	16699177	2007-08-25 12:30	RDR6, SGS3 and AGO7 act in the same pathway, which genetically interacts with the AS1-AS2 pathway for leaf development.
3702	824112	16798886	2007-08-25 21:21	Data show that small interfering RNAs and larger RNA fragments corresponding miRNA target genes accumulate in wild-type plants but not in ago1, the RNA-dependent RNA polymerase mutants rdr2 and rdr6, or the Dicer-like mutants dcl1 and dcl3.
3702	824112	17384170	2007-08-25 15:00	Improperly terminated, unpolyadenylated mRNA from transgene transcription is subject to RDR6-mediated RNA silencing, probably by acting as templates for the RNA polymerase, in Arabidopsis thaliana.
3702	824112	17400893	2007-08-25 13:24	Several gene transcripts were found to be routed through the RDR6/DCL4-dependent pathway after initial targeting by one or multiple microRNAs or trans-acting short interfering RNA.
3702	824112	17592042	2007-09-04 17:50	Study shows that unidirectional (3-->5') transitivity requires the hierarchical and redundant functions of DCL4 and DCL2 acting downstream from RDR6 to produce 21- and 22-nt-long siRNAs, respectively.
3702	824112	18063577	2008-04-05 13:00	Biochemical analysis of Arabidopsis RNA-dependent RNA polymerase 6
3702	824122	17554311	2007-08-25 13:58	data suggest that H2B deubiquitination by SUP32/UBP26 is required for heterochromatic histone H3 methylation and DNA methylation
3702	824129	16751349	2007-07-02 14:56	Analysis of BAM1 and BAM2 reveal a cell-cell communication process important for early anther development, including aspects of cell division and differentiation. [BAM2]
3702	824130	18162591	2008-07-26 10:36	most likely catalyzes the terminal steps in the chain elongation process leading to short-chain glucosinolates
3702	824131	16461581	2007-06-27 08:45	rax mutants show new phenotypes that are characterized by defects in lateral bud formation in overlapping zones along the shoot axis. RAX genes are partially redundant in function and allow a fine-tuning of secondary axis formation [RAX3]
3702	824132	16028113	2007-08-25 14:23	Data showed that the expression of ACS9 is induced during hypoxia.
3702	824168	17675404	2008-02-21 16:43	A new Arabidopsis thaliana transcription factor, MYB77, that is involved in auxin response, is reported.[MYB77]
3702	824169	17726100	2007-10-27 10:59	CYCD3 activity is important for determining cell number in developing lateral organs and the relative contribution of the alternative processes of cell production and cell expansion to overall organ growth
3702	824172	18787168	2008-09-27 10:13	findings show that a family of exoribonucleases encoded by SMALL RNA DEGRADING NUCLEASE genes degrades mature miRNAs; SDN1 acts specifically on single-stranded miRNAs in vitro & is sensitive to 2'-O-methyl modification on the 3' terminal ribose of miRNAs
3702	824211	15773856	2007-08-25 14:48	results suggest that RPW8.1 and RPW8.2 stimulate a conserved basal defence pathway that is negatively regulated by EDR1
3702	824229	16407451	2007-08-25 15:07	It is likely that the DWF4 promoter serves as a focal point in maintaining homeostasis of endogenous bioactive brassinosteroids pools in specific tissues of Arabidopsis.
3702	824229	16460510	2007-08-25 10:18	may explain the discrepancy between the in planta abundance of C27/C28/C29 sterols and C27/C28/C29 brassinosteroids
3702	824229	17908154	2008-03-22 10:20	Transcripts for dwf4 accumulated in the epidermis of young leaf primordia and targeted expression of DWF4 to a subset of these cells led to both restoration of differentiation of a specific group of leaf cells and restoration of wild-type leaf shape.
3702	824246	15722336	2007-08-25 10:58	amount of photosystem II reaction centers was compromised in plants that exhibited low amounts of the manganese-stabilizing proteins
3702	824246	15853801	2007-08-25 13:40	Results characterize the functional differences between PsbO1 and PsbO2, and show that PsbO1 is the major isoform in wild-type plants.
3702	824246	17217465	2007-08-25 10:44	interaction of PsbO2 with PSII regulates the turnover of the D1 protein
3702	824261	18088305	2008-05-10 10:04	Multiple combinations of mutations in the promoter of the XERO2 dehydrin gene were used to identify elements involved in abscisic acid and cold induction.
3702	824267	15987893	2007-08-25 11:30	Structral model of thioredoxin h1 from Arabidopsis thaliana in the oxidized state displays the conserved thioredoxin fold.
3702	824270	16740145	2007-08-25 21:27	STY1 and related genes promote normal development of the style and affect apical-basal patterning of the gynoecium through regulation of auxin homeostasis.
3702	824293	16148045	2007-08-25 12:44	ROP1 is a Rho-like GTPase from plants .Our report demonstrates the oscillation of Rho GTPase signaling, which may be a common mechanism underlying the oscillation of actin-dependent processes such as polar growth, cell movement, and chemotaxis.
3702	824293	16415208	2007-08-25 10:19	These results provide strong evidence that RopGEF1 activates ROP1 in control of polar growth in pollen tubes.
3702	824294	18222962	2008-05-31 10:27	findings suggest that VPS35, mainly VPS35b, is involved in sorting proteins to PSVs in seeds, possibly by recycling VSR from PVCs to the Golgi complex, and is also involved in plant growth and senescence in vegetative organs
3702	824318	17673660	2007-08-25 21:20	FER protein accumulates asymmetrically in the synergid membrane at the filiform apparatus; findings show that female control of pollen tube reception is based on a FER-dependent signaling pathway, which may play a role in reproductive isolation barriers
3702	824340	16091151	2006-05-01 15:00	ETO1 (ETHYLENE-OVERPRODUCER1) is a negative regulator of type 2 1-aminocyclopropane-1-carboxylate synthases(ACC synthase). [ETO1]
3702	824343	17085765	2007-08-25 21:17	These results suggest that both AtAtg2 and AtAtg5 proteins are essential for autophagy whereas AtAtg9 protein contributes to, but is not essential for, autophagy in Arabidopsis root tip cells.
3702	824346	17085765	2007-08-25 21:17	These results suggest that both AtAtg2 and AtAtg5 proteins are essential for autophagy whereas AtAtg9 protein contributes to, but is not essential for, autophagy in Arabidopsis root tip cells.
3702	824347	16887802	2007-08-25 12:28	analysis of electron transfer in Arabidopsis thaliana ACX4
3702	824347	17932459	2008-04-12 11:11	Data suggest that ATG6 is required to limit the pathogen-associated cell death response
3702	824349	16055687	2007-08-25 22:21	The functional roles of calcium exchanger 1 (CAX1), a vacuolar H+/Ca2+ transporter, and the closely related transporter CAX3 are reported.
3702	824349	17968588	2008-07-26 10:26	cax3 but not cax1 mutants sensitive to salt, lithium, and low pH
3702	824351	17114349	2007-08-25 11:49	The subcellular localization of Arabidopsis thaliana HMGA, HMGB1, and HMGB5, reveals that they localize to the cell nucleus. They display a speckled distribution pattern throughout the chromatin of interphase nuclei.
3702	824360	17885082	2008-01-19 11:42	The cloning and characterization of a novel sterol O-acyltransferase in A. thaliana are reported.
3702	824375	18007598	2008-04-10 17:17	AtCOM1 is related to the human CtIP and the yeast COM1/SAE2 gene. Results indicate that the COM1/SAE2 homologue exists in various higher eukaryotes and that it is essential for female and male meiosis in A. thaliana. [COM1]
3702	824375	18495640	2008-08-09 10:30	GR1 and GR2 are involved in the regulation of Succinic semialdehyde detoxification in plants.
3702	824378	14617080	2008-01-22 17:04	Required for the correct cellular distribution of mitochondria.
3702	824383	16623901	2007-08-25 11:55	At3g52180 binds to purified starch through its predicted carbohydrate-binding region, and mutation of key conserved residues reduces this binding.
3702	824383	16772378	2006-10-25 17:08	DSP4 acts as a bridge between light-induced redox changes and protein phosphorylation in the regulation of starch accumulation [DSP4]
3702	824405	15342780	2007-08-25 15:02	SYP122 may have a general function in secretion and a role in cell wall deposition, while its homolog PEN1 appears to have a basal function in secretion and a specialized defense-related function
3702	824408	15939664	2007-08-25 11:05	ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) and its interacting partner, PHYTOALEXIN DEFICIENT 4 (PAD4), constitute a regulatory hub that is essential for basal resistance to invasive biotrophic and hemi-biotrophic pathogens.
3702	824408	16299172	2007-08-25 12:35	PAD4 modulates the activation of senescence in aphid-infested leaves, which contributes to basal resistance to aphids
3702	824408	16813576	2007-08-25 11:53	The susceptibility of A. thaliana plants to Alternaria brassicicola that induces defensive pathways via EDS1 and PAD4 is reported.
3702	824408	17725549	2007-12-22 11:10	A PHYTOALEXIN DEFICIENT4 (PAD4) mode of action that is uncoupled from EDS1 (ENHANCED DISEASE SUSCEPTIBILITY1) determines the extent of aphid feeding in the phloem.
3702	824422	18178771	2008-05-19 02:05	UEV1D appears to express at a much higher level in germinating seeds and in pollen.
3702	824443	18055602	2008-06-06 15:00	The identification of a gene family that encodes small leucine zipper-containing proteins (LITTLE ZIPPER [ZPR] proteins) where the leucine zipper is similar to that found in REV, PHABULOSA, and PHAVOLUTA proteins, is reported. [Little Zipper]
3702	824450	18359051	2008-09-13 10:26	It is shown by dot-immunoblotting that At3g52840 is the gene expressing Gal-2 which is associated with the cell wall in Arabidopsis.
3702	824454	17043889	2007-08-25 15:03	When expressed in transgenic tobacco, confers enhanced tolerance against ozone, salt and polyethylene glycol stress.
3702	824468	16227452	2006-09-27 16:11	In addition to the role of RPL24 in ribosome-related whole-plant growth and the development of several organs, RPL24 functions specifically in auxin-mediated apical-basal patterning of the gynoecium. [RPL24B]
3702	824477	15598798	2005-11-29 15:15	CRYOPHYTE/LOS4 RNA helicase plays an important role in mRNA export, plant development, and stress responses. [LOS4]
3702	824510	18234664	2008-08-23 10:05	analysis of the subcellular trafficking of AtPIP2
3702	824516	16877699	2007-08-25 21:26	characterization of the PDR9 gene; 2,4-D, but not indole-3-acetic acid transport is affected by mutations in pdr9, suggesting that the PDR9 transporter specifically effluxes 2,4-D out of plant cells without affecting endogenous auxin transport
3702	824539	17337534	2007-08-25 10:42	CHX20 is preferentially and highly expressed in guard cells
3702	824548	18392777	2008-08-30 10:30	These data demonstrated that SGC Lectin RLK plays a critical role in pollen development.
3702	824568	16803883	2007-08-25 21:08	PAS1 regulates the function of the NAC-like transcription factor by controlling its targeting to the nucleus upon plant cell division
3702	824578	17148605	2007-05-25 11:48	The main physiological role of UCP1 in Arabidopsis leaves is related to maintaining the redox poise of the mitochondrial electron transport chain to facilitate photosynthetic metabolism. [AtUCP1]
3702	824578	17980348	2008-02-09 11:09	Cys28 substitution reduced ATP inhibitory effect, while Tyr269Phe mutant exhibited 2.8-fold increase in sensitivity to ATP.
3702	824581	15500465	2005-02-22 13:10	A new transporter mediating the uptake of di- and tripeptides was isolated from Arabidopsis thaliana. [AtPTR1]
3702	824589	17446396	2007-08-25 13:59	findings show that SCARECROW (SCR) blocks SHORTROOT (SHR) movement by sequestering it into the nucleus through protein-protein interaction and a safeguard mechanism that relies on a SHR/SCR-dependent positive feedback loop for SCR transcription
3702	824599	15500472	2005-08-17 09:36	The putative AP2/EREBP transcription factor WRINKLED1 (WRI1) is involved in the regulation of seed storage metabolism in Arabidopsis.  [WRI1]
3702	824599	15753106	2005-10-05 13:28	ASML1/WRI1 is a transcriptional activator involved in the activation of a subset of sugar-responsive genes and the control of carbon flow from sucrose import to oil accumulation in developing seeds [ASML1][WRI1] [WRINKLED1]
3702	824599	17419836	2007-10-20 12:43	WRI1 is a target of LEAFY COTYLEDON2 and is necessary for the regulatory action on fatty acid metabolism.
3702	824601	17965182	2008-04-05 13:01	truncated form, lacking the conserved C-terminal motifs, functions to direct floral organ identity specification
3702	824626	17085686	2007-08-25 21:17	These results suggest that acetylation of specific histone Lys residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.
3702	824626	17151888	2007-08-25 21:02	The isolation and characterization of EML, a protein that is regulated by GCN5, are reported.
3702	824626	18498779	2008-08-23 10:38	the gcn5 mutation seriously reduced acetylation of histone H3K14 and H3K27, whereas the T-DNA insertions of the PP2C6-6 gene enhanced the acetylation of these lysine residues
3702	824636	15928083	2005-11-30 12:00	down-regulation of AtCDT1a and AtCDT1b, members of the prereplication complex, is shown to alter both nuclear DNA replication and plastid division in Arabidopsis thaliana [CDT1b]
3702	824637	17553903	2007-10-13 10:20	auxin-derived positional information through MP carves out meristematic niches by locally overcoming a general differentiation-promoting activity involving AMP1.
3702	824646	16359389	2006-05-02 11:05	Blue Micropylar End 3 (BME3) is activated specifically in the embryonic axis and shows potential involvement in GA biosynthesis suggesting its role in the regulation of seed germination. [BME3-ZF]
3702	824649	18055610	2008-03-10 15:45	These results indicate that the two types of plant Rab5 members are functionally differentiated, even though they are regulated by the same activator, VPS9a.
3702	824652	17957256	2008-07-19 10:23	the plant-specific kinesin-related protein MRH2 is an important component that controls MT organization and is likely involved in the ROP2 GTPase-controlled coordination of AF and MT during polarized growth of root hairs
3702	824655	16829529	2007-05-08 16:46	Results describe the initial functional characterization of a plant monothiol Glutaredoxin and suggests a conserved biological function in protecting cells against protein oxidative damage [AtGRXcp].
3702	824671	18498779	2008-08-23 10:38	the gcn5 mutation seriously reduced acetylation of histone H3K14 and H3K27, whereas the T-DNA insertions of the PP2C6-6 gene enhanced the acetylation of these lysine residues
3702	824692	17644627	2008-01-12 11:12	participates in N-glycan trimming in the vacuole, capable of removing terminal GlcNAc residues from the alpha1,3- and alpha1,6-mannosyl branches of biantennary N-glycans without any strict branch preference
3702	824693	18579522	2008-10-04 10:06	Regulation of MAPK phosphatase 1 (AtMKP1) by calmodulin in Arabidopsis.
3702	824699	17827269	2008-01-19 12:04	A study evaluating the function of PPL1 and PPL2, both members of the the PsbP gene family in Arabidopsis, is presented.
3702	824702	17463005	2007-09-15 12:40	Highly conserved domains of the Tsc13p proteins that are likely to be important for enzymatic activity lie on the cytosolic face of the endoplasmic reticulum, possibly partially embedded within the membrane.
3702	824718	17573536	2007-11-08 14:11	SDIR1 (SALT- AND DROUGHT-INDUCED RING FINGER1) is a positive regulator of the ABA-dependent stress signaling pathway. [SDIR1]
3702	824740	15618414	2007-08-25 14:50	A new member of the proline transporter gene family, AtProT3, was isolated from Arabidopsis (Arabidopsis thaliana), and its properties were compared to AtProT1 and AtProT2.
3702	824746	15863701	2005-11-23 16:58	Increasing the levels of higher plant SBPase activity has the potential to increase photosynthetic capacity. [sedoheptulose-1,7-bisphosphatase] [SBPase]
3702	824749	17426055	2007-08-25 13:23	EPC1 does not affect cell adhesion but has a role in processes affecting plant growth and development.
3702	824764	17609218	2008-06-06 14:29	AtSZF1 and AtSZF2 negatively regulate the expression of salt-responsive genes and play important roles in modulating the tolerance of Arabidopsis plants to salt stress. [AtSZF1]
3702	824765	17316173	2007-10-06 10:07	Map-based cloning identified the esk1 locus as At3g55990, ESK1 gene encodes a 57-kDa protein and is a member of a large gene family of DUF231 domain protein which functions as a negative regulator of cold acclimation.
3702	824790	16585509	2007-08-25 21:03	ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, which negatively affects ATX1 activity.
3702	824790	17223078	2007-08-25 21:21	Higher plants express two types of ATX1-like Cu chaperones: the ATX1-type with a predominant function in Cu delivery to P-type ATPases, and the CCH-type with additional carboxy-terminal domain-mediated plant-specific functions.
3702	824804	15618632	2007-08-25 13:41	this paper reports the isolation and characterization of IRK interacting protein (IRKI), and shows the link between IRK1/IRK and the multicellular organization of meristems in the shoot and root apices [IRK]
3702	824807	16623907	2007-08-25 13:34	WRKY70 has a pivotal role in determining the balance between SA-dependent and JA-dependent defense pathways.
3702	824807	17310369	2007-08-25 13:25	To expand understanding on how transcriptional control coordinates leaf senescence, AtWRKY70, a gene encoding a WRKY transcription factor that functions as a negative regulator of developmental senescence was characterized.
3702	824852	15642716	2007-08-25 11:32	Characterization of AREB3 protein and two other genes of the ABI family during seed maturation.
3702	824853	18278441	2008-09-20 10:16	UBA2A encodes an hnRNP-type nuclear RNA-binding protein that functions in a novel wound signal transduction pathway.
3702	824862	16223486	2006-01-03 21:00	SIP2;1 are the small aquaporins.  They are localized in ER of all tissues except dry seeds. They do not show water channel activity but may act as ER channel for small molecules or ions. [SIP2;1]
3702	824863	17883374	2008-03-10 15:00	PIP5K4 produces PtdIns(4,5)P(2) in irradiated guard cells, inhibiting anion channels to allow full stomatal opening.
3702	824864	17260143	2007-08-21 09:09	AtbHLH38 and AtbHLH39 are induced under iron deficiency. They are involved in the iron deficiency induced synthesis and excretion of riboflavin or vitamin B2. [AtbHLH38]
3702	824865	17260143	2007-08-21 10:00	AtbHLH38 and AtbHLH39 are induced under iron deficiency. They are involved in the iron deficiency induced synthesis and excretion of riboflavin or vitamin B2. [AtbHLH39]
3702	824865	17516080	2007-12-01 12:59	up-regulated by iron deficiency in roots and leaves
3702	824876	16510519	2006-10-13 13:41	BIGYIN is an Arabidopsis FIS orthologue and is part of the Arabidopsis mitochondrial division apparatus. [BIGYIN]
3702	824880	15564519	2007-08-25 14:25	BOP1 plays a key role in Arabidopsis morphogenesis with the distinctive combinatorial architecture of the BTB/POZ and ankyrin repeat domains [BOP1]
3702	824880	15800002	2005-10-25 14:38	important regulator of the growth and development of lateral organs (BOP1)
3702	824880	15805484	2007-09-03 02:02	Here, we show that two NPR1-like genes, BLADE-ON-PETIOLE1 (BOP1) and BOP2, function redundantly to control growth asymmetry, an important aspect of patterning in leaves and flowers.
3702	824880	17601823	2007-10-20 11:55	BOP1 and BOP2 act in cells adjacent to the lateral organ boundary to repress genes that confer meristem cell fate and induce genes that promote lateral organ fate and polarity.
3702	824880	18339677	2008-06-14 10:34	BOP1/BOP2 activity is required for multiple cell differentiation events in the proximal regions of inflorescence lateral organs.
3702	824882	17712600	2008-01-19 12:33	[CBF5] Arabidopsis CBF5 interacts with NAF1 in planta.
3702	824882	18212040	2008-05-21 14:37	AtNAP57 is a conserved component of the telomerase RNP in multicellular organisms that is required for telomere maintenance. [AtNAP57]
3702	824882	18212040	2008-05-03 10:57	T66A NAP57 behaves as a dominant-negative inhibitor of telomerase. dyskerin is a conserved component of the telomerase RNP complex in higher eukaryotes that is required for maximal enzyme activity in vivo.
3702	824893	16048996	2007-08-25 21:09	Lipooligosaccharide and the lipid A and core oligosaccharides derived from it were all able to induce the defense-related gene PR2 in Arabidopsis and to prevent the hypersensitive response caused by avirulent bacteria.
3702	824896	18067529	2008-04-12 11:12	study concludes that the COP9 signalosome maintains a precise regulation of eIF3e levels, which is necessary for normal development in Arabidopsis
3702	824900	17662727	2007-10-20 10:19	ACA11 localizes to the vacuole membrane.
3702	824906	17521410	2007-09-08 10:48	Flowering time is determined by the additive effect of multiple MADS domain floral repressors, with important contributions from AGL15 and AGL18.
3702	824920	16299177	2007-08-25 12:35	CPK32 is an ABA signaling component that regulates the ABA-responsive gene expression via ABF4.
3702	824934	15772283	2006-01-27 08:42	AtLPAT2, encodes the ubiquitous, abundant, and ER-located LPAT. It is essential for female but not male gametophyte development [LAPT2]
3702	824936	17600712	2008-03-04 15:42	Required for transmitting-tract development; mutations cause reduced fertility by severely inhibiting pollen-tube movement [NTT]
3702	824961	18278578	2008-09-20 10:16	SPL15 has a role in shoot maturation.
3702	824973	17873090	2008-01-19 12:54	The action of SINAT2 may explain the recalcitrance of AtRAP2.2 protein levels to change by altering AtRAP2.2 transcription.
3702	824976	16679458	2007-01-03 16:17	GLABROUS INFLORESCENCE STEMS (GIS) is a putative C2H2 transcription factor which regulates several aspects of shoot maturation in Arabidopsis. [GIS]
3702	825037	16283071	2006-05-02 11:53	Multiprotein bridging factor 1 (MBF1) is a transcriptional coactivator that predominantly localize in nucleolus. Its function in plants is controlled on the level of transcriptional induction but not by nuclear translocation. [MBF1]
3702	825037	17234157	2007-08-25 14:01	Multiprotein bridging factor 1a (MBF1a) is overexpressed during abiotic and biotic stress tolerance.
3702	825047	16515858	2007-08-25 12:32	These experiments indicate that the ectopic co-expression of SEPALLATA3 and SHATTERPROOF1 and/or SEEDSTICK is probably not sufficient to homeotically transform vegetative tissues into carpels with ovules.
3702	825050	16709200	2006-10-25 16:33	The MTP3 protein contributes to basic cellular Zinc tolerance and controls Zinc partitioning, particularly under conditions of high rates of Zinc influx into the root symplasm. [MTP3]
3702	825054	17948056	2008-03-04 16:34	PAR1 and PAR2 act in the nucleus to broadly control plant development, acting as negative regulators of a variety of the shade avoidance syndrome (SAS) responses. [PAR2]
3702	825072	17601828	2007-10-20 11:55	TT12 is involved in the vacuolar accumulation of proanthocyanidin precursors in the seed.
3702	825075	17827270	2008-01-19 12:04	Photobiological and genetic evidence indicated that the photoactivated phytochrome molecule acts to induce PIF5 phosphorylation, phyA and phyB redundantly dominate this process.
3702	825075	18047474	2008-04-12 11:12	findings show that PIF4 and PIF5 act early in the phytochrome signaling pathways to promote the shade-avoidance response
3702	825075	18065691	2008-08-09 10:19	Data indicate that overexpressed PIF5 causes altered ethylene levels, which promote the triple response in darkness, whereas in the light, the interaction of photoactivated phyB with PIF5 causes degradation of the photoreceptor protein.
3702	825107	15469499	2007-08-25 15:08	Used to demonstrate the feasibility of bimolecular fluorescence complementation in plants.
3702	825109	15884974	2007-08-25 13:05	The physical-chemical basis for understanding GUN4 biological activity, including its role in the stimulation of Mg-chelatase activity.
3702	825111	15772284	2007-08-25 22:21	Arabidopsis ACR4 is present in two distinct compartments within cells. These represent protein export bodies and a population of internalized vesicles.
3702	825111	17376810	2007-08-25 13:59	Study suggests that ALE2 and ACR4 function in the same process, while ALE1 has a different mode of action, and that these 3 genes play overlapping roles in positively regulating protoderm-specific gene expression and for the formation of leafy organs.
3702	825124	17488242	2007-09-08 10:02	localizes primarily in the nucleolus of both meiotic and mitotic cells, essential for megagametogenesis and plays an important role in pollen
3702	825145	18223034	2008-05-17 10:16	Null alleles of oastlA or oastlB alone showed that cytosolic OAS-TL A and plastid OAS-TL B were completely dispensable, although together they contributed 95% of total OAS-TL activity. oastlC plants also showed retarded growth.
3702	825146	15923324	2007-08-25 21:24	These results suggest that the SAC9 phosphatase is involved in modulating phosphoinsitide signals during the stress response.
3702	825146	16453058	2007-08-25 10:54	This study demonstrated that SAC9 dysfunction interferes with ATP synthase deactivation, possibly by an alteration in phosphoinositide signaling inducing a stress mimicry response.
3702	825160	16824178	2007-01-05 15:57	Results suggest that ARL acts downstream of BRI1 and partially mediates brassinosteroid-related cell expansion signals during organ growth [ARGOS-LIKE] [ARL]
3702	825173	16554053	2007-08-25 21:21	an Arabidopsis SPL12 SBP-domain fragment that lacks a Cys residue involved in the C-terminal zinc-binding pocket was found to retain a folded structure, even though only a single Zn2+ ion binds to the fragment
3702	825189	16824181	2007-08-25 10:14	The edr3 mutant suggests a mechanistic link between salicylic acid signaling, mitochondria and programmed cell death in plants.
3702	825194	17316629	2007-08-25 13:25	coordinated and selective recruitment of eIF4E and eIF4G factors at a very early step in potyvirus infection
3702	825206	16434475	2006-03-16 16:00	Arabidillo-2 functions redundantly with Arabidillo-1 to promote lateral root development in Arabidopsis. [Arabidillo-2]
3702	825208	16894144	2007-03-07 15:05	FKBP20-2 is an immunophilin of the chloroplast thylakoid lumen and is required for accumulation of the PSII supercomplex in Arabidopsis thaliana [FKBP20-2].
3702	825217	15694308	2005-04-29 18:22	DUO1 controls male gamete formation in plants. [DUO1]
3702	825221	17351114	2007-07-09 14:35	CER7 protein is a putative 3'-5' exoribonuclease homologous to yeast Ribonuclease PH45 (RRP45p), a core subunit of the RNA processing and degrading exosome that controls the expression of CER3/ WAX2/YRE. [CER7]
3702	825254	16040647	2007-08-25 12:44	A critical role for the Arabidopsis ARP7 protein in the regulation of various phases of plant development is reported.
3702	825255	18263774	2008-08-02 10:05	Subcellular localization of MAP65-3 and analysis of microtubule organization in the mutant demonstrated that MAP65-3 played a critical role in organizing the mitotic microtubule array during both early and late mitosis in all plant organs.
3702	825260	18055602	2008-06-06 15:00	The identification of a gene family that encodes small leucine zipper-containing proteins (LITTLE ZIPPER [ZPR] proteins) where the leucine zipper is similar to that found in REV, PHABULOSA, and PHAVOLUTA proteins, is reported. [Little Zipper]
3702	825285	16540543	2006-05-16 13:33	Galacturonosyltransferases (GAUT1) is a homogalacturonan galacturonosyltransferase of the GAUT1-related gene family that is involved in pectin biosynthesis. [GAUT1]
3702	825291	17018034	2007-08-25 10:47	The BAP1 protein functions together with an evolutionarily conserved C2 domain protein BON1/CPN1 to negatively regulate defense responses in plants.
3702	825291	17631528	2008-01-12 12:52	general inhibitor of programmed cell death, expression in yeast alleviates cell death induced by hydrogen peroxide
3702	825320	17107674	2007-08-25 21:17	rarely expressed Lhca5 light-harvesting protein interacts with Light Harvesting Complex I in the Lhca2/Lhca3-site.
3702	825332	17496113	2007-12-01 12:14	important role in regulating plant growth and development, expression restricted to the stele and lateral root cap, cotyledonary margins, tip of the stigma, pollen, abscission zones, and developing seeds
3702	825344	17259285	2007-08-25 10:44	Arabidopsis Atg6/Vps30 functions not only in autophagy, but also plays a pivotal role in pollen germination.
3702	825344	17339883	2007-08-25 10:42	AtBECLIN 1 is required for normal plant development; genes related to autophagy, VPS and the glycosylphosphatidylinositol anchor system, were affected by the deficiency of AtBECLIN 1.
3702	825349	16849600	2007-08-25 13:32	SIN2 GTPase supports a mitochondrial role in the regulation of multiple developmental pathways, with pronounced pleiotropic effects on vegetative and floral growth pathways.
3702	825359	17114353	2007-08-25 11:49	The dynamic distribution of the Arabidopsis thaliana SR proteins RSZp22 and RSp31 in the nucleolus, are demonstrated.
3702	825402	15723828	2007-08-25 12:46	The Arabidopsis genome potentially encodes 19 proteins with sequence similarities to adp ribosylation factor and its relatives.
3702	825414	17947231	2008-03-29 13:05	The redox dependence of events leading to supramolecular complexes is consistent with a role of CP12 in coordinating the reversible inactivation of chloroplast enzymes A(4)-GAPDH and PRK during darkness in photosynthetic tissues.
3702	825435	18359753	2008-06-28 10:22	These findings indicate that AtMYB11 modulates overall growth in plants by reducing the proliferation activity of meristematic cells and delaying plant development.
3702	825452	15860012	2005-11-15 15:27	AtATG18a protein is likely to be required for autophagosome formation during nutrient stress and senescence in Arabidopsis. [AtATG18a]
3702	825458	15655675	2005-11-22 08:43	AtUXS2 is a Uxs isoform that encodes an integral membrane protein that appears to be localized in the Golgi apparatus. [AtUXS2]
3702	825466	17450416	2007-08-21 08:39	APG3 gene codes for Chloroplast ribosome release factor 1 which is essential for chloroplast translation machinery. [Chloroplast ribosome release factor 1] [AtcpRF1]
3702	825473	15546359	2007-08-25 14:45	Biochemical studies show that IAA1/AXR5 interacts with TIR1 in an auxin-dependent manner.
3702	825473	15917797	2007-08-25 11:06	results indicate that TIR1 is an auxin receptor that mediates Aux/IAA degradation and auxin-regulated transcription
3702	825473	15917798	2007-08-25 11:06	TIR1 is an auxin receptor mediating transcriptional responses to auxin
3702	825473	17410169	2007-08-25 14:00	crystal structures of the Arabidopsis TIR1-ASK1 complex, free and in complexes with three different auxin compounds and an Aux/IAA substrate peptide
3702	825476	16709201	2007-06-27 12:00	AtGID1a, AtGID1b and AtGID1c function as GA receptors in Arabidopsis.[AtGID1b]
3702	825476	17194763	2007-06-29 15:00	GID1a, GID1b, GID1c are the predominant GA receptors in regulating GA growth response in Arabidopsis.  GA binding to GID1a promotes its interaction with DELLA proteins. [GID1b]
3702	825476	17521411	2007-09-08 11:34	The stamens of the double knockout mutant atgid1a atgid1b were significantly shorter than those of the wild-type, and this leads to low fertility.
3702	825486	18184738	2008-07-26 10:16	Different subcellular localization of the farnesylated protein and the nonfarnesylated protein closely correlates with either isopentenyl-type or zeatin-type cytokinin biosynthesis.
3702	825488	15807788	2007-08-25 11:31	AtRanGAP1 has a mitotic trafficking pattern uniquely different from that of vertebrate RanGAP.
3702	825488	17600715	2008-01-05 15:16	In a wip1-1/wip2-1/wip3-1 triple mutant, RanGAP1 is dislocated from the nuclear envelope in undifferentiated root-tip cells, whereas nuclear envelope targeting in differentiated root cells and targeting to the cell plate remain intact.
3702	825500	18208517	2008-05-24 10:06	The effects of mutatios of HMT2 on methionine biosynthesis in A. thaliana are reported.
3702	825517	17220359	2007-08-25 14:01	Posttranslational modification of AGG1 is required for plasma membrane targeting.
3702	825517	17360436	2007-08-25 12:21	the Gbetagamma complex serves a signaling function in the ER independent of its function in the Galphabetagamma heterotrimer
3702	825517	17383830	2007-08-25 13:23	This research provides evidence of the functional association of alpha and beta with the gamma subunits in Arabidopsis, while also suggesting that plasma membrane localization may be critical for function of plant heterotrimeric G proteins.
3702	825527	16459333	2007-08-25 10:18	AtCCD1 from Arabidopsis thaliana is a dioxygenase
3702	825527	16870153	2007-08-25 10:13	Ectopic expression of AhNCED1 gene in 129B08/nced3 mutant Arabidopsis driven by the AtNCED3 promoter restores its ability to accumulate ABA during drought stress, and reverts its hypersensitivity to nonionic osmotic stress and soil drought.
3702	825527	18523487	2008-08-09 10:26	A cysteine residue may modulate substrate affinity and (or) the reaction rate of AtCCD1.
3702	825528	16461280	2007-09-03 02:05	The E3 ubiquitin ligase BIG BROTHER controls arabidopsis organ size in a dosage-dependent manner.
3702	825532	17220359	2007-08-25 14:01	Posttranslational modification of AGG2 is required for plasma membrane targeting.
3702	825648	15860010	2007-08-25 12:46	Genetic and physiological data to directly demonstrate that AtCUL1 is necessary for normal JA responses are presented.
3702	825648	17158585	2007-08-25 10:09	A viable and fertile weak allele of CUL1, called cul1-6, is described.
3702	825648	18550827	2008-07-19 10:40	The disruption of the CAND1-CUL1 interaction results in an increased abundance of assembled SCF(TIR1) complex; stabilization of the CAND1-CUL1 interaction diminishes SCF(TIR1) complex abundance.
3702	825655	15464979	2007-08-25 15:02	Results suggest that members of TPC1 channel family are reactive oxygen species-responsive calcium channels and are the possible targets of aluminum-dependent inhibition.
3702	825655	15772667	2007-08-25 22:21	a tpc1 knockout mutant lacks functional slow vacuolar channel activity and is defective in both abscisic acid-induced repression of germination and in the response of stomata to extracellular calcium
3702	825655	17253984	2007-10-06 12:27	a genetic screen capable of detecting the misregulated activity of 13-lipoxygenase identified a missense mutation in TPC1, indicating that cation fluxes exert control over positive feedback loop for jasmonic acid stimulates its own synthesis.
3702	825655	17981874	2008-04-05 13:01	results suggest that wild-type TPC1 contributes to their expression of PDF1.2a and THI2 by mechanisms somewhat different from those affecting their expression in fou2
3702	825655	18028262	2008-04-12 11:13	study found loss of TPC1 did not change membrane hyperpolarization-activated Ca(2+)-permeable channel activity; we conclude TPC1, under physiological conditions, functions as a vacuolar cation channel without major impact on cytosolic Ca(2+) homeostasis
3702	825793	18218969	2008-07-26 10:06	extensive posttranscriptional regulation
3702	825797	17959606	2008-02-23 11:11	A point mutation in atpC1 raises the redox potential of the Arabidopsis chloroplast ATP synthase gamma-subunit regulatory disulfide above the range of thioredoxin modulation
3702	825814	15611066	2005-04-27 12:28	results show that AtNAP1 is an iron-stimulated ATPase and is capable of forming homodimers, and suggest that AtNAP1 represents an atypical plastidic SufB-like protein important for Fe-S cluster assembly and for regulating iron homeostasis (AtNAP1)
3702	825825	15811335	2005-10-26 11:01	Cardiolipin synthase [CLS]
3702	825857	16617333	2007-08-25 10:53	AtENT3, but not AtENTs 1 and 6, is the main transporter for uridine uptake in Arabidopsis roots.
3702	825857	17253988	2007-10-06 12:27	These results indicate that ENT3 is an important pyrimidine nucleoside transporter in Arabidopsis.
3702	825864	15677481	2007-08-25 12:03	Data demonstrate that At4g05160 and At5g63380 have the capacity to contribute to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors.
3702	825866	16822865	2007-08-25 13:31	Results indicate that the loss of the PsbQ protein induces significant changes in Photosystem II function, particularly in low light-grown plants, and that the PsbQ protein is required for photoautotrophic growth under low light conditions.
3702	825867	15659646	2005-10-26 16:09	ATK5 uses plus-end tracking to reach spindle midzones, where it then organizes microtubules via minus-end-directed motor activity [ATK5]
3702	825867	17220198	2007-08-25 13:26	ATK5 participates in the search and capture of antiparallel interpolar microtubules, where it aids in generating force to coalign microtubules, thereby affecting spindle length, width, and integrity.
3702	825867	17652157	2007-12-01 11:31	These results are among the first reports of any motor with a major role in anastral spindle structure in plants and demonstrate that the conservation of kinesin-5 motor function throughout eukaryotes extends to vascular plants.
3702	825867	18088313	2008-05-29 21:00	Arabidopsis AtKIN14a and AtKIN14b genes encoding highly similar kinesins are two of the most closely related Arabidopsis paralogs. They together play important roles in controlling plant reproductive development. [AtKIN14b]
3702	825880	15546357	2007-08-25 14:45	The effect of intron location on mRNA accumulation in transgenic plants was found to decline with distance from the promoter.
3702	825890	16792691	2007-06-29 08:04	Arabidopsis cullin 4 is shown to assemble with DDB1, RBX1, DET1 and DDB2 in vitro and in planta.[DDB1A]
3702	825890	17409070	2007-09-15 10:21	DDB1A-dependent phenotypes indicate a competition between DDB2- and DET1-containing complexes for available DDB1A, while, for DDB1A-independent phenotypes, DDB1B is able to fulfill this role.
3702	825890	18551167	2008-07-26 10:32	CUL4-DDB1A-DDB2 complex is involved in global genome repair of UV-induced DNA lesions.
3702	826364	16741748	2007-08-25 21:08	Heterodimers with PENNYWISE or POUND-FOOLISH are essential for establishing early internode patterning events.
3702	826364	18390591	2008-08-09 10:18	data showed that BP and PNY restrict KNAT6 and KNAT2 expression to promote correct inflorescence development
3702	826364	18410683	2008-08-02 10:05	Expression of KNAT1 in the integuments leads to extra cell divisions in the outer layer of the outer integument, and being compensated for by a decrease of cell volume, thus showing that mechanisms exist to control proper ovule integument morphogenesis.
3702	826365	15618413	2005-09-22 13:34	Ectopic expression of Xyn3 during transdifferention in A. thaliana.[Xyn3]
3702	826409	16211390	2007-08-25 12:00	An analysis of the interation of MEKK1 and MEK1 in response to wounding stress in A. thaliana seedlings is presented.
3702	826409	17023433	2007-08-25 13:29	MEKK1 is essential for activation of MPK4 and negatively regulates temperature-sensitive and tissue-specific cell death and H(2)O(2) accumulation that are dependent on both RAR1 (resistance protein function) and SID2 (isochorismate synthase)
3702	826409	17142480	2007-08-25 13:27	This study demonstrated that analysis of plants carrying T-DNA knockout alleles indicated that MEKK1 is required for flg22-induced activation of MPK4.
3702	826409	17572407	2007-10-20 11:08	Treatment with elevated levels of sodium chloride improves the growth of mekk1 transgenic plants;the mekk1;mpk4 double-mutant combination causes seedling lethality.
3702	826409	17587183	2007-10-06 11:58	MEKK1 is a bifunctional protein: it binds to the promoter of the WRKY53 gene regulating the switch from a leaf age dependent to a plant age dependent expression
3702	826426	15842617	2005-10-26 13:10	The identification of a sulfur-responsive element in the promoter region of SULTR1;1 of A. thaliana is reported. [SULTR1;1]
3702	826426	17720755	2008-01-05 15:15	SULTR1;1 and SULTR1;2 are two essential components of the sulfate uptake system in roots and are regulated at posttranscriptional levels together with the previously reported transcriptional control.
3702	826426	18400935	2008-08-09 10:18	expression of SULTR1.1 is locally regulated in response to sulfate starvation. In contrast, accumulation of SULTR1.2 transcripts appeared to be mainly related to metabolic demand and is controlled by photoperiod
3702	826470	15751956	2007-08-25 14:49	A light-dependent conformational change in the carboxy-terminal domain of Arabidopsis Cry1 provides first biochemical evidence for the proposed conformational rearrangement of cryptochromes in response to light.
3702	826470	15774475	2007-08-25 21:15	light-induced flavin reduction via the tryptophan chain is the primary step in the signaling pathway
3702	826470	15805487	2007-08-25 13:09	Irradiation with blue light modifies the properties of the CNT1 dimer, resulting in a change in CCT1, activating CCT1, and eventually triggering the CRY1 signaling pathway.
3702	826470	16703358	2007-08-25 10:16	Primary root elongation in blue light may involve interaction between cryptochrome and auxin signaling pathways.
3702	826470	17075038	2007-08-25 14:04	The blue-light-specific trigger of apoptosis could not be attributed to a photosynthetic reaction or redox change within the chloroplast but to the activation of the blue light/UVA-specific photoreceptor cryptochrome-1.
3702	826470	17237227	2007-08-25 10:08	Cryptochrome activation via flavin photoreduction is a reversible mechanism novel to blue light photoreceptors.
3702	826470	18003924	2008-01-05 14:24	important step toward elucidation of cry1 signaling pathways is the recognition that different subcellular pools of the photoreceptor have different functions
3702	826470	18065688	2008-08-09 10:19	Data report the isolation of new cryptochrome1 (cry1) alleles from a screen for Arabidopsis thaliana genomes uncoupled mutants, which have defects in plastid-to-nucleus signaling.
3702	826470	18183416	2008-07-26 10:16	Data show that cryptochromes are shown to exert a positive effect on phototropic curvature under long-term irradiation conditions. Specifically, in a phot1-deficient genetic background (phot1 mutant), curvature is reduced in the absence of cryptochromes.
3702	826470	18252844	2008-08-02 10:05	Genetic analysis showed that CRYPTOCHROME1 acted independently from 5PTase13.
3702	826486	15908591	2005-12-02 11:58	atTOC75-IV of the Toc75 (translocon at the outer envelope membrane of chloroplasts, 75 kD)gene family is expressed uniformly throughout seed development. Homozygous atToc75-IV knockout plants displayed structural abnormalities. [TOC75-IV]
3702	826493	17559505	2007-12-01 12:59	required for recombination and acts to limit recombination between diverged sequences
3702	826571	16709193	2007-08-25 21:21	TT8 expression is controlled by different combinations of MYB and bHLH factors in planta.
3702	826586	16515858	2007-08-25 12:32	These experiments indicate that the ectopic co-expression of SEPALLATA3 and SHATTERPROOF1 and/or SEEDSTICK is probably not sufficient to homeotically transform vegetative tissues into carpels with ovules.
3702	826595	16113211	2007-08-25 15:01	The promoters of the Arabidopsis cytochrome c genes, Cytc-1 and Cytc-2, were analyzed using plants transformed with fusions to the beta-glucuronidase coding sequence.
3702	826609	15988568	2007-08-25 13:39	Findings suggests a role for DET1 in a ubiquitination pathway and identify a substrate for DET1-regulated protein turn-over.
3702	826609	16792691	2007-08-25 10:14	Arabidopsis cullin 4 is shown to assemble with DDB1, RBX1, DET1 and DDB2 in vitro and in planta.
3702	826609	17409070	2007-09-15 10:21	DDB1A-dependent phenotypes indicate a competition between DDB2- and DET1-containing complexes for available DDB1A, while, for DDB1A-independent phenotypes, DDB1B is able to fulfill this role.
3702	826623	15347798	2007-08-25 11:11	controls Na(+) homeostasis and through this function regulates K(+) nutrient status
3702	826623	16359386	2007-08-25 12:58	AtHKT1 selectively unloads sodium directly from xylem vessels to xylem parenchyma cells.
3702	826623	16540484	2007-08-25 14:11	SOS3 and AtHKT1 are major determinants of salinity resistance such that sos3 more strongly causes Na+ overaccumulation in roots, whereas athkt1 causes an increase in Na+ levels in the xylem sap and shoots and a concomitant Na+ reduction in roots.
3702	826623	17140289	2007-09-29 11:26	Using DNA microarray-based genotyping, identified AtHKT1 as the casual locus driving the natural variation in shoot Na(+) accumulation we observed in Ts-1 and Tsu-1
3702	826623	17324235	2007-08-25 11:46	AtHKT1;1 contributes to the control of both root accumulation of Na(+) and retrieval of Na(+) from the xylem, but is not involved in root influx or recirculation in the phloem.
3702	826626	15749754	2007-08-25 14:38	Analysis of the xanthophyll binding LHC proteins showed that the Lhcb5 photosystem II subunit (also called CP26) undergoes a change in its pI upon binding of zeaxanthin.
3702	826626	17850797	2007-12-01 12:40	location of the neoxanthin binding site in CP26 and CP29 was investigated by site-directed mutagenesis.
3702	826626	18381925	2008-08-09 10:05	Photosynthesis was affected in plants lacking CP24 but not in plants lacking CP26: CP24 mutant had decreased electron transport rates, lower DeltapH gradient across the grana membranes, reduced capacity for nonphotochemical quenching, and limited growth
3702	826630	16679457	2006-10-25 15:51	NIP5;1 functions as a boric acid channel for Boron uptake and is crucial for plant growth under Boron limitation in Arabidopsis.
3702	826707	15744502	2007-08-25 12:38	may play a role in mitochondrial DNA recombination
3702	826714	16798886	2007-08-25 21:21	Data show that small interfering RNAs and larger RNA fragments corresponding miRNA target genes accumulate in wild-type plants but not in ago1, the RNA-dependent RNA polymerase mutants rdr2 and rdr6, or the Dicer-like mutants dcl1 and dcl3.
3702	826714	17785412	2007-11-10 12:44	RDR2 is required for reception of long-distance mRNA silencing.
3702	826728	15976272	2005-10-28 16:26	SGT1b antagonizes RAR1 to negatively regulate R protein accumulation before infection, and SGT1b has a RAR1-independent function that regulates programmed cell death during infection [SGT1b]
3702	826728	18032631	2008-03-10 14:15	Biochemical reconstitution experiments suggest that RAR1 may function to enhance the SGT1-HSP90 interaction by promoting ternary complex formation.
3702	826728	18052881	2008-03-22 12:55	Genetic analysis revealed that ssi4-induced H(2)O(2) accumulation and spontaneous cell death require RAR1, whereas ssi4-mediated stunting is dependent on SGT1b.
3702	826728	18065690	2008-08-09 10:19	Data show that intact C-terminal SGT1-specific (SGS) domain that is required for all known SGT1b functions in immunity and development is needed for HSC70 interaction and for the nuclear accumulation of SGT1b.
3702	826730	16028113	2007-08-25 14:23	Data showed that the expression of ACS6 is induced during hypoxia.
3702	826730	18182027	2008-05-10 10:22	This study demonstrated that unphosphorylated ACS6 protein is rapidly degraded by the 26S proteasome pathway; the impact of this system on ethylene biosynthesis is discussed.
3702	826763	16725371	2007-08-25 12:30	involved in the regulation of cellular lipid homeostasis
3702	826766	17586656	2007-10-20 10:20	These data demonstrate that neither cytosolic nor mitochondrial NTRs are essential in plants.
3702	826803	18243102	2008-02-06 12:00	AT4g11960 is involved in cyclic electron transport around photosystem I and has been renamed PGRL1B. [PGRL1B]
3702	826805	16774931	2006-11-14 18:08	ADP-sugar pyrophosphatases (ASPP) catalyzes the hydrolytic breakdown of ADP-glucose linked to starch biosynthesis [ASPP]
3702	826860	17786468	2008-03-15 10:12	we propose that EARLI1 proteins have a bimodular architecture in which the proline-rich domain may interact with the cell wall and the 8CM domain with the plasma membrane to protect the cells during freezing stress
3702	826875	16179646	2005-11-30 08:09	ORC1a and ORC1b are regulated by the E2F/DP family of transcription factors and AtORC1b promoter is active exclusively in proliferating cells
3702	826884	16328543	2007-08-25 21:18	GFG1 is a key gene linking cellular metabolism and oxidative signaling.
3702	826884	16531493	2007-06-27 11:12	FMO1 and NUDT7 are important for signaling through an EDS1-dependent but SA-independent branch of plant defense and NUDT7 exerts negative control of EDS1 signaling. [NUDT7]
3702	826884	17660350	2008-01-12 12:01	functions to modulate the defense response to prevent excessive stimulation, ADP-ribose and NADH are preferred substrates
3702	826884	18393624	2008-07-26 10:36	A role for poly(ADP-ribosyl)ation in plant defense responses was suggested initially by the upregulated expression of genes encoding NUDT7 and poly(ADP-ribose) glycohydrolase in multiple R-avr interactions.
3702	826973	15734909	2007-08-25 10:59	Upregulation of the HAK5 protein in response to potassium deprivation in A. thaliana.
3702	826973	18281719	2008-05-24 10:05	AtHAK5 is a root plasma membrane uptake mechanism for K(+) and Cs(+) under conditions of low K(+) availability.
3702	826983	16806203	2007-08-25 10:13	Electrophysiological studies of Arabidopsis AtAMT1;1 expressed in oocytes revealed passive, Deltapsi-driven transport of NH(4)(+) through this protein.
3702	826983	16917981	2007-08-25 11:52	participates in concentrative NH4+ acquisition in roots, in long-distance transport to the shoots, and in re-uptake of apoplastic NH4+ that derives from photorespiration in shoots
3702	826983	17026539	2007-08-25 12:26	The results of this study suggest an additive contribution of AMT1;1 and AMT1;3 to the overall ammonium uptake capacity in Arabidopsis roots under nitrogen-deficiency conditions.
3702	826983	17172286	2007-08-25 14:02	The posttranscriptional regulation of AMT1 in transgenic N. tabacum plants is reported.
3702	826983	17293878	2007-08-25 14:01	the soluble cytosolic carboxy terminus of AMT1 from Arabidopsis thaliana serves as an allosteric regulator essential for function; mutations in the C-terminal domain led to loss of transport activity
3702	826984	16923017	2007-08-25 21:17	SMAP1 is a regulatory component that mediates responses to 2,4-dichlorophenoxyacetic acid (2,4-D), and that responses to 2,4-D and IAA are partially distinct.
3702	827004	16244908	2007-08-25 15:07	The isolation and expression of PAP23 in A. thaliana flowers is reported.
3702	827021	16396834	2007-08-25 11:59	has exonuclease properties that are similar to the human WRN protein
3702	827028	16951055	2007-08-25 14:05	A histone methylation-dependent DNA methylation pathway is uniquely impaired by deficiency in adenosylhomocysteinase.
3702	827046	15807784	2005-10-26 14:39	Two putative glycosyltransferase genes (At5g17050 and At4g14090) induced by PAP1 expression were confirmed to encode flavonoid 3-O-glucosyltransferase and anthocyanin 5-O-glucosyltransferase, respectively. [5-O-glucosyltransferase]
3702	827049	18067529	2008-04-12 11:12	study concludes that the COP9 signalosome maintains a precise regulation of eIF3e levels, which is necessary for normal development in Arabidopsis
3702	827054	17720869	2007-12-22 12:30	Kinesin-12 members serve as dynamic linkers of the plus ends of antiparallel microtubules in the phragmoplast.
3702	827058	17762870	2007-11-28 11:49	AtPRD1 is involved in meiotic recombination and is required for meiotic double-strand break repair.[AtPRD1]
3702	827061	16101912	2007-08-25 11:26	The penetrance and expressivity of RNAi-mediated silencing of the phytoene desaturase gene in A. thaliana were examined quantitatively to provide a reference for the likely severity and distribution of silencing effects.
3702	827061	17486124	2007-10-13 10:49	both the albino and dwarf phenotypes of the pds3 mutant resulted from functional disruption of the PDS3 gene. accumulated phytoene in the pds3 mutant might play an important role in certain negative feedbacks
3702	827085	16297071	2007-08-25 13:38	The effects of mutation on the structure and function of ACD6 in response to salicylic acid and disease resistance are reported.
3702	827102	16236149	2007-08-25 14:23	Tissue-specific expression of a stabilized Aux/IAA protein allows analysis of tissue-specific auxin responses in LR development by inactivating ARF functions.
3702	827102	17369427	2007-08-25 15:03	There are functional differences among the Aux/IAA gene family members MSG2, AXR2, and SLR.
3702	827103	15546359	2007-08-25 14:45	The molecular cloning of AXR5 revealed that the gene encodes the IAA1 protein, a member of the Aux/IAA family of proteins.
3702	827117	16121251	2007-08-25 11:26	HSP101B open reading frame is transcribed in the leaves and influorescences of high-temperature stress treated Arabidopsis thaliana but not in low-temperature stress and control plants.
3702	827119	16028115	2007-08-25 14:23	Elip2 expression is differentially regulated in response to light or chilling stress with mechanisms active either at transcriptional and post-transcriptional level.
3702	827119	16778010	2007-08-25 14:08	Null mutations within the ELIP2 gene do not modify sensitivity to photoinhibition, photooxidation, or the ability to recover from light stress.
3702	827119	16829586	2007-08-25 10:13	we propose that the discrepancy between amounts of Elip transcripts and proteins in light stress-preadapted or senescent leaves is related to a presence of photoprotective anthocyanins or to lower chlorophyll availability, respectively
3702	827119	17553115	2007-10-20 11:56	Elip2 works as a chlorophyll sensor that modulates chlorophyll synthesis to prevent accumulation of free chlorophyll, and hence prevent photooxidative stress.
3702	827121	16179646	2005-11-29 15:57	ORC1a and ORC1b are regulated by the E2F/DP family of transcription factors and AtORC1a is preferentially expressed in endoreplicating cells. [ORC1a]
3702	827121	16179646	2005-11-30 08:09	ORC1a and ORC1b are regulated by the E2F/DP family of transcription factors and AtORC1b promoter is active exclusively in proliferating cells
3702	827121	16537544	2007-08-25 10:17	ORC1 and Mcm3 proteins are required for DNA replication in protein extracts from human cells
3702	827123	16916932	2007-01-05 16:18	PPD locus is composed of two homologous genes, PPD1 and PPD2, which encode putative DNA-binding proteins. Overexpression of PPD reduces lamina size by promoting the early arrest of DMC proliferation during leaf and silique development. [PPD1]
3702	827125	16916932	2007-01-05 21:00	PPD locus is composed of two homologous genes, PPD1 and PPD2, which encode putative DNA-binding proteins. Overexpression of PPD reduces lamina size by promoting the early arrest of DMC proliferation during leaf and silique development. [PPD2]
3702	827145	16166087	2006-05-08 16:12	O-acetylserine sulfhydrylase catalyzes the final step of cysteine biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent conversion of O-acetylserine into cysteine. [O-Acetylserine sulfhydrylase ] [AtOASS]
3702	827145	18223034	2008-05-17 10:16	Null alleles of oastlA or oastlB alone showed that cytosolic OAS-TL A and plastid OAS-TL B were completely dispensable, although together they contributed 95% of total OAS-TL activity. oastlC plants also showed retarded growth.
3702	827149	16511155	2007-08-25 11:57	preliminary X ray structure
3702	827154	17641820	2007-12-01 11:03	Cys213Tyr mutant roots twist in a right-handed direction and have shallow left-handed cortical microtubule arrays when challenged with low doses of microtubule drugs.
3702	827173	18033885	2007-12-08 10:03	study shows FHY3 & FAR1, which encode proteins related to Mutator-like transposases, act together to modulate phyA signaling by activating transcription of FHY1 & FHL
3702	827200	16293760	2007-08-25 13:37	the importance of PEN1 and PEN2 functions in powdery mildew nonhost interaction
3702	827215	16258015	2007-08-25 11:59	In vitro HPL (Hydroperoxide lyase)activity analyses show undetectable HPL activity in the Col ecotype and reduced amounts of hexanal and no detectable trans-2-hexenal generated in the Col ecotype.
3702	827226	16915520	2007-05-25 17:34	In cotyledons pyruvate orthophosphate dikinase may be important in supplying phosphoenol pyruvate to gluconeogenesis, and in ageing leaves it allows remobilisation of nitrogen to supply reproductive tissue [pyruvate orthophosphate dikinase] [PPDK]
3702	827297	15282545	2005-11-10 14:31	identification of the Arabidopsis response regulator 2 (ARR2) as a signalling component functioning downstream of ETR1 in ethylene signal transduction [ARR2]
3702	827297	16407152	2007-08-25 10:40	Transgenic overexpression of wild-type, but not an unphosphorylatable mutant ARR2, led to delayed senescence of leaves.
3702	827308	16709189	2007-08-25 21:21	OIP16-S contains multiple G-box ABA-responsive elements (ABREs) in the promoter region, is regulated by ABI3 and ABI5 and is strongly expressed during the maturation phase in seeds and pollen grains.
3702	827319	15753105	2007-08-25 13:41	The expression of 35S:NtPHYB:GFP and 35S:AtPHYB:GFP complemented the tobacco hgl2 and Arabidopsis phyB-9 mutations, whereas the 35S:AtPHYD:GFP only rescued the hgl2 mutant
3702	827323	16421562	2007-08-25 21:09	results indicate that FCA is an ABA receptor involved in RNA metabolism and in controlling flowering time
3702	827323	16940039	2007-08-25 21:26	FLC is repressed by genes of the autonomous promotion pathway.
3702	827323	17916737	2007-10-20 11:06	it is proposed that FCA and FPA regulate chromatin silencing of single and low-copy genes and interact in a locus-dependent manner with the canonical small interfering RNA-directed DNA methylation pathway to regulate common targets
3702	827323	17996704	2008-01-26 12:02	There is a close association of FCA and FLD in mediating H3K4 demethylation and thus transcriptional silencing of FLC.
3702	827328	18308939	2008-04-12 12:08	The DOCK family protein SPIKE1 (SPK1) is a GEF, and that one function of SPK1 is to control actin polymerization via two heteromeric complexes termed WAVE and actin-related protein (ARP) 2/3.
3702	827332	13129917	2004-09-27 16:04	Transcription of At4g16370 is upregulated in Mn-, iron-, and copper-deficient plants. At4g16370 can rescue yeast CTR1 (copper deficient) and Smf1 (manganese deficient) mutants, suggesting a function in metal transport.
3702	827332	18083798	2008-06-07 10:18	AtOPT3 plays a critical role in two important aspects of iron metabolism, namely, maintenance of whole-plant iron homeostasis and iron nutrition of developing seeds.
3702	827381	15159576	2007-08-25 11:07	x-ray crystallography of two peroxisomal acyl-CoA oxidases, ACX1 and ACX4, from Arabidopsis thaliana
3702	827381	17172287	2007-08-25 14:02	The effects of mutations in ACX1 and ACX5 in A. thaliana on jasmonic acid synthesis are reported.
3702	827397	17217463	2007-08-25 10:44	One mutant that suppresses snc1-mediated constitutive resistance is modifier of snc1 5 (mos5), which carries a 15-bp deletion in UBA1.
3702	827397	17977156	2007-12-29 11:08	The regulation of SNC1 possibly exemplifies a universally complex control of R genes to ensure a repression of R activation under nonstress conditions and a robust activation of defense responses once the R gene is induced.
3702	827403	15122498	2007-08-25 11:03	The fitness costs of disease resistance in A. thaliana plants homozygous for RPS2 or RPP5 are reported.
3702	827419	16297066	2007-08-25 13:38	Carbohydrate analysis and freezing stress results of BMY8 RNAi lines indicate that increased maltose content contributes to the protection of the photosynthetic electron transport chain during freezing stress.
3702	827450	18318687	2008-09-27 10:07	Localization of AtMSH5 to the chromatin at mid-prophase I is dependent on expression of AtMSH4.
3702	827464	17204538	2007-08-25 12:23	Mutual regulation of APETALA2 and ethylene-responsive element binding protein in A. thaliana is described and discussed.
3702	827472	15964279	2005-11-18 15:43	MOS6, identified by positional cloning, encodes importin alpha3, one of eight alpha importins in Arabidopsis [MOS6]
3702	827481	17922773	2007-12-22 12:46	The results of this study imply that plasma membrane-localized CBL1- and CBL9-CIPK23 complexes simultaneously regulate potassium transport processes in roots and in stomatal guard cells.
3702	827498	16771775	2007-08-25 14:09	2-deoxyglucose stimulates Threonine 49 phosphorylation of endogenous TPS5 in Arabidopsis cells.
3702	827526	17237190	2007-08-25 10:08	At5PTase1 and At5PTase2 genes have nonredundant roles in hydrolyzing inositol second-messenger substrates and that regulation of myoinositol 1,4,5-trisphosphate levels is important during germination and early seedling development.
3702	827529	15710407	2007-08-25 10:23	Turnip mosaic virus (TuMV), another member of the genus Potyvirus, multiplied in mutant plants lacking eIF4E but not in mutant plants lacking eIF(iso)4E
3702	827529	17316629	2007-08-25 13:25	coordinated and selective recruitment of eIF4E and eIF4G factors at a very early step in potyvirus infection
3702	827550	17217470	2007-08-25 10:44	In mutants the number of starch granules per plastid dramatically decreased leading to a large increase in their size.
3702	827564	17449806	2007-11-08 12:00	DEG5 and DEG8 have a synergistic function in the primary cleavage of the CD loop of the PSII reaction center protein D1. [DEG5]
3702	827577	16766691	2007-08-25 11:54	Results suggest that due to the structural similarity of SNI1 to Armadillo repeat proteins, SNI1 may form a scaffold for interaction with proteins that modulate transcription.
3702	827577	17360504	2007-08-25 14:00	RAD51D and SNI1 have dual roles in pathogenesis-related gene transcription and DNA recombination
3702	827580	15884974	2007-08-25 13:05	Gun4 is involved in the stimulation of Mg-chelatase activity.
3702	827580	17123104	2007-08-25 14:03	Comparison of the amino acid sequence of CHLI 1 and CHLI 2 encoded in the genome of acifluorfen herbicide resistant mutant aci5 and wild type revealed in particular alterations of the C-terminal end.
3702	827611	17693534	2007-12-22 12:50	These data suggest that MYB98 functions as a transcriptional regulator in the synergid cells and activates the expression of genes required for pollen tube guidance and filiform apparatus formation.
3702	827612	15980264	2007-08-25 10:57	Microarrays have been used to identify genes that exhibit a similar expression pattern to the secondary cell wall-specific cellulose synthase genes IRX1 and IRX3.
3702	827612	15998313	2007-08-25 11:20	The isolation and characterization of new alleles of the IRX1 gene with an increased tolerance to water stress are reported.
3702	827631	15155890	2007-08-25 13:49	floral phenotype of bellringer mutants is caused by derepression of AG, suggesting that BLR functions as a transcription repressor
3702	827631	15634696	2007-08-25 14:16	AG activates biosynthesis of gibberellin, which has been proposed to promote the shift from meristem identity to differentiation
3702	827631	16679456	2007-08-25 11:56	The data provides genetic evidence for the role of AP1 in these interactions by showing that the floral phenotype in the ap1 agl24 svp triple mutant is significantly enhanced.
3702	827631	17573799	2008-01-05 16:52	AG and miR172 have distinct functions in flower development and that they largely act independently in the negative regulation of AP2.
3702	827631	17881378	2007-12-01 13:11	The Arabidopsis homologs of trithorax (ATX1) and enhancer of zeste (CLF) interact to control the expression of the flower homeotic gene AGAMOUS.
3702	827631	17981996	2008-03-10 13:39	These results indicate that stamen identity and differentiation control by AG is achieved by the regulation of different transcriptional cascades in different floral stages.
3702	827631	18256838	2008-09-27 10:17	Transgenic Arabidopsis plants harboring two tissue-specific promoters, fAGIP and rAGIP in forward and reverse orientations, fAGIP::GUS or rAGIP::GUS displayed similar GUS expression specifically in carpel and stamen tissues and their primordial cells.
3702	827642	16212604	2007-08-25 13:38	The identification of EDR2 in A. thaliana in plants resistant to powdery mildew is reported.
3702	827661	16786298	2006-11-27 14:22	AtRLI2 acts as an endogenous suppressor of RNA silencing. [AtRLI2]
3702	827663	16543410	2007-08-25 14:10	CYP707A1 is expressed in Arabidopsis seeds predominantly during mid-maturation and is down-regulated during late-maturation and plays a distinct role in seed development and postgermination growth.
3702	827706	18055610	2008-03-10 15:45	These results indicate that the two types of plant Rab5 members are functionally differentiated, even though they are regulated by the same activator, VPS9a.
3702	827710	17076807	2007-08-25 13:28	The role of NPR1, NPR3, and NPR4 in the disease resistance of A. thaliana are reported.
3702	827713	17029360	2007-11-10 12:01	Although ferrous ions and other IRT1-transported metal ions do not bind very tightly, the Histidine-rich sequence has a very high entropy-driven affinity for Fe3+, which may have biological significance.
3702	827713	18268542	2008-07-19 10:11	ferric-chelate reductase FRO2 and ferrous-transporter IRT1 are the targets of the three transcription factors and the transcription of FRO2 and IRT1 is directly regulated by a complex of FIT/AtbHLH38 or FIT/AtbHLH39.
3702	827713	18305211	2008-08-09 10:44	Expression of each of the IRT1 variants in plants from the 35S promoter revealed that K146 or K171 is required for iron-induced protein turnover, and 35S-IRT1K146R,K171R plants contain higher levels of iron compared to 35S-IRT1 and wild type
3702	827752	16496096	2007-08-25 12:32	Mutants demonstrated higher allantoate levels than wild-type plants in the presence and absence of exogenous ureides.
3702	827752	18065556	2008-06-07 10:19	The isolation and characterization of Allantoate amidohydrolase in A. thaliana and G. max are reported.
3702	827760	18088309	2008-05-21 15:42	The results of this study suggest that GASSHO1 and GASSHO2 genes are essential for the formation of a normal epidermal surface during embryogenesis.[GASSHO1] [GSO1]
3702	827785	15618421	2007-08-25 21:15	Expression of FT or TSF in winter-annual flowering A. thaliana.
3702	827785	17540570	2007-09-08 10:18	Here we show that FT mRNA is required in phloem companion cells where it acts partially redundant with its paralog TWIN SISTER OF FT (TSF) to induce flowering.
3702	827786	15347794	2007-08-25 11:11	the roles of LSD1 in light acclimation and in restricting pathogen-induced cell death are functionally linked
3702	827786	15469500	2007-08-25 15:08	Use in the implementation of bimolecular fluorescence complementation for visualization of protein-protein interactions in plant cells.
3702	827786	16957775	2007-08-25 12:27	LSD1 likely functions as a cellular hub, where its interaction with AtbZIP10 and additional, as yet unidentified, proteins contributes significantly to plant oxidative stress responses
3702	827786	18055613	2008-03-10 15:45	The balanced activities of LSD1, EDS1, and PAD4 regulate lysigenous aerenchyma formation in response to hypoxia.
3702	827826	16240180	2007-08-25 14:14	The functional role of CML42 and CML43 in A. thaliana infected with P. syringae is reported.
3702	827833	15908606	2007-08-25 13:08	The purification and characterization of tripeptidyl peptidase II from Arabidopsis thaliana is reported.
3702	827839	16111943	2007-08-25 21:14	HEN1 is a miRNA methyltransferase that adds a methyl group to the 3'-most nucleotide of miRNAs as well as siRNAs from sense transgenes, hairpin transgenes, and transposons or repeat sequences, and a new class of siRNAs known as trans-acting siRNAs.
3702	827857	16792691	2007-06-29 09:00	Arabidopsis cullin 4 is shown to assemble with DDB1, RBX1, DET1 and DDB2 in vitro and in planta.[DDB1b]
3702	827868	17644628	2008-01-12 11:12	scc7-D (suppressors of cry1cry2)is a gain-of-expression allele of the GA2ox8 gene.
3702	827869	17996018	2008-05-24 10:17	molecular cloning and functional analysis of the two unique C3 pyruvate, orthophosphate dikinase regulatory proteins, RP1 and RP2, in Arabidopsis thaliana are reported
3702	827876	18088313	2008-05-29 18:01	Arabidopsis AtKIN14a and AtKIN14b genes encoding highly similar kinesins are two of the most closely related Arabidopsis paralogs. They together play important roles in controlling plant reproductive development. [AtKIN14a]
3702	827877	16822865	2007-08-25 13:31	Results indicate that the loss of the PsbQ protein induces significant changes in Photosystem II function, particularly in low light-grown plants, and that the PsbQ protein is required for photoautotrophic growth under low light conditions.
3702	827880	16500991	2006-10-25 16:18	Hsa32 is a heat shock protein that may be required not for induction but rather maintenance of acquired thermotolerance. [Hsa32]
3702	827883	16831835	2006-11-16 14:01	DYT1 encodes a putative bHLH transcription factor and is a component of a genetic network that controls anther development and function. [DYT1]
3702	827911	16845525	2007-08-25 21:02	results demonstrate a cellular mechanism for establishing the distinct cell types and a role for IND in regulating the unequal cell divisions in the seven-layer zone
3702	827912	15860014	2005-10-28 16:11	The relative importance of UGT72B1 in the conjugation of 3,4-dichloroaniline (DCA) and 2,4,5-trichlorophenol (TCP) in knockout mutations of A. thaliana is reported. [UGT72B1]
3702	827912	18077347	2008-02-02 11:09	To investigate UGT72B1 dual activity, the structure of this protein was solved, at resolutions up to 1.45 A, in various forms including the Michaelis complex with intact donor analog and trichlorophenol acceptor.
3702	827934	16435266	2007-08-25 12:34	Embryo development in the atToc132/159 mutants proceeded slowly and was arrested at the transition to the heart stage.
3702	827934	17261588	2007-08-25 10:07	By combining these models with the measured enzymatic properties of the Toc GTPases, we provide new insights of how the chloroplast protein import cycle may be regulated
3702	827934	17636260	2007-11-10 10:19	analysis of Toc159- and Toc75-independent import of a transit sequence-less precursor into the inner envelope of chloroplasts
3702	827934	17950698	2008-01-26 12:02	the three domains commonly referred to as A, G, and M originate from the GTPase G domain, tandemly repeated, and probably evolving toward an unstructured conformation in the case of the A domain.
3702	827934	18487635	2008-08-09 10:30	Phosphorylation disturbs the association of Toc34, but not of Toc159 with the translocation pore proteins.
3702	828008	16412087	2007-08-25 14:12	EID1 is expressed during all stages of Arabidopsis development and regulates photomorphogenesis in seedlings, rosette leaf development and flowering.
3702	828013	17092311	2007-07-02 12:37	These results indicate that frataxin is an essential protein in plants, required for full activity of mitochondrial Fe-S proteins and playing a protective role against oxidative damage. [frataxin] [ATFH]
3702	828013	17258206	2007-08-25 12:22	findings suggest a key role of plant frataxin during embryogenesis
3702	828044	15361145	2007-08-25 12:59	The suppression of late flowering is caused by the inability of FRIgida to increase late flowering.
3702	828044	15908596	2007-08-25 13:08	The contribution to variation in flowering time and vernalization of the two genes FRIGIDA (FRI) and FLOWERING LOCUS C (FLC), previously shown to be important determinants in natural variation of flowering time is reported.
3702	828044	16291783	2007-08-25 21:24	Epistasis analysis between FES1, FRI and FRIGIDA-LIKE 1 (FRL1), indicates that these genes do not function in a linear pathway, but instead act cooperatively to promote the expression of FLC.
3702	828044	16547097	2007-08-25 21:01	FRI upregulates FLC expression that represses flowering
3702	828044	17940010	2007-12-01 12:37	These antagonistic pleiotropic effects reduce the adaptive value of FRI, and helps explain the maintenance of alternative life history strategies across natural populations of A. thaliana.
3702	828044	18156133	2008-05-31 10:05	The role of FLX in the timing of flowers and the expression of other flowering-related proteins, including FRIGIDA and FLC, is reported.
3702	828053	17092320	2007-06-29 10:01	AtLEA5 has a unique function among LEA proteins in that it plays a specific role in protection against oxidative stress involving decreased photosynthesis. [AtLEA5]
3702	828066	15949803	2005-10-26 16:13	Arabidopsis phosphatidylinositol phosphate (PtdInsP) kinase 10 (AtPIPK10; At4g01190) was cloned and characterized. [Arabidopsis phosphatidylinositol phosphate kinase 10 ] [AtPIPK10]
3702	828084	17557810	2007-11-08 15:04	Jagged Lateral Organs (JLO) acts from the boundary to orchestrate the drastic changes in gene expression that entail the initiation of plant lateral organs. [JLO]
3702	828149	17098812	2007-09-14 17:14	Membrane-bound transcription factor, NTM1 (for NAC with transmembrane motif1), that belongs to the plant-specific NAC transcription factor family controls cell division in Arabidopsis.[NTM1]
3702	828149	18319616	2008-06-14 10:34	Data suggest that the reduced growth observed in the ntm1-D mutant is caused by enhancement of its stress responses, possibly resulting in a cost in fitness.
3702	828151	16813576	2007-08-25 11:53	The susceptibility of A. thaliana plants to Alternaria brassicicola that induces defensive pathways via EDS1 and PAD4 is reported.
3702	828151	17023433	2007-08-25 13:29	MEKK1 is essential for activation of MPK4 and negatively regulates temperature-sensitive and tissue-specific cell death and H(2)O(2) accumulation that are dependent on both RAR1 (resistance protein function) and SID2 (isochorismate synthase)
3702	828151	17142480	2007-08-25 13:27	This study demonstrated that analysis of plants carrying T-DNA knockout alleles indicated that MEKK1 is required for flg22-induced activation of MPK4.
3702	828151	17572407	2007-10-20 11:08	Treatment with elevated levels of sodium chloride inhibits the growth of mpk4 transgenic plants; the mekk1;mpk4 double-mutant combination causes seedling lethality.
3702	828151	17630279	2007-12-01 11:49	These results demonstrate a key role for the AP2C1 phosphatase in regulating stress hormone levels, defense responses, and MAPK activities in Arabidopsis.
3702	828151	18650934	2008-09-13 10:45	These data establish direct links between MPK4 and innate immunity and provide an example of how a plant MAP kinase can regulate gene expression by releasing transcription factors in the nucleus upon activation.
3702	828165	16924116	2007-01-08 13:30	MEA and SWN are SET-domain partners of FIS2 and perform partially redundant functions in controlling the initiation of endosperm development before fertilization in Arabidopsis. [SWINGER] [SWN]
3702	828182	17384166	2007-08-25 15:00	Mg(2+) and (E,E,E,)-geranylgeranyl diphosphate (GGPP) exert synergistic substrate inhibition effects on ent-copalyl diphosphate synthase activity.
3702	828213	16133214	2007-08-25 21:06	data support the hypothesis of a subtle involvement of the PII protein in the regulation of some steps of primary C and N metabolism
3702	828213	16377628	2007-08-25 21:14	Data show that the major Arabidopsis PII-interacting protein is the chloroplast-localized enzyme N-acetyl glutamate kinase, which catalyzes the key regulatory step in the pathway to arginine biosynthesis.
3702	828213	16545809	2007-08-25 12:32	In vitro assays using purified recombinant proteins showed the catalytic activation of Arabidopsis N-acetyl glutamate kinase (NAGK) by PII giving the first evidence of a physiological role of the PII protein in higher plants.
3702	828213	17279613	2007-08-25 14:01	crystal structure; a highly conserved segment at the N-terminus that is found only in plant PII forms numerous interactions with the alpha2 helix and projects from the surface of the homotrimer opposite to that occupied by the T-loop
3702	828213	18325336	2008-06-14 10:34	A light-dependent nitrite uptake into chloroplasts is increased in PII knock-out mutants.
3702	828230	15014444	2005-09-30 15:00	essential role of Brca2 during meiosis in Arabidopsis [BRCA2(IV)]
3702	828232	16183635	2007-08-25 10:57	the riboflavin kinase and FMN hydrolase domains of AtFMN/FHy can be physically separated, with little change in their kinetic properties
3702	828254	16148005	2007-08-25 10:57	The mechanisms of reading the CTD code by two classes of protein phosphatases, plant CPLs and yeast Ssu72, that specifically dephosphorylate Ser(5) in vitro are reported.
3702	828254	18541146	2008-07-26 10:32	ANAC019 and AtMYB3 specifically interact with the C-terminal region (640-967) of AtCPL1 containing two double-stranded RNA binding motifs.
3702	828256	18310462	2008-08-02 10:16	Mutant plants that lack both GA3ox1 and GA3ox3 functions displayed stamen and petal defects, indicating that these two genes are important for GA production in the flower.
3702	828263	17301085	2007-08-25 10:43	A 101 bp fragment that conferred all aspects of ATML1 expression contained known binding sites for homeodomain transcription factors and other regulatory sequences.
3702	828311	15824192	2007-08-25 12:55	the AKT2/3 subunit constitutes the Ca2+ sensitivity of the guard cell K+ uptake channel
3702	828311	16297070	2007-08-25 13:38	The role of 2 phosphorylation sites on the switch between gating modes of AKT2 are described.
3702	828311	17146665	2007-08-25 13:27	AKT2-transformed tobacco mesophyll cells displayed inward-rectifying, rather than voltage-independent K+ channels.
3702	828316	17417719	2007-09-04 17:34	ISU1 has a role in mediating the assembly of iron-sulfur clusters in mitochondria.
3702	828321	16249174	2007-08-25 12:34	the exon 8 domain of PTOX (IMMUTANS) is required for PTOX activity and stability in Arabidopsis
3702	828321	16449381	2007-08-25 15:01	IMMUTANS appears to be a versatile electron sink, especially early in chloroplast development, when its function is crucial for carotenoid biosynthesis, and in excess light, when it serves as a 'safety valve'.
3702	828321	16891546	2007-08-25 10:12	Neither functional analyses of the immutans (IM) knockout and overexpression lines nor meta-analyses of gene expression support the model that IM acts as a safety valve to regulate the redox state of the PQ pool during stress and acclimation
3702	828321	17342448	2007-08-25 10:07	Plants lacking IM have enhanced rates of carbon assimilation with corresponding increases in the activities of Rubisco and SPS, elevated starch and sucrose pool sizes, and an altered pattern of carbohydrate partitioning that favors sucrose over starch.
3702	828388	18243102	2008-02-06 12:00	AT4g22890 is involved in cyclic electron transport around photosystem I and has been renamed PGRL1A. [PGRL1A]
3702	828391	17468209	2007-12-01 12:57	results collectively indicate that NYE1 plays an important regulatory role in chlorophyll degradation during senescence by modulating pheophorbide a oxygenase activity
3702	828394	16778081	2007-08-25 21:03	AGL19 expression is maintained at very low levels by the PcG proteins MSI1, CLF, and EMF2, and AGL19 is partly responsible for the early flowering phenotype of clf mutants.
3702	828396	16582011	2006-10-13 13:31	AESP plays an essential role in embryo development and is required for the removal of cohesin from meiotic chromosomes. [AESP]
3702	828400	15891899	2006-02-02 08:55	AtUTr2 is a nucleotide sugar transporter capable of transporting UDP-galactose that may play an important role in the synthesis of galactose-containing glycoconjugates in Arabidopsis. [UTr2]
3702	828409	17766407	2007-12-22 10:03	The thiol-based regulation of GCL provides a posttranslational mechanism for modulating enzyme activity in response to in vivo redox environment and suggests a role for oxidative signaling in the maintenance of glutathione homeostasis in plants.
3702	828420	17419849	2007-08-25 13:59	Upregulation of CRK13 leads to hypersensitive response-associated cell death, and induces defense against pathogens by causing increased accumulation of salicylic acid.
3702	828464	15500468	2007-08-25 21:23	Disruption of the TRH1 potassium transporter impairs root hair development in Arabidopsis, and also affects root gravitropic behaviour.
3702	828465	17032064	2007-08-25 10:10	CPK3 functions in guard cell ion channel regulation and provide genetic evidence for calcium sensors that transduce stomatal ABA signaling.
3702	828470	15341627	2007-08-25 14:52	AtCHX17 was expressed preferentially in epidermal and cortical cells of the mature root zones.
3702	828470	17133624	2007-08-25 10:46	results show that the proteins Arabidopsis thaliana Chx17 and Saccharomyces cerevisiae Kha1 could have similar functions.
3702	828481	17369373	2007-08-25 15:03	These results suggest that WRKY53 and ESR mediate negative crosstalk between pathogen resistance and senescence, which is most likely governed by the jasmonic acid and salicylic acid equilibrium.
3702	828481	17587183	2007-10-06 11:58	MEKK1 is a bifunctional protein: it binds to the promoter of the WRKY53 gene regulating the switch from a leaf age dependent to a plant age dependent expression
3702	828481	17977154	2007-12-29 11:08	WRKY53 and HSPRO2 appear to function downstream of salicylic acid and to be negatively regulated by signaling through jasmonic acid and ethylene.
3702	828492	17496119	2007-10-20 10:03	UGE2 and UGE4 influence growth and cell wall carbohydrate biosynthesis throughout the plant, UGE3 is specialized for pollen development, and UGE1 and UGE5 might act in stress situations.
3702	828504	17673210	2007-10-20 11:07	Arabidopsis trehalase is a plasma membrane-bound protein, probably anchored to the membrane through a predicted N-terminal membrane spanning domain.
3702	828512	16297069	2006-02-22 15:50	Yellow stripe 1 (YSL1) is responsible for long-distance circulation of iron and nicotianamine and their delivery to the seed.[YSL1]
3702	828512	16815956	2006-12-01 16:13	YSL1 and YSL3 are involved in the delivery of metal micronutrients to and from vascular tissues. [AtYSL1]
3702	828512	18042200	2008-03-10 13:38	The effects of mutations at YSL1 and YSL3 on mineral metabolism in A. thaliana throughout the life cycle are reported.
3702	828522	15155881	2007-08-25 13:49	SLY1 interacts directly with RGA and GA INSENSITIVE (GAI, a closely related DELLA protein) via their C-terminal GRAS domain
3702	828522	15161962	2007-08-25 13:06	SLY1 (the wild-type form) and sly1gar2-1 both confer substrate specificity on this complex via specific binding to the DELLA proteins
3702	828522	17384169	2007-08-25 15:00	RGL2 disappearance is not a prerequisite for seed germination in the sly1 background.
3702	828524	16231156	2006-12-22 14:15	Acyl-CoA-binding protein3 (ACBP3) localizes extracellularly and the affinities of the acyl-CoA-binding domain in ACBP3 are investigated by in vitro binding assays. [ACBP3]
3702	828525	15733871	2005-09-28 08:31	Ca(2+)-dependent Calmodulin-binding domain of AtWRKY7 is a conserved structural motif (C-motif) found in group IId of the WRKY protein family[WRKY7]
3702	828525	16963526	2007-08-25 10:48	Pathogen-induced WRKY7 transcription factor plays a negative role in defense responses to P. syringae.
3702	828531	18192441	2008-07-26 10:16	insertion knockout mutant plants exhibited variegated cotyledons, malformed leaves, growth retardation, and impaired root growth
3702	828547	18024995	2008-04-19 11:20	This study indicates that, although GWD2 is capable of phosphorylating alpha-glucans in vitro, it is not directly involved in transient starch degradation.
3702	828556	16679456	2007-08-25 11:56	The data provides genetic evidence for the role of AP1 in these interactions by showing that the floral phenotype in the ap1 agl24 svp triple mutant is significantly enhanced.
3702	828556	17428825	2007-08-25 15:03	once AP1 is activated during the floral transition, it acts partly as a master repressor in floral meristems by directly suppressing the expression of flowering time genes SVP, AGL24 and SOC1, preventing continuation of the shoot developmental program
3702	828556	18339670	2008-06-14 10:34	during floral transition, a positive-feedback loop conferred by direct transcriptional regulation between AGL24 and SOC1 at the shoot apex integrates flowering signals
3702	828556	18453531	2008-08-02 10:05	Complementation tests showed that rice OsMADS22 and OsMADS47 are unable to reverse the flowering-time phenotypes of the svp and agl24 mutants in Arabidopsis.
3702	828603	17324226	2007-08-25 11:46	AMY1 is transcriptionally induced in senescing leaves and in leaves exposed to heat stress, treated with abscisic acid or infected with Pseudomonas syringae pv. tomato expressing avrRpm1.
3702	828611	17135235	2007-08-25 21:21	is essential for the formation of chlorophyll and subsequently for the formation of photosystems I and II and cytochrome b6f complexes
3702	828617	16877495	2007-08-25 14:07	The accumulation of OLEO1 is instrumental in controlling oilbody structure and lipid accumulation in developing seeds.
3702	828623	18356953	2008-07-12 10:06	evolution of a pseudogene: diversity and divergence of HSP23.6
3702	828626	16212605	2007-08-25 13:38	Two closely related RPM1-interacting proteins, RIN2 and RIN3, are characterized in A. thaliana.
3702	828638	16500988	2006-10-26 17:36	SHB1 encodes a nuclear and cytosolic protein that has motifs homologous with SYG1 protein family members and is involved in regulating cryptochrome and possibly phytochrome-mediated light responses. [SHORT HYPOCOTYL UNDER BLUE1] [SHB1]
3702	828645	18069939	2008-07-12 10:26	Data show AtGA20ox1 and AtGA20ox2 act redundantly to promote hypocotyl and internode elongation, flowering time, elongation of anther filaments, the number of seeds that develop per silique and elongation of siliques.
3702	828645	18440929	2008-08-02 10:05	Expression of GA20ox1 is regulated at multiple levels.
3702	828651	15728337	2007-08-25 14:41	We explored the regulation of CBF1-3 by the circadian clock.
3702	828651	16244146	2007-08-25 21:05	The low freezing tolerance of FTQ4-Cvi (FREEZING TOLERANCE QTL 4) alleles was associated with a deletion of the promoter region of Cvi CBF2, and with low RNA expression of CBF2 and of several CBF target genes.
3702	828651	18093929	2008-01-19 12:54	CBF1 and CBF3, but not CBF2 have a concerted additive effect to induce the whole CBF regulon and the complete development of cold acclimation
3702	828652	15165189	2007-08-25 11:35	The recombinant DREB1A protein bound to A/GCCGACNT more efficiently than to A/GCCGACNA/G/C.
3702	828652	15728337	2007-08-25 13:05	We explored the regulation of CBF1-3 by the circadian clock.
3702	828652	15834008	2007-08-25 12:45	Makes transgenic plants more tolerant to stress conditions.
3702	828652	17416732	2007-10-06 11:59	Regulon genes repressed by siz1 did not affect expression of ICE1, which encodes a MYC transcription factor that controls CBF3/DREB1A.
3702	828652	17453213	2007-10-27 12:06	The freezing tolerance of 38 independent transgenic potato lines was tested in vitro using plantlets transgenic for the DREB1A gene under control of the rd29A promoter.
3702	828652	18093929	2008-01-19 12:54	CBF1 and CBF3, but not CBF2 have a concerted additive effect to induce the whole CBF regulon and the complete development of cold acclimation
3702	828653	15728337	2007-08-25 13:05	We explored the regulation of CBF1-3 by the circadian clock.
3702	828653	17080948	2007-08-25 21:21	Ectopic expression of AtCBF1 was sufficient to significantly increase the freezing tolerance of non-acclimated leaves and stems relative to wild-type plants.
3702	828653	18093929	2008-01-19 12:54	CBF1 and CBF3, but not CBF2 have a concerted additive effect to induce the whole CBF regulon and the complete development of cold acclimation
3702	828653	18182016	2008-05-31 10:29	Transgenic expression of CBF1 in 2 Solanum species suggested an endogenous CBFpathway is involved in many of the alterations associated with cold acclimation.
3702	828658	17144899	2007-08-25 12:25	The mechanisms of FWA silencing were studied.
3702	828658	17189287	2007-08-25 10:45	Specific interaction of FWA with FT enabled us to use FWA protein as a specific inhibitor of FT protein function
3702	828658	17921315	2008-04-26 13:06	Data show that the expression of FWA was repressed by Arabidopsis relatives of the human lysine-specific Demethylase1 and thus promote the floral transition.
3702	828658	18389059	2008-06-07 10:18	the tandem repeat structure is dispensable for the epigenetic silencing of the FWA gene
3702	828661	17699755	2007-10-27 11:06	in addition to their independent functions in phyA signaling, LAF1 and HFR1 also cooperate post-translationally to stabilize each other through inhibition of ubiquitination by COP1, thereby enhancing phyA photoresponses
3702	828703	17449644	2007-10-06 11:52	A significant amount of mitochondrial phosphatidylethanolamine is derived from the phosphatidylserine decarboxylase reaction in the endomembrane system.
3702	828706	16356489	2006-04-06 12:02	PEPPER (PEP), encodes a polypeptide with K-homology (KH) RNA-binding modules, which acts on vegetative growth and pistil development.[PEPPER] [PEP]
3702	828713	16211390	2007-08-25 13:38	An analysis of the interation of MEKK1 and MEK1 in response to wounding stress in A. thaliana seedlings is presented.
3702	828713	16913865	2007-08-25 13:30	A novel method of activating AtMPK proteins by fusion to a cis-acting mutant of a human MAPK kinase MEK1 was used to confirm that specific members of the AtMPK gene family can activate the RD29A stress pathway.
3702	828713	17059410	2007-08-25 13:28	This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.
3702	828713	17284251	2007-08-25 10:07	These results suggest that the formation of SUMO-1 foci is regulated by the MEK-ERK pathway and may induce apoptosis.
3702	828713	17728292	2008-02-02 12:03	AtMEK1 is a crucial mediator in plant stress signal transduction.
3702	828714	16365038	2007-08-25 21:24	the direct interaction between SRK2E/OST1 and ABI1 through Domain II plays a critical role in the control of stomatal closure
3702	828714	16571665	2006-08-23 08:37	ABI1 and ABI2 control fibrillin expression that is involved in mediating ABAinduced photoprotection. [ABI1]
3702	828714	16798945	2007-08-25 21:21	ABI1 works with HAB1 to negatively regulate ABA signaling.
3702	828714	17427804	2007-12-01 13:01	Study defines abscisic acid(ABA)-induced resistance to L. maculans as a subset of the ABA responses regulated via ABI-1 and ABI4.
3702	828714	18039663	2008-04-05 10:19	AtBI1 plays a pivotal role as a highly conserved survival factor during ER stress that acts in parallel to the unfolded protein response pathway
3702	828714	18298671	2008-08-16 10:37	abi1-1 acts as a hypermorphic allele, and ABI1 reprograms sensitivity towards ABA in the nucleus
3702	828715	15122498	2007-08-25 11:03	The fitness costs of disease resistance in A. thaliana plants homozygous for RPS2 or RPP5 are reported.
3702	828715	16212605	2007-08-25 13:38	Two closely related RPM1-interacting proteins, RIN2 and RIN3, are characterized in A. thaliana.
3702	828715	16845481	2007-08-25 21:02	Tobacco rattle virus based virus-induce gene silencing which require RPS2-mediated resistance.
3702	828721	17587690	2007-11-08 10:54	CGA1 encodes a GATA factor, whose expression is rapidly induced by both the light and cytokinin signals in Arabidopsis thaliana.[CGA1]
3702	828726	15699063	2005-11-17 13:00	Expression in response to plant growth regulators and abiotic stress in roots and aerial parts as demonstrated by expression of the GUS reporter in A. thaliana. [ACS7]
3702	828726	16028113	2007-08-25 14:23	Data showed that the expression of ACS7 is induced during hypoxia.
3702	828748	17220201	2007-07-02 16:00	GAMT1 and GAMT2 encode enzymes that use S-adenosine-L-methionine (SAM) as a methyl donor to methylate the carboxyl group of GAs. Both genes are expressed most highly in the siliques during seed development. [GAMT1]
3702	828749	17307927	2007-09-03 02:06	Results indicate that although CSN6A and CSN6B retain mostly redundant functions, CSN5A and CSN5B play unequal roles in the regulation of plant development.
3702	828756	17452319	2007-08-25 21:26	SufE3 is the NadA enzyme of A. thaliana, involved in a critical step during NAD biosynthesis
3702	828777	15557099	2007-08-25 12:39	Bound to GFP to label actin networks in multiple cell types in Nicotiana, Medicago, and Lycopersicon.
3702	828777	18028299	2008-03-10 14:58	To improve fluorescence for enhanced in vivo F-actin imaging, transgenic Arabidopsis plants were generated expressing a construct with green fluorescent protein fused to both the C- and N-termini of the actin binding domain.
3702	828791	17644626	2008-01-12 11:12	SIZ1-mediated conjugation of SUMO1 and SUMO2 to other intracellular proteins is essential in Arabidopsis, possibly through stress-induced modification of a potentially diverse pool of nuclear proteins.
3702	828792	16720601	2007-08-25 14:09	A high proportion of the primary roots of the vtc2 plants grown on soil had lost the wild-type responses to gravity.
3702	828792	17462988	2007-09-15 12:40	VTC2 from A. thaliana is a specific GDP-L-galactose/GDP-D-glucose phosphorylase
3702	828792	17485667	2007-08-21 09:18	At4g26850 codes for GDP-L-galactose-hexose-1-phosphate guanyltransferase which catalyzing the transfer of GMP from GDP-L-galactose to a hexose-1-P, most likely D-mannose-1-phosphate in vivo. [galactose guanyltransferase]
3702	828792	17877701	2008-03-10 15:00	Data show that a GDP-L-galactose phosphorylase, encoded by the Arabidopsis thaliana VTC2 gene, catalyses this step in the ascorbate biosynthetic pathway.
3702	828792	18463094	2008-08-23 10:38	Arabidopsis VTC2 and VTC5 proteins are enzymes that guanylylate a conserved active site His residue with GDP-L-galactose, forming L-galactose 1-phosphate for vitamin C synthesis, and regenerate the enzyme with phosphate to form GDP.
3702	828792	18516687	2008-09-27 10:17	The VTC2 gene was expressed in all developmental stages, and the mRNA was expressed at a higher level in green tissues than in the root.
3702	828805	17437406	2007-08-25 13:23	The identification of ACO1, ACO2, and ACO3 in A. thaliana is reported, and it was demonstrated that, in plants, the cytosolic ACOs are not converted into iron regulatory proteins.
3702	828814	15557095	2005-08-17 10:08	The role of SPIRAL2 in growth, chromosome mapping; its amino acid sequence, and phylogenetic relation to other Arabidopsis proteins. [SPR2]
3702	828826	17244481	2007-08-25 14:02	The microtubule-binding site at the tail domain of KatB or KatC can induce microtubules bundling only when the stalk domain is present.
3702	828834	17602188	2008-01-19 12:33	Results provide support for WES1 regulating hypocotyl growth by mediating phytochrome B-perceived light signals.
3702	828834	17704230	2008-01-05 14:24	This study shows that GH3.5 acts as a bifunctional modulator in both salicylic acid and auxin signaling during pathogen infection.
3702	828841	15299139	2005-01-26 14:17	Nozzle protein may coordinate proximal-distal and adaxial-abaxial polarity establishment in the developing ovule by interacting with YABBY proteins in vitro in Arabidopsis. [Nozzle (NZZ)]
3702	828841	17146616	2007-11-10 12:28	The cell-free method was used to synthesize SPL as a correctly folded and functional zinc-binding protein.
3702	828849	15341629	2007-08-25 14:52	RD26 functions as a transcriptional activator in abscisic acid-inducible gene expression under abiotic stress in plants.
3702	828853	15842619	2007-08-25 10:58	The analysis of PORA and PORB import into plastids of intact seedlings revealed an unexpected multiplicity of import routes that differed by their substrate, cell, tissue and organ specificities.
3702	828859	16279950	2007-08-25 13:03	PPI1 can bind the H(+)-ATPase independently of the C-terminus conformation, but is not able to suppress the C-terminus auto-inhibitory action.
3702	828859	18304198	2008-08-09 10:30	Data show that Ppi1 expression is strong in root and shoot vascular systems, particularly in meristematic and sink tissues, as well as in pollen, stigmas and siliques, but not in developing embryos.
3702	828881	18356953	2008-07-12 10:06	evolution of a pseudogene: diversity and divergence of HSP21
3702	828889	16805736	2006-11-27 14:18	ISI1 is part of a plant-specific mechanism that co-ordinates carbohydrate availability with gene expression and plant growth and development.[ISI1]
3702	828907	17522887	2007-12-01 11:52	MTM1(At4g27940)encodes a mitochondrial protein that may be playing an important role in activation of MnSOD1 [MTM1]
3702	828934	15342527	2005-05-27 17:48	Ultrapetal1 negatively regulates WUS to establish floral meristem determinacy [UTL1]
3702	828934	15673576	2005-05-25 17:57	ULTRAPETALA1 encodes a SAND domain putative transcriptional regulator that controls shoot and floral meristem activity in Arabidopsis [ULT1]
3702	828934	18441215	2008-08-09 10:44	genetic data suggest that RBL, SQN, and, to a lesser extent, ULT1 also influence SUPERMAN activity
3702	828970	15912356	2007-08-25 21:18	The isolation and characterization of deletion mutations of the alpha-subunits of cruciferin B and cruciferin C in A. thaliana are reported.
3702	828972	16126836	2006-03-10 15:04	PAPK1 represents a novel plant protein kinase that is targeted to plasmodesmata and may play a regulatory role in macromolecular trafficking between plant cells.[PAPK1]
3702	828981	17517886	2007-09-22 11:34	AtATM1, AtATM2, and AtATM3 are a subfamily of Arabidopsis half-molecule ATP-binding cassette transporters implicated in iron homeostasis
3702	828981	18179725	2008-09-20 10:43	These data suggested that ATM1 functions differently in different root cells and can be involved in different steps of endocytosis, brefeldin A-sensitive and insensitive pathways, endoplasmic reticulum tethering and plasmodesmatal activity.
3702	828996	17503073	2007-12-01 11:52	The psae1-3 psae2-1 double mutant totally lacked the E subunit of photosystem I but was still able to grow photoautotrophically.
3702	829019	16856985	2007-06-18 16:25	CDKF;1 plays a major role in cyclin-dependent kinase and carboxy-terminal domain phosphorylation.
3702	829022	17544464	2007-10-13 11:06	Aim1 mutants are impaired in wound-induced formation of jasmonic acid.
3702	829038	16442857	2007-08-25 11:57	These results suggest that AtMnd1 is also required for double-strand breaks (DSB) repair in somatic cells.
3702	829038	16763194	2007-08-25 10:50	a key role in homologous synapsis and in DNA double-strand break repair during meiotic recombination
3702	829038	16872528	2007-08-25 12:28	AtMND1 is required for homologous pairing and is likely to play a role in the repair of DNA double strand breaks during meiosis in Arabidopsis.
3702	829042	17316176	2007-10-06 10:07	This study identifies gamma-glutamyltransferase 3 as catalyzing the obligate initial step in glutathione conjugate metabolism, and suggests that it has an important role in protecting plants from some xenobiotic chemicals.
3702	829042	17561001	2007-10-20 11:08	study identifies gamma-glutamyl transpeptidase 4 (At4g29210, GGT4) as the first step of vacuolar degradation of glutathione conjugates [GGT4]
3702	829068	16140037	2007-08-25 12:58	Data describe the cloning and functional characterization of a phospholipase (PL)A2 cDNA from Arabidopsis thaliana, AtsPLA2-alpha, which represents one of four secretory PLA2 genes in Arabidopsis.
3702	829068	16669612	2007-08-25 21:08	Mutagenesis of amino acids supposed to be involved in catalysis has shown that His62, the calcium-coordinating Asp63, and the above-mentioned Ser79 residue are essential for activity
3702	829068	17692850	2007-10-20 10:19	Rapid auxin-regulated gene expression was tested for sensitivity to PLA(2) inhibitors using seedlings expressing beta-glucuronidase (GUS) under the control of the synthetic auxin-responsive promoter DR5.
3702	829072	17711414	2008-02-21 16:48	Arabidopsis-methylated DNA-binding protein AtMBD7 is able to interact in vitro and in vivo with the arginine methyltransferase AtPRMT11. [AtPRMT11]
3702	829093	17122409	2007-06-29 08:51	flavin amine oxidase (FAO1) affects shoot regeneration by regulating cellular polyamines. [FAO1]
3702	829103	17506336	2007-08-25 10:05	Data indicate that MKK2 plays a role in abiotic stress tolerance and plant disease resistance.
3702	829105	16716192	2007-06-27 10:01	We showed that the Arabidopsis Ski8 was required for normal plant development and growth, suggesting a conserved somatic function, but that it was not required for meiotic recombination or progression [SKI8]
3702	829106	16319072	2007-08-25 11:24	S-adenosylmethionine binds to a novel site on threonine synthase, reorganizing the pyridoxal phosphate site
3702	829108	16113228	2006-02-01 11:17	TAN interacts with other proteins to control many aspects of embryo development [TAN]
3702	829112	18065565	2008-06-07 10:19	The functional characterization of ACA10 in leaves and flowers in adult A. thaliana is reported.
3702	829131	16006581	2005-11-29 16:20	ARF10 and ARF16 control root cap formation in root. Auxin and micro RNA 160(miR160) regulate the expression of ARF10 and ARF16 genes independently. [ARF16]
3702	829134	17550234	2007-08-25 11:44	plant Zn2+-ATPase N-terminal metal binding domains (N-MBDs) have folding & function similar to Cu+-ATPase N-MBDs. unique Zn2+ coordination via two thiols and a carboxyl group provides selective binding of the activating metals to these regulatory domains
3702	829142	17483306	2007-10-20 12:43	These results suggest that PKS5 is part of a calcium-signaling pathway mediating PM H+ -ATPase regulation.
3702	829142	18075595	2008-01-26 12:52	first structure of a P-type proton pump (AHA2) determined by X-ray crystallography
3702	829151	16477366	2006-08-21 17:05	Principal role for the AtXTH18 gene is primary root elongation [AtXTH18]
3702	829157	16081412	2007-08-25 13:04	molecular cloning and characterization of AtDGK7; phosphorylates diacylglycerol molecular species that are typically found in plants; expression is strongest in flowers and young seedlings
3702	829184	16123046	2007-08-25 10:20	BRS1 is a secreted and active serine carboxypeptidase and may process a protein involved in an early event in the BRI1 signaling pathway
3702	829211	16945961	2007-08-25 12:27	The role of AtMUS81 in meiotic and mitotic recombination.
3702	829211	17696612	2007-11-10 11:06	AtMUS81 is involved in a secondary subset of meiotic crossovers that are interference insensitive.
3702	829211	18182028	2008-05-10 10:22	The role of MUS81 in the reproduction and growth of A. thaliana, via its expression and metabolism during meiosis, is reported.
3702	829217	16698901	2007-08-25 10:51	The nfd3, nfd4, nfd5, and nfd6 mutants contain T-DNA insertions in genes predicted to encode proteins that localize to mitochondria, suggesting a role for this organelle in nuclear fusion.
3702	829240	17363895	2007-08-25 21:11	SKB1-mediated H4R3sme2 is a novel histone mark required for repression of FLC expression and flowering time control.
3702	829240	17573539	2007-12-01 10:46	involved in promotion of vegetative growth and FlOWERING LOCUS C-dependent flowering time regulation
3702	829282	17114354	2007-08-25 10:10	These results provide genetic evidence for the importance of WRKY11 and WRKY17 in plant defense.
3702	829282	18523729	2008-09-27 10:28	Data show that even subtle amino acid substitutions within the DNA binding region of AtWRKY11 strongly impinge on its binding activity.
3702	829285	17114353	2007-08-25 11:49	The dynamic distribution of the Arabidopsis thaliana SR proteins RSZp22 and RSp31 in the nucleolus, are demonstrated.
3702	829300	16945932	2007-06-05 07:41	Overexpression of TAF10 in Arabidopsis improves seed tolerance to salt stress during germination and the knocked-down mutant is more sensitive to salt stress.[TAF10]
3702	829300	17148695	2007-07-02 14:19	TAF10 is a selective TATA-box binding protein-associated factor in plants, involved in pleiotropic, but selected morphological events in Arabidopsis. [TAF10]
3702	829301	17157837	2007-08-25 21:16	presence of this domain and the membrane localisation are both necessary for the function of the GDU1 protein
3702	829308	16603654	2007-08-25 12:32	WRKY18 interacts both physically and functionally with WRKY40 and WRKY60 in a complex pattern of overlapping, antagonistic, and distinct roles in plant responses to different types of microbial pathogens.
3702	829311	16107478	2008-05-05 02:02	Enhancer of Pinoid (ENP) protein specifically regulates cotyledon development through control of PIN1 polarity in concert with Pinoid.
3702	829311	17913786	2008-05-28 13:56	a novel gene, MAB4, which is involved in organogenesis in concert with PID has been reported. It encodes a NPH3-like protein and is identical to ENP. [MACCHI-BOU 4] {MAB4]
3702	829311	18000043	2008-05-21 12:34	NPY1 works with the protein kinase PID, which is homologous to PHOT1, to regulate auxin-mediated plant development. [NPY1]
3702	829322	17132632	2007-08-25 14:03	ARR10 and ARR12play pivotal roles in the histidine kinase-dependent phosphorelay signaling in response to cytokinin in roots.
3702	829322	18037673	2008-05-24 10:35	The results of this study suggested that ARR1, ARR10 and ARR12 together play essential (or general) roles in cytokinin signal transduction.
3702	829353	17395603	2007-09-22 10:21	Data showed that double mutant plants carrying as1/as2 (ASYMMETRIC LEAVES1 and 2 mutants) and mutations of several key transcription factors enhanced as1/as2 defects by producing more severely abaxialized leaves.
3702	829376	16891551	2007-08-25 10:12	The effects of CESA1 and CESA3 mutations and chimeric proteins on the temperature sensitivity of A. thaliana is reported.
3702	829376	18495638	2008-08-30 10:39	CESA 1, 3, and 6 form a complex which is important for cellulose synthesis.
3702	829389	17704214	2007-12-22 11:06	These data demonstrate that auxin synthesized by the YUC flavin monooxygenases is an essential auxin source for Arabidopsis thaliana embryogenesis and postembryonic organ formation.
3702	829390	16625397	2007-08-25 10:52	SEUSS and LEUNIG control blade cell number and vasculature development within the petal and regulate petal polarity along the adaxial/abaxial axis.
3702	829390	18390806	2008-08-09 10:18	Functional diversification between LUH and LUG is evidenced by the inability of 35S::LUH overexpression to rescue lug mutants and by the opposite expression trends of LUG and LUH in response to biotic and abiotic stresses
3702	829406	16819516	2007-08-25 21:17	1,N6-ethenodeoxyadenosine attaches to the active ssiteand presents its 'Hoogsteen edge' for hydrogen-bonding with incoming dTTP or dCTP.
3702	829408	17459889	2007-08-25 21:20	Inactivation of AtLa1 (At4g32720) function is lethal and leads to an early developmental arrest of the embryo.
3702	829409	17287251	2007-08-25 12:23	Our results suggest that a pair of structurally related myb3r1 myb3r4 transcription factors may positively regulate cytokinesis mainly through transcriptional activation of the KN gene.
3702	829413	15665245	2007-08-25 13:41	Evaluation of tocopherol cyclase over- and under-expression on metabolism of tocopheol, ascorbate, glutathione, and oxidative stress in A. thaliana transgenics and mutants.
3702	829413	16414959	2007-08-25 10:18	analysis of VTE1 localization and vitamin E accumulation in chloroplast plastoglobule lipoprotein particles
3702	829417	15342640	2005-01-31 15:00	the sequential cleavages of beta-carotene by AtCCD7 and AtCCD8 may be initial steps in the synthesis of a carotenoid-derived signaling molecule necessary for the regulation lateral branching. [AtCCD8]
3702	829419	16028112	2007-08-25 14:23	Aurora kinase AtAUR1 localized at the nuclear membrane in interphase and located in mitotic spindles and cell plates during cell division.
3702	829424	15286295	2005-04-26 21:00	Class III HD-Zip AND KANADI genes required for root development [ATHB8]
3702	829431	16043487	2007-08-25 14:23	gammaVPE is the proteinase that exhibits a caspase-1 activity
3702	829435	17908157	2008-03-10 16:17	ATH1 controls floral competency as a specific activator of FLOWERING LOCUS C (FLC) expression.
3702	829437	17449811	2007-10-06 11:58	SCABP8 and SOS3 are only partially redundant in their function, and each plays additional and unique roles in the plant salt stress response.
3702	829437	17825054	2008-01-26 10:20	findings suggest that CBL10 and CIPK24 (SOS2) constitute a novel salt-tolerance pathway that regulates the sequestration/compartmentalization of Na(+) in plant cells
3702	829452	15569707	2007-08-25 12:59	The regulation of lysine catabolism in Arabidopsis through these two gene products of the AtLKR/SDH gene in response to various hormones and stress signals.
3702	829466	17108323	2007-08-25 21:16	In Atnuc-L1 plants the AtNUC-L2 gene is activated, suggesting that AtNUC-L2 might rescue, at least partially, the loss of AtNUC-L1.
3702	829480	15548744	2007-08-25 10:23	We propose that the AtSERK3 protein is involved in changing the equilibrium between plasma membrane-located BRI1 homodimers and endocytosed BRI1-AtSERK3 heterodimers.
3702	829480	15894717	2007-08-25 21:28	In vivo association of BRI1 and BAK1 was affected by endogenous and exogenous BR levels and that phosphorylation of both BRI1 and BAK1 on Thr residues was BR dependent.
3702	829480	16126860	2007-08-25 12:44	A previously identified photomorphogenesis mutant, elg, enhances high-light phototropism and represents a unique allele of BAK1/SERK3, a receptor kinase implicated in brassinosteroid perception.
3702	829480	17027118	2007-08-25 15:03	The effects of ectopic expression of BAK1 in transgenic rice on plant growth and plant growth regulators is reported.
3702	829480	17600708	2008-01-05 15:16	study demonstrates that BAK1 and BKK1 (AtSERK4) have dual physiological roles: positively regulating a brassinosteroid (BR)-dependent plant growth pathway, and negatively regulating a BR-independent cell-death pathway
3702	829480	17625569	2007-09-04 17:50	FLS2 and BAK1 form a complex in vivo, in a specific ligand-dependent manner, within the first minutes of stimulation with flagellin
3702	829480	17626179	2007-09-04 17:50	SERK3/BAK1 appears to integrate diverse perception events into downstream pathogen-associated molecular pattern responses, leading to immunity against a range of invading microbes.
3702	829480	18621007	2008-09-06 10:41	The paper shows that AvrPto and AvrPtoB bind the Arabidopsis receptor-like kinase BAK1, a shared signaling partner of both the flagellin receptor FLS2 and the brassinosteroid receptor BRI1.
3702	829480	18694562	2008-09-06 10:21	Brassinosteroids-dependent activation of BRI1 precedes association with BAK1 in planta, and that BRI1 positively regulates BAK1 phosphorylation levels in vivo.
3702	829487	16407439	2006-08-23 08:19	RPD1 encodes a member of a novel protein family specific to the plant kingdom and functions in the maintenance of active cell proliferation. [RPD1]
3702	829504	15539603	2005-04-26 15:21	inactivation of a single gene, EXECUTER1, is sufficient to abrogate stress responses of Arabidopsis thaliana caused by the release of singlet oxygen. [EXECUTER1]
3702	829504	18182022	2008-05-24 10:26	The impact of the EXECUTER1 utation and the prevalence of enzymatic or non-enzymatic lipid peroxidation on the modes of singlet oxygen activity in flu mutant A. thaliana is reported.
3702	829506	14754924	2008-08-26 08:05	This study uses a T-DNA knockout to confirm the role of ADL2a/DRP3A in the regulation of plant mitochondrial morphology.
3702	829521	16980563	2007-05-25 17:56	CER4 is an alcohol-forming fatty acyl-coenzyme A reductase (FAR) that has specificity for very-long-chain fatty acids and is responsible for the synthesis of primary alcohols in the epidermal cells of aerial tissues and in roots. [CER4]
3702	829541	16365038	2007-08-25 21:24	the direct interaction between SRK2E/OST1 and ABI1 through Domain II plays a critical role in the control of stomatal closure
3702	829541	16682349	2007-08-25 12:30	involved in the stomatal response to reduced relative humidity
3702	829541	16766677	2007-08-25 11:54	The identification of key residues involved in regulation OST1 activity is discussed.
3702	829541	16828085	2007-08-25 15:04	the function of UBA2a is independent of OST1 phosphorylation.
3702	829547	15834008	2007-08-25 12:45	Makes transgenic plants more tolerant to stress conditions.
3702	829547	16247556	2007-08-25 13:38	The redundancy of function among genes in the families of ABF3 and ABI5 in A. thaliana is reported.
3702	829552	17409185	2007-08-25 12:20	DML3 excises 5-methylcytosine in vitro.
3702	829552	18493721	2008-08-23 10:38	Results suggest that DML3 is required not only for removing DNA methylation marks from improperly-methylated cytosines, but also for maintenance of high methylation levels in properly targeted sites.
3702	829557	17670821	2008-01-12 11:12	PAB2 was partially retargeted to the nucleolus in the presence of TuMV VPg-Pro. In addition, the membrane association of PAB2 during TuMV infection resulted from the internalization of the host protein in 6K-VPg-Pro-induced vesicles.
3702	829557	18222516	2008-05-24 10:05	Thus, Hsc70-3 and PABP2 are potentially integral components of the replicase complex and could have important roles to play in the regulation of potyviral RdRp functions.
3702	829561	16794327	2006-11-22 16:59	AtGT-2 encodes a flavonoid 7-O-glucosyltransferase [AtGT-2]
3702	829564	15501911	2007-08-25 14:50	Effect of expression in tobacco on plant shoot apical meristem development.
3702	829564	16517759	2007-08-25 21:27	CYCD3;1 dominantly drives the G1/S transition, and in sucrose-depleted cells the decline in CYCD3;1 levels leads to G1 arrest, which is overcome by ectopic CYCD3;1 expression.
3702	829564	17726100	2007-10-27 10:59	CYCD3 activity is important for determining cell number in developing lateral organs and the relative contribution of the alternative processes of cell production and cell expansion to overall organ growth
3702	829572	16633561	2007-08-25 15:04	determined the crystal structures of AtCAD5 in the apo-form and as a binary complex with NADP+, respectively, and modeled that of AtCAD4. The substrate-binding pockets of both AtCAD5 and AtCAD4 were also examined.
3702	829572	17287892	2007-08-25 21:07	These results suggest that AtGRP9 may be involved in lignin synthesis in response to salt stress as a result of its interaction with AtCAD5 in A. thaliana.
3702	829573	17080931	2007-08-25 21:21	Constitutive or stress-inducible expression of ALDH3I1 confers tolerance to osmotic and oxidative stress.
3702	829585	15863698	2005-11-21 10:40	IspH null mutants having an albino phenotype show that the development of chloroplasts is severely impaired in the IspH-deficient albino tissues. Arabidopsis IspH is involved in plastid isoprenoid biosynthesis. [IspH]
3702	829589	17999646	2008-04-12 10:17	study describes initial functional characterization of XLG1, XLG2 & XZLG3 genes & reveals a role for XLG proteins in the regulation of root growth and seed germination by sugars and phytohormones
3702	829597	17360436	2007-08-25 12:21	the Gbetagamma complex serves a signaling function in the ER independent of its function in the Galphabetagamma heterotrimer
3702	829597	17383830	2007-08-25 13:23	This research provides evidence of the functional association of alpha and beta with the gamma subunits in Arabidopsis, while also suggesting that plasma membrane localization may be critical for function of plant heterotrimeric G proteins.
3702	829597	17492287	2007-12-15 10:21	AGB1 is widely expressed throughout development in a complex manner.
3702	829597	18541915	2008-07-19 10:40	AGB1 particupates in regulation of G protein-coupled inwardly rectifying K+ (GIRK) channels.
3702	829600	17538023	2007-10-20 10:19	These results and the understanding of other actin-binding proteins implicate CAP1 as a central player in regulating the pool of unpolymerized ATP-actin.
3702	829600	17635992	2007-12-08 12:29	findings show that mutants in CAP1 display a phenotype that establishes CAP1 as a fundamental facilitator of actin dynamics over a wide range of plant tissues
3702	829610	15546352	2005-08-22 11:19	The N-terminus of the COW1 protein is 32% identical to an essential phosphatidylinositol transfer protein (PITP), the yeast Sec14 protein (sec14p) while the C-terminus is 34.5% identical to a late nodulin of Lotus japonicus, Nlj16. [COW1]
3702	829611	18088315	2008-05-24 10:17	bZIP11 target processes are identified using transiently increased nuclear bZIP11 levels and genome-wide expression analysis; the effect of bZIP11 on ASN1 and GBF6 are reported.
3702	829616	18236008	2008-09-20 10:17	SQS1 is the only functional squalene synthase in Arabidopsis.
3702	829623	15733873	2007-08-25 15:05	Arginine decarboxylase genes are required for production of polyamines that are essential for normal seed development in Arabidopsis
3702	829626	17616508	2007-12-01 12:23	DAS734 is a potent, slow-binding inhibitor.
3702	829636	18342331	2008-05-17 10:33	AtMTAN2 was characterized kinetically.
3702	829641	17872919	2008-01-05 15:15	RNA interference was used to generate transgenic lines of this species in which AtXDH1 and AtXDH2, the two paralogous genes for XDH in this plant, were silenced simultaneously.
3702	829642	17872919	2008-01-05 15:15	RNA interference was used to generate transgenic lines of this species in which AtXDH1 and AtXDH2, the two paralogous genes for XDH in this plant, were silenced simultaneously.
3702	829652	16873450	2007-08-25 12:29	Loss of function in APX3 does not affect Arabidopsis growth and development.
3702	829654	17242203	2007-08-25 21:23	upon GTP binding and activation, AtROP6 and possibly other ROPs are transiently S acylated, which induces their partitioning into detergent-resistant membranes
3702	829661	16891552	2007-08-25 10:12	Using CAT2 as an example, it was demonstrated that increasing the distance between direct and adjacent target sequences in a transgenic primary target delays the onset of silencing of a secondary target gene
3702	829661	17080932	2007-08-25 21:21	CAT2 expression is down-regulated during leaf senescence
3702	829661	17785451	2008-03-29 13:06	Data suggest that the interaction of SOS2 with both NDPK2 and CATs2 and 3 reveals a point of cross talk between salt stress response and other signaling factors including H2O2.
3702	829661	17931347	2008-03-22 12:03	Data show that cat2-1 mutant phenotype include more H(2)O(2), reduced size, paler green color, smaller secondary roots and increased sensitivity to H(2)O(2), NaCl, norspermidine, high light and cold stress. The germination is more tolerant to lithium.
3702	829676	18653891	2008-08-09 10:12	3 homologous brassinosteroid (BR)-signaling kinases(BSK1 encoded by At4g35230, BSK2, BSK3)were identified; the BSKs are phosphorylated by BRI1; results demonstrate that BSKs are the substrates of BRI1 kinase that activate downstream BR signal transduction
3702	829679	17468208	2007-12-01 12:57	Leaf IDH activity reduced by 60% in mutant
3702	829692	17277098	2007-08-21 08:10	AGF1 plays a role in the homeostasis of gibberellins through binding to the cis-acting sequence of the GA-negative feedback of AtGA3ox1. [AGF1]
3702	829697	18193034	2008-05-03 11:21	AKR2A functions as a cytosolic mediator for sorting and targeting of nascent chloroplast OEM proteins to the chloroplast.
3702	829698	15642341	2005-09-01 14:23	AtNTRB gene encodes two mRNAs and appeares to express the major mitochondrial thioredoxin reductases (AtNTRB).
3702	829709	17114349	2007-08-25 11:49	The subcellular localization of Arabidopsis thaliana HMGA, HMGB1, and HMGB5, reveals that they localize to the cell nucleus. They display a speckled distribution pattern throughout the chromatin of interphase nuclei.
3702	829716	16525754	2007-08-25 10:54	From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
3702	829717	16527867	2007-08-25 11:56	Four of the IDH genes were expressed in all plant organs tested. One gene (At4g35650) was expressed mainly in the pollen. In leaves, the IDH genes were highly expressed in the veins, and to a lesser extent in mesophyll cells.
3702	829731	17090544	2007-08-25 21:16	The protein kinase AT4G35780 could represent a subunit of a regulatory network involved in the cytosolic events of chloroplast protein import.
3702	829733	17962199	2008-06-21 10:24	Report show that the presence of PLDdelta correlates with reduced lipid hydrolysis during post-freezing recovery, suggesting a positive role for PLDdelta in freezing tolerance.
3702	829737	17437406	2007-08-25 13:23	The identification of ACO1, ACO2, and ACO3 in A. thaliana is reported, and it was demonstrated that, in plants, the cytosolic ACOs are not converted into iron regulatory proteins.
3702	829744	16099979	2007-08-25 13:04	FD, preferentially expressed in the shoot apex required for FT to promote flowering
3702	829744	16099980	2007-08-25 13:04	a complex of FT and FD proteins in turn can activate floral identity genes such as APETALA1
3702	829779	16332414	2007-06-14 15:57	In Camptotheca acuminata, F5H, a cytochrome P450-dependent monooxygenase that catalyses the hydroxylation of ferulic acid, coniferaldehyde and coniferyl alcohol, leads to sinapic acid and syringyl lignin biosynthesis. Wounding stimulates its expression.
3702	829786	18191794	2008-05-29 18:27	CRT1, an ATPase, is an important mediator of defense signaling triggered by distinct classes of R proteins. [CRT1]
3702	829790	17138693	2007-08-25 10:09	In vitro biochemical assays using insect cell-expressed proteins revealed that both CYP90C1 and CYP90D1 catalyze C-23 hydroxylation of various 22-hydroxylated Brassinosteroids with markedly different catalytic efficiencies.
3702	829800	17194770	2007-09-03 02:05	The predicted gene for Arabidopsis thaliana LCB1 encodes a genuine subunit of Serine palmitoyltransferase (SPT) that rescues the sphingolipid long-chain base auxotrophy of Saccharomyces cerevisiae SPT mutants when coexpressed with Arabidopsis LCB2.
3702	829800	18218968	2008-07-26 10:06	expression confined in microspores during microgametogenesis, suggesting that serine palmitoyltransferase-modulated programmed cell death plays an important role in the regulation of male gametophyte development
3702	829840	17873098	2008-06-06 15:11	These data suggest that BLH2/SAW1 and BLH4/SAW2 establish leaf shape by repressing growth in specific subdomains of the leaf at least in part by repressing expression of one or more of the KNOX genes. [SAW1]
3702	829845	15708974	2007-08-25 14:49	Control of seed mass and seed yield by the floral homeotic gene APETALA2.
3702	829845	15708976	2007-08-25 14:49	a role for AP2 in controlling seed mass.
3702	829845	16387832	2007-08-25 21:27	Genetic analysis shows that termination of the primary shoot meristem in l28 mutants requires an active CLV signaling pathway, indicating that AP2 functions in stem cell maintenance by modifying the WUS-CLV3 feedback loop.
3702	829845	16897492	2007-08-25 13:31	The expression of AP2 under the control of miR172 in N. benthiana is reported.
3702	829845	17204538	2007-08-25 12:23	Mutual regulation of APETALA2 and ethylene-responsive element binding protein in A. thaliana is described and discussed.
3702	829845	17573799	2008-01-05 16:52	miR172, a microRNA, serves as a negative regulator of AP2.
3702	829847	16303558	2007-08-25 11:59	SPATULA is a light-stable repressor of seed germination and mediates the germination response to temperature.
3702	829847	18315540	2008-09-27 10:43	conserved acidic domain is essential for carpel function, supported by conserved amphipathic helix
3702	829854	15500474	2007-08-25 21:23	Used to elicit the role of mitochondria in programmed cell death as evaluated by flow cytometry.
3702	829854	16113212	2007-08-25 15:01	The roles of ACD2 and PAO1 enzymes in chlorophyll breakdown during leaf sensescence in A. thaliana are reported.
3702	829854	16387834	2007-08-25 21:27	The Arabidopsis thaliana chloroplast protein ACCELERATED CELL DEATH2 (ACD2) modulates the amount of programmed cell death (PCD) triggered by Pseudomonas syringae and protoporphyrin IX (PPIX) treatment.
3702	829854	17237353	2007-08-25 11:48	RCCR (At4g37000), together with pheophorbide a oxygenase, is required for the detoxification of chlorophyll catabolites.
3702	829855	15155891	2004-09-29 16:27	Role in homologous recombination and nucleotide excision repair. [CENTRIN2]
3702	829855	16786311	2007-08-25 11:54	RAD4 interacts with the distal EF-hand Ca(2+) binding domain of CEN2 and this interaction is required for efficient nucleotide excision repair. [CEN2]
3702	829874	16997915	2007-08-25 21:02	This study suggests that HCF164 serves as an important transducer of reducing equivalents to proteins in the thylakoid lumen.
3702	829881	18252706	2008-05-31 10:17	that AtHMA1 functions as a Ca(2+)/heavy metal pump. This protein is the first described plant P-type pump specifically inhibited by thapsigargin.
3702	829900	17294240	2007-08-25 14:01	Organ- and tissue-specific expression patterns and subcellular localization of AtAGP18 were studied and compared to other Lys-rich AGPs. AtAGP18 was highly expressed in roots, flowers and stems and weakly expressed in seedlings and rosettes
3702	829913	17071622	2007-08-25 10:09	These results suggest that HLS1 plays a negative role in sugar and auxin signaling.
3702	829913	18084766	2008-08-23 10:14	the hookless1 (hls1-1) mutant, a suppressor of the ethylene response phenotypes of ctr1 and eto1 mutants, is capable of dramatically enhancing shoot organogenesis. The effects of ACC and loss of HLS1 function on shoot organogenesis were largely additive.
3702	829918	18073213	2008-04-05 11:12	ACA2 has a role in modulation of cytosolic calcium signature and activation of adaptive Na+ homeostasis
3702	829919	15955927	2007-08-25 12:36	The role of SHORT-ROOT and SCARECROW proteins in the maturation of A. thaliana roots, including cell organization, is reported.
3702	829919	16640459	2007-08-25 10:51	Combined analysis of global expression profiles of A. thaliana after modulating SHR activity in order to identify the direct targets of SHR is reported.
3702	829919	17446396	2007-08-25 13:59	findings show that SCARECROW (SCR) blocks SHORTROOT (SHR) movement by sequestering it into the nucleus through protein-protein interaction and a safeguard mechanism that relies on a SHR/SCR-dependent positive feedback loop for SCR transcription
3702	829931	16523347	2007-08-25 21:18	ANT is nuclear localized and that the sequence KKKR (amino acids 252-255) is required for nuclear localization of the protein.
3702	829931	16714408	2007-08-25 10:51	ANT acts in combination with the YABBY gene FILAMENTOUS FLOWER (FIL) to promote organ polarity by up-regulating the expression of the adaxial-specifying HD-ZIP gene PHABULOSA.
3702	829931	18184731	2008-07-26 10:16	SEU and ANT are part of a complex and robust molecular system that coordinates patterning cues and cellular proliferation along the three positional axes of the developing gynoecium.
3702	829932	17426032	2007-08-25 13:23	isolated and characterized Arabidopsis sqe1 mutants and discovered severe developmental defects, including reduced root and hypocotyl elongation
3702	829934	15347654	2007-08-25 11:07	Data suggest a model in which combinatorial interactions with co-activators enable R2R3 MYB factors with very similar DNA binding preferences to discriminate between target genes in vivo.
3702	829949	15659103	2005-09-22 08:54	The characterization and expression of SHMT1 in A. thaliana. [SHMT1]
3702	829949	16339799	2007-08-25 10:19	SHM1 expression is required for mitochondrial serine hydroxymethyltransferase activity and proper function of the C2 cycle during growth in ambient air.
3702	829969	15749761	2006-01-26 09:09	HDA19 may regulate gene expression involved in jasmonic acid and ethylene signaling of pathogen response in Arabidopsis.[HDA19]
3702	829969	16699543	2007-08-25 10:52	Data suggest that AtHD1 is a nuclear protein and possesses histone deacetylase activities responsible for global transcriptional regulation important to plant growth and development.
3702	829969	17085686	2007-08-25 21:17	These results suggest that acetylation of specific histone Lys residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.
3702	829969	18024558	2008-03-29 10:21	These results suggest that during germination in Arabidopsis, HDA6 and HDA19 redundantly regulate the repression of embryonic properties directly or indirectly via repression of embryo-specific gene function.
3702	830003	17090544	2007-08-25 21:16	The protein kinase AT4G38470 could represent a subunit of a regulatory network involved in the cytosolic events of chloroplast protein import.
3702	830018	17993626	2008-03-10 13:39	Arabidopsis thaliana mutant sensitive to ABA and drought2 (sad2), which harbors a T-DNA insertion in an importin beta-like gene, is more tolerant to UV-B radiation than the wild type.
3702	830024	17123099	2007-08-25 14:03	The expression of GRP2 in flowers and seeds during development is reported.
3702	830024	17376161	2007-08-25 13:25	The functional roles of GRP2 in Arabidopsis thaliana under high-salinity, cold or osmotic stress are reported.
3702	830029	15746386	2007-08-25 11:06	activates Pseudomonas syringiae AvrRpt2
3702	830035	16909418	2007-08-25 14:06	determined the high-resolution structure of 5'-methylthioadenosine nucleosidase from Arabidopsis thaliana (AtMTAN)
3702	830035	18342331	2008-05-17 10:33	AtMTAN1 was characterized kinetically.
3702	830043	17616508	2007-12-01 12:23	inhibited by DAS734
3702	830058	18557905	2008-09-27 10:28	Results suggest that, in addition to R gene-mediated gene-for-gene resistance, EDS5 is also important for basal resistance to viruses.
3702	830076	15598655	2007-08-25 13:45	patterns of expression and sugar regulation of Arabidopsis thaliana ADP-glucose pyrophosphorylase
3702	830082	17924945	2008-03-22 12:03	Data show that AtGRP8 binds to AtGRP7 and levels of the alternatively spliced AtGRP8 transcripts that contain premature termination codons are strongly elevated in mutants impaired in the nonsense-mediated decay (NMD) components UPF1 or UPF3.
3702	830090	17085513	2007-08-25 13:28	CESA2 is involved in microtubule orientation.
3702	830095	15548744	2007-08-25 10:23	We propose that the AtSERK3 protein is involved in changing the equilibrium between plasma membrane-located BRI1 homodimers and endocytosed BRI1-AtSERK3 heterodimers.
3702	830095	15650741	2007-08-25 15:08	brassinosteroids bind directly to the 94 amino acids comprising ID-LRR22 in the extracellular domain of BRI1, and define a new binding domain for steroid hormones
3702	830095	15894717	2007-08-25 21:28	In vivo association of BRI1 and BAK1 was affected by endogenous and exogenous BR levels and that phosphorylation of both BRI1 and BAK1 on Thr residues was BR dependent.
3702	830095	15998311	2007-08-25 11:20	This study suggests a role for TRIP-1 in the molecular mechanisms of brassinosteroid-regulated plant growth and development, possibly as a cytoplasmic substrate of the BRI1 receptor kinase.
3702	830095	16473966	2007-08-25 14:11	BRI1 is part of the Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 protein complex.
3702	830095	16857903	2007-08-25 11:53	a BRI1-interacting protein, BKI1,which is a negative regulator of brassinosteroid signaling is reported; BKI1 is a substrate of BRI1 kinase & limits interaction of BRI1 with its proposed coreceptor, BAK1, suggesting that BKI1 prevents activation of BRI1
3702	830095	17611230	2007-09-29 12:22	Attenuation of brassinosteroid signaling enhances FLC expression and delays flowering.
3702	830095	18332904	2008-04-26 11:18	These results suggest that bri1-301, even with extremely impaired kinase activity, still retains partial function in regulating plant growth and development.
3702	830095	18653891	2008-08-09 10:12	3 homologous brassinosteroid (BR)-signaling kinases (BSK1, BSK2 & BSK3)were identified; the BSKs are phosphorylated by BRI1; results demonstrate that BSKs are the substrates of BRI1 kinase that activate downstream BR signal transduction
3702	830095	18694562	2008-09-06 10:21	Brassinosteroids-dependent activation of BRI1 precedes association with BAK1 in planta, and that BRI1 positively regulates BAK1 phosphorylation levels in vivo.
3702	830101	16950860	2007-06-28 10:00	SAMC1 and SAMC2 are two isoforms of a SAM transporter in Arabidopsis. SAMC1 is expressed at a significantly higher level than SAMC2, although both genes are transcriptionally active. [SAMC1]
3702	830101	17098813	2007-03-07 15:15	SAM TRANSPORTER1 (SAMT1) encodes a plastid metabolite transporter required for the import of S-Adenosylmethionine from the cytosol. [SAMT1]
3702	830144	11706205	2008-03-28 15:23	pxa1 mutants are sucrose-dependent and IBA resistant following germination, probably because of a failure to import beta-oxidation substrates into peroxisomes.
3702	830144	15761209	2005-09-30 14:10	The role of the transporter COMATOSE in the biosynthesis of Jasmonic acid in A. thaliana leaves is described. [COMATOSE] [CTS]
3702	830144	16844736	2007-08-25 10:14	CTS has a role following after-ripening within pathways related to the progression of germination prior to radicle emergence.
3702	830144	17468211	2007-12-01 12:57	Beta-oxidation could play a role in the mobilization of lipids in both pollen and female tissues.  Expression of CTS in either male or female tissues was sufficient to support pollen tube growth in vivo.
3702	830150	17905865	2008-01-19 10:52	This study reports on the characteristics of UBP3 and UBP4 in A. thaliana.
3702	830160	15155878	2004-09-29 16:17	RabA4b regulates membrane trafficking through a compartment involved in the polarized secretion of cell wall components in plant cells. [RabA4b]
3702	830283	16473965	2006-08-21 11:34	SDP1 encodes a lipase that initiates oil breakdown in germinating Arabidopsis seeds. [SDP1]
3702	830292	16034598	2007-08-25 11:26	Expression of GLU1 in mesophyll cells implies that Fd-GOGAT assimilates photorespiratory and primary ammonium. GLU1 expression in vascular cells indicates that Fd-GOGAT provides amino acids for nitrogen translocation.
3702	830293	17516080	2007-12-01 12:59	up-regulated by iron deficiency in roots and leaves
3702	830299	17110382	2007-08-25 13:28	the mature processed form is not prone to NO inhibition due to the presence of a second S-nitrosylation-insensitive cysteine that can replace the S-nitrosylated cysteine residue within the catalytic center of the processed AtMC9
3702	830303	18467490	2008-06-21 10:33	BES1 recruits transcriptional regulators ELF6 and REF6 to regulate target gene expression and coordinate brassinosteroids responses with other developmental processes such as control of flowering time.
3702	830313	17224141	2007-08-25 11:48	AtSWP1 and AtCZS (a C2H2 zinc finger-SET domain protein) represent two main components of a co-repressor complex that fine tunes flowering and is unique to plants.
3702	830313	17631527	2008-01-12 12:52	repressor of primary root growth and regulates phosphate homeostasis through the control of root architecture
3702	830325	18467588	2008-05-24 10:05	conformational changes in CP29 can "tune" the electronic coupling between the chlorophylls in this dimer, thereby modulating the energy of the chlorophyll-zeaxanthin charge-transfer state and switching on and off the charge-transfer quenching during qE
3702	830326	17098811	2007-06-29 08:45	SIM encodes a plant-specific CDK (Cyclin dependent kinase) inhibitor with a key function in the mitosis-to-endoreplication transition. [SIAMESE] [SIM]
3702	830326	17764505	2008-03-04 16:48	A novel interaction between mutant alleles of two genes, gl3-sst derived from GL3, and SIM exhibits mounds of cells derived from the proliferation of single trichome precursors. [SIAMESE] [SIM]
3702	830330	16125835	2007-08-25 12:35	PDK1 undergoes autophosphorylation at several sites; mutation of Ser-276 to Ala resulted in enzyme with no detectable autophosphorylation; other sites important for autophosphorylation &/or activity were Asp-167, Thr-176, & Thr-211
3702	830330	16601102	2007-08-25 21:23	PDK1 is a potent enhancer of PID activity.
3702	830330	17040918	2007-08-25 12:26	specific lipid signaling pathways converge on PTI1-2 via the PDK1-OXI1 axis
3702	830335	16624880	2007-08-25 10:52	Data suggest that a function of REPRESSOR OF SILENCING 1 (ROS1) and DEMETER is to initiate erasure of 5-meC through a base excision repair process and provide strong biochemical evidence for the existence of an active DNA demethylation pathway in plants.
3702	830335	17409185	2007-08-25 12:20	Demethylation by DEMETER is necessary for genomic imprinting and defines the genomic methylation profile of Arabidopsis genes.
3702	830335	17964287	2007-12-22 11:09	Gene ontology analysis identified three molecular functions enriched in the DME-inducible RNA list: DNA or RNA binding, kinase activity, and transcription factor activity.
3702	830335	18536342	2008-08-02 10:35	control DNA methylation in Arabidopsis thaliana.[review]
3702	830350	17108323	2007-08-25 21:16	In Atnuc-L1 plants the AtNUC-L2 gene is activated, suggesting that AtNUC-L2 might rescue, at least partially, the loss of AtNUC-L1.
3702	830366	17476573	2007-08-25 21:23	ACPK1 is involved in ABA signal transduction as a positive regulator, and suggesting that the ACPK1 gene may be potentially used for elevating plant biomass production.
3702	830382	16435266	2007-08-25 12:34	Embryo development in the atToc33/34 mutants proceeded slowly and was arrested at the transition to the globular stage.
3702	830382	17261588	2007-08-25 10:07	By combining these models with the measured enzymatic properties of the Toc GTPases, we provide new insights of how the chloroplast protein import cycle may be regulated
3702	830382	18487635	2008-08-09 10:30	Phosphorylation disturbs the association of Toc34, but not of Toc159 with the translocation pore proteins.
3702	830399	16891551	2007-08-25 10:12	The effects of CESA1 and CESA3 mutations and chimeric proteins on the temperature sensitivity of A. thaliana is reported.
3702	830399	18495638	2008-08-30 10:39	CESA 1, 3, and 6 form a complex which is important for cellulose synthesis.
3702	830403	17911168	2008-02-02 10:19	study reports the physical interaction of an Arabidopsis POT1 protein, POT1A (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
3702	830424	16617101	2007-08-25 12:31	The region between DREB2A residues 136 and 165 plays a role in the stability of this protein in the nucleus, which is important for protein activation.
3702	830424	17030801	2007-08-25 10:47	Functions in both water-stress and heat shock-stress responses.
3702	830424	17999647	2008-04-12 10:17	Altogether these data demonstrate that HsfA3 is transcriptionally controlled by DREB2A and important for the establishment of thermotolerance.
3702	830424	18261981	2008-04-12 10:20	These results indicate that HsfA3 regulates expression of many heat-inducible genes in the transcriptional cascade downstream of the DREB2A stress-regulatory system and functions in acquisition of thermotolerance under the control of the DREB2A cascade.
3702	830432	16176934	2006-02-03 10:00	REC8 and SCC3 are necessary not only to maintain centromere cohesion at anaphase I, but also for the monopolar orientation of the kinetochores during the first meiotic division [AtREC8]
3702	830432	16897472	2007-08-25 13:31	ASK1 is required for normal SYN1 distribution during meiotic prophase I and suggest that ask1 associated defects may be primarily related to SYN1 mislocalization.
3702	830441	15545277	2007-08-25 21:04	the regulation of post-translational stability of FAD8 provides an important regulatory mechanism for modifying its activity in response to temperature
3702	830453	16531479	2007-08-25 21:18	The complex diurnal expression profile of CPD is determined by dual, light-dependent, and circadian control.
3702	830461	16531497	2007-08-25 21:18	Evidence for SNARE-mediated traffic of the K(+) channel and a role in its distribution within subdomains of the plasma membrane.
3702	830494	16412084	2007-08-25 14:12	RBE acts to maintain two different types of spatial boundaries in young flowers: boundaries between organ primordia within a whorl and boundaries of homeotic gene expression between whorls.
3702	830497	15722475	2007-08-25 14:17	Transformation with MYB33 containing the mutated microRNA target had dramatic pleiotrophic developmental defects, suggesting that restricting MYB33 expression, especially in the shoot apices, is essential for proper plant development.
3702	830501	16936718	2007-01-08 16:52	Arabidopsis thaliana SORTING NEXIN 1 (AtSNX1) is involved in the auxin pathway and that PIN2, but not PIN1 or AUX1, is transported through AtSNX1-containing endosomes [AtSNX1]
3702	830504	15361146	2005-01-26 12:00	Sucrose transporter 9 encodes functional sucrose transporter and is expressed in floral tissue. [SUC9]
3702	830504	17098854	2007-08-25 12:24	AtSUC9 activity leads to a delay in floral transition.
3702	830517	18553980	2008-07-19 10:40	2-cysteine peroxoredoxins from Homo sapiens, Arabidopsis thaliana, and Pisum sativum as well as a carboxy-terminally truncated variant were subjected to isothermal titration calorimetry analysis.
3702	830519	16107718	2005-12-01 12:00	AtPot1 (protection of telomeres 1) and AtPot2 (protection of telomeres 2)are ubiquitously expressed at low levels in Arabidopsis. AtPot2 is involved in chromosome end protection. [Atpot2]
3702	830519	18387366	2008-07-12 10:06	The domains responsible for that interaction AtTRB1 and AtPOT1b were identified.
3702	830546	17595195	2008-06-04 11:44	AtGDH contributes to glycolate metabolism in Arabidopsis, indicating conservation of the chlorophyte pathway in higher plants. [AtGDH] [GDH]
3702	830577	16903359	2007-08-25 21:17	PGIP1 activity contributes to basal resistance to Botrytis cinerea and is suggested to play a role in Arabidopsis innate immunity.
3702	830609	16002616	2005-11-30 12:00	Three ERECTA-family leucine-rich repeat-receptor-like kinases (ER, ERL1,ERL2) together control stomatal patterning, with specific family members regulating specification of stomatal stem cell fate & differentiation of guard cells [ERL2]
3702	830609	17652352	2007-11-10 12:44	ERL2 is haploinsufficient for maintaining female fertility in the absence of ER and ERL1.
3702	830619	16055681	2007-08-25 22:21	Genetic analysis showed that the activation of cell division in the transgenic carpels of A. thaliana by TPD1 was dependent on EMS1/EXS, as it did not happen in the ems1/exs mutant.
3702	830628	15618435	2005-09-21 12:10	The physiological function of an A. thaliana gene encoding inositol polyphosphate kinase in pollen germination and root growth.[AtIPK2α]
3702	830635	16418233	2007-08-25 10:54	In leaves and stems of arabidopsis and tobacco, both the alpha- and beta-subunits of Glutamate dehydrogenase are targeted to the mitochondria of the companion cells.
3702	830635	18296429	2008-05-24 10:05	role in amino acid breakdown under C-deficient conditions
3702	830638	15516509	2007-08-25 11:33	The effects of under- and over-expression of the gene on the response of transgenic Arabidopsis to chemical and radiation stresses.
3702	830662	17420480	2007-10-20 12:25	Myb29 presumably plays an accessory function for methyl jasmonate-mediated induction of a set of aliphatic glucosinolate biosynthetic genes.
3702	830662	18042203	2008-05-24 10:35	HAG1/MYB28, HAG2/MYB76 and HAG3/MYB29 reciprocally transactivated each other in the control of aliphatic glucosinolate biosynthesis and downregulated the expression of genes involved in the control of indolic glucosinolate biosynthesis.
3702	830663	18042203	2008-05-24 10:35	HAG1/MYB28, HAG2/MYB76 and HAG3/MYB29 reciprocally transactivated each other in the control of aliphatic glucosinolate biosynthesis and downregulated the expression of genes involved in the control of indolic glucosinolate biosynthesis.
3702	830686	18466768	2008-07-26 10:16	DGK1 and DGK2 from cluster I in Arabidopsis thaliana possess amino-terminal hydrophobic segments that are sufficient to address them to endoplasmic reticulum membranes.
3702	830711	16709198	2006-10-13 13:45	SOB5 plays a role in cytokinin-mediated plant development.
3702	830763	17556511	2008-01-19 11:43	suggest that STRS1 and STRS2 attenuate the expression of stress-responsive transcriptional activators and function in abiotic stress signaling networks
3702	830779	16115070	2007-08-25 14:14	ATAF2 overexpressing plants showed a higher susceptibility to the soil-borne fungal pathogen F.oxysporum, and repression of a number of pathogenesis-related proteins.
3702	830825	17376163	2007-08-25 13:25	The function of PEROXISOMAL NAD-MALATE DEHYDROGENASE 1 and PEROXISOMAL NAD-MALATE DEHYDROGENASE 2 in fatty acid beta-oxidation and the glyoxylate cycle in Arabidopsis are reported.
3702	830827	17322552	2007-10-13 11:08	Sorting signals of this tail-anchored proteins is studied in plant cells and compared with those of mammalian proteins in rabbits.
3702	830833	16798843	2007-08-25 14:08	able to degrade all terminal arabinosyl residues; specifically expressed in the seed endosperm at the globular stage of the embryo
3702	830839	16771839	2007-01-09 09:32	ATXR5 and ARXR6 interact with proliferating cell nuclear antigen (PCNA) and are associated with a role in the cell cycle or DNA replication. [ATXR5]
3702	830864	15891117	2007-08-25 12:38	RNR1,(At5g02250), catalyzes 3' maturation of chloroplast ribosomal RNAs.
3702	830878	15734903	2005-09-22 15:32	We propose a hypothesis to illustrate the distinct mechanism by which vernalization regulates the expression of FLC in cabbage and Arabidopsis. [FLC]
3702	830878	15908596	2005-11-30 11:51	The contribution to variation in flowering time and vernalization of the two genes FRIGIDA (FRI) and FLOWERING LOCUS C (FLC), previously shown to be important determinants in natural variation of flowering time is reported. [FLC]
3702	830878	16008094	2005-09-22 15:37	The effects of Arabidopsis Flowering Locus C on flowering initiation and biomass in transgenic N. tabacum is reported. [FLC]
3702	830878	16236152	2007-08-25 14:23	The role of DNA methylation of FLC in the vernalization pathway of A. thaliana is reported.
3702	830878	16299497	2007-08-25 15:07	SDG8-mediated H3K36 methylation is a novel epigenetic memory code required for FLC expression in preventing early flowering
3702	830878	16473970	2007-08-25 14:11	FLC lengthens the circadian period specifically at 27 degrees C, contributing to temperature compensation of the circadian clock.
3702	830878	16495307	2007-08-25 10:18	ATARP6 positively regulates FLC accumulation.
3702	830878	16547097	2007-08-25 13:35	FRI upregulates FLC expression that represses flowering
3702	830878	16549797	2007-08-25 12:33	lhp1 mutants revealed a role for LIKE HETEROCHROMATIN PROTEIN 1 in maintaining epigenetic silencing of FLC
3702	830878	16600915	2007-08-25 10:16	FLC delays flowering by repressing production in the leaf of at least two systemic signals, one of which is controlled by the RAF kinase inhibitor-like protein FT.
3702	830878	16623882	2007-08-25 11:55	FLC is a component of a multimeric protein complex in vivo and that more than one FLC polypeptides can be present in the complex.
3702	830878	16728410	2007-08-25 21:03	under-expressed in the MGO3 mutant background
3702	830878	16737527	2007-08-25 11:54	This study has aided in the understanding of Flowering Locus C's role in the clock, as it reveals that the network affecting circadian timing is partially overlapping with the floral-regulatory network.
3702	830878	17114581	2007-08-25 10:10	Variation in epigenetic silencing of FLC appears to have contributed to Arabidopsis adaptation.
3702	830878	17138694	2007-08-25 10:09	SUF4 bound to the promoter of FLC in a chromatin immunoprecipitation assay, suggesting that SUF4 acts as a transcriptional activator of FLC after forming a complex with FRI and FRL1.
3702	830878	17220196	2007-08-25 10:08	FLC activation by the histone variant H2A.Z is required for the repression of flowering.
3702	830878	17470967	2007-08-25 21:20	Arabidopsis SWC6 (AtSWC6), SUPPRESSOR OF FRIGIDA 3 (SUF3) and PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1 (PIE1) are homologs of SWC6, ARP6 and SWR1 with roles in development, including floral repression through full activation of FLOWERING LOCUS C
3702	830878	17611230	2007-09-29 12:22	Attenuation of brassinosteroid signaling enhances FLC expression and delays flowering.
3702	830878	17908157	2008-03-10 16:17	ARABIDOPSIS THALIANA HOMEOBOX 1 (ATH1)controls floral competency as a specific activator of FLOWERING LOCUS C (FLC) expression.
3702	830878	17921315	2008-04-26 13:06	Data show that the expression of FLOWERING LOCUS C was repressed by Arabidopsis relatives of the human lysine-specific Demethylase1 and thus promote the floral transition.
3702	830878	17980595	2008-02-23 10:02	Trimethyl-lysine 27 (K27me3) is enriched at the start of the FLC gene during cold treatment, before spreading across the locus after vernalization.
3702	830878	17996704	2008-01-26 12:02	There is a close association of FCA and FLD in mediating H3K4 demethylation and thus transcriptional silencing of FLC.
3702	830878	18069938	2008-07-12 10:26	Data show that FLC expression can be promoted by SIZ1 by repressing FLD activity through sumoylation.
3702	830878	18156133	2008-05-31 10:05	The role of FLX in the timing of flowers and the expression of other flowering-related proteins, including FRIGIDA and FLC, is reported.
3702	830878	18178621	2008-02-09 11:09	arginine methylation of FLC chromatin is part of the histone code that is required for mitotic stability of the vernalized state
3702	830878	18375656	2008-08-02 10:27	Data show that the epigenetic regulation of the floral repressor FLOWERING LOCUS C was done by ATX1 and ATX1 directly binds the active FLC locus before flowering and that this interaction is released upon the transition to flowering.
3702	830878	18444908	2008-08-02 10:05	Variation in regulation of this protein may generate different flowering behaviors.[REVIEW]
3702	830882	15531709	2007-08-25 14:17	Colocalization with SULTR3;5 and coexpression in sulfate transport.
3702	830897	16815950	2006-11-29 18:20	A mutation within the HPA1 gene results in reduced histidine content which is associated with root meristem maintenance. [HPA1]
3702	830909	17764516	2008-01-26 10:20	findings show that AtTPK1 (KCO1)interacts with 14-3-3 proteins (general regulating factors, GRFs); TPK1 and GRF6 co-localize at the vacuolar membrane
3702	830912	16698944	2007-08-25 10:51	The balance between cell division and differentiation is regulated through the interaction between CDKA;1 and the antiphosphatase PAS2.
3702	830913	16401419	2006-03-13 12:00	Two MscS-like proteins, MSL2 and MSL3, alter ion flux in response to changes in membrane tension to regulate plastid size, shape, and perhaps division during normal plant development. [MSL2]
3702	830916	17572409	2007-10-20 11:08	At5g02310 is not identical to CER3, a gene involved in establishment of a protective surface wax layer. At5g02310 has therefore been re-designated PROTEOLYSIS 6 (PRT6), in accordance with its ubiquitin ligase function.
3702	830916	17624331	2007-09-22 10:19	CER3 is not At5g02310 and instead corresponds to WAX2/YRE/FLP1 (At5g57800), a gene of unknown function required for wax biosynthesis
3702	830917	18088316	2008-05-24 10:17	the developmental context of RBK1 gene expression is predominantly associated with vasculature and is also locally upregulated in leaves exposed to Phytophthora infestans and Botrytis cinerea pathogens
3702	830938	18560512	2008-08-23 10:14	findings identify an integral signalling function for AHK5 that acts to integrate multiple signals via H(2)O(2) homeostasis and is independent of ABA signalling in guard cells
3702	830959	17651442	2007-10-20 11:07	Results indicate an arginine-dependent activity in argininosuccinate lyase.
3702	830996	17001643	2007-08-25 12:26	the first structural and biophysical characterization of HY5 is reported here.
3702	830996	17121469	2007-08-25 21:01	The data support the hypothesis that the opposite root system phenotypes of hy5 single and hy5 hyh double mutants represent the morphological response to a quantitative gradient in the same molecular process.
3702	830996	17337630	2007-08-25 14:00	HY5 is a high hierarchical regulator of the transcriptional cascades for photomorphogenesis.
3702	830996	17929051	2008-07-26 10:16	necessary for high nitrate reductase expression in far-red light
3702	830996	18053005	2008-04-12 13:03	Gibberellins signaling regulates protein stability of HY5, and the activity of PIF3.
3702	830996	18055587	2008-06-07 10:30	This research provides evidence that, in ultraviolet B (UV-B) signaling, UVR8, HY5, and HYH act together and demonstrates a new role for HYH in UV-B responses.
3702	830996	18065688	2008-08-09 10:19	Data show that at part of the remodeling of light signaling networks involves converting HY5, a positive regulator of PhANGs, into a negative regulator of PhANGs.
3702	830996	18082144	2008-04-05 12:05	Arabidopsis HY5 functions as a novel DNA-binding tag (DBtag) for proteins. We also demonstrate that the DBtagged proteins could be immobilized and purified on a newly designed agarose/DNA microplate
3702	830996	18182030	2008-05-24 10:26	The isolation and characterization of light-regulated zinc finger protein 1 (LZF1), a HY5-regulated factor, is reported.
3702	830997	15923348	2006-01-26 09:04	OCP3 is an important factor for the COI1-dependent resistance of plants to infection by necrotrophic pathogens.[OCP3]
3702	831015	16897495	2007-02-28 16:34	IPD1 regulates the endocycle leading to hypocotyl elongation and this function is controlled by blue and far-red light.[IPD1]
3702	831020	18065690	2008-08-09 10:19	Data conclude that an HSC70-SGT1 chaperone complex is important for multiple plant environmental responses and that the evolutionarily conserved SGS domain of SGT1 is a key determinant of the HSC70-SGT1 association.
3702	831023	17287251	2007-08-25 12:23	Our results suggest that a pair of structurally related myb3r1 myb3r4 transcription factors may positively regulate cytokinesis mainly through transcriptional activation of the KN gene.
3702	831043	16905657	2006-11-29 18:04	EPSIN1 has a role in the vacuolar trafficking of soluble proteins at the trans-Golgi network via its interaction with gamma-ADR, VTI11, VSR1, and clathrin. [EPSIN1]
3702	831068	17048257	2007-08-25 12:25	X-ray crystal structures of the conserved hypothetical proteins from Arabidopsis thaliana gene loci At5g11950
3702	831104	18208519	2008-05-21 13:45	DGS1 encodes a mitochondrial membrane protein and in the dgd1 dgs1 double mutant, expression of nuclear genes encoding enzymes of the alternative galactoglycerolipid pathway is increased and hydrogen peroxide levels are elevated.[DGS1]
3702	831127	17890373	2008-04-28 02:05	These results demonstrate that MYB46 is a direct target of SND1 and is another key player in the transcriptional network involved in the regulation of secondary wall biosynthesis in Arabidopsis.
3702	831130	15618632	2007-08-25 13:41	this paper reports the isolation and characterization of IRK interacting protein (IRKI), and shows the link between IRK1/IRK and the multicellular organization of meristems in the shoot and root apices
3702	831139	16055633	2007-08-25 14:44	Data suggest that CLV3, CLE19 and CLE40 peptides represent the major active domain of the CLE proteins, which interact with an unknown cell identity-maintaining CLAVATA2 receptor complex in roots, leading to consumption of the root meristem.
3702	831144	15888445	2007-08-25 13:10	analysis of an insertional mutation in the Arabidopsis 5-CHO-THF cycloligase (5-FCL) gene (At5g13050) under photorespiratory and non-photorespiratory conditions
3702	831169	16731588	2007-08-25 10:15	Results describe the dimeric structure of a lysine and S-adenosylmethionine-sensitive aspartate kinase isoform from Arabidopsis thaliana in complex with its two inhibitors.
3702	831169	17140415	2007-06-29 16:00	The Arabidopsis genome contains three genes for monofunctional aspartate kinases. Aspartate kinase 2 and aspartate kinase 3 are inhibited only by lysine, and aspartate kinase 1 is inhibited in a synergistic manner by lysine and SAM. [AK1]
3702	831170	18381924	2008-10-06 16:23	The novel receptor kinase CORYNE (CRN) and CLV2 act together, and in parallel with CLV1, to perceive the CLV3 signal. [CORYNE] [CRN]
3702	831171	15743878	2005-09-22 10:54	expression of this gene is induced by auxin and positively regulated by VAN3 itself (VAN3)
3702	831171	15923323	2005-11-29 15:00	VAN3 is involved in vesicle trafficking and DRP1A is responsible for the vascular formation synergistically working with the VAN3 protein. [VAN3]
3702	831171	16698946	2006-10-13 18:27	Scarface (SFC) is required for normal intracellular transport of PIN1 from the plasma membrane to the endosome. [Scarface] [SFC]
3702	831173	17468220	2007-10-06 11:58	Amino acid conjugation plays a critical role in salicylic acid (SA) metabolism and induced defense responses, with PBS3 acting upstream of SA, directly on SA, or on a competitive inhibitor of SA.
3702	831173	17521413	2007-11-08 13:41	Molecular characterization of the GH3-LIKE DEFENSE GENE 1 (GDG1), a member of the GH3-like gene family, shows that GDG1 is an important component of salicylic acid mediated defense against the bacterial pathogen P. syringae.[GDG1]
3702	831173	17918621	2007-12-29 10:18	WIN3 (At5g13320) is a key element of the RPS2 defense response pathway and a basal and systemic defense component.
3702	831173	18266921	2008-08-09 10:19	WIN3 is partially required for Pseudomonas syringae HopW1-1-induced disease resistance.
3702	831191	16033802	2005-11-21 15:19	The expression domain of FY supports its roles in essential and flowering-time functions; FY may mediate both regulated and constitutive RNA 3'-end processing [FY]
3702	831191	16940039	2007-08-25 21:26	FCA interaction with FY mediates changes in FCA transcript processing.
3702	831197	17194765	2007-09-03 02:05	KEG is central to abscisic acid signaling by maintaining low levels of ABI5 in the absence of stress.
3702	831201	17485080	2007-09-29 11:02	AtDCP2 is essential for post-embryonic development and supplies new insights into the role of decapping-dependent mRNA turnover.
3702	831201	18025047	2008-02-16 11:00	Mutational analysis of the putative RNA-binding domain of Dcp2 confirmed the functional significance of an 11-residue loop region and the conserved Box B.
3702	831207	17051210	2007-08-25 13:29	Arabidopsis ABAR/CHLH specifically binds ABA (abscisic acid), and mediates ABA signalling as a positive regulator in seed germination, post-germination growth and stomatal movement, showing that ABAR/CHLH is an ABA receptor [ABAR]
3702	831213	16943431	2007-01-04 16:03	Elongator is important for plants to respond to ABA and drought exposure and that ABO1/ELO2 may play a vital role in ABA signal transduction pathways.[ABO1]
3702	831215	16778015	2006-11-29 17:57	AtPAO1 is the first plant Polyamine oxidase reported to be involved in a polyamine back-conversion pathway.
3702	831218	16243785	2007-08-25 12:58	Plastid NAD(P)H dehydrogenase activity is regulated on the transcriptional level by an ndhF-specific plastid sigma factor, SIG4.
3702	831224	15686521	2007-08-25 11:31	Regions important for the level of expression, including a region involved in expression in response to auxin, were identified. Additionally, AGL15 expression was found to respond to AGL15 accumulation amounts and to altered forms of AGL15.
3702	831224	17521410	2007-09-08 11:34	Flowering time is determined by the additive effect of multiple MADS domain floral repressors, with important contributions from AGL15 and AGL18.
3702	831227	17272298	2007-08-25 14:01	Results suggest that AtTBP1 is involved in the telomere length mechanism in A. thaliana and that the Myb-extension domain of AtTBP1 may stabilize plant telomeric DNA binding.
3702	831238	16339853	2006-04-28 14:55	LEP is a positive regulator of GA-induced germination acting independently of RGL2. [LEAFY PETIOLE] [LEP]
3702	831241	16575575	2007-08-25 21:12	Simulations carried out at different temperatures pointed to optimized positioning of key residues in the active site or dimerization domain as underlying the higher activity of two temperature-sensitive variants at lower temperatures.
3702	831241	16731548	2007-08-25 10:15	results suggest the presence of unknown stilbene isomerase activities in Arabidopsis.
3702	831244	16287862	2007-08-25 12:34	H3 lysine 9 methylation epigenetic modifications are reduced in an suvh4 suvh6 double mutant
3702	831255	17140415	2007-06-29 16:00	The Arabidopsis genome contains three genes for monofunctional aspartate kinases. aspartate kinase 2 and aspartate kinase 3 are inhibited only by lysine, and aspartate kinase 1 is inhibited in a synergistic manner by lysine and SAM. [AK2]
3702	831256	18036205	2008-05-26 02:06	Two CC-type glutaredoxins ROXY1 and ROXY2 together control anther development in Arabidopsis thaliana.
3702	831270	15849421	2005-12-01 11:55	IPMDH is involved in leucine biosynthetic pathway. Three IPMDH ORF sequences designated as AtIMD1, AtIMD2, and AtIMD3 are localized in plastids. AtIMD1 transcripts were the highest in roots. [AtIMD1; IPMDH]
3702	831275	18434413	2008-09-27 10:43	Data suggest that Arabidopsis csn mutants undergo DNA damage, which might be the cause of the delay in G2 cell cycle progression.
3702	831308	17540716	2007-10-20 11:08	These results demonstrate that ATNRT2.7 plays a specific role in nitrate accumulation in the seed.
3702	831326	16407270	2007-08-25 12:34	CA2 is an integral membrane protein localized on the matrix-exposed side of the membrane arm of complex I.
3702	831327	17644729	2007-12-01 12:56	The functional relationship of the R2R3-type MYB gene WEREWOLF (WER) and the R3-type MYB gene CAPRICE (CPC), was analyzed.
3702	831332	15602813	2007-08-25 15:07	NADP levels in transgenic plants in response to heat and drought stress as compared to wild-type plants.
3702	831339	17726111	2007-10-27 10:12	CNGCs have a widespread role in regulating cell-growth dynamics in both plant and animals
3702	831345	16040633	2007-08-25 12:36	Data show that EDS1 interacts in vivo with another protein, SENESCENCE-ASSOCIATED GENE101 (SAG101), and that interactions of EDS1 and its signaling partners are important for plant defense signal relay.
3702	831375	17284469	2007-08-25 10:07	Phenotypic analyses of GASA4 loss-of-function and gain-of-function lines indicate that GASA4 regulates floral meristem identity and also positively affects both seed size and total seed yield.
3702	831375	17761429	2008-01-26 10:19	functionally characterized the GASA4 gene and found that heat induced GASA4 expression.
3702	831393	17384171	2007-08-25 15:00	Arabidopsis thaliana CYCLIC NUCLEOTIDE GATED CHANNEL2 (CNGC2/DND1) conducts Ca(2+) into cells and provide a model linking this Ca(2+) current to downstream nitric oxide production.
3702	831393	18307990	2008-05-17 10:24	Transcriptional responses to growth in high environmental calcium concentrations were characterized and compared between wild-type and mutant Arabidopsis plants containing a knockout mutation in the gene encoding a cyclic nucleotide-gated channel (CNGC2).
3702	831398	16995899	2007-03-14 17:12	APG6 functions as a molecular chaperone involved in plastid differentiation mediating internal thylakoid membrane formation and conferring thermotolerance to chloroplasts during heat stress. [APG6]
3702	831411	17038516	2007-06-28 13:00	Results indicate that LONGIFOLIA1 (LNG1) and LNG2 are new components that regulate leaf morphology by positively promoting longitudinal polar cell elongation independently of ROT3 in Arabidopsis [LNG1] [LONGIFOLIA1]
3702	831419	17071651	2007-08-25 13:28	RGP2 is required during microspore development and pollen mitosis, either affecting cell division and/or vacuolar integrity.
3702	831441	15299137	2007-08-25 11:08	CO-derived signal(s), or possibly CO itself, fits the definition of the hypothetical flowering stimulant, florigen.
3702	831441	16002617	2007-08-25 10:21	findings show that FKF1 controls daily CONSTANS expression in part by degrading CYCLING DOF FACTOR 1 (CDF1), a repressor of CONSTANS transcription
3702	831441	16006578	2007-08-25 12:37	Promotes flowering specifically under long days.
3702	831441	16183837	2007-08-25 12:36	inactivation of FT caused down-regulation of SOC1 even in plants overexpressing CO, indicating that FT is required for SOC1 induction by CO
3702	831441	16709197	2007-08-25 21:21	RFI2 represses the expression of CONSTANS.
3702	831441	17138697	2007-08-25 10:09	These data suggest that CO might replace At HAP2 in the HAP complex to form a trimeric CO/At HAP3/At HAP5 complex.
3702	831441	17344804	2007-08-25 10:43	COb was retained for a long period after duplication, but a recent fixation of a detrimental mutation, possibly as an effect of a bottleneck, resulted in its nonfunctionalization in brassica nigra.
3702	831441	17504813	2007-10-13 12:37	The role of clock-associated genes PRR9, PRR7 and PRR5 are involved in activation of CONSTANS and CO-FLOWERING LOCUS T are reported.
3702	831441	18296627	2008-08-02 10:16	Results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness, thereby stabilizing CO, activating FT transcription, and inducing flowering.
3702	831441	18453150	2008-07-26 10:16	determines flowering timing with circadian clock.
3702	831442	15860010	2007-08-25 12:46	The data demonstrate that ax6 enhances the effect of coi1 on JA responses, implying a genetic interaction between COI1 and AtCUL1 in JA signaling.
3702	831443	16870359	2007-08-25 21:23	At5g15860 gene confers prenylcysteine alpha-carboxyl methylesterase (PCME) activity in Arabidopsis thaliana membranes.
3702	831462	15960617	2007-08-25 11:16	AN3 and AtGRF5 act together and are required for the development of appropriate leaf size and shape through the promotion and/or maintenance of cell proliferation.
3702	831476	17071648	2007-08-25 10:09	The mutant phenotype associated with T-DNA insertions in the Arabidopsis gene AtCRS1, encoding the ortholog of the maize chloroplast splicing factor CRS1, was examined.
3702	831492	17559514	2007-12-01 12:59	substantial effect on Arabidopsis shoot development, especially with respect to inflorescence architecture
3702	831493	16291783	2007-08-25 21:24	Epistasis analysis between FES1, FRI and FRIGIDA-LIKE 1 (FRL1), indicates that these genes do not function in a linear pathway, but instead act cooperatively to promote the expression of FLC.
3702	831505	18303110	2008-06-06 14:44	IPI plays a critical role in isoprenoid biosynthesis via the MVA pathway, and IPI is essential for the maintenance of appropriate levels of IPP and DMAPP in different subcellular compartments in plants. [IPI1]
3702	831505	18319397	2008-08-02 10:40	Each of Arabidopsis IPP2 and IPP1 isomerases is found in multiple but partially overlapping subcellular locations, and each can compensate for the loss of the other through partial redundancy in the cytosol.
3702	831518	16199616	2007-08-25 14:14	As KANADI is not required for either ETT or ARF4 transcription, and their overexpression cannot rescue kanadi mutants, cooperative activity is implied.
3702	831524	15659100	2005-11-17 11:56	The interaction of Tic110, Tic40 and Hsp93 in A. thaliana chloroplast protein transport is described. [AtTic40]
3702	831524	17327256	2007-08-25 10:43	The interaction of Tic40 with rhomboid proteases in a yeast mitochondria-based assay is reported.
3702	831524	17535810	2007-09-22 11:51	analysis of similarity between the chloroplast translocon component, Tic40, and the human co-chaperone, Hsp70-interacting protein
3702	831524	17883373	2008-03-10 15:00	the sorting of AtTic40 requires a bipartite transit peptide, which is first cleaved by the stromal processing peptidase (SPP), thus generating a soluble AtTic40 stromal intermediate.
3702	831525	16786311	2007-08-25 11:54	RAD4 interacts with the distal EF-hand Ca(2+) binding domain of CEN2 and this interaction is required for efficient nucleotide excision repair. [RAD4]
3702	831538	17616738	2007-12-01 13:12	Mutation of the TORMOZ (TOZ) gene yields embryos with aberrant cell division planes and arrested embryos that appear not to have established normal patterning.
3702	831546	16935987	2007-08-25 10:49	PEP12/SYP21 is involved in vacuolar sorting and excess of this syntaxin in the prevacuolar complex can be detrimental for further transport from this organelle.
3702	831548	17911168	2008-02-02 10:19	study reports the physical interaction of an Arabidopsis POT1 protein, POT1A (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
3702	831548	18212040	2008-05-03 10:57	AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 associates with active telomerase RNP particles in an RNA-dependent manner.
3702	831548	18239859	2008-06-07 10:29	Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.
3702	831560	17028190	2007-08-25 11:50	Crystal study of Arabidopsis alkenal double bond reductase encoded by At5g16970 determines that it belongs to the zinc-independent medium chain dehydrogenase/reductase superfamily.
3702	831568	15807784	2005-10-26 15:00	Two putative glycosyltransferase genes (At5g17050 and At4g14090) induced by PAP1 expression were confirmed to encode flavonoid 3-O-glucosyltransferase and anthocyanin 5-O-glucosyltransferase, respectively. [flavonoid 3-O-glucosyltransferase]
3702	831568	17277900	2007-11-08 10:47	ANL1 gene encodes UDP-glucose:flavonoid-3-O-glucosyltransferase and is expressed in all tissues examined, including rosette leaves, stems, flower buds and roots. Anthocyaninless1] [ANL1]
3702	831581	17485445	2007-09-07 18:14	ENH1 functions in the detoxification of reactive oxygen species resulting from salt stress by participating in a new salt tolerance pathway that may involve SOS2 but not SOS3.[ENH-1]
3702	831599	15604684	2007-08-25 11:32	Insertion mutants of GAD1 revealed that GABA levels in roots were drastically reduced compared with those in the wild type.
3702	831599	17392553	2007-08-25 14:00	Antibody titers to this enzyme identify two subgroups of patients with adult-onset autoimmune diabetes having distinct clinical, autoimmune, and genetic features.
3702	831608	15980264	2007-08-25 10:57	Microarrays have been used to identify genes that exhibit a similar expression pattern to the secondary cell wall-specific cellulose synthase genes IRX1 and IRX3.
3702	831608	17041031	2007-08-25 21:11	CesA7 has a role in cellulose biosynthesis, primary, and secondary cell wall structure.
3702	831608	17427041	2007-08-25 13:24	AtCesA7 is phosphorylated in vivo at two serine residues.
3702	831635	16025407	2005-11-17 13:48	We investigated the influence of heat stress on metabolites in the tu8 (a novel allele of TERMINAL FLOWER2) mutant. [TU8]
3702	831635	16244868	2007-08-25 15:07	In transgenic plants expressing the LHP1-GFP fusion protein, two major localization patterns were observed according to cell types suggesting that localization evolves with age or differentiation states.
3702	831635	16361394	2007-08-25 11:24	Results imply that LIKE HETEROCHROMATIN PROTEIN1 (LHP1) recruitment to chromatin is mediated through interaction with methyl K9 and that LHP1 controls different nuclear processes via transient binding to its nuclear sites.
3702	831635	16549797	2007-08-25 12:33	chromodomain protein LIKE HETEROCHROMATIN PROTEIN (LHP)1 might play a role in vernalization
3702	831635	16682972	2007-08-25 11:55	LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) is necessary to maintain the epigenetically repressed state of FLC upon return to warm conditions typical of spring
3702	831635	16972870	2007-08-25 10:47	LHP1, like its animal homologues, has a high binding affinity for A/T-rich regions.
3702	831635	17542647	2007-12-01 10:43	Recognizes specifically trimethylated Histone H3 in vivo as part of a mechanism that represses the expression of many genes targeted by Polycomb repressive complex 2.
3702	831635	17676062	2007-12-01 11:34	Arabidopsis thaliana chromodomain-containing protein LHP1 colocalizes with H3K27me3 genome-wide. The LHP1 chromodomain also binds H3K27me3 with high affinity, suggesting that LHP1 has functions similar to those of Polycomb
3702	831647	15340011	2005-11-21 10:25	These results indicate that variegated 3 (var3) is a part of a protein complex required for normal chloroplast and palisade cell development [var3].
3702	831656	17114357	2007-09-03 02:06	Arabidopsis constitutive shade-avoidance1 (csa1) mutant shows a shade-avoidance phenotype in the absence of shade and enhanced growth of a bacterial pathogen.
3702	831660	15326182	2007-08-25 14:35	x-ray crystallographic structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate
3702	831681	15607746	2007-08-25 13:11	characterization of the two Arabidopsis orthologs of Raptor (AtRaptor1 and 2); disruption of the AtRaptor2 gene, which is expressed at a lower level than AtRaptor1, has no visible effects on embryo and plant development[AtRaptor2]
3702	831683	16424903	2007-08-25 14:13	A region important in vivo localizes to a 14-amino-acid segment that evolves very rapidly in TFL1 orthologs, but is almost invariant in FT orthologs.
3702	831683	16676184	2007-08-25 12:31	TFL1 gene plays an important role in hormone-regulated inflorescence formation.
3702	831683	17369370	2007-08-25 15:03	Signals from LFY in floral meristems may feed back to promote TFL1 protein movement in the shoot meristem.
3702	831683	18003908	2008-01-05 14:24	TFL1 localizes to endomembrane compartments and colocalizes with the putative delta-subunit of the AP-3 adapter complex
3702	831710	15014444	2005-09-30 14:45	essential role of Brca2 during meiosis in Arabidopsis [Brca2(V)]
3702	831720	15998312	2007-08-25 11:20	Ferritin accumulation during infection of Arabidopsis by E. chrysanthemi is a basal defense mechanism which is mainly activated by bacterial siderophores.
3702	831733	16553900	2007-08-25 14:11	AtHD2C can modulate abscisic acid and stress responses.
3702	831738	17227548	2007-07-02 11:58	This study shows that the spatial and temporal expression patterns of PDX1.1 and PDX1.3, investigated at the transcript and protein level, largely overlap, but PDX1.3 is more abundant than PDX1.1. [PDX1.3]
3702	831741	16040609	2007-08-25 14:15	STN8 protein kinase in Arabidopsis thaliana is specific in phosphorylation of photosystem II core proteins.
3702	831741	16237446	2005-11-10 13:44	In Arabidopsis a second protein kinase, STN8, is required for the quantitative phosphorylation of PSII core proteins; acclimation to changes in light quality is defective in stn7 but not in stn8 mutants [STN8]
3702	831743	16148005	2007-08-25 10:57	The mechanisms of reading the CTD code by two classes of protein phosphatases, plant CPLs and yeast Ssu72, that specifically dephosphorylate Ser(5) in vitro are reported.
3702	831743	18506580	2008-08-23 10:14	Arabidopsis plants that express CPL2 mutants exhibited leaf expansion defects, early flowering, low fertility, and increased salt sensitivity.
3702	831745	15155890	2007-08-25 13:49	floral phenotype of blr mutants is caused by derepression of AGAMOUS, suggesting that BLR functions as a transcription repressor
3702	831745	18298668	2008-08-16 10:37	results from this study support a model in which PNY and PNF promote LFY expression during reproductive development
3702	831745	18390591	2008-08-09 10:18	data showed that BP and PNY restrict KNAT6 and KNAT2 expression to promote correct inflorescence development
3702	831748	18000017	2008-04-19 12:44	It was shown that phosphatidic acid (PA) binds CTR1 and inhibits its kinase activity; Subsequent deletion analysis of CTR1's kinase domain revealed a novel PA-binding region at the C-terminus of the kinase.
3702	831749	17999647	2008-04-12 10:17	Altogether these data demonstrate that HsfA3 is transcriptionally controlled by DREB2A and important for the establishment of thermotolerance.
3702	831749	18261981	2008-04-12 10:20	These results indicate that HsfA3 regulates expression of many heat-inducible genes in the transcriptional cascade downstream of the DREB2A stress-regulatory system and functions in acquisition of thermotolerance under the control of the DREB2A cascade.
3702	831757	18080804	2008-05-03 11:22	Data suggest that accurate temporal and spatial expression of PTL is essential for its proper functional implementation during plant development.
3702	831765	15665497	2007-08-25 13:44	Induction of the gene by mono- and disaccharides and localization of expression to the leaf vasculature.
3702	831765	18237745	2008-03-29 11:16	Structural comparison of the two structures shows that the recognition of CBL by CIPK is performed in a similar manner, but inherent interactions confer binding affinity and specificity.
3702	831765	18785584	2008-10-04 10:13	Comparing with wild types, the lines inserted with the T-DNA in which CIPK14 gene expression was knocked out were also more sensitive to ABA and salt stimulus, showing low germination rate and the less root elongation
3702	831793	15695441	2007-08-25 15:07	PRR5 and PRR7 coordinately (or synergistically) play essential clock-associated roles close to the central oscillator.
3702	831793	15705949	2007-08-25 14:38	single prr7-3 or prr9-1 mutants exhibit modest period lengthening, but the prr7-3 prr9-1 double mutant shows dramatic and more than additive period lengthening in the light and becomes arrhythmic in constant darkness
3702	831793	15767265	2007-08-25 12:37	PRR9/PRR7/PRR5 together act as period-controlling factors, and they play overlapping and distinctive roles close to (or within) the central oscillator in which the relative, PRR1/TOC1, plays an essential role
3702	831793	17504813	2007-10-13 12:37	The role of clock-associated genes PRR9, PRR7 and PRR5 are involved in activation of CONSTANS and CO-FLOWERING LOCUS T are reported.
3702	831793	17877705	2008-01-26 12:53	findings show that the overexpression of PRR7 leads to severely compromised circadian rhythms & that the PRR7 protein is phosphorylated in a circadian regulated manner & its levels are post-translationally regulated by both diurnal & circadian mechanisms
3702	831795	16460506	2006-08-21 16:01	At4 is involved in the internal allocation of phosphate (Pi) between shoot and roots . [At4]
3702	831809	16942608	2007-05-08 16:36	The putative exocyst subunit EXO70A1 is involved in cell and organ morphogenesis. [EXO70A1]
3702	831813	17461792	2007-10-20 10:21	an active transcriptional repressor that has a role in regulating cell elongation in plants.
3702	831826	17510065	2007-10-13 10:02	WRKY62, a member of WRKY group III transcription factors, was induced by methyl jasmonate and salicylic acid treatment; it acts downstream of cytosolic NPR1 and negatively regulates JA-responsive gene expression.
3702	831832	15720653	2005-10-21 10:41	Arath;CDC25 can function as a mitotic accelerator, however, expression of Arath;CDC25 was not enhanced in rapidly dividing compared with non-proliferative Arabidopsis tissues. [CDC25]
3702	831845	15723040	2005-10-28 16:37	PROMOTION OF CELL SURVIVAL 1 (PCS1) gene in Arabidopsis, which encodes an aspartic protease, has an important role in determining the fate of cells in embryonic development and in reproduction processes [PCS1]
3702	831845	15809863	2007-08-25 14:15	results enable us to propose an advanced model of PC synthesis, describing substrate specificity, heavy metal requirement, and the active site in the PCS1 enzyme
3702	831847	16920782	2007-08-25 10:49	The interaction of E2FC with DPB is a key factor in controlling the balance between cell proliferation and the switch to the endocycle program.
3702	831861	17261580	2007-07-02 13:51	Thylakoid ATP/ADP carrier (TAAC) supplies ATP for energy-dependent reactions during thylakoid biogenesis and turnover in plants. [TAAC]
3702	831884	17468208	2007-12-01 12:57	Leaf IDH activity is reduced by 92% in mutant
3702	831889	15466219	2007-08-25 11:10	EIN2 membrane protein is required for both the first and second phases of growth inhibition by ethylene in Arabidopsis seedling hypocotyls.
3702	831889	16798939	2007-08-25 21:21	RCN1 and EIN2 modulate hypocotyl gravitropism and ethylene responses through independent pathways.
3702	831889	17084699	2007-08-25 12:25	Planar polarity in root tips studied and found that combinatorial action of the auxin influx carrier AUX1, ETHYLENE-INSENSITIVE2, and GNOM genes mediates the vector for coordinate hair positioning.
3702	831889	17533512	2007-09-22 11:51	EIN2 is a cross-link node in ethylene, ABA and stress signaling pathways, and EIN2 is necessary to induce developmental arrest during seed germination, and seedling establishment, as well as subsequent vegetative growth
3702	831914	16244449	2007-08-25 21:05	fluctuation of AtFLA11 transcripts during the maturation process of sclerenchyma cells suggests its role in the formation of the secondary cell wall
3702	831935	16418233	2007-08-25 10:54	In leaves and stems of arabidopsis and tobacco, both the alpha- and beta-subunits of Glutamate dehydrogenase are targeted to the mitochondria of the companion cells.
3702	831935	18296429	2008-05-24 10:05	role in amino acid breakdown under C-deficient conditions
3702	831938	16519510	2006-05-08 15:47	Catalytic properties of the protein encoded by At5g18200 shows that it is an adenylyltransferase that uses ADP-glucose as the donor substrate and catalyzes transfer of the adenylyl moiety to a broad range of phosphate acceptors.
3702	831942	15361138	2007-08-25 12:59	survey of the MYB proteins that interact with R/B-like Bbasic helix-loop-helix proteins
3702	831946	17434987	2007-10-06 10:53	acts to reduce the concentration of extracellular nucleotides, highest expression in rapidly growing tissues and/or tissues that accumulate high auxin levels
3702	831947	16223486	2006-01-03 16:31	SIP1;2 are the smallest aquaporins. When expressed in yeast gave water-channel activity. They are localized in ER of all tissues except dry seeds. [SIP1;2]
3702	831959	15516496	2007-08-25 11:33	The multiple growth and developmental phenotypes of Atnap and Atpir mutants reveals these proteins are also required for a wider variety of cellular functions in addition to regulating trichome cell growth.
3702	831974	17630277	2007-12-13 15:04	These results suggest that PUCHI acts downstream of auxin signaling and that this gene contributes to lateral root morphogenesis.[PUCHI]
3702	831984	15632054	2005-11-02 15:48	An Arabidopsis mutant that accumulated divinyl chlorophyll. Cloning of this mutant resulted in the identification of a gene that shows sequence similarity with isoflavone reductase genes. DVR is involved in monovinyl chlorophyll synthesis. [DVR]
3702	832038	17449645	2007-10-06 11:52	The ecr1-1 mutant is resistant to the auxin-like compound indole-3-propionic acid, produces fewer lateral roots than wild type, displays reduced adult height, and stabilizes a reporter fusion protein that is degraded in response to auxin.
3702	832048	16042389	2007-08-25 11:05	Phosphopeptide binding introduces conformational fluctuations to residues of the long recognition loop of the kinase-interacting-forkhead-associated domain of KAPP; rigidity of this domain appears to couple as a whole to phosphothreonine peptide binding.
3702	832048	17499048	2007-08-25 12:20	The crystal structure of the binary complex of Ca-SOS3 with the C-terminal regulatory moiety of SOS2 resolves central questions regarding the dual function of SOS2 as a kinase and a phosphatase-binding protein.
3702	832048	18162596	2008-06-07 10:07	These results implicate KAPP as a functional component of the RLK signaling pathway, which also mediates adaptation to Na(+) stress.
3702	832053	15516505	2005-05-26 17:32	ARIA (arm repeat protein interacting with ABF2) is a positive regulator of abscisic acid response. [ARIA]
3702	832073	15894745	2005-11-21 10:23	The thickvein mutation that affects vein thickness, was found to reside in the ACL5 gene, which encodes a spermine synthase and whose expression is specific to provascular cells. [ACL5]
3702	832073	16936072	2007-08-25 15:04	Results suggest a model in which ACL5 plays a role in the translational activation of SAC51, which may lead to the expression of a subset of genes required for stem elongation.
3702	832073	17560575	2007-08-25 13:23	Putative spermine synthases from Arabidopsis thaliana could be identified as thermospermine synthases.
3702	832073	18599510	2008-10-01 14:49	ACL5 has a prominent role in the correct specification of xylem cells through its action on the duration of xylem element differentiation. [ACAULIS 5] [ACL5]
3702	832080	15531709	2007-08-25 14:17	Colocalization with SULTR2;1, and coexpression in sulfate transport.
3702	832086	17662035	2008-01-05 15:45	required for cleaving bZIP17 in response to salt stress
3702	832145	16143720	2007-08-25 12:00	The effects of AtBCB and NtGDI1 on aluminum tolerance in plants and S. cerevisiae are reported.
3702	832145	18251883	2008-03-10 16:16	Data show type III secretion system-independent upregulation of BCB, which might contribute to an early induced, cell wall-based defence mechanism, occurs in response to non-adapted bacteria.
3702	832146	17965182	2008-04-05 13:01	C-terminal PI motif not essential for floral organ identity function
3702	832154	16040244	2007-08-25 14:15	DCL4 is the primary processor of endogenous RDR6-dependent trans-acting siRNAs (tasiRNAs).
3702	832154	16129836	2005-11-09 13:44	dcl4-2 mutant resembled an RNA-dependent RNA polymerase 6 mutant in that both mutants lacked ta-small interfering RNAs [DCL4]
3702	832154	16273107	2006-05-02 11:34	DICER-LIKE 4 (DCL4) produces the 21-nt siRNA from the inverted repeat transgenes is the RNA component of cell-to-cell silencing signal in plants. [DCL4]
3702	832154	16741077	2007-08-25 14:09	DCL4 and DCL2 exhibit specific, hierarchical antiviral activities; inhibition of DCL4 by a viral-encoded suppressor revealed the subordinate antiviral activity of DCL2
3702	832154	16810317	2007-01-04 15:02	DCL4 is the primary producer of Cucumber mosaic virus (CMV) derived siRNAs and also produces turnip crinkle virus (TCV)-derived siRNAs. DCL2 appears to be the major producer of TCV-derived siRNAs, likely because TCV suppresses the activity of DCL4.[DCL4]
3702	832154	17400893	2007-08-25 13:24	Several gene transcripts were found to be routed through the RDR6/DCL4-dependent pathway after initial targeting by one or multiple microRNAs or trans-acting short interfering RNA.
3702	832154	17592042	2007-09-04 17:50	Study shows that unidirectional (3-->5') transitivity requires the hierarchical and redundant functions of DCL4 and DCL2 acting downstream from RDR6 to produce 21- and 22-nt-long siRNAs, respectively.
3702	832154	17609283	2007-09-29 11:22	DCL4 is capable of accessing flexibly structured single-stranded RNA substrates (preferably T-shaped hairpins) to produce satsiRNAs. This result reveals that viral RNA of diverse structures may stimulate antiviral DCL activities in plant cells.
3702	832157	16100337	2007-08-25 11:26	Results demonstrate that S-acylation is essential for normal plant cell growth and identify TIP GROWTH DEFECTIVE1 (TIP1), a plant S-acyl transferase.
3702	832163	16762032	2007-08-25 21:17	Exogenous auxin activates MGD2 expression during Phosphate starvation, whereas expression is repressed by cytokinin treatment in the root.
3702	832171	18178669	2008-07-26 10:05	knockouts exhibited defects in root hair elongation suggesting that the myosin-driven motility plays a significant role in a polar tip growth
3702	832171	18503043	2008-08-09 10:12	Arabidopsis myosins XIE, and XIK, are involved in Golgi, peroxisome, and mitochondrial movement.
3702	832196	15923351	2007-08-25 10:21	ARF7 plays a major role in regulating expression of a subset of auxin response genes in leaf mesophyll cells.
3702	832196	15960621	2007-08-25 21:05	Mutations in ARF19 have little effect on their own, but in combination with mutations in NPH4/ARF7, encoding the most closely related ARF, they cause several phenotypes.
3702	832196	17259263	2007-08-25 10:44	ARF7 acts to regulate the auxin-mediated transcription of LATERAL ORGAN BOUNDARIES-DOMAIN16/ASYMMETRIC LEAVES2-LIKE18 (LBD16/ASL18) and/or LBD29/ASL16 in roots.
3702	832208	17921313	2008-04-26 13:06	results show that loss of RAD51 caused hypersensitivity to the double-strand break-inducing agent bleomycin in P. patens but not Arabidopsis; data show importance of RAD51 for viability is independent of taxonomic position or complexity of an organism
3702	832217	17110953	2007-08-25 10:45	Our results provide direct evidence for a crucial role of the TOUSLED protein kinase in the maintenance of transcriptional gene silencing in some genomic regions in a DNA-methylation-independent manner in Arabidopsis.
3702	832272	16212602	2007-08-25 13:38	role of DNA polymerase epsilon during gametophyte and seed development in A. thaliana, encoded by POL2a and POl2b, with a main regulatory subunit DPB2, is reported
3702	832274	15772281	2007-09-03 02:02	The different phenotype of pnt1 cells in embryos and callus suggest a differential requirement for GPI-anchored proteins in cell wall synthesis in these two tissues and points to the importance of GPI anchoring in coordinated multicellular growth.
3702	832283	16055635	2007-08-25 14:44	Results suggest that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.
3702	832283	16514015	2007-08-25 21:18	AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.
3702	832286	16908508	2007-08-25 13:30	MS1 has a role in the regulation of tapetal programmed cell death.
3702	832286	18032629	2008-03-10 14:15	MS1 plays a critical role in the induction of pollen wall and pollen coat materials in the tapetum and, ultimately, the production of viable pollen.
3702	832286	18032630	2008-03-10 14:15	The role of MS1 in pollen and tapetum development and the conservation of MS1 function in flowering plants, is discussed.
3702	832321	15213437	2007-08-25 11:17	Solution structure of At5g22580
3702	832338	18310306	2008-08-09 10:44	RAD5-dependent error-free branch of postreplication repair is conserved between yeast and plants, and that AtRad5a might be functionally homologous to ScRad5
3702	832364	16461581	2007-06-27 09:00	rax mutants show new phenotypes that are characterized by defects in lateral bud formation in overlapping zones along the shoot axis. RAX genes are partially redundant in function and allow a fine-tuning of secondary axis formation [RAX1]
3702	832364	16473968	2006-08-21 14:51	RAX1 functions to positionally specify a stem cell niche for axillary meristem formation and affects the timing of developmental phase transitions by negatively regulating gibberellic acid levels in the shoot apex. [RAX1]
3702	832366	17369439	2007-08-25 15:03	MAM3 (formerly known as MAM-L)catalyzes the formation of all glucosinolate chain lengths in vivo as well as in vitro.
3702	832370	17347443	2007-08-25 11:46	results show [Ca2+]i oscillations are synchronized to extracellular Ca2+ concentration oscillations largely through Ca2+-sensing receptor CAS; CAS regulates inositol 1,4,5-trisphosphate concentration which directs release of Ca2+ from internal stores
3702	832370	18331354	2008-06-09 16:36	Arabidopsis lines revealed a significant role for calcium-sensing receptor (CaS) in plant growth and development. [calcium-sensing receptor] [CaS]
3702	832372	16024589	2006-01-25 15:41	The evolutionarily conserved TOUGH (TGH) protein is a novel regulator required for Arabidopsis thaliana development. It plays a role in RNA binding or processing. [TOUGH] [TGH]
3702	832379	17764945	2008-01-12 10:20	Natural variation in HUA2 activity coordinates changes in two important life-history traits, flowering time and shoot morphology.
3702	832386	17587307	2007-12-01 10:13	able to degrade nicotinamide
3702	832387	17587307	2007-12-01 10:13	Seed of a knockout mutant had reduced nicotinamidase activity, retarded germination and impaired germination potential.
3702	832391	15565288	2005-09-28 09:21	AtSTP11 transporter plays a role in the supply of monosaccharides to growing pollen tubes. [AtSTP11]
3702	832406	16563436	2007-08-25 10:53	At2g34450 protein is a nuclear protein, whereas the At5g23405 protein is found mainly in the cytoplasm
3702	832422	16682354	2007-08-25 12:30	Null sgs3 mutants lack TAS1, TAS2, and TAS3 ta-siRNAs and overaccumulate ARF3/ETTIN and ARF4 mRNAs, which are TAS3 ta-siRNA targets.
3702	832422	16699177	2007-08-25 12:30	RDR6, SGS3 and AGO7 act in the same pathway, which genetically interacts with the AS1-AS2 pathway for leaf development.
3702	832432	18208516	2008-05-24 10:06	The roles of the LCB2a and LCB2b subunits in sphingolipid biosyntesis in A. thaliana were studied.
3702	832432	18218968	2008-07-26 10:06	T-DNA insertions in two homologous LCB2 genes showed a phenotype similar to fumonisin B(1) resistant11-2 mutant, an allele of lcb1-1.
3702	832437	16889651	2007-08-25 14:06	PHS1, which encodes a dual-specificity PTP, is a negative regulator of ABA signalling.
3702	832461	15918888	2007-08-25 12:45	The florally expressed genes At5g23960 and At5g44630, are responsible for the formation of virtually all sesquiterpenes found in the Arabidopsis floral volatile blend.
3702	832463	16741749	2007-08-25 21:08	Heterologous expression in transgenic soybean significantly enhances Fe(+3) reduction in roots and leaves.
3702	832463	16845482	2007-08-25 21:02	The large water soluble domain of FRO2, which contains NADPH, FAD and oxidoreductase sequence motifs, was located on the inside of the membrane.
3702	832467	15126639	2007-08-25 11:36	formation of functional AtMinD1 homodimers is paramount for appropriate AtMinD1 localization, ultimately ensuring correct division machinery placement and chloroplast division in plants
3702	832467	16014621	2007-08-25 12:44	Correct intraplastidic MinD1 localization is dependent on AtMinE1-stimulated, Ca2+-dependent AtMinD1 ATP hydrolysis
3702	832467	18204083	2008-06-28 10:11	The chloroplast division site placement involves a balance between the opposing activities of AtMinE1 and AtMinD1, which acts to prevent FtsZ ring formation anywhere outside of the mid-chloroplast.
3702	832477	17118361	2007-08-25 14:04	The NEP (the (phage-type) plastid RNA polymerase) promoter cluster can help maintain RNA synthesis in situations where no functional sigma factor is available for PEP (the bacterial-type plastid RNA polymerase).
3702	832494	15213389	2007-08-25 11:17	purification and X ray structure
3702	832494	15644219	2007-08-25 10:23	calcium binding is responsible for the dimerization of SOS3
3702	832494	16540484	2007-08-25 14:11	SOS3 and AtHKT1 are major determinants of salinity resistance such that sos3 more strongly causes Na+ overaccumulation in roots, whereas athkt1 causes an increase in Na+ levels in the xylem sap and shoots and a concomitant Na+ reduction in roots.
3702	832494	17499048	2007-08-25 12:20	SOS2 family of protein kinases and their activators, the SOS3 family of calcium-binding proteins, function together; SOS2 is activated by Ca-SOS3 and subsequently phosphorylates ion transporter SOS1 to protect cellular ion homeostasis under salt stress
3702	832503	16771839	2007-01-09 14:00	ATXR5 and ARXR6 interact with proliferating cell nuclear antigen (PCNA) and are associated with a role in the cell cycle or DNA replication. [ATXR6]
3702	832509	15753101	2005-11-23 14:29	AtYSL2 is involved Fe and Zn homeostasis [AtYSL2]
3702	832518	15695441	2007-08-25 21:05	PRR5 and PRR7 coordinately (or synergistically) play essential clock-associated roles close to the central oscillator.
3702	832518	15725674	2005-11-10 14:08	PRR5 plays an antagonistic role(s) to the putative CCA1 clock component.[PRR5] [PSEUDO-RESPONSE REGULATOR 5]
3702	832518	15767265	2007-08-25 12:37	PRR9/PRR7/PRR5 together act as period-controlling factors, and they play overlapping and distinctive roles close to (or within) the central oscillator in which the relative, PRR1/TOC1, plays an essential role
3702	832518	17284847	2007-08-25 21:26	PRR5 seedlings showed a phenotype of hypersensitivity to red light during early photomorphogenesis
3702	832518	17504813	2007-10-13 12:37	The role of clock-associated genes PRR9, PRR7 and PRR5 are involved in activation of CONSTANS and CO-FLOWERING LOCUS T are reported.
3702	832518	17693530	2007-12-22 12:50	These results show that ZTL targets PRR5 for degradation by 26S proteasomes in the circadian clock and in early photomorphogenesis.
3702	832518	18178585	2008-05-31 10:29	The linkages between TOC1 and PRR5 in the regulation of the biological clock of A. thaliana were studied.
3702	832523	16709193	2007-08-25 21:21	TTG1 is involved in the regulation of TT8 expression.
3702	832523	18036197	2008-05-24 10:35	This study showed that overexpression of Myb113 or Myb114 results in substantial increases in pigment production, and that pigment production remains TTG1- and bHLH-dependent.
3702	832523	18434419	2008-09-27 10:43	Data show that TTG1-bHLH-MYB complex directly regulating activators and repressors and the movement of repressors to affect trichome patterning on the Arabidopsis leaf.
3702	832523	18547143	2008-10-04 10:39	the role of TTG1 in Arabidopsis trichome formation
3702	832534	18055605	2008-05-19 02:05	An Arabidopsis thaliana mutant, brassinosteroid-insensitive4 (bin4), in which the growth of various organs is dramatically reduced, is dexcribed.
3702	832546	16258019	2007-08-25 10:55	VSP2 is an anti-insect protein and that its defense function is correlated with its acid phosphatase activity
3702	832554	17101984	2007-06-29 09:03	Cry-DASH (Cryptochrome-Drosophila, Arabidopsis, Synechocystis, Human) subfamily proteins may be able to preserve the DNA repair activity toward single-stranded cyclobutane pyrimidine dimer (CPD)-containing DNA substrate. [At-Cry3] [AtCry3].
3702	832607	17307926	2007-08-25 14:00	Data show that through control of EIN3/EIL1 levels, EBF1 and EBF2 fine-tune ethylene responses by repressing signaling in the absence of hormone, dampening signaling at high concentrations, and promoting rapid recovery after ethylene levels dissipate.
3702	832638	17885085	2008-01-19 11:42	results identify YUCCA6 as a functional member of the YUCCA family with unique roles in growth and development
3702	832642	18543065	2008-09-27 10:17	GFP transient assay identified two homologues, AtRBL11 (At5g25752) and AtRBL12 (At1g18600) to be targeted into plastids and mitochondria, respectively.
3702	832645	16272432	2008-03-28 15:42	PEX4 is necessary for Arabidopsis peroxisomal function.  pex4 mutants are sucrose dependent during germination and display reduced responses to the auxin precursor indole-3-butyric acid, presumably due to peroxisomal beta-oxidation defects.
3702	832658	18596113	2008-08-30 10:25	IAA28 overexpressing and knock-down lines showed no major morphological changes, whereas IAA13 and ARF2 overexpressing plants grew more slowly than the wild type.
3702	832667	16640593	2007-08-25 10:51	Arabidopsis myrosinases TGG1 and TGG2 are functionally redundant.
3702	832669	16640593	2007-08-25 10:51	Arabidopsis myrosinases TGG1 and TGG2 are functionally redundant.
3702	832669	18202003	2008-06-28 10:11	The molecular bases underlying differences of the glucosinolate-myrosinase system in suspension cells and hypocotyls are reported.
3702	832672	17416636	2007-10-06 10:25	induced in photosynthetic tissues under oxidative conditions to supply heme for defensive hemoproteins outside plastids
3702	832693	17376158	2007-08-25 13:25	The functional role of CLC-D in the trans-Golgi network is reported.
3702	832706	15618411	2007-08-25 14:50	The expression and characterization of this phosphoglucan,water dikinase in A. thaliana.
3702	832706	15686522	2005-09-22 13:51	An Arabidopsis thaliana gene encoding a homologue of the potato alpha-glucan, water dikinase GWD, previously known as R1, was identified by screening the Arabidopsis genome and named AtGWD3. [GWD3]
3702	832706	15894744	2007-08-25 21:28	The role of alpha-glucan/water dikinase in the development of cold tolerance in conjunction with SEX1 protein is reported.
3702	832707	17099079	2007-08-25 13:27	Spatial and temporal expression of ARR24 (At5g26594) is discussed.
3702	832733	15447654	2007-08-25 12:39	In vivo co-immunoprecipitation with ZTL into an SCF complex.
3702	832773	15546358	2007-08-25 14:45	Use of the T-DNA insertional mutant of AtNHX1 (nhx1 plants) and DNA arrays to assess differences in transcriptional profiles and further characterize the roles of this protein.
3702	832773	16249341	2007-08-25 12:35	the presence of a vacuolar calmodulin-like protein acting on the vacuolar-localized AtNHX1 C terminus in a Ca(2+)- pH-dependent manner suggests the presence of signaling entities acting within the vacuole.
3702	832773	17411438	2007-08-25 12:21	AtNHX1 has a role in calcium signaling, sulfur metabolism, cell structure and cell growth, as well as vesicular trafficking and protein processing.
3702	832773	17561307	2008-01-05 15:45	To generate salt-tolerant turf and forage, tall fescue (Festuca arundinacea) was transformed with AtNHX1.
3702	832790	16709201	2007-06-27 11:32	AtGID1a, AtGID1b and AtGID1c function as GA receptors in Arabidopsis. [AtGID1c]
3702	832790	17194763	2007-06-29 15:00	GID1a, GID1b, GID1c are the predominant GA receptors in regulating GA growth response in Arabidopsis.  GA binding to GID1a promotes its interaction with DELLA proteins. [GID1c]
3702	832790	17521411	2007-09-08 11:34	The double knockout mutant atgid1a atgid1c showed a dwarf phenotype.  The triple knockout mutant atgid1a atgid1b atgid1c did not germinate voluntarily, and only started to grow when the seed coat was peeled off after soaking.
3702	832797	17452339	2007-08-25 12:20	Comparison of the pH profiles and the solvent deuterium isotope effects of A. thaliana glutathione synthetase and the Arg-132 and Arg-454 mutants suggest distinct mechanistic roles for these residues
3702	832814	18344283	2008-08-02 10:40	Findings suggest that mitochondrial morphology is influenced by MIRO1 and plays a vital role during embryogenesis and pollen tube growth.
3702	832820	16256065	2007-08-25 13:38	The expression profile of AtLACS6, AtLACS7, AtPEX5, and AtPEX7 revealed that AtLACS6 and 7 have distinct patterns of expression.
3702	832873	17425333	2007-08-25 13:23	Binding of the C-terminus of serine acetyltransferase by acetylserine sulfhydrylase contributes a large portion of the total binding energy during formation of the plant cysteine synthase complex.
3702	833310	17650510	2007-12-08 11:40	Recombinant CDR1 was characterized.
3702	833406	16963519	2007-08-25 10:48	The purification and characterization of PAP26 is reported.
3702	833437	16608867	2007-08-25 12:31	Homologous recombinations were detected in transgenic Arabidopsis plants that carried in their genome a beta-glucuronidase recombination marker. The distribution of recombination events towards the vascular tissue.
3702	833476	15659096	2005-09-22 08:49	The isolation and expression of EGY1, which affects both chlorophyll accumulation and gravitropism in A. thaliana seedlings. [EGY1]
3702	833476	18097640	2008-05-17 10:33	Role of EGY1 in regulation of endodermal plastid size and number as well as the stimulatory effect of ethylene on hypocotyl gravitropism in Arabidopsis
3702	833502	17449811	2007-10-06 11:58	SCABP8 and SOS3 are only partially redundant in their function, and each plays additional and unique roles in the plant salt stress response.
3702	833502	17499048	2007-08-25 12:20	SOS2 family of protein kinases and their activators, the SOS3 family of calcium-binding proteins, function together; SOS2 is activated by Ca-SOS3 and subsequently phosphorylates ion transporter SOS1 to protect cellular ion homeostasis under salt stress
3702	833502	17785451	2008-03-29 13:06	Data suggest that the interaction of SOS2 with both NDPK2 and CATs2 and 3 reveals a point of cross talk between salt stress response and other signaling factors including H2O2.
3702	833502	17825054	2008-01-26 12:03	findings suggest that CBL10 and CIPK24 (SOS2) constitute a novel salt-tolerance pathway that regulates the sequestration/compartmentalization of Na(+) in plant cells
3702	833502	17875927	2008-03-29 11:16	Results suggest that regulation of V-ATPase activity is an additional key function of SOS2 in coordinating changes in ion transport during salt stress and in promoting salt tolerance.
3702	833524	15772282	2007-09-03 02:02	We propose that PAA1 and PAA2 function sequentially in copper transport over the envelope and thylakoid membrane, respectively.
3702	833534	15710407	2007-08-25 10:23	Turnip mosaic virus (TuMV), another member of the genus Potyvirus, multiplied in mutant plants lacking eIF4E but not in mutant
3702	833552	15155880	2007-08-25 13:49	growth and development of the ahk2 ahk3 ahk4 triple mutant were markedly inhibited in various tissues and organs, including the roots and leaves in the vegetative growth phase and the influorescence meristem in the reproductive phase
3702	833552	16361392	2007-08-25 11:24	Results reveal partially redundant functions of the cytokinin receptors and prominent roles for the AHK2/AHK3, but not AHK4, receptor combination in quantitative control of organ growth in plants, with opposite regulatory functions in roots and shoots.
3702	833635	17478634	2007-12-01 10:31	Combined data establish At5g36700 as the gene encoding the photorespiratory 2-phosphoglycolate phosphatase, PGLP1.
3702	833672	15469491	2007-08-25 15:08	We characterized the function of auxin response factor 8 in Arabidopsis by investigating a T-DNA insertion line (arf8-1) and overexpression lines (ARF8 OX) of ARF8.
3702	833672	16107481	2007-08-25 14:15	Auxin response factors ARF6 and ARF8 promote jasmonic acid production, while their gene dosage affects the timing of flower maturation.
3702	833672	16699541	2007-08-25 10:52	Enhance expression of microRNA, miR167, which has a complementary sequence to a portion of the AUXIN RESPONSE FACTOR 8 (ARF8), can cause plant fertility defect.
3702	833672	16829592	2007-08-25 10:13	ARF8 restricts signal transduction processes in ovules and growth in pistils until the fruit initiation cue.
3702	833672	17021043	2007-08-25 14:04	Data show that Arabidopsis microRNA167 controls patterns of ARF6 and ARF8 expression, and regulates both female and male reproduction.
3702	833672	17766399	2008-01-05 14:24	The results of this study suggest that similar mechanisms involving auxin signaling exist to inhibit parthenocarpic fruit set in tomato and Arabidopsis.
3702	833676	17142478	2007-07-02 13:47	SERRATED LEAVES AND EARLY FLOWERING (SEF) gene represses flowering at least in part by positively regulating the expression of the FLC and MAF4 genes in A. thaliana. It interacts with ATARP6 and PIE1 to form a molecular complex. [SEF]
3702	833676	17470967	2007-08-21 09:44	Arabidopsis SWC6 (AtSWC6), SUPPRESSOR OF FRIGIDA 3 (SUF3) and PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1 (PIE1) are homologs of SWC6, ARP6 and SWR1 with roles in development, including floral repression through activation of FLOWERING LOCUS C [SWC6]
3702	833676	18296430	2008-05-24 10:05	part of an Arabidopsis SWR1 chromatin remodelling complex involved in the regulation of diverse aspects of plant development, including floral repression through the activation of FLC and FLC-like genes
3702	833700	17587236	2007-12-13 11:00	CIR1 is possibly part of a regulatory feedback loop that controls a subset of the circadian outputs and modulates the central oscillator.[CIR1] [Circadian 1]
3702	833738	16472779	2006-04-28 21:00	AtGLN1;1 is a substrate of AtCRK3 and their interaction may control nitrogen remobilization during leaf senescence. [AtGLN1;1]
3702	833755	16113225	2006-02-01 11:43	CML24, a gene expressed in diverse organs and responsive to diverse stimuli, encodes a potential Ca(2+) sensor that may function to enable responses to ABA, daylength, and presence of various salts.[CML24]
3702	833756	16267044	2007-08-25 21:03	the cytosolic face of ACA8 mediates early CaM recognition and CaM subsequently competes with the intramolecular autoinhibitor in binding to the other face of the helix
3702	833758	17556585	2007-08-25 15:03	data indicate that AtRHD6(At1g66470)and AtRSL1 (At5G37800) are bHLH transcription factors that are specifically required for the development of root hairs and act downstream of the genes that regulate epidermal pattern formation
3702	833763	17873088	2008-01-19 12:54	The phenotype, stress responses, vitamer levels, and regulation of the vitamin B6 pathway genes in Arabidopsis plants mutant in pyridoxine/pyridoxamine 5'-phosphate oxidase (PDX3) and SALT OVERLY SENSITIVE4 (SOS4) are reported.
3702	833853	17376442	2007-08-25 21:25	We demonstrate here that the optical spectra, EPR spectra and redox potentials of recombinant TCytb are similar to those of the well characterized bovine chromaffin granule Cyt-b561.
3702	833889	15821873	2007-08-25 14:24	investigated the temporal and spatial expression patterns of CYP85A1 and CYP85A2; both promoters of CYP85A1 and CYP85A2 showed maximum activity during the first week following germination, particularly in the vascular tissues
3702	833896	17171374	2007-08-25 15:03	The characterization of ALS1 using aluminum stress and map-based cloning is reported.
3702	833917	16359395	2007-08-25 14:41	CRR7 (At5g39210) is suggested to be the 15th subunit of the chloroplast NDH complex.
3702	833946	17653190	2007-09-14 17:54	Large ARF-GEFs of the GBF1 class perform a conserved role in endoplasmic reticulum-Golgi trafficking and secretion, which is done by GNL1 and GNOM in Arabidopsis. [GNL1]
3702	833946	17653191	2007-09-14 17:58	GNL1 is a BFA-resistant GBF protein that functions with a BFA-sensitive ARF-GEF both at the Golgi and in selective endocytosis, but not in recycling from endosomes. [GNL1]
3702	833951	18704160	2008-09-27 10:38	VIM1, VIM2, and VIM3 have overlapping functions in maintenance of global CpG methylation and epigenetic transcriptional silencing.
3702	833968	16754964	2007-08-25 13:32	The three-dimensional structure of Arabidopsis thaliana protein At5g39720.1 was determined by NMR spectroscopy. Conservation of residues in a hydrophilic cavity able to bind small ligands suggests an active site in AIG2-like proteins.
3702	833979	17449806	2007-11-08 11:31	DEG5 and DEG8 have a synergistic function in the primary cleavage of the CD loop of the PSII reaction center protein D1. [DEG8]
3702	833982	16527868	2006-12-08 18:38	PRE genes may have a regulatory role in gibberellin-dependent development in Arabidopsis thaliana [PRE1].
3702	834014	16786300	2007-08-25 11:54	EMB506 gene expression is required for correct cotyledon-, true leaf- and cauline leaf margin development.
3702	834014	17092312	2007-08-25 10:10	Results lead to the conclusion that EMB506 and AKRP are involved in crucial and tightly controlled events in plastid differentiation linked to cell differentiation, morphogenesis and organogenesis during the plant life cycle.
3702	834026	15469499	2007-08-25 15:08	Used to demonstrate the feasibility of bimolecular fluorescence complementation in plants.
3702	834033	16972096	2007-08-25 11:52	results suggest an important role of AtMYB24 in the normal development of anthers
3702	834042	17369371	2007-08-20 16:17	MAPK KINASE 3 (MKK3)-MAPK 6 (MPK6) unit plays a key role in jasmonic acid-dependent negative regulation of ATMYC2/JIN1 expression.[MKK3]
3702	834042	17933903	2008-04-26 13:09	Results reveal that the MKK3 pathway plays a role in pathogen defense and further underscore the importance and complexity of MAPK signaling in plant stress responses.
3702	834060	16415206	2007-08-25 10:19	gpdhc1 T-DNA insertional mutants exhibited increased NADH/NAD+ ratios compared with wild-type plants under standard growth conditions, as well as impaired adjustment of NADH/NAD+ ratios under stress simulated by abscisic acid treatment.
3702	834065	15563621	2007-08-25 14:17	An analysis of the expression of SDH2-1, SDH2-2, and SDH2-3 (not detected) in A. thaliana, including differential expression in plant organs.
3702	834065	16249327	2007-08-25 12:35	during germination the embryo-specific SDH2-3 is replaced by SDH2-1 or SDH2-2 in mitochondrial complex II
3702	834076	17993547	2008-03-29 12:13	results suggest that loss of cytosolic G6PDH activity affects the metabolism of developing seeds by increasing carbon substrates for synthesis of storage compounds rather than by decreasing the NADPH supply specifically for fatty acid synthesis
3702	834077	17525078	2007-09-04 17:33	AtPHB3 has a role as a positive regulator of expression of a subset of ethylene-regulated genes along with a group of genes required to maintain growth in the presence of ethylene.
3702	834078	16816136	2007-08-25 21:26	LHT1 functions in the uptake of amino acids in roots and the supply of leaf mesophyll with xylem-derived amino acids.
3702	834082	17227549	2007-07-02 12:27	Both ATM and ATR contribute to the induction of a CYCB1;1:GUS fusion by IR, but only ATR is required for the persistence of this response. [ATR]
3702	834088	17143579	2007-08-25 12:25	AtUK/UPRT1 has a dual role in coding for both uridine kinase and uracil phosphoribosyltransferase that form UMP through the pyrimidine salvage pathway in Arabidopsis.
3702	834090	16878138	2007-08-25 10:50	Arabidopsis thaliana CLCa (AtCLCa) is localized to an intracellular membrane, the tonoplast of the plant vacuole; direct evidence for its anion transport ability
3702	834101	16126835	2006-03-08 15:30	GDSL LIPASE1 (GLIP1), in association with ethylene signaling, may be a critical component in plant resistance to necrotrophic fungus Alternaria brassicicola.[GLIP1]
3702	834133	15590742	2005-08-29 09:49	GL3 and EGL3 participate in an intercellular regulatory circuit that controls cell patterning in the Arabidopsis root epidermis [GL3]
3702	834133	17764505	2007-12-22 10:50	A novel interaction between mutant alleles of GLABRA3 and SIAMESE, both required for differentiation, is reported.
3702	834133	17885086	2008-01-19 11:42	The role of GL3 in the initiation of trichomes from pluripotent epidermal cells in Arabidopsis is reported.
3702	834133	18434419	2008-09-27 10:43	Data show that GL3 associates with TRANSPARENT TESTA GLABRA1 in vivo, forming a complex.
3702	834133	18547143	2008-10-04 10:39	the role of GL3 in Arabidopsis trichome formation
3702	834143	17693535	2007-12-22 12:50	BEL1 interacts with the ovule identity MADS box factors when they dimerize with SEPALLATA proteins.
3702	834207	16781668	2007-08-25 13:32	BiP is induced by sugar independent of the cis-element responsible for the unfolded protein response
3702	834213	15923323	2005-11-29 14:56	DRP1 modulates the VAN3 function in vesicle budding from the trans-Golgi network, which regulates vascular formation in Arabidopsis.  [DRP1A]
3702	834213	18256049	2008-04-12 11:06	absence causes impaired endocytosis which may contribute to the development of shorter, fatter roots, probably by reducing cellulose synthesis
3702	834255	16170638	2007-08-25 13:03	The effect of reduced chloroplast number on the photosynthetic competence of leaves of A. thaliana with mutations at accumulation and replication of chloroplasts (ARC) sites ARC3, ARC5, and ARC6 are reported.
3702	834255	18284374	2008-07-12 10:16	Results describe the in vivo quantitative relationship between plastid division proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex.
3702	834261	17993620	2008-03-10 13:39	The nuclear exoribonucleases XRN2 and XRN3 the nucleotidase/phosphatase FIERY1 are endogenous posttranscriptional gene silencing suppressors.
3702	834267	16425307	2007-08-25 22:21	Results describe marneral synthase, an oxidosqualene cyclase that catalyzes iridal skeleton formation by Grob fragmentation.
3702	834270	16623911	2007-08-25 13:34	The Arabidopsis aberrant testa shape mutant encodes a member of the KANADI family of transcription factors (previously referred to as KAN4) that plays a role in integument growth.
3702	834284	16857903	2007-08-25 11:53	a BRI1-interacting protein, BKI1, a negative regulator of brassinosteroid signaling is reported; BKI1 is a substrate of BRI1 kinase & limits interaction of BRI1 with its proposed coreceptor, BAK1, suggesting that BKI1 prevents activation of BRI1 [BKI1]
3702	834292	16223361	2007-08-25 14:13	The isolation and characterization of ATIPK1 is reported.
3702	834300	15456765	2005-01-04 12:52	Arabidopsis SCP-2 is localised to peroxisomes and showed in vitro transfer activity of BODIPY-phosphatidylcholine (BODIPY-PC) from donor membranes to acceptor membranes.
3702	834300	15456765	2007-08-25 22:19	analysis of SCP-2 from Arabidopsis
3702	834312	18434413	2008-09-27 10:43	Data suggest that Arabidopsis csn mutants undergo DNA damage, which might be the cause of the delay in G2 cell cycle progression.
3702	834313	15960617	2007-08-25 11:16	AN3 and AtGRF5 act together and are required for the development of appropriate leaf size and shape through the promotion and/or maintenance of cell proliferation.
3702	834313	17322408	2007-08-25 14:01	Data show that thioredoxin h5 (ATTRX5), but not ATTRX3, is highly induced in sensitive Arabidopsis following victorin treatment.
3702	834313	18635760	2008-08-30 10:25	regulation of NPR1 is through the opposing action of S-nitrosoglutathione and thioredoxins; findings suggest a link between pathogen-triggered redox changes and gene regulation in plant immunity
3702	834353	17400898	2007-08-25 13:24	An Arsenic(V)-tolerant mutant of Arabidopsis thaliana named pht1;1-3, was identified which harbors a semidominant allele coding for the high-affinity Pi transporter PHT1;1. pht1;1-3 displays a slow rate of As(V) uptake.
3702	834363	16923016	2007-08-25 21:17	ETF-beta has a role as part of the electron transfer flavoprotein complex in the catabolism of leucine and involvement in the chlorophyll degradation pathway activated during dark-induced carbohydrate deprivation.
3702	834367	15546349	2005-09-07 15:29	HRT-turnip crinkle virus interaction is unable to generate sufficient amounts of salicylic acid required for a stable resistance phenotype. [HRT]
3702	834367	18182023	2008-05-10 10:22	The evolutionary history of RPP8 in A. thaliana was studied.
3702	834403	14564520	2007-08-25 11:38	proposed that ZWILLE buffers meristem stability non-cell-autonomously by ensuring the critical number of apical cells required for proper meristem function
3702	834408	15598807	2007-08-25 10:59	We propose that AtCLH1 is involved in plant damage control and can modulate the balance between different plant defense pathways.
3702	834408	17996203	2008-02-09 12:01	AtCLHs are not required for senescence-related chlorophyll breakdown in vivo and propose that genuine chlorophyllase has not yet been molecularly identified
3702	834411	16126863	2006-02-01 10:49	YUCCA5 is a dominant suppressor of the ERECTA (ER)gene and the suppression of the er inflorescence phenotype was due to overexpression of YUCCA5. [YUCCA5]
3702	834412	15792961	2007-08-25 13:11	the peroxisome is one of the cargos translocated by MYA2 on actin filaments
3702	834412	18178669	2008-07-26 10:05	knockouts exhibited defects in root hair elongation suggesting that the myosin-driven motility plays a significant role in a polar tip growth
3702	834412	18598361	2008-09-06 10:41	The localization of the head of MYA2 in living plant cells suggests a close linkage between this myosin XI and cytoplasmic microfilaments that support the rapid streaming of organelles.
3702	834417	17277089	2007-08-25 13:25	S-nitrosoglutathione reductase is an important and widely utilized component of pathogen resistance protein signaling networks conserved in animals and plants.
3702	834421	18215111	2008-05-24 10:05	PDLP1a is targeted to plasmodesmata via the secretory pathway in a Brefeldin A-sensitive and COPII-dependent manner
3702	834430	15653797	2007-08-25 11:33	When AtPCS1 was overexpressed in Arabidopsis the A2::AtPCS1 plants were highly resistant to arsenic, accumulating 20-100 times more biomass on 250 and 300 microM arsenate than wild type.
3702	834430	16133212	2007-08-25 21:06	Cd(2+) tolerance in cultured rolB roots was increased as a result of overexpression of AtPCS1, and further enhanced when reduced glutathione (GSH, the substrate of PCS1) was added to the culture medium.
3702	834430	16766112	2007-08-25 10:14	Arabidopsis PCS1 in the cytosol importantly decreased cadmium tolerance, both cadmium tolerance and accumulation of plants expressing plastidial PCS1 were not significantly affected compared to wild-type.
3702	834430	18467325	2008-08-02 10:40	In contrast to wild type and CePCS transformants, AtPCS1 transformants were Cd-hypersensitive although there was no difference in cadmium accumulation between studied lines.
3702	834469	17059405	2007-08-25 13:28	Mmutations of WRKY33 gene encoding a WRKY transcription factor cause enhanced susceptibility to Botrytis cinerea and Alternaria brassicicola concomitant with reduced expression of the jasmonate-regulated plant defensin PDF1.2 gene.
3702	834473	16240180	2007-08-25 14:14	The functional role of CML42 and CML43 in A. thaliana infected with P. syringae is reported.
3702	834478	18424557	2008-05-29 18:11	TAO1 Encodes a TIR-NB-LRR Protein Required for AvrB-Induced Chlorosis in rpm1 Host Plants. [TAO1]
3702	834489	17337629	2007-08-20 16:21	MAP18 may play a role in regulating directional cell growth and cortical microtubule organization by destabilizing microtubules.[MAP18]
3702	834491	15918888	2007-08-25 12:45	The florally expressed genes At5g23960 and At5g44630, are responsible for the formation of virtually all sesquiterpenes found in the Arabidopsis floral volatile blend.
3702	834499	18088309	2008-05-21 16:00	The results of this study suggest that GASSHO1 and GASSHO2 genes are essential for the formation of a normal epidermal surface during embryogenesis.[GASSHO2] [GSO2]
3702	834503	16857217	2006-10-03 15:49	AtPolH is a Y-family DNA polymerase, homologous to Polymerase eta from yeast, human and other organisms. It is involved in DNA translesion synthesis. [AtPolH]
3702	834503	18366182	2008-06-14 10:23	Evolutionary conservation of efficient T[CPD]T bypass by HsPoleta and AtPoleta may reflect a high degree of exposure of human skin and plants to solar UV-B radiation
3702	834504	15908599	2005-12-06 16:49	A translesion synthesis mechanism exists in higher plants and AtREV1 and AtREV7 have important roles in tolerating exposure to DNA-damaging agents. [AtREV1]
3702	834504	17827267	2008-01-19 12:04	A study was conducted to clarify the function of REV1 by in vitro analysis using a primer extension assay.
3702	834545	17076807	2007-06-27 15:55	NPR3 and NPR4 negatively regulate PR gene expression and pathogen resistance through their association with TGA2 and its paralogs.[NPR3]
3702	834549	15509844	2007-08-25 12:50	Rha1 and Ara7 localize to the perivacuolar compartment(PVC) and that GTP-binding motifs as well as the effector domain are important for localization of Rha1 to the PVC
3702	834549	15546360	2007-08-25 14:45	Localization to endosomes.
3702	834549	18381353	2008-06-28 10:22	The gene, cloned through TAIL-PCR, was found to be a heat-shock factor that maps on chromosome 5, close to and above the RFLP marker m61 and the rha1 structure, mRNA, and translation product are reported.
3702	834561	17951452	2008-04-05 11:13	RPS4 function is regulated at multiple levels, including gene expression, alternative splicing, and protein stability, presumably to fine-tune activity and limit damage inflicted by activated RPS4 protein.
3702	834570	16623881	2007-08-25 11:55	Determins threshold levels of abscisic acid during dehydration and after rehydration.
3702	834607	17655280	2007-10-13 12:36	None of the immunophilins in the chloroplast thylakoid lumen of Arabidopsis except AtCYP20-2 and AtFKBP13 appear to possess prolyl isomerase activity toward peptide substrates.
3702	834629	15743448	2007-08-25 10:23	The localization and function of vacuolar compartments containing SAG12 in senescing leaves of A. thaliana and G. max transgenics.
3702	834629	15797940	2007-08-25 13:41	RT-PCR studies were performed to quantify SAG12 gene expression in waterlogged plants.
3702	834629	16883480	2007-08-25 11:52	Two promoters of senescence-associated ARABIDOPSIS genes, SAG12 and SAG13, were used in tomato plants to express IPT that catalyzes the rate-limiting step in cytokinin biosynthesis.
3702	834633	17123104	2007-08-25 14:03	Comparison of the amino acid sequence of CHLI 1 and CHLI 2 encoded in the genome of acifluorfen herbicide resistant mutant aci5 and wild type revealed in particular alterations of the C-terminal end.
3702	834638	17706632	2008-01-12 12:51	combinatorial action of WOX transcription factors is essential for Arabidopsis embryonic development.
3702	834638	18539115	2008-07-19 10:40	Differential expression of WOX8 gene mediates apical-basal axis formation in the Arabidopsis embryo.
3702	834646	15889294	2007-08-25 10:22	a strong induction of the AtPTR3 gene was obtained in the whole plant upon exposure to salt; results suggest that the AtPTR3 protein is involved in stress tolerance in seeds during germination.
3702	834646	17143616	2007-08-25 12:25	The function and expression regulation of PTR3 are reported.
3702	834660	18419821	2008-07-19 10:11	Ornithine-delta-aminotransferase (deltaOAT, At5g46180), the enzyme converting Orn to pyrroline-5-carboxylate (P5C), is localised in mitochondria and is essential for Arg catabolism.
3702	834663	16792691	2007-08-25 10:14	Arabidopsis cullin 4 is shown to assemble with DDB1, RBX1, DET1 and DDB2 in vitro and in planta.
3702	834663	16844902	2007-08-25 10:14	Arabidopsis CULLIN4 (CUL4) associates with the CDD complex and a common catalytic subunit to form an active E3 ubiquitin ligase both in vivo and in vitro.
3702	834663	18551167	2008-07-26 10:32	CUL4-DDB1A-DDB2 complex is involved in global genome repair of UV-induced DNA lesions.
3702	834666	15842627	2005-11-22 10:35	Phosphatidylinositol phosphates were identified as essential regulators for the voltage-dependent and -independent activation of A. thaliana potassium channels expressed in X. laevis oocytes. [KAT1]
3702	834666	16263909	2007-08-25 11:59	KAT1 was expressed in mammalian HEK293 cells and measured with patch clamp technology in the whole cell configuration. The data show that a depletion of extracellular potassium results in a decrease in channel conductance.
3702	834666	16531497	2007-08-25 21:18	Evidence for SNARE-mediated traffic of the K(+) channel and a role in its distribution within subdomains of the plasma membrane.
3702	834666	16950859	2007-08-25 21:11	This study demonstrated trafficking of plant plasma membrane ion channels is controlled via a conserved mechanism.
3702	834666	17187053	2007-08-25 21:16	Structure prediction for the down state of the Kat1 voltage sensor
3702	834666	17683934	2007-12-08 10:17	Study reports that the hormone abscisic acid, which controls ion transport and transpiration in plants under water stress, triggers the selective endocytosis of the KAT1 K+ channel protein in epidermal and guard cells.
3702	834666	18638455	2008-09-06 10:21	The combination use of the selected detergents enabled the effective purification of functional KAT1 with affinity and gel-filtration chromatography.
3702	834676	16377758	2007-08-25 11:23	these results show that FLS2 constitutes the pattern-recognition receptor that determines the specificity of flagellin perception.
3702	834676	17530419	2007-08-25 12:20	Species-specific differences in flagellin perception abilities to identify LeFLS2 as the flagellin receptor in Ararbidopsis.
3702	834676	17625569	2007-09-04 17:50	FLS2 and BAK1 form a complex in vivo, in a specific ligand-dependent manner, within the first minutes of stimulation with flagellin
3702	834676	17925310	2008-04-05 10:20	Data suggest that the reduced mobility of FLS2 after binding flg22 and its existence in monomeric form are important mechanistic features of FLS2 early signaling.
3702	834700	18653891	2008-08-09 10:12	3 homologous brassinosteroid (BR)-signaling kinases(BSK1, BSK2 encoded by At5g46570, BSK3)were identified; the BSKs are phosphorylated by BRI1; results demonstrate that BSKs are the substrates of BRI1 kinase that activate downstream BR signal transduction
3702	834730	16306062	2007-08-25 12:00	has a plant-specific function in development of myrosin cells
3702	834747	16540482	2006-12-11 16:39	AtUPF1 is involved in the control of seed size and shape and is essential for seedling growth. [AtUPF1]
3702	834747	16740149	2007-08-25 21:27	lba1 is a missense mutation of UPF1 RNA helicase involved in nonsense-mediated mRNA decay
3702	834747	16813578	2007-01-04 15:53	Nonsense-mediated mRNA decay and RNA interference (RNAi) in plants requires UPF1. [UPF1]
3702	834747	17924945	2008-03-22 12:03	Data show that in mutants impaired in the nonsense-mediated decay (NMD) components UPF1, levels of the alternatively spliced AtGRP7 and AtGRP8 transcripts are strongly elevated, implicating UPF1 in the decay of these clock-regulated transcripts.
3702	834756	17922773	2007-12-22 12:46	The results of this study imply that plasma membrane-localized CBL1- and CBL9-CIPK23 complexes simultaneously regulate potassium transport processes in roots and in stomatal guard cells.
3702	834758	16507080	2007-08-25 13:36	BAX INHIBITOR 1 is an attenuator for cell death progression triggered by both biotic and abiotic types of cell death signals in Arabidopsis.
3702	834758	16565524	2007-08-25 13:35	The expression of AtBI-1, which suppresses Bax-induced cell death, in the tapetum at the tetrad stage inhibits tapetum degeneration and subsequently results in pollen abortion, while activation of AtBI-1 at the later stage does not.
3702	834758	17142482	2007-08-25 13:27	A study evaluating the effect of AtBI-1 on calcium homeostasis is reported.
3702	834758	17825821	2007-12-01 12:37	BI-1 requires normal electron transport activity to suppress cell death in yeast
3702	834806	15728336	2005-11-22 09:52	AttDT is critical for regulation of pH homeostasis under certain conditions. [AttDT] [tonoplast dicarboxylate transporter]
3702	834815	17631525	2008-01-12 12:52	can promote flowering by enhancing expression of key flowering time genes such as FLOWERING LOCUS T and SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1
3702	834828	16786301	2007-01-04 15:46	Overexpression of FPS1L leads to mitochondrial dysfunction that renders plants more sensitive to the oxidative stress induced by continuous light. [FPS1L]
3702	834839	16113224	2007-08-25 15:01	This is the first attempt at functional characterization of a release factor in vivo in plants and demonstrates the importance of eRF1-1 function in Arabidopsis.
3702	834842	18218618	2008-05-24 10:05	Ca(2+) binding and phosphorylation synergistically activate the ROS-producing enzyme activity of AtrbohD.
3702	834862	16779554	2007-08-25 21:03	involved in lignin synthesis in plants
3702	834883	15341628	2005-01-27 13:19	Post-translational activation of ADP-glucose pyrophosphorylase [ADPG pyrophosphorylase(AGPase)]
3702	834883	15598655	2007-08-25 13:45	patterns of expression and sugar regulation of Arabidopsis thaliana ADP-glucose pyrophosphorylase
3702	834904	16820699	2007-08-25 14:07	implicated in systemic acquired resistance in planta, and crystallized
3702	834917	16482433	2007-08-25 12:33	results reveal a critical role for AtCAP-C during cell division
3702	834925	16798889	2007-09-03 02:05	AGL80 functions as a transcription factor within the central cell gene regulatory network and controls the expression of downstream genes required for central cell development and function.
3702	834942	17932772	2008-05-10 10:05	panC transgene increased the total pantothenate synthase activity in leaves by up to 500-fold but did not affect the steady-state level of pantothenate, indicating that pantothenate synthase is essential but not limiting for pantothenate production
3702	834951	15161961	2005-09-01 14:35	function of the acyltransferase in phenylpropanoid biosynthesis [hydroxycinnamoyl-coenzyme A shikimate/quinate hydroxycinnamoyltransferase [HCT]
3702	834974	16055690	2007-08-25 22:21	The expression of GEX2 during pollen development is reported.
3702	834975	17012404	2007-08-25 13:29	Maternal and paternal genomes play distinct roles in the regulation of seed size in Arabidopsis, as determined by mutation status of DDM1 and MET1.
3702	834975	18536342	2008-08-02 10:35	control DNA methylation in Arabidopsis thaliana.[review]
3702	834983	17916114	2008-03-10 13:40	HRB1 represents a signaling step that regulates FLOWERING LOCUS T (FT) expression downstream of red and blue light perception.
3702	835019	15299133	2005-08-17 08:19	the AtPng1p gene product acts as a transglutaminase; the first reported plant protein, characterized at molecular level showing TGase activity. [AtPng1p]
3702	835036	16489134	2006-10-06 18:20	FRO6 facilitates the acquisition of iron in response to distinctive developmental cues and the expression is light regulated in a tissue- or cell differentiation-specific manner. [FRO6]
3702	835037	18647837	2008-08-30 10:25	FRO7 plays a role in chloroplast iron acquisition and is required for efficient photosynthesis in young seedlings and for survival under iron-limiting conditions
3702	835052	15310822	2007-08-25 11:11	Expression of AtCLC-c was down-regulated in the presence of nitrate, but ammonium had a much smaller effect while chloride and sulphate did not affect expression.
3702	835054	18192441	2008-07-26 10:16	redundant but also distinct functions compared to cpHsc70-1
3702	835057	15361144	2005-01-28 15:31	requirement of Nfu2 protein for iron-sulfate proteins and ferredoxin cluster assembly [Nfu2]
3702	835061	17224143	2007-08-25 11:48	cDNA corresponding to putative PPOX was obtained
3702	835061	17873088	2008-05-28 13:20	The phenotype, stress responses, vitamer levels, and regulation of the vitamin B6 pathway genes in Arabidopsis plants mutant in pyridoxine/pyridoxamine 5'-phosphate oxidase (PDX3) and SALT OVERLY SENSITIVE4 (SOS4) are reported.[PDX3]
3702	835085	16415212	2006-11-03 17:54	The constitutive high-affinity influx and nitrate-inducible high-affinity influx (but not the low-affinity influx) of higher plant roots require a functional AtNRT3 gene. [AtNRT3.1]
3702	835085	16998085	2007-06-18 16:57	The NRT3.1 gene encodes a key component of the HATS (high-affinity NO3 transport system) and repression of NRT2.1 and NRT3.1 by high nitrates is specifically mediated by the NRT1.1 transporter. [NRT3.1]
3702	835085	17012411	2007-06-28 12:20	AtNAR2.1 is essential for high-affinity transport system of nitrate in Arabidopsis.[NAR2.1]
3702	835129	17616511	2008-01-12 11:13	involved in regulating growth and development in plants and likely to promote or mediate brassinosteroid effects
3702	835164	18434419	2008-09-27 10:43	Data show that TTG1-bHLH-MYB complex directly regulating activators and repressors and the movement of repressors to affect trichome patterning on the Arabidopsis leaf.
3702	835165	15563614	2005-06-10 16:21	data suggest that overall ClpC as a stromal molecular chaperone plays a vital role in chloroplast function and leaf development and is likely involved in photosystem biogenesis. [clpC1]
3702	835165	15659100	2005-11-17 12:00	The interaction of Tic110, Tic40 and Hsp93 in A. thaliana chloroplast protein transport is described. [Hsp93]
3702	835165	17291312	2007-10-06 10:53	Study indicated that a chloroplast Clp protease is involved in regulating chlorophyll b biosynthesis through the destabilization of chlorophyllide a oxygenase protein in response to the accumulation of chlorophyll b.
3702	835179	18309082	2008-03-15 10:10	findings demonstrate how a positive feedback mechanism involving RHD2, reactive oxygen species, and Ca2+ can determine root hair cell shape
3702	835180	17233795	2007-08-25 14:01	co-overexpression of the ZFHD1 and NAC genes restored the morphological phenotype of the transgenic plants to a near wild-type state and enhanced expression of ERD1 in both Arabidopsis T87 protoplasts and transgenic Arabidopsis plants
3702	835218	18356953	2008-07-12 10:06	evolution of a pseudogene: diversity and divergence of HSP23.5
3702	835219	16212605	2007-08-25 13:38	Two closely related RPM1-interacting proteins, RIN2 and RIN3, are characterized in A. thaliana.
3702	835244	15976272	2007-08-25 13:08	SGT1b antagonizes RAR1 to negatively regulate R protein accumulation before infection, and SGT1b has a RAR1-independent function that regulates programmed cell death during infection
3702	835244	17023433	2007-08-25 13:29	MEKK1 is essential for activation of MPK4 and negatively regulates temperature-sensitive and tissue-specific cell death and H(2)O(2) accumulation that are dependent on both RAR1 (resistance protein function) and SID2 (isochorismate synthase)
3702	835244	17148606	2007-08-25 12:24	RAR1 molecularly links pathogen-associated molecular pattern (PAMP)-triggered immunity, effector virulence, and effector-triggered immunity
3702	835244	18052881	2008-03-22 12:02	Genetic analysis revealed that ssi4-induced H(2)O(2) accumulation and spontaneous cell death require RAR1, whereas ssi4-mediated stunting is dependent on SGT1b.
3702	835250	17461784	2007-09-08 11:50	Mutants showed hypersensitivity to ABA, NaCl, KCl, mannitol, glucose and sucrose during germination and post-germination growth, but did not display any significant phenotypes in adult plants.
3702	835256	18069939	2008-07-12 10:26	Data show AtGA20ox1 and AtGA20ox2 act redundantly to promote hypocotyl and internode elongation, flowering time, elongation of anther filaments, the number of seeds that develop per silique and elongation of siliques.
3702	835257	16463203	2007-08-25 14:12	Sucrose-inducible genes are upregulated in pgm leaves at the end of a light treatment, when soluble sugars levels are higher than in the wild type.
3702	835286	17727612	2008-05-05 02:05	results suggest that CRR1 is involved in biogenesis or stabilization of the NDH complex, possibly via the reduction of an unknown substrate
3702	835300	15608331	2005-11-25 17:00	Expression of MSBP1 in hypocotyls is suppressed by darkness and activated by light, suggesting that MSBP1, as a negative regulator of cell elongation, plays a role in plant photomorphogenesis. [MSBP1]
3702	835306	16913865	2007-08-25 13:30	A novel method of activating AtMPK proteins by fusion to a cis-acting mutant of a human MAPK kinase MEK1 was used to confirm that specific members of the AtMPK gene family can activate the RD29A stress pathway.
3702	835307	16913865	2007-08-25 13:30	A novel method of activating AtMPK proteins by fusion to a cis-acting mutant of a human MAPK kinase MEK1 was used to confirm that specific members of the AtMPK gene family can activate the RD29A stress pathway.
3702	835307	17453213	2007-10-27 12:06	The freezing tolerance of 38 independent transgenic potato lines was tested in vitro using plantlets transgenic for the DREB1A gene under control of the rd29A promoter.
3702	835328	16517761	2006-10-12 15:49	PRORS1 codes for PROLYL-tRNA SYNTHETASE that is imported into chloroplasts and mitochondria and is involved in novel aspects of interorganellar crosstalk. Complete absence of PRORS1 disrupts early plant development and causes lethality. [PROS1]
3702	835333	16557401	2007-08-25 12:32	AtUSP (At5g52560) has a critical role in pollen development.
3702	835333	16757173	2007-08-25 13:32	The substrate specificity and kinetic properties of UDP-sugar pyrophosphorylase in Arabidopsis are reported.
3702	835333	17341835	2007-09-14 17:41	AtUSP functions as a UDP-sugar pyrophosphorylase in the salvage pathway, and that the generation of UDP-sugars from monosaccharide 1-phosphates catalyzed by AtUSP is essential for pollen development in Arabidopsis.[AtUSP]
3702	835341	15582930	2005-09-28 10:00	The regulation of AtHSP90-1 and AtHSP90-3 proteins during seed development in A. thaliana. [HSP90-1]
3702	835341	18032631	2008-05-21 14:07	Biochemical reconstitution experiments suggest that RAR1 may function to enhance the SGT1-HSP90 interaction by promoting ternary complex formation. [HSP90]
3702	835369	17892448	2008-01-26 12:53	exhibited significant expression in maturing seeds; results obtained outlined the importance of these plastidial pyruvate kinases for fatty acid synthesis and embryo development
3702	835369	17965177	2008-04-05 13:01	mutant shows delayed germination and seedling establishment dependent on an exogenous sugar supply
3702	835393	17027276	2007-08-25 21:26	Channels formed (at least in part) by AtCNGC1 contribute (along with other channels) to Ca(2+) uptake into plants, and that Ca(2+) uptake into roots through AtCNGC1 affects some aspects of growth in the primary root of Arabidopsis seedlings.
3702	835398	16247555	2007-08-25 13:38	AtFtsH4 is an exclusively mitochondrial protein while AtFtsH11 is found in both chloroplasts and mitochondria.
3702	835398	16972866	2007-08-25 10:47	The A. thaliana FtsH11-encoded protease has a direct role in thermotolerance.
3702	835402	18453151	2008-07-26 10:16	regulates cell-cell interaction involved in stomatal development.
3702	835428	18182029	2008-05-10 10:22	When grown on Pb(II)-containing medium, transgenic Arabidopsis lines overexpressing ACBP1 were more tolerant to Pb(II)-induced stress than the wild type.
3702	835437	16815956	2006-12-01 21:01	YSL1 and YSL3 are involved in the delivery of metal micronutrients to and from vascular tissues. [AtYSL3]
3702	835437	18042200	2008-03-10 13:38	The effects of mutations at YSL1 and YSL3 on mineral metabolism in A. thaliana throughout the life cycle are reported.
3702	835478	15500463	2007-08-25 21:23	The molecular basis for the activity of the protein.
3702	835478	17098808	2007-08-25 12:25	The balance between coexpressed CUC2 and MIR164A then determines the extent of serration.
3702	835478	17251269	2007-08-25 12:23	We show here that plants expressing a miR164-resistant CUP-SHAPED COTYLEDON2 (CUC2) gene have an abnormal phyllotactic pattern in the fully grown stem, despite the pattern of organ initiation by the meristem being normal.
3702	835478	18346190	2008-09-27 10:07	Regulation of axillary meristem formation by miR164 is mediated through CUC1 and CUC2, which in turn regulate LAS.
3702	835493	17220197	2007-08-25 13:26	Developmental expression of HsfA9 is regulated by the seed-specific transcription factor ABSCISIC ACID-INSENSITIVE3 (ABI3).
3702	835504	15331056	2007-08-25 10:28	Data report the determination of the 3-D structure of Arabidopsis thaliana O-methyltransferase, AtOMT1 as well as its dynamics when complexed with its substrate.
3702	835507	15773849	2007-08-25 14:48	Interaction of Toc33 and Oep16 with PORA protein transport in A. thaliana.
3702	835507	15842619	2007-08-25 10:58	The analysis of PORA and PORB import into plastids of intact seedlings revealed an unexpected multiplicity of import routes that differed by their substrate, cell, tissue and organ specificities.
3702	835514	18293007	2008-09-27 10:43	The cytological behavior of a possible early recombination nodules component, MRE11, a protein that is important for the repair of the numerous, programmed deoxyribonucleic acid double-strand breaks (DSBs) that occur early in the meiotic prophase.[
3702	835516	17517886	2007-09-22 11:34	AtATM1, AtATM2, and AtATM3 are a subfamily of Arabidopsis half-molecule ATP-binding cassette transporters implicated in iron homeostasis
3702	835516	18393384	2008-08-23 10:14	results indicate the class VIII myosin ATM2 binds to early endosomes and mediates transportation through the endocytic pathway
3702	835526	17540573	2007-09-08 10:18	THE1 mediates the response of growing plant cells to the perturbation of cellulose synthesis and may act as a cell-wall-integrity sensor.
3702	835550	17656846	2007-09-08 12:35	Polymorphisms and nucleotide variations of the ANK gene cluster are consistent with a tandem gene duplication.
3702	835553	16751347	2007-08-25 11:55	Data suggest that, with respect to Agrobacterium-mediated transformation, all Arabidopsis histone H2A proteins are functionally redundant.
3702	835556	17244481	2007-08-25 15:03	The microtubule-binding site at the tail domain of KatB or KatC can induce microtubules bundling only when the stalk domain is present.
3702	835558	17237350	2007-07-02 16:26	IRX8 affects the level of glucuronoxylan and homogalacturonan in higher plants and it provides an important link between the xylan polymer and the secondary cell wall matrix and directly affects secondary cell wall integrity. [IRX8] [irregular xylem8]
3702	835558	17322407	2007-08-25 14:01	Results suggest that IRREGULAR XYLEM9 (IRX9) is required for normal glucuronoxylan (GX)elongation and indicate roles for IRX8 and FRA8 in the synthesis of the glycosyl sequence at the GX reducing end.
3702	835564	17592111	2007-09-29 10:24	A knockout mutation in the DEG15 gene of Arabidopsis (At1g28320) prevents processing of the glyoxysomal malate dehydrogenase precursor to the mature form.
3702	835567	15546360	2007-08-25 14:45	Localization to endosomes.
3702	835567	16912043	2007-08-25 21:02	analysis of the thiazole biosynthetic enzyme THI1 from Arabidopsis thaliana
3702	835571	17039373	2007-08-25 12:26	The TSB1 system provides a novel selection system distinct from conventional antibiotic selection systems.
3702	835603	17877701	2008-03-10 15:00	Data show that At5g55120, a homologue of GDP-L-galactose phosphorylase (VTC2), encodes a second GDP-L-galactose phosphorylase with similar properties to VTC2.
3702	835603	18463094	2008-08-23 10:38	Arabidopsis VTC2 and VTC5 proteins are enzymes that guanylylate a conserved active site His residue with GDP-L-galactose, forming L-galactose 1-phosphate for vitamin C synthesis, and regenerate the enzyme with phosphate to form GDP.
3702	835609	17644626	2008-01-12 11:12	SIZ1-mediated conjugation of SUMO1 and SUMO2 to other intracellular proteins is essential in Arabidopsis, possibly through stress-induced modification of a potentially diverse pool of nuclear proteins.
3702	835612	17008347	2007-08-25 12:27	This study showed that AtMBD5 becomes localized to the vicinity of chromosomes with the aid of AtRAN3 during cell division.
3702	835616	15908607	2007-08-25 13:08	evidence that AtMAP65-1 and AtMAP65-6, two related proteins, may regulate microtubule organization in different manners
3702	835616	16098102	2007-08-25 14:15	AtMAP65-1 plays a role in the central spindle at anaphase to early cytokinesis but is not essential at the midline of the phragmoplast at later stages.
3702	835616	16847052	2007-08-25 14:07	Data suggest that normal metaphase spindle organisation and the transition to anaphase is dependent on inactivation of AtMAP65-1
3702	835616	17394772	2007-07-02 13:34	AtMAP65-1 might promote tubulin assembly by binding to tubulin dimers in vivo.[AtMAP65-1]
3702	835616	17504815	2007-10-13 12:37	The predicted three-dimensional structure of AtMAP65-1 was used as a basis for analyzing the actual cross-bridging with microtubules in detail.
3702	835618	16169896	2006-03-10 15:14	Indole-3-Acetic Acid Carboxyl Methyltransferase [IAMT1]is involved in Arabidopsis leaf development and has broad implications for auxin-regulated developmental processes.[IAMT1]
3702	835621	17468127	2007-10-13 11:52	A study evaluating the structure-activity relationships in FtsZ1 in A. thaliana is reported.
3702	835621	17725544	2008-01-12 11:11	plastid division protein FtsZ1 may have a function during leaf development in thylakoid organization
3702	835621	18204083	2008-06-28 10:11	The chloroplast division site placement involves a balance between the opposing activities of AtMinE1 and AtMinD1, which acts to prevent FtsZ ring formation anywhere outside of the mid-chloroplast.
3702	835621	18284374	2008-07-12 10:16	Results describe the in vivo quantitative relationship between plastid division proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex.
3702	835632	17253987	2007-10-06 12:27	In edm2 mutants both constitutive and Hyaloperonospora parasitica isolate Hiks1-induced RPP7 transcript levels are reduced, suggesting that EDM2 is either a direct or an indirect regulator of RPP7 expression.
3702	835642	16055690	2007-08-25 22:21	The expression of GEX1 during pollen development is reported.
3702	835643	15686448	2007-08-25 11:31	The substrate specificity of XylT permits the enzyme to act at multiple stages of the plant N-glycosylation pathway.
3702	835643	16675551	2007-08-25 10:16	Data show that expression of a hybrid enzyme of Arabidopsis thaliana xylosyltransferase and human beta-1,4-galactosyltransferase I in tobacco causes a reduction of N-glycans with potentially immunogenic core-bound xylose and fucose residues.
3702	835653	16980565	2007-09-03 02:05	The role of QUARTET1 (QRT1), a pectin methylesterase gene, in the separation of pollen tetrads in A. thaliana is reported.
3702	835657	16113216	2007-08-25 15:01	data clearly demonstrate that TPK1 (KCO1) is a voltage-independent, Ca(2+)-activated, K(+)-selective ion channel in the vacuolar membrane that does not mediate SV-type ionic currents [TPK1]
3702	835657	17563365	2007-08-25 13:58	The two-pore channel TPK1 gene encodes the vacuolar K+ conductance and plays a role in K+ homeostasis.
3702	835657	17764516	2008-01-26 10:20	findings show that AtTPK1 (KCO1), interacts with 14-3-3 proteins (general regulating factors, GRFs; TPK1 seems to provide for a Ca(2+)- and 14-3-3-sensitive mechanism capable of controlling cytoplasmic potassium homeostasis in plants
3702	835664	18390594	2008-08-09 10:18	data suggest that BAM4 facilitates or regulates starch breakdown and operates independently of BAM1 and BAM3
3702	835697	18237745	2008-03-29 11:16	Structural comparison of the two structures shows that the recognition of CBL by CIPK is performed in a similar manner, but inherent interactions confer binding affinity and specificity.
3702	835699	18295718	2008-05-10 10:13	These results suggest that the preferential translation of Hsp81-3 mRNA in heat-shocked Arabidopsis cells involves a ribosome scanning from the 5'-end of the 5'-UTR rather than ribosome entry to the internal site.
3702	835701	15582930	2005-09-28 09:11	The regulation of AtHSP90-1 and AtHSP90-3 proteins during seed development in A. thaliana. [HSP90-3]
3702	835701	17965410	2008-04-10 17:45	HSP90.2 is involved in the heat shock response in A. thaliana. It interacts with AtHsfA7a and AtHsfB1 but only weakly interacts or does not interact with AtHsfA4c.
3702	835717	18385164	2008-07-12 10:06	These findings provide the first insight into the possible contributions of plant ARP8 to nucleolar functions.
3702	835727	17307927	2007-08-25 14:00	Results indicate that although CSN6A and CSN6B retain mostly redundant functions, CSN5A and CSN5B play unequal roles in the regulation of plant development.
3702	835728	11063705	2008-03-28 15:20	A genetic screen for peroxisome defective mutants revealed a pex5 mutant that is sucrose dependent during germination and resistant to the inhibitory effects of IBA on root elongation.
3702	835728	15548601	2008-03-28 15:56	The Arabidopsis pex5-1 mutant is specifically defective in PTS2 (but not PTS1) protein import into peroxisomes, probably because of reduced interaction with the PEX7 PTS2 receptor.
3702	835728	15637057	2007-08-25 15:06	Pex5p and Pex7p play different roles in the maintenance of glyoxysomal and leaf peroxisomal functions in plants
3702	835728	16256065	2007-08-25 13:38	The expression profile of AtLACS6, AtLACS7, AtPEX5, and AtPEX7 revealed that AtLACS6 and 7 have distinct patterns of expression.
3702	835728	18308759	2008-05-31 10:29	Pex5p recognizes Cat1 in a manner distinct from typical PTS1.
3702	835729	17220201	2007-07-02 15:50	GAMT1 and GAMT2 encode enzymes that use S-adenosine-L-methionine (SAM) as a methyl donor to methylate the carboxyl group of GAs. Both genes are expressed most highly in the siliques during seed development. [GAMT2]
3702	835764	17485088	2007-09-29 10:02	cDNAs resulted in elevated phosphofructokinase, but not a prophosphate-dependt form, after transient expression in tobacco leaves.
3702	835778	16525754	2007-08-25 10:54	From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
3702	835780	17991462	2008-01-26 12:52	A mutation analysis showed that AtET2 (At5g56780) affects the expression of various KNAT genes involved in the maintenance of the undifferentiated state of cambial meristem cells and plays a role in the regulation of GA5 and the cell-cycle-related GASA4.
3702	835805	17827350	2008-05-21 12:52	Protein N-myristoylation is systematically associated with shoot meristem development and that SnRK1 (for SNF1-related kinase) is one of its essential primary targets. [NMT1]
3702	835813	15807782	2005-11-16 09:48	Our data suggest that protein phosphatases, sensitive to cantharidin and okadaic acid, are likely involved in regulating AGR1/PIN2-mediated root basipetal auxin transport and gravitropism. [AGR1] [PIN2]
3702	835813	16489343	2007-08-25 13:35	Redistribution of auxin during the gravitropic response may be involved in the regulation of PIN2 protein.
3702	835813	16601151	2007-08-25 13:35	results demonstrate that PIN polarity is a primary factor in determining the direction of auxin flow in meristematic tissues
3702	835813	17889649	2007-11-10 11:55	PP2A and PINOID both partially colocalize with PINs and act antagonistically on the phosphorylation state of their central hydrophilic loop, hence mediating PIN apical-basal polar targeting.
3702	835815	16267044	2007-08-25 21:03	the cytosolic face of ACA8 mediates early CaM recognition and CaM subsequently competes with the intramolecular autoinhibitor in binding to the other face of the helix
3702	835815	16821193	2007-08-25 10:50	Upregulation of ACA8 and ACA9 in response to abscissic acid in A. thaliana seedlings is reported.
3702	835821	15361138	2007-08-25 12:59	survey of the MYB proteins that interact with R/B-like Bbasic helix-loop-helix proteins
3702	835822	17897968	2007-12-29 12:47	DNA ligase IV (LIG4) is not essential for telomere joining.
3702	835842	15447654	2007-08-25 12:39	The SCFZTL complex is characterized in detail.
3702	835842	16258016	2007-08-25 10:40	We show that the effects of ZTL and ELF3 on circadian clock function and early photomorphogenesis are additive.
3702	835842	16428597	2007-08-25 12:33	11 new ztl alleles encompassing mutations in each of the ZTL protein domains are described.
3702	835842	17693530	2007-12-22 12:50	These results show that ZTL targets PRR5 for degradation by 26S proteasomes in the circadian clock and in early photomorphogenesis.
3702	835842	17704763	2007-10-13 11:51	GIGANTEA is essential to establish and sustain oscillations of ZTL by a direct protein-protein interaction
3702	835844	16983073	2007-08-25 12:27	VRN2 and VIN3 are part of a large protein complex that can include the PcG proteins FERTILIZATION INDEPENDENT ENDOSPERM, CURLY LEAF, and SWINGER, that is responsible for histone deacetylation at FLC and histone methylation at FLC in vernalized plants.
3702	835856	18192438	2008-07-26 10:16	elevated in stamen, petal, and sepal abscission zones
3702	835863	17993549	2008-03-29 12:13	The characterization of dethiobiotin synthetase (BIO3) in relationship to BIO1, the second enzyme in the biotin synthesis pathway, is reported.
3702	835864	17993549	2008-03-29 12:13	The characterization of dethiobiotin synthetase (BIO3) in relationship to BIO1, the second enzyme in the biotin synthesis pathway, is reported.
3702	835882	15584963	2007-04-16 15:48	XBAT32 is a novel ubiquitin ligase required for lateral root initiation. Mutation in XBAT32 causes a number of phenotypes including severe defects in lateral root production. XBAT32 gene is expressed abundantly in vascular system of the primary root.
3702	835889	17624331	2007-09-22 10:19	CER3 is not At5g02310 and instead corresponds to WAX2/YRE/FLP1 (At5g57800), a gene of unknown function required for wax biosynthesis
3702	835895	15500462	2005-02-15 11:41	The full-length Arabidopsis ADC lyase polypeptide was translocated into isolated pea chloroplasts and directed the passenger protein to Arabidopsis chloroplasts. [ADC lyase]
3702	835916	16282318	2007-08-25 10:20	results indicate that the Arabidopsis Fip1, like its human counterpart, is an RNA-binding protein
3702	835916	18221017	2008-05-10 10:31	polyadenylation factor subunit, CstF77 was identified as interacting with Fip1[V]; the domain of CstF77 that interacts with Fip1 [V] lies at its extreme C-terminus
3702	835918	15919093	2005-11-10 14:24	YKT61 and YKT62 interact with SYP41 and are essential for membrane fusion mediated by either SYP41 or SYP61 [YKT61]
3702	835926	16113208	2007-08-25 15:01	The interaction of JAC1 with PHOT1 and PHOT2 in chloroplast movement in A. thaliana is reported.
3702	835926	17085510	2007-08-25 13:28	The light, oxygen, or voltage domain (LOV2) of phot2 plays a major role in phototropism and leaf expansion.
3702	835926	17618649	2007-10-20 11:07	analysis of a major conformational change of the linker region in the photochemical reaction of phototropin
3702	835926	17652112	2008-02-09 11:12	results indicate that phot2 mediates the blue light-dependent nuclear positioning and the proper positioning of nuclei and chloroplasts
3702	835926	17662032	2008-01-05 15:45	kinase activity associated with localization to functional sites and triggering of light signal transduction
3702	835926	18252844	2008-08-02 10:05	Data show that the expression level of 5PTase13 was significantly enhanced in phot1 single or phot1 phot2 double mutants under blue light, and suppression of 5PTase13 expression rescued the elongated hypocotyls in the phot1 or phot1 phot2 mutants.
3702	835930	15919093	2005-11-10 15:00	YKT61 and YKT62 interact with SYP41 and are essential for membrane fusion mediated by either SYP41 or SYP61 [YKT62]
3702	835935	16554362	2007-08-25 11:56	MSI1 is a novel gene which regulates flowering.
3702	835935	17021044	2007-08-25 14:04	These results reveal that the functions of FAS1, FAS2 and MSI1 are not restricted to meristems, but are also needed to control genome replication at multiple steps of development.
3702	835935	17855429	2008-02-16 12:57	Data suggest that the Polycomb group protein MSI1 functions in the female gametophyte to determine seed development in plants.
3702	835939	16461380	2007-08-25 21:18	AtATM3 contributes to heavy metal resistance and it may mediate transport of glutamine synthetase-conjugated Cd(II) across the mitochondrial membrane in Arabidopis.
3702	835939	16751345	2007-09-03 02:06	Results show that STABILIZED1 (STA1) is a pre-mRNA splicing factor required not only for splicing but also for the turnover of unstable transcripts and that it has an important role in plant responses to abiotic stresses.
3702	835990	16786303	2007-01-05 15:46	AtUV-DDB2 functions in DNA repair and has a direct or indirect influence on cell proliferation in the plant meristem. [UV-DDB2]
3702	835990	17409070	2007-09-15 10:21	DDB1A-dependent phenotypes indicate a competition between DDB2- and DET1-containing complexes for available DDB1A, while, for DDB1A-independent phenotypes, DDB1B is able to fulfill this role.
3702	835990	18551167	2008-07-26 10:32	CUL4-DDB1A-DDB2 complex is involved in global genome repair of UV-induced DNA lesions.
3702	836003	18544608	2008-08-09 10:11	cytochrome P450 fatty acid omega-hydroxylase CYP86A1 (At5g58860) was identified as a key enzyme for aliphatic root suberin biosynthesis in Arabidopsis.
3702	836013	16640600	2007-08-25 10:51	GIL1 is necessary for light-dependent randomization of hypocotyl growth orientation in Arabidopsis.
3702	836053	17706632	2008-01-12 12:51	combinatorial action of WOX transcription factors is essential for Arabidopsis embryonic development.
3702	836053	18539115	2008-07-19 10:40	Differential expression of WOX2 gene mediates apical-basal axis formation in the Arabidopsis embryo.
3702	836063	18036198	2008-05-24 10:35	Identification of this gene emphasizes the importance of control of the metabolism of DNA in the regulation of the G(1)/S-phase transition at fertilization.
3702	836092	17496122	2007-10-20 10:03	VIP2 interaction with VIP1, a basic domain/leucine zipper motif-containing protein is required for nuclear import and integration of T-DNA.
3702	836101	17711414	2007-12-22 12:50	The characterization of proteins interacting with MBD7, especially PRMT11, is reported.
3702	836101	18211904	2008-05-24 10:06	poly-MBD proteins can directly affect chromatin structure by inducing intra- and inter-chromatin compaction via bridging over multiple methylated CpG sites
3702	836103	16183833	2007-08-25 12:36	Zat12 expression is activated at the transcriptional level during different abiotic stresses and in response to a wound-induced systemic signal
3702	836132	18055606	2008-03-10 15:45	These results indicate that PRR3 might function to modulate TOC1 stability by hindering ZTL-dependent TOC1 degradation.
3702	836152	16361528	2007-08-25 11:24	The lectin receptor kinase encoded by At5g60300 is involved in protein-protein interactions with RGD-containing proteins as potential ligands, and may play a structural and signaling role at the plant cell surfaces.
3702	836163	17041025	2007-08-25 21:11	SIZ1 and sumoylation facilitate basal thermotolerance through processes that are salicylic acid independent.
3702	836163	17163880	2007-06-29 13:48	SIZ1 is required for salicylic acid and PAD4-mediated R gene signalling, which in turn confers innate immunity in Arabidopsis.[SIZ1]
3702	836163	17416732	2007-10-06 11:59	SIZ1 is a SUMO E3 ligase that facilitates conjugation of SUMO to protein substrates.
3702	836163	17644626	2008-01-12 11:12	SIZ1-mediated conjugation of SUMO1 and SUMO2 to other intracellular proteins is essential in Arabidopsis, possibly through stress-induced modification of a potentially diverse pool of nuclear proteins.
3702	836163	17905899	2008-01-12 11:59	SIZ1 regulates Arabidopsis growth and that this SUMO E3 ligase plays a role in drought stress response likely through the regulation of gene expression.
3702	836163	18069938	2008-07-12 10:26	Results suggest that SIZ1 is a floral repressor that not only represses the SA-dependent pathway, but also promotes FLC expression by repressing FLD activity through sumoylation, which is required for full FLC expression in a FRIGIDA background.
3702	836165	18334668	2008-08-02 10:40	Data suggest that AGL62 suppresses cellularization during the syncytial phase of endosperm development and that endosperm cellularization is triggered via direct or indirect AGL62 inactivation by the FIS polycomb complex.
3702	836166	16818444	2007-08-25 14:07	regulation establishes the threshold at which leaves respond to a temporal signal, rather than being a component of this signal.
3702	836175	17468224	2007-10-06 11:58	Based on a model of the PDX1/PDX2 complex, mutation of a single residue uncouples enzyme coordination and in turn provides tangible evidence for the existence of the recently proposed ammonia tunnel through the core of PDX1.
3702	836176	17041027	2007-06-29 10:42	Geminivirus Rep-interacting kinase 1, GRIK1 and GRIK2, interact with the geminivirus replication protein AL1 function by mediating one or more processes during early plant development and geminivirus infection by activating SNF1-related kinases.  [GRIK2]
3702	836181	16167903	2006-01-27 08:21	CSB3 represents a point of metabolic convergence modulating the magnitude of SA-mediated disease resistance to biotrophic pathogens.[CSB3]
3702	836190	15286295	2005-01-26 13:00	Class III HD-Zip AND KANADI genes required for root development
3702	836210	15579661	2007-08-25 11:10	The role of ATR1 in the expression of mulitple gene affecting tryptophan metabolism.
3702	836210	18165328	2008-08-09 10:30	Results conclude that ATR1 positively contribute to pathogen virulence inside host cells.
3702	836213	16284708	2007-08-25 14:14	COBRA's function in maintaining anisotropic expansion may be microtubule-dependent.
3702	836213	16873454	2007-08-25 12:29	Mutations within the COBRA gene that result in a loss of function result in abnormal cell growth throughout the entire plant body and the accumulation of massive amounts of stress response chemicals such as anthocyanins and callose.
3702	836248	18252845	2008-08-02 10:05	Data provide evidence that the mechanism by which PIF7 operate on the phyB signaling pathway under prolonged red light is through maintaining low phyB protein levels, in an additive or synergistic manner.
3702	836252	17569080	2008-02-02 11:13	enhanced stress tolerance seemed to be due to a combination of an increase in transcription and translation rates in comparison to those of COX5C plants transformed with the Hahb-4 promoter
3702	836259	15516515	2007-08-25 11:33	This study demonstrated a light-entrained circadian clock regulates ethylene release from unstressed, wild-type Arabidopsis (Arabidopsis thaliana) seedlings, with a peak in the mid-subjective day.
3702	836259	16212608	2007-08-25 13:38	The function of ELF3 and ELF4 in their light-regulated expression associated with CCA1, LHY, and TOC1 as part of the central oscillator of the circadian clock in Arabidopsis is reported.
3702	836259	17483414	2007-09-29 10:26	TOC1 regulates the floral transition in a CCA1/LHY-dependent manner while CCA1/LHY functions upstream of TOC1 in regulating a photomorphogenic process.
3702	836259	17540692	2007-12-01 11:25	The linkages of TOC1, CCA1 and LHY genes and the canonical CO-FT flowering pathway were studied.
3702	836259	18055606	2008-03-10 15:45	These results indicate that PRR3 might function to modulate TOC1 stability by hindering ZTL-dependent TOC1 degradation.
3702	836259	18178585	2008-05-31 10:29	The linkages between TOC1 and PRR5 in the regulation of the biological clock of A. thaliana were studied.
3702	836263	17420480	2007-10-20 12:25	Myb28 is a positive regulator for basal-level production of aliphatic glucosinolates.
3702	836263	17521412	2007-10-13 11:06	We hypothesize that HAG1/MYB28 is a novel regulator of aliphatic glucosinolate biosynthesis that controls the response to biotic challenges
3702	836269	17570668	2007-09-08 10:48	the PXY gene encodes for a receptor-like kinase (RLK) that defines a novel role for RLKs in the meristem where it functions to maintain the cell polarity required for the orientation of cell division during vascular development
3702	836298	17434984	2007-10-06 10:53	for AtIpk2beta in axillary shoot branching through the auxin signaling pathway
3702	836307	9783581	2007-02-01 10:37	LEAFY activates the expression of floral organ identity genes APETALA3, AGAMOUS and APETALA1
3702	836307	15695467	2007-08-25 21:23	FT regulates SOC1 expression, and SOC1 regulates LFY expression
3702	836307	16554366	2007-08-25 11:56	The transcription factor LFY controls the switch from vegetative to reproductive development.
3702	836307	16915521	2007-08-25 12:28	Mustard plsnt LcrLFY has diverged from A. thaliana in both the cis-regulatory and protein-coding regions which contribute to the evolution of rossette flowering.
3702	836307	16920780	2007-08-25 10:49	GA(4) is the active GA in the regulation of LFY transcription and Arabidopsis flowering time under short-day conditions.
3702	836307	18287201	2008-06-14 10:14	Activation of the LFY transcriptrion factor is required.
3702	836311	17631528	2008-01-12 12:52	Overexpression of BAP1 or BAP2 with their partner BON1 inhibits programmed cell death induced by pathogens, the proapoptotic gene BAX, and superoxide-generating paraquat.
3702	836321	15960614	2005-11-21 15:25	ARF2 is a part of transcriptional complexes responsible for regulating diverse signaling pathways leading to pleiotropic developmental defects. [ARF2][Auxin Response Factor 2]
3702	836321	16176952	2007-08-25 21:05	ARF2 expression was induced in senescing leaves. ARF2 regulated leaf senescence and floral organ abscission independently of the ethylene and cytokinin response pathways
3702	836321	16339187	2007-08-25 13:02	mutant phenotype and gene expression studies provide evidence that MNT/ARF2 is a repressor of cell division and organ growth
3702	836321	18596113	2008-08-30 10:25	IAA28 overexpressing and knock-down lines showed no major morphological changes, whereas IAA13 and ARF2 overexpressing plants grew more slowly than the wild type.
3702	836321	18599455	2008-09-06 10:41	study describes a direct connection between the brassinosteroid-regulated BIN2 kinase and ARF2; phosphorylation by BIN2 results in loss of ARF2 DNA binding and repression activities
3702	836344	16002616	2005-11-30 12:00	Three ERECTA-family leucine-rich repeat-receptor-like kinases (ER, ERL1,ERL2) together control stomatal patterning, with specific family members regulating specification of stomatal stem cell fate & differentiation of guard cells. [ERL1]
3702	836344	17652352	2007-11-10 12:44	ERL2 is haploinsufficient for maintaining female fertility in the absence of ER and ERL1.
3702	836359	16103214	2005-11-18 15:00	Transcription switch for plant metaxylem and protoxylem vessel formation [Vnd6] [VASCULAR-RELATED NAC-DOMAIN6 ]
3702	836364	16002617	2007-08-25 10:21	findings show that FKF1 controls daily CONSTANS expression in part by degrading CYCLING DOF FACTOR 1 (CDF1), a repressor of CONSTANS transcription [CDF1]
3702	836365	15341625	2007-07-06 10:00	DOMINO1 encodes a protein essential for nuclear and nucleolar functions. GFP protein fusion experiment shows that DOMINO1 is targeted to the nucleus. [DOMINO1]
3702	836370	18281505	2008-08-02 10:05	Data find that antibodies directed against EB1 proteins colocalize with microtubules in roots, and that mutants with reduced expression from EB1B genes have roots that deviate toward the left on vertical or inclined plates.
3702	836372	16377568	2007-08-25 21:14	It was found that SR05 together with P5CDH generates 2 types of SiRNAs.
3702	836373	15548746	2007-08-25 10:23	Accordingly, overexpression of AtP5CDH resulted in decreased sensitivity to externally supplied Pro. Thus, Pro and P5C/Glu semialdehyde may serve as a link between stress responses and cell death.
3702	836373	16377568	2007-08-25 21:14	It was found that the antisense overlapping gene pair of P5CDH and SR05 generates 2 types of siRNAs.
3702	836379	16055690	2007-08-25 22:21	The expression of VEX1 during pollen development is reported.
3702	836431	16648464	2007-08-25 10:16	HDA6 erases histone acetylation as a key step in an epigenetic switch mechanism that silences rRNA genes through concerted histone and DNA modifications.
3702	836431	18024558	2008-03-29 10:21	These results suggest that during germination in Arabidopsis, HDA6 and HDA19 redundantly regulate the repression of embryonic properties directly or indirectly via repression of embryo-specific gene function.
3702	836431	18212027	2008-04-12 11:11	involved in jasmonate response, senescence, and flowering
3702	836451	15465053	2007-08-25 14:18	Data suggest that binding of nucleotide to nucleoside diphosphate kinase 2 (NDPK2) plays a regulatory role in phytochrome signaling and that the C-terminal extension of NDPK2 provides a potential binding surface for interaction with phytochromes.
3702	836451	15561724	2007-08-25 15:01	characterization of the interaction between phytochrome and NDPK2
3702	836451	17562072	2007-12-01 10:46	localizes only to chloroplasts, not to the cytosol
3702	836451	17785451	2008-03-29 13:06	Data suggest that the interaction of SOS2 with both NDPK2 and CATs2 and 3 reveals a point of cross talk between salt stress response and other signaling factors including H2O2.
3702	836451	18628957	2008-09-27 10:06	NDPK2 plays a critical role in the AtPP7 regulation of the phytochrome pathway
3702	836457	15677481	2007-08-25 12:03	Data demonstrate that At4g05160 and At5g63380 have the capacity to contribute to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors.
3702	836459	16891550	2007-08-25 10:12	a role for ADK and the S-adenosyl-L-methionine pathway in the control of root gravitropism and cap morphogenesis
3702	836478	17719613	2008-05-03 10:58	structure activity relatiionship of FLS
3702	836497	18466768	2008-07-26 10:16	DGK1 and DGK2 from cluster I in Arabidopsis thaliana possess amino-terminal hydrophobic segments that are sufficient to address them to endoplasmic reticulum membranes.
3702	836500	18165329	2008-08-09 10:30	Results show MUM2 is localized to the cell wall and it is proposed that MUM2 is involved in modifying mucilage to allow it to expand upon hydration, establishing a link between the galactosyl side-chain structure of pectin and its physical properties.
3702	836500	18165330	2008-08-09 10:30	Data conclude that the MUM2/BGAL6 beta-D-galactosidase is required for maturation of rhamnogalacturonan I in seed mucilage by the removal of galactose/galactan branches, resulting in increased swelling and extrusion of the mucilage on seed hydration.
3702	836506	17720867	2007-12-22 12:30	UV-B stimulates the nuclear accumulation of both a green fluorescent protein (GFP)-UVR8 fusion and native UVR8.
3702	836506	18055587	2008-06-07 10:30	This research provides evidence that, in ultraviolet B (UV-B) signaling, UVR8, HY5, and HYH act together and demonstrates a new role for HYH in UV-B responses.
3702	836507	17238907	2007-08-25 13:26	AtPP7 interacts with calmodulin and with a heat shock transcription factor.
3702	836507	18628957	2008-09-27 10:06	NDPK2 plays a critical role in the AtPP7 regulation of the phytochrome pathway
3702	836519	15500469	2007-08-25 21:23	HOS2 is identical to the FIERY1 gene previously described.
3702	836519	17993620	2008-03-10 13:39	The nuclear exoribonucleases XRN2 and XRN3 the nucleotidase/phosphatase FIERY1 are endogenous posttranscriptional gene silencing suppressors.
3702	836528	16567499	2007-08-25 10:53	PI-4Kbeta1 interacts with RabA4b through a novel homology domain, and interacts with a Ca2+ sensor through its NH2 terminus.
3702	836562	16149917	2007-08-25 11:25	ScOPT1 and AtOPT4 are proton-coupled OPTs with broad but distinct substrate specificities and affinities.
3702	836565	16880402	2007-01-08 16:16	AtFAAH is one, but not the only, modulator of endogenous N-Acylethanolamines (NAE) levels in plants, and that NAE depletion likely participates in the regulation of plant growth [fatty acid amide hydrolase] [AtFAAH]
3702	836574	18069942	2008-07-12 10:26	Findings suggest that XND1 affects tracheary element growth through regulation of secondary wall synthesis and programmed cell death.
3702	836584	16436052	2007-08-25 12:34	We conclude that CAF-1 ensures the stable inheritance of epigenetic states through growth and development in Arabidopsis.
3702	836584	16452472	2007-08-25 12:33	results suggest that chromatin assembly factor CAF-1 functions in heterochromatin formation
3702	836584	17021044	2007-08-25 14:04	These results reveal that the functions of FAS1, FAS2 and MSI1 are not restricted to meristems, but are also needed to control genome replication at multiple steps of development.
3702	836584	17110925	2007-08-25 10:45	Depletion of FAS2 increased the frequency of somatic homologous recombination (HR) in planta approximately 40-fold.
3702	836595	16404578	2007-08-25 11:58	The ordered transverse orientation of microfibrils at the inner face of the cell wall was severely disrupted in prc-1 hypocotyls, particularly in the early growth phase.
3702	836595	18485206	2008-07-19 10:40	The Arabidopsis procuste1 (prc1-1) cellulose synthase mutant was studied in order to investigate the role of the cell wall loosening during the early stages of hair formation.
3702	836595	18495638	2008-08-30 10:39	CESA 1, 3, and 6 form a complex which is important for cellulose synthesis.
3702	836596	16227468	2006-02-14 09:15	AP2-like ABA repressor 1 (ABR1) gene functions as a negative regulator of ABA responses. [ABR1]
3702	836603	17683937	2008-01-12 10:21	LIP1 plays a unique negative role in controlling circadian light input and is required for precise entrainment of the plant clock.
3702	836613	16785434	2007-05-25 11:58	AtPep1 is a 23-aa peptide derived from AtPep1 precursor gene PROPEP1, which activates transcription of the defensive gene defensin (PDF1.2). [AtPep1]
3702	836617	18033818	2008-04-19 11:50	CPR5 has early-life beneficial effects by repressing cell death and insuring normal plant development, but late-life deleterious effects by promoting developmental senescence.
3702	836617	18485217	2008-07-19 10:40	CPR5 is unlikely to be a specific regulator of pathogen response pathways or senescence, but rather functions either in cell wall biogenesis or in multiple cell signaling or transcription response pathways.
3702	836620	18208522	2008-05-24 10:06	The function and metabolism of CDKC2 is reported.
3702	836640	16249327	2007-08-25 12:35	during germination the embryo-specific SDH2-3 is replaced by SDH2-1 or SDH2-2 in mitochondrial complex II
3702	836699	16751349	2007-07-02 15:00	Analysis of BAM1 and BAM2 reveal a cell-cell communication process important for early anther development, including aspects of cell division and differentiation [BAM1]
3702	836701	17417719	2007-09-04 17:34	NFS1 has a role in mediating the assembly of iron-sulfur clusters in mitochondria.
3702	836709	15699063	2005-11-17 12:36	Expression in response to plant growth regulators and abiotic stress in roots and aerial parts as demonstrated by expression of the GUS reporter in A. thaliana. [ACS5]
3702	836724	11404361	2008-03-28 15:31	CHY1 encodes an enzyme acting in valine catabolism; seedlings deficient in CHY1 are sucrose-dependent during germination, probably because accumulation of a valine catabolic intermediate blocks fatty acid beta-oxidation.
3702	836733	15605178	2007-08-25 11:32	The isolation and characterization of the protein, its homology to proteins of other plants, and targeting to the Golgi apparatus.
3702	836737	17092312	2007-07-02 12:44	Results lead to the conclusion that EMB506 and AKRP are involved in crucial and tightly controlled events in plastid differentiation linked to cell differentiation, morphogenesis and organogenesis during the plant life cycle. [AKRP]
3702	836745	15165187	2007-08-25 11:35	a mutant Rad17 pathway is associated with a general deregulation of DNA repair, which seems to be correlated with a deficiency in non-homologous double strand break repair.
37